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| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | Twenty-five years of research on the effects of exercise training in breast cancer survivors:A systematic review of the literature显示文摘AIM:To investigate the role of exercise training the past 25 years on major physiological-psychological outcomes studied thus far in this patient population.METHODS:Pub Med, Medline Plus, the Cochrane Library, Web of Science, SportD iscus, Embase, Scorpus, and Google Scholar were searched from September to November 2013 to identify exercise training studies that used objective measurements of fitness and/or patient reported outcomes assessed pre and post-exercise training with statistical analyses performed in at least one of the following outcome measurements:Cardiorespiratory function, body composition, muscular strength, fatigue, depression, and overall quality of life. Five reviewers independently identified the studies that met the criteria for the review and discrepancies were resolved by consensus among all authors.RESULTS:Fifty-one studies were included in this review with 5 from the period between 1989-1999, 11 from 2000-2006, and 35 from 2007-2013. The evolution of study designs changed from aerobic only exercise training interventions(1989-1999), to a combination of aerobic and resistance training(2000-2006), to studies including an arm of resistance training or examining the effects of resistance training as the main mode of exercise(2007-2013). Overall, the benefits of exercise showed improvements in cardiorespiratory function, body composition, strength, and patient reported outcomes including fatigue, depression, and quality of life.CONCLUSION:Exercise training appears to be safe for most breast cancer patients and improvements in physiological, psychological, and functional parameters can be attained with regular participation in moderate intensity exercise. | Claudio L Battaglini Robert C Mills Brett L Phillips Jordan T Lee Christina E Story Marcelo GB Nascimento Anthony Carl Hackney | 2014 | World Journal of Clinical Oncology2014，5，2： | 3 |
| 3 | The Use of Negative-Pressure Wound Therapy (NPWT) in the Temporary Treatment of Soft-Tissue Injuries Associated With High-Energy Open Tibial Shaft Fractures显示文摘 | Barnaby T Dedmond Bill Kortesis Kathleen Punger Jordan Simpson Joseph Argenta Brenda Kulp Michael Morykwas Lawrence X Webb | 2007 | Journal of Orthopaedic Trauma2007，，1： | 2 |
| 4 | The precautionary principle in contemporary environmental polities显示文摘 | O' Riordan T Jordan A | 1995 | Environ Values1995，4，： | 2 |
| 5 | In vitro and in vivo comparisons of valnemulin, tiamulin, tylosin, enrofloxacin, and lincomycird spectinomycin against Mycoplasma gallisepticum显示文摘 | Jordan F T | 1998 | Avian Dis1998，42，4： | 1 |
| 6 | Venous Access Ports:Frequency and Management of Complications in On- cology Patients显示文摘 | Jordan K Behlendorf T Surov A | 2008 | Onkologle2008，31，7： | 1 |
| 7 | Phytochrome A overex- pression in transgenic tobacco: Correlation of dwarf phenotype with high concentrations of phytochrome in vascular tissue and attenuated gibberellin levels 显示文摘 | Jordan E T Hatfield P M Hondred D | 1995 | Plant Physiol1995，107，： | 1 |
| 8 | Evaluation of invivo endoscopic autofluorescence spectroscopy in gastriccancer显示文摘 | Mayinger B Jordan M Horbach T | 2004 | Gastrointest Endosc2004，59，2： | 1 |
| 9 | A photogrammetric technique for measuring soil erodion显示文摘 | Welth R Jordan T R Thomas A | 1984 | Journal of Soil and Water Conservation1984，39，3： | 1 |
| 10 | Beaver pond biogeochemical effects in the Maryland Coastal Plain显示文摘 | Correll D L Jordan T E Weller D E | 2000 | Biogeochemistry2000，49，3： | 1 |
| 11 | A nitrogen budget of the ribbed mussel, Geukensla demissa and its significance in nitrogen flow in New England salt marsh显示文摘 | Jordan T E Valiela I | 1982 | Limnol Oceanogr1982，27，： | 1 |
| 12 | A nitrogen budget of the ribbed mussel, Geukensla demissa and its significance in nitrogen flow in New England salt marsh显示文摘 | Valiela I | 1982 | Limnol Oceanogr1982，27，： | 1 |
| 13 | Cancer stem cells显示文摘 | Jordan C T Guzman M L Noble M | 2006 | N Engl J Med2006，355，12： | 1 |
| 14 | Diffusion layer parameters influencing optimal fuel cell performance显示文摘 | Jordan L R Shukla A K Behrsing T | 2000 | J Power Sources2000，86，12： | 1 |
| 15 | Efficacy of Vaporized Hydrogen Peroxide against Exotic Animal Viruses显示文摘 | Heckert RA BEST ML Jordan T | | 0，，10： | 1 |
| 16 | In limitations to efficient water use in crop production显示文摘 | Taylor H Jordan W Sinclair T | | 0，，： | 1 |
| 17 | Promising cytotoxic activ-ity profile of fermented wheat germ extract (Avemar (R显示文摘 | Mueller T Jordan K Voigt W | | 0，，： | 1 |
| 18 | Modelling of residual stress relaxation around cold expanded holes in carbon steel显示文摘 | JORDAN T M GALYA V D IVAN N M | 2009 | Journal of Constructional Steel Research2009，65，： | 1 |
| 19 | Evaluation of invivo endoscopic autofluorescence spectroscopy in gastriccancer显示文摘 | Mayinger B Jordan M Horbach T | 2004 | Gast Rointest Endosc2004，59，2： | 1 |
| 20 | Changes in mRNA levels and polypetide subunits of ribulose-1,5-biophosphate carboxylase in response to supplementary ultraviolet-B radiation显示文摘 | JORDAN B R HE T CHOW W S | 1992 | Plant Cell Environment1992，15，： | 1 |
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