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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | 急性脊髓损伤患者治疗的临床操作指南:关于MRI基线在临床治疗决策与结果预测中作用的几点建议(英文)显示文摘The objective of this guideline is to outline the role of magnetic resonance imaging(MRI) in clinical decision making and outcome prediction in patients with traumatic spinal cord injury(SCI).Methods A systematic review of the literature was conducted to address key questions related to the use of MRI in patients with traumatic SCI.This review focused on longitudinal studies that controlled for baseline neurologic status.A multidisciplinary Guideline Development Group(GDG) used this information,their clinical expertise,and patient input to develop recommendations on the use of MRI for SCI patients.Based on GRADE(Grading of Recommendation,Assessment,Development and Evaluation),a strong recommendation is worded as ' we recommend,' whereas a weaker recommendation is indicated by 'we suggest.' Results Based on the limited available evidence and the clinical expertise of the GDG,our recommendations were:(1) 'We suggest that MRI be performed in adult patients with acute SCI prior to surgical intervention,when feasible,to facilitate improved clinical decision-making'(quality of evidence,very low) and(2) 'We suggest that MRI should be performed in adult patients in the acute period following SCI,before or after surgical intervention,to improve prediction of neurologic outcome '(quality of evidence,low).Conclusions These guidelines should be implemented into clinical practice to improve outcomes and prognostication for patients with SCI. | Fehlings MG Martin AR Tetreault LA Aarabi B Anderson P Arnold PM Brodke D Burns AS Chiba K Dettori JR Furlan JC Hawryluk G Holly LT Howley S Jeji T Kalsi-Ryan S Kotter M Kurpad S Kwon BK Marino RJ Massicotte E Merli G Middleton JW Nakashima H Nagoshi N Palmieri K Singh A Skelly AC Tsai EC Vaccaro A Wilson JR Yee A Harrop JS | 2017 | 中华神经外科疾病研究杂志2017，16，6： | 8 |
| 3 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 4 | Resistance to cusp fracture in endodonticallytreated teeth 显示文摘 | Wendt S L Jr Harris B M Hunt T E | 1987 | Dent Mater1987，3，5： | 1 |
| 5 | Crown ether-doped sol-gel materiaIs for strontium( 1I ) separation显示文摘 | YOST T L Jr FAGAN B C ALLAIN L R | 2000 | Analytical Chemis- try2000，72，21： | 1 |
| 6 | Apoptosis induced by the sonomechanical effects of low intensity pulsed ultrasound in a human leukemia cell line显示文摘 | Feril L B Jr Kondo T Cui Z G | | 0，，02： | 1 |
| 7 | Critical incident stress management(CISM) :A review of the literature 显示文摘 | Everly Jr G S Flannery Jr R B Mitchell J T | 2000 | Aggression and Violent Behavior2000，15，1： | 1 |
| 8 | Introducing mothur: open-source, platform-independent, community-supported software for describing and comparing microbial communities 显示文摘 | Schloss PD Westcott SL Ryabin T Hall JR Hartmann M Hollister EB Lesniewski RA Oakley BB Parks DH Robinson CJ Sahl JW Stres B Thallinger GG Van Horn DJ Weber CF | 2009 | Appl Environ Microbiol2009，75，23： | 1 |
| 9 | Stability and confinement of nonrelativistic sheet electron beams with periodic cusped magnetic focusing显示文摘 | Booske J H McVey B D Antonsen T M Jr | 1993 | JAppl Phys1993，73，9： | 1 |
| 10 | Results of medial patellofemoral ligament reconstruction in the treatment of patellar dislocation显示文摘 | Drez D Jr Edwards T B Williams C S | 2001 | Arthroscopy2001，17，3： | 1 |
| 11 | Supplemental energy dissipation: State-of-the-art and state-of-the-practice显示文摘 | SOONG T T SPENCER JR B F | 2002 | Engineering Structures2002，24，： | 1 |
| 12 | Optimization of 2,3-butanediol production by Klebsiella oxytoca through oxygen transfer rate control显示文摘 | Beronio Jr P B Tsao G T | 1993 | BiotechnolBioeng1993，42，11： | 1 |
| 13 | Hole doping of the CuO2 chains(La,Sr,Ca)14Cu24 O41显示文摘 | CARTER S A BATLOGG B CAVA R J KRAJEWSKI J J PECK JR W F RICE T M | 1996 | Phys Rev Lett1996，77，7： | 1 |
| 14 | The ribosomal database project: improved alignments and new tools for rRNA analysis 显示文摘 | Cole JR Wang Q Cardenas E Fish J Chai B Farris RJ Kulam-Syed-Mohideen AS Mcgarrell DM Marsh T Garrity GM Tiedje JM | 2009 | Nucleic Acids Res2009，37，： | 1 |
| 15 | The university hospital consortium guidelines for the use of albumin,nonprotein colloid,and crystalloid solutions显示文摘 | VERMEULEN L C JR RATIKO T A ERSTAD B L | 1995 | Arch Intern Med1995，155，4： | 1 |
| 16 | Electron density measurements of high density plasma using soft X-ray laser interferometry显示文摘 | Da SILVA L B BARBEE Jr T W CAUBLE R | 1995 | Phys Rev Lett1995，74，20： | 1 |
| 17 | Supplemental energy dissipation:State-of-the-art and state-of-the practice显示文摘 | Soong T T Spencer B F Jr | 2002 | Engineering Structures2002，24，： | 1 |
| 18 | Molecular targeting of growth factor receptor-bound 2 (Grb2) as an anti-cancer strategy显示文摘 | Dharmawardana P G Peruzzi B Giubellino A Burke T R Jr Bottaro D P | 2006 | Anticancer Drugs2006，17，： | 1 |
| 19 | Ityponatremia in a-cute spinal cord injury 显示文摘 | PERUZZI W T SHAPIRO B A MEYER P R JR | 1994 | Crit Care Med1994，22，2： | 1 |
| 20 | Stability and confinement of nonrelativistic sheet electron beams with periodic cusped magnetic focusing显示文摘 | Booske J H McVey B D Antonsen T M Jr | 1993 | J Appl Phys1993，73，9： | 1 |
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