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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病源性轻度认知障碍诊断标准推荐显示文摘美国国立老化研究所(NIA)和阿尔茨海默病协会(ADA)组织了一个工作组,负责阿尔茨海默病(AD)痴呆前症状阶段——即本文所称的AD源性轻度认知障碍(MCI)的诊断标准的制订及完善。该工作组制订了以下两套标准:(1)在缺乏相应条件进行先进影像技术及脑脊液检查时,医务人员适用的核心临床标准;(2)适用于包括临床试验在内的科学研究的研究标准。后者纳入了基于影像技术及脑脊液检查的生物标志物的应用。并根据所出现的生物标志物的性质,将最终MCI诊断的确定性程度分为4个级别。而要使生物标志物有效应用于诊断,并在社区医疗服务中规范使用,尚需做大量的工作。 | McKhann GM Knopman DS Chertkow H Hyman BT Jack CR Jr Kawas CH Klunk WE Koroshetz WJ Manly JJ Mayeux R Mohs RC Morris JC Rossor MN Schehens P Carrillo MC Thies B Weintraub S Phelps CH 贾建平(译) 陆璐(译) 张逸驰(译) 黄丽黄(译) 礼媛(译) | 2012 | 中华神经科杂志2012，45，5： | 51 |
| 2 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病痴呆诊断标准的推荐显示文摘由美国国立老化研究所(NIA)和阿尔茨海默病(AD)协会组织了一个工作组,负责修订1984年版AD痴呆的诊断标准。旨在确保修订后的标准具有足够的灵活性,既可供缺乏神经心理学测验、先进的影像技术和脑脊液检查措施的普通医务人员使用,也可供具备上述措施的科研、临床试验的专业研究者使用。新的标准广泛适用于各种原因的痴呆以及专门针对AD痴呆的标准,保留了1984年版标准中的“很可能的AD痴呆”的总体框架。在过去27年的经验基础上,工作组对临床诊断标准做了一些修改,保留了“可能的AD痴呆”的术语,但对其进行了更有针对性的重新定义。在科研用的“很可能的和可能的AD痴呆”的诊断标准中纳入了生物标志物证据。AD痴呆的核心临床标准仍将是临床实践中诊断的基础,但用生物标志物证据来提高AD痴呆诊断的病理生理学特异性也被人们寄予厚望。要实现AD痴呆的生物标志物诊断,还有许多工作摆在面前。 | McKhann GM Knopman DS Chertkow H Hyman BT Jack CR Jr Kawas CH Klunk WE Koroshetz WJ Manly J J Mayeux R Mohs RC Morris JC Rossor MN Scheltens P Carrillo MC Thies B Weintraub S Phelps CH 贾建平(译) 陆璐(译) 张逸驰(译) 黄丽(译) 韩阅(译) | 2012 | 中华神经科杂志2012，45，5： | 52 |
| 3 | Autoantibody profiles in autoimmune hepatitis and chronic hepatitis C identifies similarities in patients with severe disease显示文摘AIM To determine how the auto-antibodies(Abs) profiles overlap in chronic hepatitis C infection(CHC) and autoimmune hepatitis(AIH) and correlate to liver disease.METHODS Levels of antinuclear Ab, smooth muscle antibody(SMA) and liver/kidney microsomal-1(LKM-1) Ab and markers of liver damage were determined in the sera of 50 patients with CHC infection, 20 AIH patients and 20 healthy controls using enzyme linked immunosorbent assay and other immune assays. RESULTS We found that AIH patients had more severe liver disease as determined by elevation of total Ig G, alkaline phosphatase, total serum bilirubin and serum transaminases and significantly higher prevalence of the three non-organ-specific autoantibodies(auto-Abs) than CHC patients. Antinuclear Ab, SMA and LKM-1 Ab were also present in 36% of CHC patients and related to disease severity. CHC cases positive for auto-Abs were directly comparable to AIH in respect of most markers of liver damage and total Ig G. These cases had longer disease duration compared with auto-Ab negative cases, but there was no difference in gender, age or viral load. KLM-1+ Ab CHC cases showed best overlap with AIH. CONCLUSION Auto-Ab levels in CHC may be important markers of disease severity and positive cases have a disease similar to AIH. Auto-Abs might have a pathogenic role as indicated by elevated markers of liver damage. Future studies will unravel any novel associations between these two diseases, whether genetic or other. | Kawa Amin Aram H Rasool Ali Hattem Taha AM Al-Karboly Taher E Taher Jonas Bystrom | 2017 | World Journal of Gastroenterology2017，23，8： | 5 |
| 4 | High serum IgG4 concentrations in patients with sclero sing pancreatitis 显示文摘 | Hamano H Kawa S Horiuchi A | 2001 | N Engl J Med2001，344，： | 1 |
| 5 | Rhokimase as anovel therapeutic target in treatment of cardiovascular diseases显示文摘 | shimo kawa H | 2002 | cardiovasc pnarmacd2002，39，3： | 1 |
| 6 | High serum lgG4 concentrations in patients with selerosing pancreatitis显示文摘 | Hamano H Kawa S Horiuchi A | 2001 | N Engl J Med2001，344，10： | 1 |
| 7 | High serum IgG4 concentrations in patients with sclerosing pancreatitis显示文摘 | Hamano H Kawa S Horiuchi A | 2001 | N Engl J Med2001，344，10： | 1 |
| 8 | Optical constants of ZnO显示文摘 | Kawa H Y Adachi S | 1997 | Japan J Appl Phys1997，36，： | 1 |
| 9 | High serum IgG4 concentration in patients with sclerosing pancreatitis 显示文摘 | Hamano H Kawa S Horiucbi A | 2001 | N Engl J Med2001，344，： | 1 |
| 10 | High-Resolution Inkjet Printing of All-Polymer Transistor显示文摘 | Sirringhaus H Kawas T Friend RH | 2000 | Science2000，290，： | 1 |
| 11 | Improved leakage and ferroelectric properies of Mn and Ti codoped BiFeO3 thin film 显示文摘 | KAWAE T TERAYCHI Y TSUDA H | 2009 | Appl Phys Lett2009，94，11： | 1 |
| 12 | Sclerosing pancreato-cholangitis responsive to corticosteroid theropy: report of 2 case reports and review显示文摘 | HoriuchiA Kawa S Hamano H | 2001 | Gastrointest Endosc2001，53，： | 1 |
| 13 | Nationwide survey of hemophagocytic lymphohistiocytosis in Japan 显示文摘 | Ishii E Ohga S Imashuku S Yasukawa M Tsuda H Miura I Yamamoto K Horiuchi H Takada K Ohshima K Nakamura S Kinukawa N Oshimi K Kawa K | 2007 | IntJ Hematol2007，86，1： | 1 |
| 14 | Proposed guide- lines for diagnosing chronic active Epstein -Barr virus infec- tion显示文摘 | OKANO M KAWA K KIMURA H | 2005 | Am J Hematol2005，80，1： | 1 |
| 15 | High serum IgG4 concentrations in patients with sclerosing pancreatitis 显示文摘 | Hamano H Kawa S Horiuchi A | | N Engl J Med0，344，： | 1 |
| 16 | Hilar and pancreatic gallium-67 accumulation is characteristic feature of autoimmune panereatitis显示文摘 | Saegusa H Momose M Kawa S | 2003 | Pancreas2003，27，1： | 1 |
| 17 | Hydronephrosis associated with retroperitoneal fibrosis and selerosing panereatitis 显示文摘 | Hamano H Kawa S Ochi Y | 2002 | lancet2002，359，9315： | 1 |
| 18 | Immunohistochemi-cal analysis of P(53) and bcl-2 in benign and malignant salivary glands tumors显示文摘 | A1-Rawi NH Omer H AI Kawas S | 2010 | J Oral Pathol Med2010，39，1： | 1 |
| 19 | Proposed guide- lines for diagnosing chronic active Epstein-Barr virus infection显示文摘 | OKANO M KAWA K KIMURA H | 2005 | Am J Hematol2005，80，： | 1 |
| 20 | High serum IgG4concentrations in patients with sclerosing pancreatitis显示文摘 | Hamano H Kawa S Horiuchi A | 2001 | N Engl J Med2001，344，10： | 1 |
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