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| 1 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 2 | 气候变化和紫外线辐射对北极淡水鱼类及溯河产卵鱼类渔业的影响显示文摘北极淡水鱼类和洄游鱼类渔业为北方经济做出了重大贡献。但是,对于淡水水体,气候变化和增长的紫外线辐射对渔业产生的巨大影响有3个方面:可获鱼的数量、质量和捕捞成功率。因此,在这些影响发生作用之际,可能需要实质有效的适应行为以引导北极未来的渔业走向可持续性。当务之急是为商业渔业选择灵活和快速反应的'适宜管理'方式;改变生计渔业的当地土地和资源利用模式;改变很多休闲渔业的特性、管理方式和地点。总的来说,在气候变化及其对北极淡水水域和生物区影响的复杂性和不确定性情况下,为保证生态系统和主导鱼种有足够的恢复力和应对将来变化的能力,需要对渔业的各个方面实施更保守的管理办法。 | James D.Reist Frederick J.Wrona Terry D.Prowse J.Brian Dempson Michael Power Günter Kck Theresa J.Carmichael Chantelle D.Sawatzky Hannu Lehtonen Ross F.Tallman 曾首英 | 2006 | AMBIO-人类环境杂志2006，35，7： | 4 |
| 3 | Constitutive renal Rel/nuclear factor-κB expression in Lewis polycystic kidney disease rats显示文摘AIM:To determine the temporal expression and pattern of Rel/nuclear factor(NF)-κB proteins in renal tissue in polycystic kidney disease(PKD). METHODS: The renal expression of Rel/NF-κB proteins was determined by immunohistochemistry, immunofluorescence and immunoblot analysis in Lewis polycystic kidney rats(LPK, a genetic ortholog of human nephronopthsis-9) from postnatal weeks 3 to 20. At each timepoint, renal disease progression and the mR NA expression of NF-κB-dependent genes(TNFa and CCL2) were determined. NF-κB was also histologicaly assessed in human PKD tissue.RESULTS: Progressive kidney enlargement in LPK rats was accompanied by increased renal cell proliferation and interstitial monocyte accumulation(peaking at weeks 3 and 10 respectively), and progressive interstitial fibrosis(with a smooth muscle actin and Sirius Red deposition significantly increased compared to Lewis kidneys from weeks 3 to 6 onwards). Rel/NF-κB proteins(phosphorylated-p105, p65, p50, c-Rel and RelB) were expressed in cystic epithelial cells(CECs) of LPK kidneys as early as postnatal week 3 and sustained until latestage disease at week 20. From weeks 10 to 20, nuclear p65, p50, Rel B and cytoplasmic IκBa protein levels, and TNFa and CCL2 expression, were upregulated in LPK compared to Lewis kidneys. NF-κB proteins were consistently expressed in CECs of human PKD. The DNA damage marker γ-H2AX was also identified in the CECs of LPK and human polycystic kidneys. CONCLUSION: Several NF-κB proteins are consistently expressed in CECs in human and experimental PKD. These data suggest that the upregulation of both the canonical and non-canonical pathways of NF-κB signaling may be a constitutive and early pathological feature of cystic renal diseases. | Michelle HT Ta Kristina G Schwensen David Liuwantara David L Huso Terry Watnick Gopala K Rangan | 2016 | World Journal of Nephrology2016，5，4： | 2 |
| 4 | Blastocyst score affects implantation and pregnancy outcome: towards a single blastocyst transfer显示文摘 | David K Gardner Michelle Lane John Stevens Terry Schlenker William B Schoolcraft | 2000 | Fertility and Sterility2000，，6： | 2 |
| 5 | How computational technique and spike train properties affect coherence detection显示文摘 | TERRY K GRIFFIN L | 2008 | J Neurosci Methods2008，168，： | 1 |
| 6 | Rho signaling and tight junction functions显示文摘 | Terry S Nie M Matter K | 2010 | Physiology (Bethesda)2010，25，： | 1 |
| 7 | Supercritical fluid extraction of polychlorinated dibenzo-p-dioxins from municipal incinerator fly ash显示文摘 | ONUSKA F I TERRY K A | 1991 | Journal of High Resolute Chromatography1991，14，： | 1 |
| 8 | Programma- ble imaging: towards a flexible camera显示文摘 | Shree K Nayar Vlad Branzoi Terry E Boult | 2006 | International Journal of Computer Vision2006，78，1： | 1 |
| 9 | Hydroxylamine oxidoreductase: a 20- heme, 200 000 molecular weight cytot:hromee with unusual denaturation properties which forms a 63 000 molecular weight monomer after heme removal显示文摘 | Terry K R Hooper A B | 1981 | Biocheudstry1981，20，24： | 1 |
| 10 | Furfural hydrogenation over carbon-supported copper显示文摘 | Rao Rajeev S Baker R Terry K | 1999 | Catal Lett1999，60，12： | 1 |
| 11 | Random systematic versus directed ultrasound guided transrectal core biopsies of the prostate显示文摘 | Hodge K K McNeal J E Terris M K | 1989 | J Urol1989，142，1： | 1 |
| 12 | Natural product as a source of agrochenicals and leads for chemical synthesis显示文摘 | PILLMOOR B O WRIGHT K TERRY S A | 1993 | Pesticide Sci1993，39，： | 1 |
| 13 | Natural products as a source of agrochemicals and leads for chemical synthesis显示文摘 | Pillmoor B O Wright K Terry S A | 1993 | Pestic Sci1993，39，： | 1 |
| 14 | Qscore: an algorithm for evaluating SEQUEST database search results显示文摘 | Roger E Moore Mary K Young Terry D Lee | 2002 | Journal of the American Society for Mass Spectrometry2002，13，4： | 1 |
| 15 | Rho signaling and tight junction functions显示文摘 | Terry S Nie M Matter K | 2010 | Physiology(Bethesda)2010，25，1： | 1 |
| 16 | Nitrogen source regulation of photosynthesis in Beta vulgaris L显示文摘 | Raab T K Terry N | 1994 | Plant Physiol1994，105，： | 1 |
| 17 | The efficacy of corticos- teroids in postparotidectomy facial nerve paresis显示文摘 | LEE K J FEE WE JR TERRIS DJ | 2002 | Laryngoscope2002，112，11： | 1 |
| 18 | A tale of two theories: A criti-cal comparison of identity theory with social identity theory 显示文摘 | Hogg M A Terry D White K | 1995 | Social Psychology Quarterly1995，58，4： | 1 |
| 19 | Virtual human modeling from photographs for garment industry显示文摘 | Charlie C L Wang Yu Wang Terry K K Chang | 2003 | Computer-Aided Design2003，35，： | 1 |
| 20 | A tandem periodically-poled lithium niobate (PPLN) optical parametric oscillator(OPO) 显示文摘 | McEwan K J Terry J A C | 2000 | Opt Comm2000，182，： | 1 |
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