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| 1 | Assessment of neovascularization within carotid plaques in patients with ischemic stroke显示文摘AIM:To assess neovascularization within human ca-rotid atherosclerotic soft plaques in patients with isch-emic stroke.METHODS:Eighty-one patients with ischemic stroke and 95 patients without stroke who had soft athero-sclerotic plaques in the internal carotid artery were studied.The thickest soft plaque in each patient was examined using contrast-enhanced ultrasound.Time-intensity curves were collected from 5 s to 3 min after contrast injection.The neovascularization within the plaques in the internal carotid artery was evaluated using the ACQ software built into the scanner by 2 of the experienced investigators who were blinded to the clinical history of the patients.RESULTS:Ischemic stroke was present in 7 of 33 patients(21%) with grade Ⅰ plaque,in 14 of 51 pa-tients(28%) with grade Ⅱ plaque,in 26 of 43 patients(61%) with grade Ⅲ plaque,and in 34 of 49 patients(69%) with grade Ⅳ plaque(P < 0.001 comparing grade Ⅳ plaque with grade I plaque and with grade Ⅱ plaque and P = 0.001 comparing grade Ⅲ plaque with grade Ⅰ plaque and with grade Ⅱ plaque).Analysis of the time intensity curves revealed that patients with ischemic stroke had a significantly higher intensity of enhancement(IE) than those without ischemic stroke(P < 0.01).The wash-in time(WT) of plaque was signifi-cantly shorter in stroke patients(P < 0.05).The sensi-tivity and specificity for IE in the plaque were 82% and 80%,respectively,and for WT were 68% and 74%,respectively.There was no significant difference in the peak intensity or time to peak between the 2 groups.CONCLUSION:This study shows that the higher the grade of plaque enhancement,the higher the risk of ischemic stroke.The data suggest that the presence of neovascularization is a marker for unstable plaque. | Wilbert S Aronow Chandra K Nair David Cosgrove | 2010 | World Journal of Cardiology2010，2，4： | 29 |
| 2 | Novel virulence factor dupA of Helicobacter pylori as an important risk determinant for disease manifestation:An overview显示文摘Helicobacter pylori(H.pylori)is a microaerophilic,Gram-negative,human gastric pathogen found usually in the mucous lining of stomach.It infects more than 50%of the world’s population and leads to gastroduodenal diseases.The outcome of disease depends on mainly three factors:Host genetics,environment and bacterial factors.Among these,bacterial virulence factors such as cagA,vacA are well known for their role in disease outcomes.However,based on the global epidemiological results,none of the bacterial virulence(gene)factors was found to be associated with particular diseases like duodenal ulcer(DU)in all populations.Hence,substantial importance has been provided for research in strain-specific genes outside the cag pathogenicity island,especially genes located within the plasticity regions.dupA found within the plasticity regions was first demonstrated in 2005 and was proposed for duodenal ulcer development and reduced risk of gastric cancer in certain geographical regions.Due to the discrepancies in report from different parts of the world in DU development related to H.pylori virulence factor,dupA became an interesting area of research in elucidating the role of this gene in the disease progression.In this review,we shed light on the detailed information available on the polymorphisms in dupA and their clinical relevance.We have critically appraised several pertinent studies on dupA and discussed their merits and shortcomings.This review also highlights dupA gene as an important biomarker for DU in certain populations. | Jawed Alam Avijit Sarkar Bipul Chandra Karmakar Mou Ganguly Sangita Paul Asish K Mukhopadhyay | 2020 | World Journal of Gastroenterology2020，26，32： | 5 |
| 3 | 铁鞣新方法显示文摘将铁鞣与铬鞣进行了优化结合,这种鞣制技术不仅可以加工出质量上呈的皮革制品,同时又可以满足废液中铬与铁的含量低于100mg/kg的标准。此工艺制造的皮革可耐沸水试验,阐述了其鞣制技术和鞣制机理。对铁鞣法在加工山羊绒面革和绵羊全粒面服装革中出现的问题进行了研究。用扫描电镜对鞣革的结构特性进行了研究,对成革的物理机械性能及染色特性也做了分析和阐述。 | N K Chandra Babu R Karthikeyan R Ramesh Usha Ramamurthi T Ramasami 范贵洋 李彦春 | 2007 | 中国皮革2007，36，9： | 4 |
| 4 | Distribution of hepatitis B virus genotypes:Phylogenetic analysis and virological characteristics of Genotype C circulating among HBV carriers in Kolkata,Eastern India显示文摘AIM: To evaluate the genotype distribution of hepatitis B virus (HBV) in Eastern India and to clarify the phyloge- netic origin and virological characteristics of the recently identifi ed genotype C in this region. METHODS: Genotype determination, T1762/A1764 mutation in the basal core promoter (BCP) and A1896 mutation in the precore region of 230 subjects were de- termined by restriction fragment length polymorphism method (RFLP) and the result was confi rmed by direct sequencing. RESULTS: The predominant genotypes D (HBV/D) and A (HBV/A) were detected in 131/230 (57%) and 57/230 (25%) samples. In addition, genotype C (HBV/C) was detected in 42/230 (18%) isolates. Surface gene region was sequenced from 45 isolates (27 HBV/C, 9 HBV/A and 9 HBV/D). Phylogenetic analysis revealed that all of the HBV/C sequences clustered with South East Asian subgenotype (HBV/Cs). The sequence data showed re- markable similarity with a Thai strain (AF068756) (99.5% ± 0.4% nucleotide identities) in 90% of the genotype C strains analyzed. T1762/A1764 mutation in BCP re- gion, associated with high ALT was signifi cantly higher in HBeAg negative isolates than HBeAg positive isolates. Frequency of A1896 mutation leading to HBeAg negativ- ity was low.CONCLUSION: The present study reports the genotypic distribution and the characteristics of partial genome sequences of HBV/C isolates from Eastern India. Low genetic diversity and confi nement of HBV/C in Eastern India possibly indicate a recent, limited, spread in this region. Genotype C with T1762/A1764 mutation has been reported to increase the risk for hepatocellular car- cinoma; therefore genotype C carriers in Eastern India should be carefully monitored. | Arup Banerjee Sibnarayan Datta Partha K Chandra Susanta Roychowdhury Chinmoy Kumar Panda Runu Chakravarty | 2006 | World Journal of Gastroenterology2006，12，37： | 3 |
| 5 | 铁鞣新方法(续)显示文摘将铁鞣与铬鞣进行了优化结合,这种鞣制技术不仅可以加工出质量上乘的皮革制品,同时又可以满足废液中铬与铁的含量低于100mg/kg的标准。此工艺制造的皮革可耐沸水试验,阐述了其鞣制技术和鞣制机理。对铁鞣法在加工山羊绒面革和绵羊全粒面服装革中出现的问题进行了研究。用扫描电镜对鞣革的结构特性进行了研究,对成革的物理机械性能及染色特性也做了分析和阐述。 | N K Chandra Babu R Karthikeyan R Ramesh Usha Ramamurthi T Ramasami 范贵洋 李彦春 | 2007 | 中国皮革2007，36，11： | 2 |
| 6 | Structural,Wettability and Optical Investigation of Titanium Oxynitride Coatings:Effect of Various Sputtering Parameters显示文摘The objective of the present work is to investigate the effect of various sputtering parameters such as nitrogen flow rate,deposition time and sputtering pressure on structural,wettability and optical properties of titanium oxynitride films deposited on glass substrate by reactive magnetron sputtering.The X-ray diffraction graphs of titanium oxynitride films show evolution of various textures of TiO_xN_y and TiN phases with increasing nitrogen flow rate and deposition time,but an increase in sputtering pressure from 4.0 to 8.0 Pa results in decline of various textures observed for TiO_xN_y and TiN phases.The stress and strain calculated by sin^2Ψ method are compressive,which decrease with increasing nitrogen flow rate from 55 to 100 sccm(standard cubic centimeter per minute) and increase with increasing deposition time from 80 to 140 min due to atomic penning effect and increasing thickness of the deposited films.The titanium oxynitride films have contact angle values above 90 deg.,indicating that films are hydrophobic.The maximum contact angle of 109.1 deg.is observed at deposition time of 140 min.This water repellent property can add value to potential protective,wear and corrosion resistant application of titanium oxynitride films.The band gap decreases from 1.98 to 1.83 eV as nitrogen flow rate is increased from 55 to 100 sccm;it decreases from 1.93 to 1.79 eV as deposition time is increased from 80 to 140 min as more nitrogen incorporation results in higher negative potential of valence band N2p orbital.But it increases from 2.26 to 2.34 eV for titanium oxynitride films as sputtering pressure increases from 4.0 to 8.0 Pa. | Sushant K Rawal Amit Kumar Chawla R.Jayaganthan Ramesh Chandra | 2012 | Journal of Materials Science & Technology2012，28，6： | 2 |
| 7 | Hepatocellular carcinoma xenograft supports HCV replication:A mouse model for evaluating antivirals显示文摘AIM: To develop a hepatocellular carcinoma (HCC) xenograft model for studying hepatitis C virus (HCV) replication in a mice, and antiviral treatment.METHODS: We developed a stable S3-green fluorescence protein (GFP) cell line that replicated the GFP-tagged HCV sub-genomic RNA derived from a highly efficient JFH1 virus. S3-GFP replicon cell line was injected subcutaneously into γ-irradiated SCID mice. We showed that the S3-GFP replicon cell line formed human HCC xenografts in SCID mice. Cells were isolated from subcutaneous tumors and then serially passaged multiple times in SCID mice by culturing in growth medium supplemented with G-418. The mouse-adapted S3-GFP replicon cells were implanted subcutaneously and also into the liver of SCID mice via intrasplenic infusion to study the replication of HCV in the HCC xenografts. The tumor model was validated for antiviral testing after intraperitoneal injection of interferon-α (IFN-α). RESULTS: A highly tumorigenic S3-GFP replicon cell line was developed that formed subcutaneous tumors within 2 wk and diffuse liver metastasis within 4 wk in SCID mice. Replication of HCV in the subcutaneous and liver tumors was confirmed by cell colony assay, detection of the viral RNA by ribonuclease protection assay and real-time quantitative reverse transcription polymerase chain reaction. High-level replication of HCV sub-genomic RNA in the tumor could be visualized by GFP expression using fluorescence microscopy. IFN-α cleared HCV RNA replication in the subcutaneous tumors within 2 wk and 4 wk in the liver tumor model. CONCLUSION: A non-infectious mouse model allows us to study replication of HCV in subcutaneous and metastatic liver tumors. Clearance of HCV by IFN-α supports use of this model to test other anti-HCV drugs. | Sidhartha Hazari Henry J Hefler Partha K Chandra Bret Poat Feyza Gunduz Tara Ooms Tong Wu Luis A Balart Srikanta Dash | 2011 | World Journal of Gastroenterology2011，17，3： | 2 |
| 8 | A new control approach to three-phase active power filter for harmonics and reactive power eompensation显示文摘 | Singh B Al-Haddad K Chandra A | 1998 | IEEE Transactions on Power Systems1998，13，1： | 1 |
| 9 | Nitric oxide and apoptosis during human head and neck squamous cell carcinoma development显示文摘 | Chandra R Haines G K 3rd | 2002 | Am J Otolaryngol2002，23，1： | 1 |
| 10 | A mechanistic role for cardiac myocyte apoptosis in heart failure显示文摘 | Wencker D Chandra M Nguyen K | 2003 | Cell2003，111，： | 1 |
| 11 | System-on-a-Chip test data compression and decompression architectures based on Golomb codes 显示文摘 | Chandra A Chakrabarty K | 2001 | IEEE Transactions on CAD of Integrated Circuits and System2001，20，3： | 1 |
| 12 | Gabapentin versus nortriptyline in post-herpetic neuralgia patients: a randomized, double-blind clinical trial-the GONIP Trial 显示文摘 | Chandra K Shafiq N Pandhi P | 2006 | Int J Clin Pharmaeol Ther2006，44，8： | 1 |
| 13 | Spec-trum Challenges and Solutions by Cognitive Radio: anOverview 显示文摘 | SRIDHARA K CHANDRA A TRIPATHI P S M | 2008 | Wireless Personal Communications2008，45，3： | 1 |
| 14 | Therapy insight:treatment of gastroesophageal reflux in adults with chronic cough显示文摘 | CHANDRA K M HARDING S M | 2007 | Nat Clin Pract Gastroenterol Hepatol2007，4，： | 1 |
| 15 | Chemistry and structural evaluation of dif-ferent phospholipase A2 inhibitors in arachidonic acidpathway mediated inflammation and snake venom toxicity显示文摘 | Narendra Sharath Chandra J N Ponnappa K C Sadashi-va C T | 2007 | Curr Top Med Chem2007，7，8： | 1 |
| 16 | Wear behaviour of AE42+20% Saffil Mg-MMC显示文摘 | MONDAL A K CHANDRA RAO B S S KUMAR S | 2007 | Tribology International2007，40，： | 1 |
| 17 | Twin support vector machines for pattern classification显示文摘 | JAYADEVA K R CHANDRA S | 2007 | IEEE Transaction on Pattern Analysis and Machine Intelligence2007，29，5： | 1 |
| 18 | A review of active power filters for power quality improvement 显示文摘 | SINGH B AL-HADDAD K CHANDRA A | 1999 | IEEE Trans Ind Electron1999，46，5： | 1 |
| 19 | Characterization and partial purification of Candida albicans secretory IL-12 inhibitory factor 显示文摘 | WANG Ming-yue MUKHERJEE P K CHANDRA J | 2008 | BMC Microbiol2008，8，1： | 1 |
| 20 | Wear behaviour of AE42+20% saffil Mg-MMC显示文摘 | MONDAL A K CHANDRA RAO B S S KUMAR S | 2007 | Tribology International2007，40，2： | 1 |
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