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| 1 | Inflammatory bowel disease serology in Asia and the West显示文摘AIM:To study serological antibodies in Caucasians and Asians,in health and inflammatory bowel disease(IBD),in Australia and Hong Kong(HK).METHODS:Anti-glycan antibodies[anti-chitobioside(ACCA),anti-laminaribioside(ALCA)],and anti-mannobioside(AMCA),anti-Saccharomyces cervisiae(gASCA);and atypical perinuclear anti-neutrophil cytoplasmic antibody(pANCA)were tested in IBD patients,their unaffected relatives,and healthy controls in Australia and HK(China).Antibody status(positive or negative)and titre was compared between subjects of different geography,ethnicity and disease state.RESULTS:Ninety subjects were evaluated:21 Crohn’s disease(CD),32 ulcerative colitis(UC),29 healthy controls,and 8 IBD patient relatives.Forty eight subjects were Australian(29 Caucasian and 19 ethnic Han Chinese)and 42 were from HK(all Han Chinese).Caucasian CD patients had a significantly higher antibody prevalence of gASCA(67%vs 3%,P<0.001),ALCA(44%vs 6%,P=0.005),and AMCA(67%vs 15%,P=0.002),whereas HK CD patients had a higher prevalence of only AMCA(58%vs 25%,P=0.035),when compared with UC and healthy subjects in both countries.Caucasian CD had significantly higher gASCA prevalence(67%vs 0%,P<0.001)and titre(median59 vs 9,P=0.002)than HK CD patients.Prevalence and titres of ALCA,ACCA and AMCA did not differ between CD in the two countries.Presence of at least one antibody was higher in Caucasian than HK CD patients(100%vs 58%,P=0.045).pANCA did not differ between countries or ethnicity.CONCLUSION:Serologic CD responses differ between HK Asian and Australian Caucasian patients.Different genetic,environmental or disease pathogenic factors may account for these differences. | Lani Prideaux Michael A Kamm Peter De Cruz Daniel R van Langenberg Siew C Ng Iris Dotan | 2013 | World Journal of Gastroenterology2013，19，37： | 10 |
| 2 | Vasoactive in testinal Polypepatide Levels diseasein sigm oid idiopation and diverticular显示文摘 | Milner P Crowe R Kamm M A | 1990 | Gastroenterology1990，99，3： | 1 |
| 3 | Mechanotransduction in cardiac myocytes显示文摘 | Lammerding J Kamm R D Lee R T | 2004 | Ann N Y Acad Sci2004，1015，： | 1 |
| 4 | Haemorrhoids: pathology, pathophysiology and aetiology显示文摘 | Loder P B Kamm M A Nicholls R J | 1994 | Br J Surg1994，81，7： | 1 |
| 5 | An experimental study of gas exchange in laminar oscillatory flow显示文摘 | Joshi C H Kamm R D Drazan J M | 1983 | J Flu id Mech1983，133，： | 1 |
| 6 | Cell mechanics and mechanotrans- ductionpathways, probes, and physiology显示文摘 | Huang H Kamm R D Lee R T | 2004 | Ame J Physiol Cell Physiol2004，287，1： | 1 |
| 7 | Ultrasound-guided needle positioning in sensory nerve conduction study of the sural nerve显示文摘 | KAMM C P SCHEIDEGGER O RSLER K M | 2009 | Clin Neurophysiol2009，120，7： | 1 |
| 8 | Topical phenylephrine increases anal canal resting pressure in patients with fecal incontinence 显示文摘 | CHEETHAM M J KAMM M A PHILIPS R K S | 2001 | Gut2001，48，： | 1 |
| 9 | Computational analysis of a crosslinked actin-like network显示文摘 | Kim T Hwang W Kamm R | 2009 | Exp Mech2009，49，1： | 1 |
| 10 | Me- chanical stress is communicated between different cell types to elicit matrix remodeling显示文摘 | SWARTZ M A TSCHUMPERLIN D J KAMM R D | 2001 | Proceedings of the National Academy of Sciences of the United States of America2001，98，11： | 1 |
| 11 | Serotonin and 5 - hydroxyindoleacetic acid are increased in the sigmoid colon in se- vere idiopathic constipation 显示文摘 | Lincoln J Crowe R Kamm MA | 1990 | Gastroenterology1990，98，12： | 1 |
| 12 | Forward displacement analysis of a six-DOF parallel manipulator actuated by 3R3P and 4R2P chains显示文摘 | KAMM R KOHLI D DHINGRA A K | | 0，，11： | 1 |
| 13 | Evaluating new business opportunities from food wastes显示文摘 | R Kamm | 1997 | Food Teeh1997，6，： | 1 |
| 14 | Pharmacokinetics of oral mycophenolate mofetil in volunteer subjects with varying degrees of hepatic oxidative impairment 显示文摘 | Parker G Bullingham R kamm B | 1996 | J Clin Pharmocol1996，36，4： | 1 |
| 15 | Prospective study of the extent of internal anal sphincter division during lateral sphineterotomy 显示文摘 | Sultan AH Kamm MA Nicholls R J | 1994 | Dis Colon Rectum1994，37，10： | 1 |
| 16 | Single-cell rnicroarray analysis in hippocampus CA1 : demonstration and validation of cellular heterogeneity显示文摘 | Kamme F Salunga R Yu J | 2003 | J Neurosci2003，23，9： | 1 |
| 17 | Intersti- tial flow influences direction of tumor cell migration through competing mechanisms显示文摘 | POLACHECK WJ CHARESTJ L KAMM R D | 2011 | Proc Natl Acad Sci USA2011，108，11： | 1 |
| 18 | Gastrointestinal hormones in short bowel syndrome, Peptide YY may be the “colonic brake” togastric emptying显示文摘 | Nightingale J M Kamm M A ver der sijp J R | 1996 | Gut1996，39，2： | 1 |
| 19 | Evaluating new business opportunities from food wastes显示文摘 | Kamm R | 1977 | Food Technology1977，，7： | 1 |
| 20 | Clinical pharmacokinetics of mycophenolate mofetil 显示文摘 | BULLINGHAM R E NICHOLLS A J KAMM B R | 1998 | Clin Pharmacokinet1998，34，6： | 1 |
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