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| 1 | Predictors of suboptimal bowel preparation in asymptomatic patients undergoing average-risk screening colonoscopy显示文摘AIM To identify risk factors for a suboptimal preparation among a population undergoing screening or surveillance colonoscopy.METHODS Retrospective review of the University of Michigan and Veteran's Administration(VA) Hospital records from 2009 to identify patients age 50 and older who underwent screening or surveillance procedure and had resection of polyps less than 1 cm in size and no more than 2 polyps. Patients with inflammatory bowel disease or a family history of colorectal cancer were excluded. Suboptimal procedures were defined as procedure preparations categorized as fair, poor or inadequate by the endoscopist. Multivariable logistic regression was used to identify predictors of suboptimal preparation.RESULTS Of 4427 colonoscopies reviewed, 2401 met our inclusion criteria and were analyzed. Of our population, 16% had a suboptimal preparation. African Americans were 70% more likely to have a suboptimal preparation(95%CI: 1.2-2.4). Univariable analysis revealed that narcotic and tricyclic antidepressants(TCA) use, diabetes, prep type, site(VA vs non-VA), and presence of a gastroenterology(GI) fellow were associated with suboptimal prep quality. In a multivariable model controlling for gender, age, ethnicity, procedure site and presence of a GI fellow, diabetes [odds ratio(OR) = 2.3; 95%CI: 1.6-3.2], TCA use(OR = 2.5; 95%CI: 1.3-4.9), narcotic use(OR = 1.7; 95%CI: 1.2-2.5) and Miralax-Gatorade prep vs 4L polyethylene glycol 3350(OR = 0.6; 95%CI: 0.4-0.9) were associated with a suboptimal prep quality. CONCLUSION Diabetes, narcotics use and TCA use were identified as predictors of poor preparation in screening colonoscopies while Miralax-Gatorade preps were associated with better bowel preparation. | Shail M Govani Eric E Elliott Stacy B Menees Stephanie L Judd Sameer D Saini Constantinos P Anastassiades Annette L Urganus Suzanna J Boyce Philip S Schoenfeld | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，17： | 7 |
| 2 | Pharmacological effects of lipid-lowering drugs on circulating adipokines显示文摘The cardioprotective effects of lipid-lowering drugs have been primarily attributed to their effects on blood lipid metabolism.However,emerging evidence indicates that lipid-lowering drugs also modulate the synthesis and secretion of adipose tissue-secreted proteins referred to as adipokines.Adipokines influence energy homeostasis and metabolism and have also been shown to modulate the vascular inflammatory cascade.The purpose of this review will be to examine the reported effects of commonly used lipid-lowering drugs(statins,fibrates,niacin and omega-3-fatty acids) on the circulating concentrations of leptin,adiponectin,tumor necrosisfactor-α(TNF-α),Retinol binding protein 4(RBP4) and resistin.Overall,the lipid-lowering drugs reviewed have minimal effects on leptin and resistin concentrations.Conversely,circulating adiponectin concentrations are consistently increased by each lipid-lowering drug reviewed with the greatest effects produced by niacin.Studies that have examined the effects of statins,niacin and omega-3-fatty acids on TNF-α demonstrate that these agents have little effect on circulating TNF-α concentrations.Niacin and fibrates appear to lower RBP4 but not resistin concentrations.The results of the available studies suggest that a strong relationship exists between pharmacological reductions in blood lipids and adiponectin that is not obvious for other adipokines reviewed. | Desiree Wanders Eric P Plaisance Robert L Judd | 2010 | World Journal of Diabetes2010，1，4： | 5 |
| 3 | Gut microbiome profiling and colorectal cancer in African Americans and Caucasian Americans显示文摘AIM To determine whether and to what extent the gut microbiome is involved in regulating racial disparity in colorectal cancer(CRC). METHODS All patients were recruited and experiments were performed in accordance with the relevant guidelines and regulations by the Institutional Review Boards (IRB), committees of the John D. Dingell VAMC and Wayne State University guidelines. African American (AA) and Caucasian American (CA) patients were scheduled for an outpatient screening for colonoscopy, and no active malignancy volunteer patients were doubly consented, initially by the gastroenterologist and later by the study coordinator, for participation in the study. The gut microbial communities in colonic effluents from AAs and CAs were examined using 16 sRNA profiling, and bacterial identifications were validated by performing SYBR-based Real Time PCR. For metagenomic analysis to characterize the microbial communities, multiple software/tools were used, including Metastats and R statistical software.RESULTS It is generally accepted that the incidence and mortality of CRC is higher in AAs than in CAs. However, the reason for this disparity is not well understood. We hypothesize that the gut microbiome plays a role in regulating this disparity. Indeed, we found significant differences in species richness and diversity between AAs and CAs. Bacteroidetes was more abundant in AAs than in CAs. In particular, the pro-inflammatory bacteria Fusobacterium nucleatum and Enterobacter species were significantly higher in AAs, whereas probiotic Akkermansia muciniphila and Bifidobacterium were higher in CAs. The polyphyletic Clostridia class showed a divergent pattern, with Clostridium XI elevated in AAs, and Clostridium IV, known for its beneficial function, higher in CAs. Lastly, the AA group had decreased microbial diversity overall in comparison to the CA group. In summary, there were significant differences in pro-inflammatory bacteria and microbial diversity between AA and CA, which may help explain the CRC disparity between groups.CONCLUSION Our current investigation, for the first time, demonstrates microbial dysbiosis between AAs and CAs, which could contribute to the racial disparity of CRC. | Lulu Farhana Fadi Antaki Farhan Murshed Hamidah Mahmud Stephanie L Judd Pratima Nangia-Makker Edi Levi Yingjie Yu Adhip PN Majumdar | 2018 | World Journal of Gastrointestinal Pathophysiology2018，9，2： | 3 |
| 4 | Polyoxometalates in medicine显示文摘 | Rhule J T Hill C L Judd D A | | 0，，： | 2 |
| 5 | Partial discharge monitoring for power transformers using UHF sensors, part 1 : sensors and signal interpretation显示文摘 | Judd M D Yang L Hunter B B | 2005 | IEEE Electrical Insulation Magazine2005，21，2： | 1 |
| 6 | Polyoxometalates in medicine 显示文摘 | RHULE J T HILL C L JUDD D A | 1998 | Chem Rev1998，98，1： | 1 |
| 7 | Social Security and Individual Welfare: Precautionary Saving, Borrowing Constraints, and the Payroll Tax 显示文摘 | Hubbard R G Judd K L | 1987 | American Economic Review1987，77，4： | 1 |
| 8 | Impact of aeration, solids concentration and membrane characteristics on the hydraulic performance of a membrane bioreactor 显示文摘 | Clech P L Jefferson B Judd S J | 2003 | Journal of Membrane Science2003，218，12： | 1 |
| 9 | 显示文摘 | HILL C L JUDD D A TANG J | 1997 | Antivir Res1997，34，： | 1 |
| 10 | The geological methane budget at continental margins and its influence on climate change显示文摘 | Judd A G Hovland M Dimitrov L I | 2002 | Geofluids2002，2，2： | 1 |
| 11 | Subsyndromal symptomatic depression: A new mood disorder? 显示文摘 | Judd L L Rapaport M H Paulus M P | 1994 | Journal of Clinical Psychiatry1994，55，4： | 1 |
| 12 | Dynamics from multivariate time series显示文摘 | Cao L Mees A Judd K | 1998 | Physica D: Nonlinear Phenomena1998，121，1： | 1 |
| 13 | Credible spatial preemption显示文摘 | Judd K L | 1985 | Rand Journal of Economies1985，16，2： | 1 |
| 14 | Dynamics from multivariate time series显示文摘 | CAO L Mt! ES A JUDD K | 1998 | Physica D1998，121，1： | 1 |
| 15 | Alterations in vitamin D status and anti-microbial peptide levels in patients in the intensive care unit with sepsis显示文摘 | Jeng L Yamshchikov AV Judd SE | 2009 | J Transl Med2009，7，1： | 1 |
| 16 | Reeognising multiple partial discharge sources in power transformers by wavelet analysis of UHF signals显示文摘 | Yang A L Judd M D | 2003 | IEE Proceedings Science Measurement and Technology2003，150，3： | 1 |
| 17 | Sensory gating deficits in schizophrenia:New results显示文摘 | Judd LL McAdams L Budnick B | 1992 | Am J Psychiatry1992，149，4： | 1 |
| 18 | Population suppres- sion of Campylomma verbasci ( Heteroptera: Miridae ) by at- mospheric permeation with symhetic sex pheromone显示文摘 | McBrien H L Judd G J R Borden J H | 1997 | Journal of Economic Entomology1997，90，3： | 1 |
| 19 | The geological methane budget at continental margins and its influence on climate change显示文摘 | Judd A G Hovland M Dimitrov L I | 2002 | Geofluids2002，2，： | 1 |
| 20 | Gastric H+ ,K+ -daenosine triphosphatase β-subunit is required for normal function, development, and membrane structure of mouse parietal cells显示文摘 | Scarff K L Judd L M Toh B H | 1999 | Gastroenterology1999，117，3： | 1 |
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