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| 1 | 烟酰胺磷酸核糖基转移酶促进肺血管重塑,是肺动脉高压的治疗靶点显示文摘肺动脉高压(pulmonary arterial hypertension,PAH)是一种严重的进行性疾病,其标志之一是肺血管重塑。烟酰胺磷酸核糖基转移酶(nicotinamide phosphoribosyl transferase,NAMPT)是调节细胞内烟酰胺腺嘌呤二核苷酸水平、细胞氧化还原状态,调节组蛋白脱乙酰酶,促进细胞增殖和抑制凋亡的一种细胞酶。研究人员假设NAMPT可促进肺血管重塑, | Chen J Sysol JR Singla S Zhao S Yamamura A Valdez-Jasso D Abbasi T Shioura KM Sahni S Reddy V Sridhar A Gao H Torres J Camp SM Tang H Ye SQ Comhair S Dweik R Hassoun P Yuan JX Garcia JG Machado RF 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，2： | 10 |
| 2 | 非诺贝特治疗与2型糖尿病患者长期心血管病风险的关系显示文摘2型糖尿病患者心血管病风险高,部分原因在于高三酰甘油和低高密度脂蛋白胆固醇血症。而在他汀类药物治疗基础上,加强降低三酰甘油治疗,能否降低这种风险尚不清楚。该研究的目的是在使用他汀类药物治疗的2型糖尿病患者中,确定非诺贝特能否降低心血管病风险。 | 刘莉 叶鹏 Elam MB Ginsberg HN Lovato LC Corson M Largay J Leiter LA Lopez C O'Connor PJ Sweeney ME Weiss D Friedewald WT Buse JB Gerstein HC Probstfield J Grimm R Ismail-Beigi F Goff DC Jr Fleg JL Rosenberg Y Byington RP ACCORDION study investigators | 2017 | 中华高血压杂志2017，25，6： | 7 |
| 3 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 4 | Softening by fluidized bed crystallizers 显示文摘 | Willard D Harms Jr Robinson R Brace | 1992 | J Environ Eng1992，118，4： | 2 |
| 5 | Production of transgenic sheep with growth-regulating genes显示文摘 | Jr Rexroad C E Hammer R E Bolt D J | 1989 | Molecular reproduction & development1989，1，： | 1 |
| 6 | Grb2 signaling in cell motility and cancer显示文摘 | Giubellino A Burke T R Jr Bottaro D P | 2008 | Expert Opin Ther Targets2008，12，8： | 1 |
| 7 | Accumalation of uranium by Saccgarimyces cererisiae and Pseudomonas aeruginosa 显示文摘 | Strandberg D W Shumate S E Parrot J R Jr | 1981 | Appl Environ Microbiol1981，41，： | 1 |
| 8 | Failure of acetabular autogenous grafts in total hip arthroplasty,Increasing incidence;A follow up note显示文摘 | MULROY Jr R D HARRIS W H | 1990 | J Bone Joint Surg(Am)1990，72，： | 1 |
| 9 | Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS) 显示文摘 | Festa A D'Agostino R Jr Howard G | 2000 | Circulation2000，102，1： | 1 |
| 10 | A closed loop logistics model for remanufacturing显示文摘 | Jayaraman V Guide V D R Jr Sricastava R | 1999 | Journal of Operational Research Society1999，，50： | 1 |
| 11 | Chronic subclinical inflammation as part of the insulin-resistance syndrome: the insulin resistance atherosclerosis study (IRAS)显示文摘 | Festa A D Agostino R Jr Howard G | 2000 | Circulation2000，102，1： | 1 |
| 12 | Reduction ofantibody response to an 11-valent pneumococcal vaccine coad-ministered with a vaccine containing acellular pertussis com-ponents显示文摘 | Dagan R Goldblatt D Maleckar JR | 2004 | Infect Immun2004，72，9： | 1 |
| 13 | DNA polymorphism in the conserved 190 kDa antigen gene repeat region among spotted fever group Rickettsiae 显示文摘 | Gilmore R D Jr Hackstadt T | 1991 | Biochim Biophys Acta1991，1097，1： | 1 |
| 14 | Cellulose microfibrils :visualization of biosynthetic and orienting complexes in association with the plasma mem- brane 显示文摘 | BROWN R M JR MONTEZINOS D | 1976 | Proc Natl Acad Sci USA1976，73，1： | 1 |
| 15 | Chronic sub clinical inflammation as part of the insulin resistance syn drome: the insulin resistance atherosclerosis study (IRAS) 显示文摘 | Festa A D'Agostino R Jr Howard G | 2000 | Circulation2000，102，1： | 1 |
| 16 | Steady-state quantum interference in resonance fluorescence 显示文摘 | CARDIMONA D A RAYMER M G STROUD JR C R | 1982 | Journal of Physial B1982，15，： | 1 |
| 17 | Step - up therapy for children with uncontrolled asthma receiving in- haled corticosteroids显示文摘 | Lemanske Jr R F Manger D T Sorkness C A | 2010 | New England Journal of Medicine2010，362，11： | 1 |
| 18 | Serum levels of d- norgestrel, luteinizing hormone, follicle- stimulating hor- mone, estradiol and progesterone in women during and follow- ing ingestion of combination oral contraceptives containing DL- norgestrel显示文摘 | Brenner P F Mishell D R Jr Stanczyk F Z | 1977 | American Journal of Obstetrics and Gynecology1977，129，2： | 1 |
| 19 | Hiring for the Organization, Not the Job显示文摘 | Bowen D E Ledford G E Jr Nathan B R | 1991 | Ademy of Management Executive1991，5，4： | 1 |
| 20 | A static-output-feedback design procedure for robust emergency lateral control of a highway vehicle显示文摘 | Benton R E Jr Smith D | 2005 | IEEE Trans Contr Syst Technol2005，13，4： | 1 |
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