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| 1 | 饮水微量元素与老年人群认知能力关系研究显示文摘在中国山东与河南两省农村研究了饮水中微量元素与老年人群认知能力 (CognitiveFunction)之间的关系。采用中国国标方法分析了饮水中氟、钙、硒、铝、铁、锌、镉、铅、砷微量元素和pH值 ;用老年性痴呆症 (Dementia)调查表 ,进行了≥ 6 5岁老年暴露人群认知能力的测定。调整年龄、性别和文化水平后 ,对微量元素与老年认知能力之间的关系进行直线模型、二次方模型和联合作用模型的统计分析 ,评价饮水中每种微量元素浓度对老年认知能力的影响。结果表明 ,单因素分析时发现几种微量元素对老年认知能力有明显作用。然而 ,在调整其它元素水平后 ,其中一些元素的作用消失。饮水中钙浓度对老年认知能力呈现一作用曲线 ,即随着饮水钙水平升高而认知能力增加 ;到某一点高峰后 ,又随钙水平增加而认知能力降低。而锌与镉之间存在一种相互作用 ,即在低饮水镉水平时 ,锌浓度与认知能力呈正相关 ,但在高饮水镉水平时 。 | 梁超轲 吉荣娣 曹静祥 姜玉亭 余波 马凤 吴云鹏 应波 张妍 孙淑庄 Li Yiming Christine L Emsley Gao Sujuan Kathleen S Hall Hugh C Hendrie | 2003 | 卫生研究2003，32，5： | 12 |
| 2 | Elevated blood pressure: Our family's fault?The genetics of essential hypertension显示文摘AIM: To provide an updated review on current genetic aspects possibly affecting essential hypertension(EH), and to further elucidate their role in EH. METHODS: We searched for genetic and epigenetic factors in major studies associated with EH between Jan 2008-Oct 2013 using PubMed. We limited our search to reviews that discussed mostly human studies, and were accessible through the university online re-source. We found 11 genome wide association studies(GWAS), as well as five methylation and three miRNA studies that fit our search criteria. A distinction was not made between genes with protective effects or nega-tive effects, as this article is only meant to be a sum-mary of genes associated with any aspect of EH.RESULTS: We found 130 genes from the studies that met our inclusion/exclusion criteria. Of note, genes withmultiple study references include: STK39, CYP17A1, MTHFR-NPPA, MTHFR-NPPB, ATP2B1, CSK, ZNF652, UMOD, CACNB2, PLEKHA7, SH2B3, TBX3-TBX5, ULK4, CSK-ULK3, CYP1A2, NT5C2, CYP171A, PLCD3, SH2B3, ATXN2, CACNB2, PLEKHA7, SH2B3, TBX3-TBX5, ULK4, and HFE. The following genes overlapped between the genetic studies and epigenetic studies: WNK4 and BDKRB2. Several of the identified genes were found to have functions associated with EH. Many epigenetic factors were also correlated with EH. Of the epigenetic factors, there were no articles discussing siRNA and its effects on EH that met the search criteria, thus the topic was not included in this review. Among the miRNA tar-gets found to be associated with EH, many of the genes involved were also identified in the GWAS studies.CONCLUSION: Genetic hypertension risk algorithms could be developed in the future but may be of limited benefit due to the multi-factorial nature of EH. With emerging technologies, like next-generation sequenc-ing, more direct causal relationships between genetic and epigenetic factors affecting EH will likely be discov-ered creating a tremendous potential for personalized medicine using pharmacogenomics. | Aniket Natekar Randi L Olds Meghann W Lau Kathleen Min Karra Imoto Thomas P Slavin | 2014 | World Journal of Cardiology2014，6，5： | 7 |
| 3 | Sperm counts and sperm sex ratio in male infertility patients显示文摘在最近的年里,调查者在许多工业化国家向男出生的一个衰退比例注意了一个趋势。当人们忍受决定性的染色体时,它与授精或流产相关的女搭挡的角色可以也改变性比率。我们试图由直接检验他的精子的性染色体决定一个人的第二等的性比率(F1 产生) 。我们为在 situ 杂交(鱼) 经历了精液荧光的所有人检验了我们的男不孕诊所数据库。人口统计的病人和精液参数被记录。摆平 Chi 的分析被用来比较性比率(Y 染色体 / 总数染色体) 。Multivariable 逻辑回归被用来预言在财务以后拥有一个忍受 Y 精子为的机会人口统计并且精液参数。185 个人的一个总数经历了精子鱼。为全部队, Y 忍受染色体的精子的比例是 51.5 %。有不到 500 万个能动精子的人有 Y 忍受染色体的精子的一个显著地更低的比例(50.8 %) 与有更高的精子计数的人相比(51.6 %P=0.02 ) 。在 multivariable 调整以后,更高的精子集中,全部的能动精子计数和精液体积显著地增加了有 Y 的机会忍受染色体的精子(P< 0.01 ) 。作为一个人的精子生产衰落,那么做 Y 忍受染色体的精子的比例。因此,一个人的繁殖潜力可以预言他的能力到陛下男性后代。 | Michael L Eisenberg Lata Murthy Kathleen Hwang Dolores J Lamb Larry I Lipshultz | 2012 | Asian Journal of Andrology2012，14，5： | 3 |
| 4 | Experience with PICC at a university medical center显示文摘 | | 1997 | J Intraven Nuts1997，20，6： | 1 |
| 5 | Experience eith PICC at a univeversity medical center显示文摘 | Kathleen Christine L | 1997 | J Intrave Nurs1997，20，： | 1 |
| 6 | Blood donation is an act of be- nevolence rather than altruism显示文摘 | Eamonn F Kathleen F Claire L | 2008 | Health Psychology2008，27，3： | 1 |
| 7 | Performance monitoring and stop signal inhibition in abstinent patients with cocaine dependence显示文摘 | Chiang-shan Ray L Verica M Kathleen K | 2006 | Drug Alcohol Depend2006，，85： | 1 |
| 8 | Experience with PICC at a university medical center显示文摘 | Kathleen C L | 1997 | J Interaven Nurs1997，20，6： | 1 |
| 9 | The Stereospecific Determination of Fluoxetine and Norfluoxetine Enantiomers in Human Plasma by High-Pressure Liquid Chromatography (HPLC) with Fluorescence Detection显示文摘 | Albert L Peyton Russell Carpenter Kathleen Rutkowski | | 0，，12： | 1 |
| 10 | Experience with PICC at a university medical center显示文摘 | Kathleen D Christine L | 1997 | Jintrowen Nurs1997，20，： | 1 |
| 11 | The ultrasonographic appearance of ovarian ectopic pregnancies显示文摘 | Christine C Kathleen H Wesley L | 2005 | Obstet Gynecol2005，105，： | 1 |
| 12 | Anaerobic biotransformation of estrogens显示文摘 | CYNTHIA P C KATHLEEN L L | 2006 | Sci Total Environ2006，367，23： | 1 |
| 13 | Tourist ' perceptions of environmentally re- sponsible innovations at tourism businesses显示文摘 | Kathleen L A | 2009 | Journal of Sustainable Tourism2009，17，48： | 1 |
| 14 | Ascorbic Acid Selectively Improves Large Elastic Artery Compliance in Postmenopausal Women 显示文摘 | Kerrie L Moreau Kathleen M | 2005 | Hypertension2005，45，： | 1 |
| 15 | Struetural and kinetic analysis of the substrate specificity of human fibroblast activation protein a 显示文摘 | Kathleen A Irena L Lihong S | 2005 | J Bid Chem2005，280，19： | 1 |
| 16 | Nursing PHD consortia: A model for maximizing scarce resources显示文摘 | Kathleen A L | 2007 | J Prof Nurs2007，23，5： | 1 |
| 17 | Experience with PICC at a university medical center显示文摘 | Kathleen Christine L | 1997 | J Intraven Nurs1997，20，： | 1 |
| 18 | Cellular and molecular biology of candida albicns estrogen response 显示文摘 | Georgina Cheng Kathleen M Yeater Lois L Hoyer | 2006 | Eukaryotic Cell2006，，： | 1 |
| 19 | Management of acidosis during lung protective ventilation in acute respiratory distress syndrome显示文摘 | Richard HK Kathleen L Julin T | 2003 | Respir Care Clin2003，9，： | 1 |
| 20 | Long-term safety and once-daily niacin/lovastatin formulation for patients with dyslipidemia 显示文摘 | Moti L K Mark E M Kathleen B | 2002 | Am J Cardiol2002，89，6： | 1 |
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