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| 1 | Efficacy and safety of metformin and sitagliptin based triple antihyperglycemic therapy(STRATEGY):a multicenter,randomized,controlled,non-inferiority clinical trial显示文摘Despite the current guideline's recommendation of a timely stepwise intensification therapy,the 'clinical inertia',termed as the delayed treatment intensification,commonly exists in the real world,which may be partly due to the relatively little substantial evidence and no clear consensus regarding the efficacy and safety of triple oral agents in patients inadequately controlled with dual therapy.In this clinical trial performed in 237 centers in China,5,535 type 2 diabetic patients inadequately controlled by previous therapies were treated with a stable metformin/sitagliptin dual therapy for 20 weeks.The patients who did not reach the glycated hemoglobin A1c(HbA1c) goal were then further randomized into glimepiride,gliclazide,repaglinide,or acarbose group for an additional 24-week triple therapy.A mean HbAlc reduction of 0.85%was observed when sitagliptin was added to the patients inadequately controlled with metformin in 16 weeks.Further HbAlc reductions in the 24-week triple therapy stage were 0.65%in glimepiride group,0.70%in gliclazide group,0.61%in repaglinide group,and 0.45%in acarbose group.The non-inferiority criterion for primary hypotheses was met for gliclazide and repaglinide,but not for acarbose,compared with glimepiride,when added to metformin/sitagliptin dual therapy.The incidences of adverse events(AEs) were 29.2%in the dual therapy stage and30.3%in the triple therapy stage.Metformin/sitagliptin as baseline therapy,with the addition of a third oral antihyperglycemic agent,including glimepiride,gliclazide,repaglinide,or acarbose,was effective,safe and well-tolerated for achieving an HbAlc<7.0%goal in type 2 diabetic patients inadequately controlled with previous therapies.The timely augmentation of up to three oral antihyperglycemic agents is valid and of important clinical benefit to prevent patients from exposure to unnecessarily prolonged hyperglycemia. | Wen Xu Yiming Mu Jiajun Zhao Dalong Zhu Qiuhe Ji Zhiguang Zhou Bin Yao Anhua Mao Samuel S.Engel Bin Zhao Yan Bi Longyi Zeng Xingwu Ran Juming Lu Linong Ji Wenying Yang Weiping Jia Jianping Weng | 2017 | Science China(Life Sciences)2017，60，3： | 19 |
| 2 | Template-free synthesis of carbon doped TiO2 mesoporous microplates for enhanced visible light photodegradation显示文摘钛二氧化物(TiO 2) 广泛地为太阳能变换和环境补习作为稳固的光催化剂被采用。与控制粒子尺寸和缩小的 bandgap 构造多孔的 TiO 2 的能力是为设计的一个必要要求高度有效并且 recyclable 光催化剂。这里,我们报导没有模板的醋酸与高 crystallinity 和 mesoporous 结构为可见光的应答的做碳的 TiO 2 microplates 的合成导致了方法。从醋酸导出的撤退电子的有二齿的羧化物 ligands 能缩小 TiO 2 的 bandgap,这被显示出(1.84 ? eV ) 实质地。而且,结果的 microplate 光催化剂展出优秀 photocatalytic 效率和稳固液体的分离性能,它将为未来是有益的工业应用。 | Juming Liu Lu Han Huiyan Ma Hao Tian Jucai Yang Qiancheng Zhang Benjamin J. Seligmann Shaobin Wang Jian Liu | 2016 | Science Bulletin2016，61，19： | 4 |
| 3 | Effects of antioxidants on homocysteine thiolactone-induced apoptosis in human umbilical vein endothelial cells显示文摘Background and objectives Hyperhomocysteinemia is an independent risk factor for cardiovascular disease. Homocysteine thiolactone (HcyT), one of the homocysteine metabolites in vivo, is toxic both in vivo and in vitro. The aim of this study was to investigate the effect of HcyT on apoptotic damage in human umbilical vein endothelial cells (HUVECs) and the role of antioxidants in the reduction of HcyT-induced apoptosis. Methods HUVECs were cultured in DMEM supplemented with 20% heat inactivated fetal bovine serum cell cultures were maintained in a humidified 5% CO2 atmosphere at 37 ℃. Cytotoxicity was determined by MTT assay,which consists of hypodiploid cells with propidium iodide labeling and intracellular reactive oxygen species levels using 2',7'-dichlorofluorescein diacetate as the probe by flow cytometry. Results HcyT (250-2000μM) induced HUVECs apoptosis in a time- and concentration-dependent manner. Reactive oxygen species levels rose in response to increasing HcyT concentrations at 24-h incubation.The reduction of cell apoptosis by N-acetylcysteine, vitamin E, or pyrrolidine dithiocarbamate, occurred simultaneously with a significant decrease in intracellular reactive oxygen species levels. Conclusion HcyT exerts its cytotoxic effects on endothelial cells through an apoptotic mechanism involving cellular reactive oxygen species production. The capacity of N-acetylcysteine, vitamin E, and pyrrolidine dithiocarbamate to scavenge HcyT-induced cellular reactive oxygen species correlates well with their efficiency to protect against HcyT-promoted apoptotic damage. The protective effect of pyrrolidine dithiocarbamate on cell apoptosis indicates HcyT-generated hydrogen peroxide may provoke cell apoptosis via activating nuclear factor-kappa binding protein. | Weijun GU Juming LU Guoqing YANG Qinghua GUO Baoan WANG Yiming MU Changyu PAN | 2006 | Journal of Geriatric Cardiology2006，3，2： | 3 |
| 4 | Empirical formulae for electric double-layer repulsion between two arbitrarily inclined clay particles显示文摘To understand the mesoscopic mechanism of clayey soil in view of macroscopic behavior, it is essential to quantitatively calculate the electric double-layer repulsion between arbitrarily inclined clay particles.However, suitable calculation methods with high efficiency and accuracy are still rare at present in literature. Based on a great number of numerical calculations of the repulsion between two inclined platy clay particles, explicit empirical formulae for estimating electric double-layer repulsion between clay particles are put forward. Comparison between the empirical solutions and corresponding numerical results shows that the proposed formulae have a reasonable accuracy, and application of the presented formula is easy and efficient. | Xiangyu Shang Juming Lu Lianfei Kuang Chen Yang Guoqing Zhou | 2018 | Journal of Rock Mechanics and Geotechnical Engineering2018，10，6： | 3 |
| 5 | Prevalence of diabetes among men and women in China显示文摘 | Yang Wenying Lu Juming Weng Jianping | 2010 | N Engl J Med2010，362，： | 1 |
| 6 | Prevalence of diabetes among men and women in China 显示文摘 | Yang Wenying Lu Juming Weng Jianping | | N Engl J Med0，362，19： | 1 |
| 7 | Preva-lence of diabetes among men and women in China显示文摘 | YANG WENYIN LU JUMING WENG JIANPING | 2010 | N Engl JMed2010，362，12： | 1 |
| 8 | Prevalence of Diabetes among Men and Women in China 显示文摘 | Wenying Yang Juming Lu Jianping Weng | 2010 | The New England Journal of Medicine2010，，3： | 1 |
| 9 | Prevalence of Diabetes among Men And Women in China显示文摘 | Wenying Yang Juming Lu Jianping Weng | 2010 | NEngl JMed2010，362，12： | 1 |
| 10 | Prevalence of diabetes among men and women in China显示文摘 | Wenying Yang Juming Lu Jianping Weng | 2010 | NEJM2010，362，： | 1 |
| 11 | Prevalence ofdiabetes among men and women in China 显示文摘 | Wenying Yang Juming Lu Jianpeng Weng ei al | 2010 | Ann Engl J Medy2010，362，12： | 1 |
| 12 | Prova- lence of Diabetes among Men and Women in China 显示文摘 | Wenying Yang Juming Lu Jianping Weng el al | 2010 | N Engl2010，，362： | 1 |
| 13 | Prevalence of diabetes among men and women in China 显示文摘 | Yang Wenying Lu Juming Weng Jianping | 2010 | N Engl J Med2010，362，12： | 1 |
| 14 | Prevalence of Diabetes among Men and Women in China 显示文摘 | YANG Wenying LU Juming WENG Jianping | 2010 | N Engl J Med2010，362，12： | 1 |
| 15 | Preva- lence of diabetes among men and women in China显示文摘 | Wenying Yang Juming Lu Jianping Weng | 2010 | NEJM2010，632，： | 1 |
| 16 | Prevalence of diabetes among men and women in China显示文摘 | Yang Wenying Lu Juming Wang Jianping | 2010 | Engl J Med2010，362，1： | 1 |
| 17 | Prevalence of Diabetes among Men and Women in China 显示文摘 | Wenying Yang Juming Lu Jianping Weng | 2010 | The New England Journal of Medicine2010，，12： | 1 |
| 18 | Prevalence of Diabetes among Men and Women in China显示文摘 | Wenying Yang Juming Lu Jianping Weng | 2010 | N Engl J Med2010，362，12： | 1 |
| 19 | Prevalence of Diabetes among Men and Women in China显示文摘 | Wenying Yang Juming Lu Jianping Weng | | 0，，12： | 1 |
| 20 | Prevalence of diabetes among men and women in China显示文摘 | Wenying Yang Juming Lu Jianping Weng | 2010 | N Eng J Meal2010，362，12： | 1 |
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