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| 1 | Early chronic obstructive pulmonary disease: Beyond spirometry显示文摘The significant healthcare burden associated with chronic obstructive pulmonary disease(COPD) is driving us to improve our understanding of the natural history of this disease. Historically, the focus has been largely centred on diagnosing and treating individuals with moderate and severe disease. However, it is now recognised that the speed of decline in lung function as measured by forced expiratory volume in 1 s occurs faster in the earlier stages of the disease process. As a result, a clearer understanding of the potential benefits of treatment in early COPD is needed. It is recognised that many patients with COPD remain undiagnosed in the community which has prompted global case-finding initiatives. In this review we discuss the difficulties in diagnosing COPD in its early stages, examine the roleof case-finding and look at the evidence for early intervention with therapeutic agents. There is a growing interest in the phenotypic variation amongst patients with COPD and we explore the role of phenotyping in early COPD and its potential benefits in providing a more individualised approach to COPD management. The majority of patients with COPD are known to die from non-respiratory causes such as cardiovascular disease. The mechanistic link is thought to relate to systemic inflammation, causing us to question whether earlier interventions could have a beneficial impact on the burden of co-morbidities for patients with COPD. | Judith A Brebner Alice M Turner | 2013 | World Journal of Respirology2013，3，3： | 5 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | Probiotics for childhood functional gastrointestinal disorders: a systematic review and meta‐analysis显示文摘 | Judith J Korterink Lize Ockeloen Marc A Benninga Merit M Tabbers Mirrian Hilbink Judith M Deckers‐Kocken | 2014 | Acta Paediatr2014，，4： | 2 |
| 4 | Immediate and de- layed cord clamping in infants born between 24 and 32 weeks:a pilot randomized controlled trial显示文摘 | Judith S Margaret M Hensman A | 2003 | J Perinatol2003，23，6： | 1 |
| 5 | GenomeWide Identification of Nodule-Specific Transcripts in the Model Legume Medicago truncatula显示文摘 | Fedorova M Judith van de Mortel Matsumoto P A | 2002 | Plant Physiol2002，130，： | 1 |
| 6 | CO2 control on carbon isotope fractionation during aqueous photosynthesis:A paleo-pCO2 barometer显示文摘 | David J H Judith A M | 1991 | Geology1991，19，： | 1 |
| 7 | Gemini virus-mediated genesilencing firom cotton leaf crumple virus is enhanced by low tempera-ture in cotton显示文摘 | John R T Idris A M Judith K B | 2008 | Plant Physiology2008，1148，： | 1 |
| 8 | Mim- icking live flavivirus immunization with a noninfectious RNA vac- cine显示文摘 | REGINA M K JUDITH H A STEPHAN W A | 2014 | Proc Natal Acad Sci USA2014，101，7： | 1 |
| 9 | Renal impairment and heart failure with preserved ejection fraction early post-myocardial infarction显示文摘AIM:To study if impaired renal function is associated with increased risk of peri-infarct heart failure (HF) in patients with preserved ejection fraction (EF).METHODS:Patients with occluded infarct-related arteries (IRAs) between 1 to 28 d after myocardial infarction (MI) were grouped into chronic kidney disease (CKD) stages based on estimated glomerular filtration rate (eGFR).Rates of early post-MI HF were compared among eGFR groups.Logistic regression was used to explore independent predictors of HF.RESULTS:Reduced eGFR was present in 71.1% of 2160 patients,with significant renal impairment (eGFR < 60 mL/min every 1.73 m2) in 14.8%.The prevalence of HF was higher with worsening renal function:15.5%,17.8% and 29.4% in patients with CKD stages 1,2 and 3 or 4,respectively (P < 0.0001),despite a small absolute difference in mean EF across eGFR groups:48.2 ± 10.0,47.9 ± 11.3 and 46.2 ± 12.1,respectively (P=0.02).The prevalence of HF was again higher with worsening renal function among patients with preserved EF:10.1%,13.6% and 23.6% (P < 0.0001),but this relationship was not significant among patients with depressed EF:27.1%,26.2% and 37.9% (P= 0.071).Moreover,eGFR was an independent correlate of HF in patients with preserved EF (P=0.003) but not in patients with depressed EF (P=0.181).CONCLUSION:A significant proportion of post-MI patients with occluded IRAs have impaired renal function.Impaired renal function was associated with an increased rate of early post-MI HF,the association being strongest in patients with preserved EF.These findings have implications for management of peri-infarct HF. | Vinod Jorapur Gervasio A Lamas Zygmunt P Sadowski Harmony R Reynolds Antonio C Carvalho Christopher E Buller James M Rankin Jean Renkin Philippe Gabriel Steg Harvey D White Carlos Vozzi Eduardo Balcells Michael Ragosta C Edwin Martin Vankeepuram S Srinivas William W Wharton III Staci Abramsky Ana C Mon Shari S Kronsberg Judith S Hochman | 2010 | World Journal of Cardiology2010，2，1： | 1 |
| 10 | Diffuse backscattering Mueller matrices of highly scattering media显示文摘 | Andreas H H Angelia A E Judith R M | 1997 | Optics Express1997，1，13： | 1 |
| 11 | Effects of cyclophosphamide on murinecandidiasis 显示文摘 | Stephen A M Judith E D | 1980 | Infect Immunity1980，27，： | 1 |
| 12 | Carboxymethylation of cashew tree exudate polysaecharide 显示文摘 | I)URCII ENE A S REGINA C M JUDITH P A | 2004 | Carbohydrate Polymers2004，58，2： | 1 |
| 13 | Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial显示文摘 | Stephen M Davis Geoffrey A Donnan Mark W Parsons Christopher Levi Kenneth S Butcher Andre Peeters P Alan Barber Christopher Bladin Deidre A De Silva Graham Byrnes Jonathan B Chalk John N Fink Thomas E Kimber David Schultz Peter J Hand Judith Frayne Graeme | 2008 | Lancet Neurology2008，，4： | 1 |
| 14 | Simple sugars, oligosaccharides and starch concentrations in raw and cooked sweet potato 显示文摘 | Truong V D Christopher J B Judith A M | 1986 | Journal of Agricultural and Food Chemistry1986，34，3： | 1 |
| 15 | An Unfermented Gel Component of Psyllium Seed Husk Promotes Laxation as aLubricant in Humans显示文摘 | Judith A Marlett Theresa M Kajs Milton H Fischer | 2000 | American Journal of Clinlical Nutrition2000，72，3： | 1 |
| 16 | Perlyn Long-term outcome of autogenous rib graft nasal reconstruction 显示文摘 | Judith M Gurley Thomas Pilgrarn Chad A | 2001 | Plast Reconstr Surg2001，108，： | 1 |
| 17 | Analysis of stress distribution in lumbar interbody fusion显示文摘 | Kumar N Judith M R Kumar A | 2005 | Spine2005，30，15： | 1 |
| 18 | Gene ontology:tool for the unification of biology显示文摘 | Ashburner M Catherine A B Judith A B | 2000 | Nature Genetics2000，25，1： | 1 |
| 19 | Inhibition of protein in cultured tobacco cells by radiaton显示文摘 | Terence M Murphy Lawrence A Wright Jr Judith B Murphy | 1975 | Photochemistry and Photobiology1975，21，： | 1 |
| 20 | Functional health literacy,medication -taking self -efficacy and adherence to antiretroviral therapy显示文摘 | Alison M Colbert Susan M Sereika Judith A Erlen | | 0，，02： | 1 |
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