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| 1 | Is endoscopic papillary balloon dilatation really a risk factor for post-ERCP pancreatitis?显示文摘Endoscopic papillary balloon dilatation(EPBD) is useful for decreasing early complications of endoscopic retrograde cholangio-pancreatography(ERCP), including bleeding, biliary infection, and perforation, but it is generally avoided in Western countries because of a relatively high reported incidence of post-ERCP pancreatitis(PEP). However, as the efficacy of endoscopic papillary largeballoon dilatation(EPLBD) becomes widely recognized, EPBD is attracting attention. Here we investigate whether EPBD is truly a risk factor for PEP, and seek safer and more effective EPBD procedures by reviewing past studies. We reviewed thirteen randomised control trials comparing EPBD and endoscopic sphincterotomy(EST) and ten studies comparing direct EPLBD and EST. Three randomized controlled trials of EPBD showed significantly higher incidence of PEP than EST, but no study of EPLBD did. Careful analysis of these studies suggested that longer and higher-pressure inflation of balloons might decrease PEP incidence. The paradoxical result that EPBD with small-calibre balloons increases PEP incidence while EPLBD does not may be due to insufficient papillary dilatation in the former. Insufficient dilatation could cause the high incidence of PEP through the use of mechanical lithotripsy and stress on the papilla at the time of stone removal. Sufficient dilation of the papilla may be useful in preventing PEP. | Toshio Fujisawa Koichi Kagawa Kantaro Hisatomi Kensuke Kubota Atsushi Nakajima Nobuyuki Matsuhashi | 2016 | World Journal of Gastroenterology2016，22，26： | 23 |
| 2 | Effect of in vitro interferon-beta administration on hepatitis C virus in peripheral blood mononuclear cells as a predictive marker of clinical response to interferon treatment for chronic hepatitis C显示文摘AIM:To test whether in vitro incubation of peripheral blood mononuclear cells (PBMC) with interferon (IFN) could efficiently decrease hepatitis C virus-RNA (HCV-RNA) amount and to analyze whether this effect was associated with clinical response to IFN.METHODS:Twenty-seven patients with histologically proven chronic hepatitis C were given intravenous administration of 6 million units (MU) IFN-β daily for 6 weeks followed by three times weekly for 20 weeks. PBMC collected before IFN therapy were incubated with IFN-β and HCV-RNA in PMBC was semi-quantitatively determined.RESULTS: Twenty-five patients completed IFN therapy.Eight patients (32%) had sustained loss of serum HCV-RNA with normal serum ALT levels after IFN therapy (complete responders).HCV-RNA in PBMC was detected in all patients,whereas it was not detected in PBMC from healthy subjects.In vitro administration of IFN-β decreased the amount of HCV-RNA in PMBC in 18 patients (72%). Eight of these patients obtained complete response. On the other hand,none of the patients whose HCV-RNA in PBMC did not decrease by IFN-β was complete responders. Multiple logistic regression analysis revealed that the decrease of HCV-RNA amount in PBMC by IFN-β was the only independent predictor for complete response (P<0.05).CONCLUSION:The effect of in vitro IFN-β on HCV in PBMC reflects clinical response and would be taken into account as a predictive marker of IFN therapy for chronic hepatitis C. | Kaori Mochizuki Tatehiro Kagawa Shinji Takashimizu Kazuya Kawazoe Sei-Ichiro Kojima Naruhiko Nagata Atsushi Nakano Yasuhiro Nishizaki Koichi Shiraishi Masaru Itakura Norihito Watanabe Tetsuya Mine Shohei Matsuzaki | 2004 | World Journal of Gastroenterology2004，10，5： | 12 |
| 3 | Molecular diagnosis and therapy for occult peritoneal metastasis in gastric cancer patients显示文摘To apply an individualized oncological approach to gastric cancer patients,the accurate diagnosis of disease entities is required.Peritoneal metastasis is the most frequent mode of metastasis in gastric cancer,and the tumor-node-metastasis classification includes cytological detection of intraperitoneal cancer cells as part of the staging process,denoting metastatic disease.The accuracy of cytological diagnosis leaves room for improvement;therefore,highly sensitive molecular diagnostics,such as an enzyme immunoassay,reverse transcription polymerase chain reaction,and virusguided imaging,have been developed to detect minute cancer cells in the peritoneal cavity.Molecular targeting therapy has also been spun off from basic research in the past decade.Although conventional cytologyis still the mainstay,novel approaches could serve as practical complementary diagnostics to cytology in near future. | Shunsuke Kagawa Kunitoshi Shigeyasu Michihiro Ishida Megumi Watanabe Hiroshi Tazawa Takeshi Nagasaka Yasuhiro Shirakawa Toshiyoshi Fujiwara | 2014 | World Journal of Gastroenterology2014，20，47： | 11 |
| 4 | Fatal liver failure due to reactivation of lamivudine-resistant HBV mutant显示文摘We report a case of fatal liver failure due to reactivation of lamivudine-resistant HBV. A 53-year-old man was followed since 1998 for HBV-related chronic hepatitis. Serum HBV-DNA was 150 MEq/mL (branched DNA signal amplification assay) and ALT levels fluctuated between 50-200 IU/L with no clinical signs of liver cirrhosis. Lamivudine (100 mg/d) was started in May 2001 and serum HBV-DNA subsequently decreased below undetectable levels. In May 2002, serum HBV-DNA had increased to 410 MEq/mL, along with ALT flare (226 IU/L). The YMDD motif in the DNA polymerase gene had been replaced by YIDD. Lamivudine was continued and ALT spontaneously decreased to the former levels. On Oct 3 the patient presenting with general fatigue, nausea and jaundice was admitted to our hospital. The laboratory data revealed HBV reactivation and liver failure (ALT: 1828 IU/L, total bilirubin: 10 mg/dL, and prothrombin INR: 3.24). For religious reasons, the patient and his family refused blood transfusion, plasma exchange and liver transplantation. The patient died 10 d after admission. The autopsy revealed remarkable liver atrophy. | Tatehiro Kagawa Norihito Watanabe Hisashi Kanouda Ichiro Takayama Tadahiko Shiba Takashi Kanai Kazuya Kawazoe Shinji Takashimizu Nobue Kumaki Kazuo Shimamura Shohei Matsuzaki Tetsuya Mine | 2004 | World Journal of Gastroenterology2004，10，11： | 10 |
| 5 | Skin toxicity predicts efficacy to sorafenib in patients with advanced hepatocellular carcinoma显示文摘AIM:To study the relationship between adverse events(AEs),efficacy,and nursing intervention for sorafenibtherapy in patients with hepatocellular carcinoma(HCC).METHODS:We enrolled 37 consecutive patients withadvanced HCC who received sorafenib therapy.Relationships among baseline characteristics as well as AEoccurrence and tumor response,overall survival(OS),and treatment duration were analyzed.The nursingintervention program consisted of education regardingself-monitoring and AEs management,and telephoneRESULTS:A total of 37 patients were enrolled in the study,comprising 30 males(81%) with a median age of 71 years.The disease control rate at 3 mo was 41%,and the median OS and treatment duration were 259 and 108 d,respectively.Nursing intervention was given to 24 patients(65%).Every patient exhibited some kinds of AEs,but no patients experienced G4 AEs.Frequently observed AEs > G2 included anorexia(57%),skin toxicity(57%),and fatigue(54%).Factors significantly associated with longer OS in multivariate analysis demonstrated that age ≤ 70 years,presence of > G2 skin toxicity,and absence of > G2 hypoalbuminemia.The disease control rate in patients with > G2 skin toxicity was 13/20(65%),which was significantly higher compared with that in patients with no or G1 skin toxicity.Multivariate analysis revealed that nursing intervention and > G2 skin toxicity were independent significant predictors for longer treatment duration.CONCLUSION:Skin toxicity was associated with favorable outcomes with sorafenib therapy for advanced HCC.Nursing intervention contributed to better adher-ence,which may improve the efficacy of sorafenib. | Masako Shomura Tatehiro Kagawa Koichi Shiraishi Shunji Hirose Yoshitaka Arase Tetsuya Mine Jun Koizumi | 2014 | World Journal of Hepatology2014，6，9： | 6 |
| 6 | Ni-Mo基催化剂上卟啉加氢脱氮(英文)显示文摘The hydrodenitrogenation(HDN) of porphyrins was carried out over a series of phosphorus containing NiMo/Al 2 O 3 catalysts using a fixed‐bed flow reaction system.A method of quantitative analysis of the porphyrin and its derivatives produced by HDN was established.In HDN of porphyrin,four types of hydrocarbons:C8 alkanes,C 8 alkenes,C9 alkanes,and C10 alkanes,and two groups of nitrogen‐containing compounds:alkyl substituted bipyrrolidines(alkylbipyrrolidines) and alkyl substituted tripyrrolidines(alkyltripyrrolidines) were identified.The hydrogenolysis of porphyrins occurred rapidly at lower temperature but higher temperatures were required for the HDN of porphyrins.The NiMoP3 catalyst showed the highest catalytic activity for the HDN of porphyrins.Based on the characterization of the supports and catalysts,it is suggested that the dispersion of Mo is improved and the number of weak acidic sites on the NiMoP catalysts increases with the addition of phosphorus. | Eika W.QIAN Satoshi ABE Yusaku KAGAWA Hiroyuki IKEDA | 2013 | 催化学报2013，34，1： | 5 |
| 7 | Development of ICPF Actuated Underwater Microrobots显示文摘发展是我们的目标在水下为医药、工业的应用程序的 microrobots。这种在水下 microrobots 应该有灵活性,好反应和安全的特征。它的结构应该简单,它能被低电压驾驶并且不生产污染或噪音。低激活电压和爱奥尼亚的进行的聚合物电影(ICPF ) 的快弯曲回答被认为为构造致动器和传感器的各种各样的类型很有用、吸引人。在这篇论文,我们将首先学习致动器使用了在的 ICPF 的特征在水下认识到游泳并且走的 microrobot。然后,我们建议作为伺服致动器利用仅仅一个 ICPF 的在水下的游泳 microrobot 的一个新原型模型。通过理论上的分析, microrobot 的运动机制被说明。它能向前并且垂直地游泳。在动人的速度和信号电压振幅和信号频率之间的关系在试验性的学习以后被获得。最后,我们在场一篇小说在水下的像螃蟹的走 microrobot 说出 crabliker-1。它有八条腿,并且每条腿由二 ICPF 组成。八足类动物步法的三个样品过程与一个新分析方法被建议。试验性的结果显示像螃蟹在水下 microrobot 能表现横向并且旋转运动螃蟹的腿什么时候协作。关键词在水下 microrobot -爱奥尼亚的进行聚合物电影( ICPF )致动器-运动机制-汝收到了的步法Xiu分她在自动化的学士度和在从哈尔滨造船工程的控制理论和申请的 M.Sc 度开创,哈尔滨,在 1987 和 1990 的中国,分别地并且在从设计大学的哈尔滨的控制理论和控制工程的博士学位,哈尔滨,在 2003 的中国。她当前是在 Biomimetic 微机器人和系统的实验室的一个教授,哈尔滨工程大学,中国。她出版了超过 40 份杂志和会议报纸。她的当前的研究兴趣包括 biomimetic microrobot 系统,网络计算,图象处理和模式识别。高宝凤在辽宁出生了,在 1981 的中国。他收到了 B.Sc。在来自东北福雷斯特大学的森林工程(国际工程工程管理) 的度,哈尔滨,在 2003 的中国。他当前从 Biomimetic 微机器人和系统的实验室在控制理论和控制工程正在追求他的 M.Sc 学位,自动化的学院,哈尔滨工程大学,哈尔滨,中国。他的研究兴趣包括微机器人学和自动化,特别象步法控制那样的微机器人学的控制在水下 microrobot。郭淑祥从光学和好力学的长春研究所在 mechanical engineering 收到了他的学士和硕士学位,长春,在 1983 和 1986 的中国,分别地并且在来自名古屋大学的 mechano 信息科学和系统的博士学位,名古屋,在 1995 的日本。在 1995,他是在 Mie 大学的一个教师成员, Mie,日本并且在 1998 在 Kagawa 大学, Kagawa,日本。当前,他是在在 Kagawa 大学的聪明的机械系统工程的部门的一个教授。他出版了大约 140 篇审阅杂志和会议论文。他的当前的研究兴趣包括微机器人学和 mechatronics,为最小的侵略外科的微机器人学系统,微导管系统,微泵,和聪明的材料(SMA, ICPF ) 基于致动器。收到的研究从机械工程师( JSME )的日本协会的 Tokai 节授于的郭教授, Tokai 科技基础,和最好糊 IS 国际会议的奖品,控制科技上的 2003 国际会议的最好的论文奖品和 IEEE ROBIO2004 的最好的会议论文奖品在 1997 , 1998 , 2000 , 2003 和 2004 ,分别地。 | Xiu-Fen Ye,Bao-Feng Gao Automation College, Harbin Engineering University, Harbin 150001, PRC Shu-Xiang Guo Automation College, Harbin Engineering University, Harbin 150001, PRC Faculty of Engineering, Kagawa University, Takamatsu 761-0396, Japan Li-Quan Wang College of Mechanical Electrical Engineering, Harbin Engineering University, Harbin 150001, PRC | 2006 | International Journal of Automation and computing2006，3，4： | 4 |
| 8 | Surgery and chemotherapy for intrahepatic cholangiocarcinoma显示文摘Cholangiocarcinoma, arising from bile duct epithelium, is categorized into intrahepatic cholangiocarcinoma (ICC) and extrahepatic cholangiocarcinoma (ECC), including hilarcholangiocarcinoma. Recently, there has been a worldwide increase in the incidence and mortality from ICC. Complete surgical resection is the only approach to cure the patients with ICC. However, locoregional extension of these tumors is usually advanced with intrahepatic and lymph-node metastases at the time of diagnosis. Resectability rates are quite low and variable (18%-70%). The five-year survival rate after surgical resection was reported to be 20%-40%. Median survival time after ICC resection was 12-37.4 mo. Only a small number of ICC cases, accompanied with ECC, gall bladder carcinoma, and ampullary carcinoma, have been reported in the studies of chemotherapy due to the rarity of the disease. However, in some reports, significant anti-cancer effects were achieved with a response rate of up to 40% and a median survival ofone year. Although recurrence rate after hepatectomy is high for the patients with ICC, the residual liver and the lung are the main sites of recurrence after tentative curative surgical resection. Several patients in our study had a long-term survival with repeated surgery and chemotherapy. Repeated surgery, combined with new effective regimens of chemotherapy, could benef it the survival of ICC patients. | Zenichi Morise Atsushi Sugioka Takamasa Tokoro Yoshinao Tanahashi Yasuhiro Okabe Tadashi Kagawa Chinatsu Takeura | 2010 | World Journal of Hepatology2010，2，2： | 4 |
| 9 | Extracorporeal cardiopulmonary resuscitation for adult cardiac arrest patients显示文摘Cardiac arrest is a major cause of unexpected death in developed countries, and patients with cardiac arrest generally have a poor prognosis. Despite the use of conventional cardiopulmonary resuscitation(CPR), few patients could achieve return of spontaneous circulation(ROSC). Even if ROSC was achieved, some patients showed re-arrest and many survivors were unable to fully resume their former lifestyles because of severe neurological deficits. Safar et al reported the effectiveness of emergency cardiopulmonary bypass in an animal model and discussed the possibility of employing cardiopulmonary bypass as a CPR method. Because of progress in medical engineering, the system of venoarterial extracorporeal membrane oxygenation(ECMO) became small and portable, and it became easy to perform circulatory support in cardiac arrest or shock patients. Extracorporeal cardiopulmonary resuscitation(ECPR) has been reported to be superior to conventional CPR in in-hospital cardiac arrest patients. Venoarterial ECMO is generally performed in emergency settings and it can be used to perform ECPR in patients with out-of-hospital cardiac arrest. Although there is no sufficient evidence to support the efficacy of ECPR in patients with out-of-hospital cardiac arrest, encouraging results have been obtained in small case series. | Eisuke Kagawa | 2012 | World Journal of Critical Care Medicine2012，1，2： | 2 |
| 10 | Green coffee bean extract and its metabolites have a hypotensive effect in spontaneously hypertensive rats 显示文摘 | Suzuki A Kagawa D Ochiai R | 2002 | J Hypertens Res2002，25，1： | 1 |
| 11 | Uniformly sized molecularly imprinted polymer for d-chlorpheniramine evaluation of retention and molecular recognition properties in an aqueous mobile phase 显示文摘 | Haginaka Jun Kagawa Chino | 2002 | Z of Chromatography A2002，948，： | 1 |
| 12 | The effect of continuous drainage of cerebrospinal fluid in patient with subarachnoid hemorrhage : a retrospective analysis of 108 patients显示文摘 | Kasuya H Simizu T Kagawa M | 1991 | Neurosurgery1991，28，： | 1 |
| 13 | Successful laparoscopic Ladd's procedure and appendectomy for intestinal malrotation with appendicitis 显示文摘 | Tsumura H Ichikawa T Kagawa T Nishihara M Stollma NH | 2003 | Surg Endosc2003，17，4： | 1 |
| 14 | Overexpression of the p21 sdil gene induces senescence-like state in human cancer cells:implication for senescence-directed molecular therapy for cancer显示文摘 | Fujiwara T Kadowaki Y | 1999 | Cell Death Differ1999，6，8： | 1 |
| 15 | Study on dynamic characteristic analysis of air spring with auxiliary chamber显示文摘 | Katsuya Toyofuku Chuuji Yamada Toshiharu Kagawa | 1999 | JSAE Review1999，20，： | 1 |
| 16 | Estimation of gonadal status of Japanese female eel Anguilla japonica by a single injection of salmon pituitary extract显示文摘 | Kagawa H | 2005 | Fisheries Science2005，71，： | 1 |
| 17 | Catal显示文摘 | Tatamei Ishihara Masaru Kagawa J | 1997 | (169):93~1021997，，169： | 1 |
| 18 | Angiogenesis in hepatocellular carcinoma as evaluated by CD34 immunohistochemistry显示文摘 | Kimura H Nakajina T Kagawa K | 1998 | Liver1998，18，： | 1 |
| 19 | Influence of the simultaneous substitution of Cu and Ru in the pervoskite-type(La,Sr) MO3 (M = Al,Mn,Fe,Co) on the catalytic activity for CO oxidation and CO-NO reaction显示文摘 | TERAOKA Y NII H KAGAWA S | 2000 | Applied Catalysis A:General2000，19，： | 1 |
| 20 | Duration of fertility after fresh and frozen ovary transplantation 显示文摘 | Silber S Kagawa N Kuwayama M | 2010 | Fertil Steril2010，94，6： | 1 |
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