|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 诊断性试验和策略的证据质量和推荐强度的分级显示文摘GRADE系统能对诊断性试验或策略的证据质量和推荐强度进行分级。本文旨在阐释在此过程中如何考虑患者的重要结局, | Holger J Schünemann Andrew D Oxman Jan Brozek Paul Glasziou Roman Jaeschke Gunn E Vist John W Williams Jr Regina Kunz Jonathan Craig Victor M Montori Patrick Bossuyt Gordon H Guyatt 李晓 黄程 陈耀龙 李幼平 | 2009 | 中国循证医学杂志2009，9，5： | 7 |
| 2 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 3 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 4 | The nature of the extended analog computer显示文摘 | JONATHAN W M | 2008 | Physica D: Nonlinear Phenomena2008，237，9： | 1 |
| 5 | The business value of digital supply networks: a program of re- search on the impacts of globalization 显示文摘 | Jonathan W Areham Lars M Athiassen Arun Rai | 2005 | Journal of Interna- tional Management2005，，11： | 1 |
| 6 | Fast and robust spatially constrained Gaussian mixture model for image segmentation显示文摘 | NGUYEN T M JONATHAN W Q M | 2013 | IEEE Trans on Circuits and Systems for Video Technology2013，23，4： | 1 |
| 7 | How insulin engages its primary binding site on the insulin receptor显示文摘 | Menting J G Jonathan W Mai B M | 2013 | Nature2013，493，7431： | 1 |
| 8 | The epithelial-mesenchymal transition:new insights in signaling,development,and disease显示文摘 | Jonathan M L Shoukat D Raghu K Erik W T | 2006 | JCB2006，172，7： | 1 |
| 9 | Product platform design: method and application显示文摘 | SIMPSON T W JONATHAN R A M MISTREE F | 2001 | Research in Engineering Design2001，13，1： | 1 |
| 10 | Changes in pore size distribution upon thermal cycling of TATB-based explosives measured by ultra-small angle X-Ray scattering显示文摘 | Trevor M W Tony van B Jonathan R I L | 2006 | Propellants Explosives Pyrotechnics2006，31，6： | 1 |
| 11 | The role of the aryl hydrocarbon receptor nuclear translocator(ARNT) in hypoxic induction of gene expression显示文摘 | S Morwenna Wood Jonathan M Gleadle Christopher W Pugh | 1996 | The Journal of Biological Chemistry1996，271，15： | 1 |
| 12 | Interplay between the cardiac rennin angiotensin system and JAKSTAT signaling: role in ca-rdiac hypertrophy, ischemia/repe fusion dysfunction, and heart failure 显示文摘 | Jonathan N E Day Kenneth M Baker | 2002 | J Mol Cell Cardiol2002，34，11： | 1 |
| 13 | Face recognition by curvelet based feature extraction 显示文摘 | Mandal T Majumdar A Jonathan W Q M | 2007 | Lecture Notes in Computer Science2007，4633，1： | 1 |
| 14 | Product platform design: method and application 显示文摘 | SIMPSON T W JONATHAN R A M MISTREEF | 2001 | Research in Engineering Design2001，13，1： | 1 |
| 15 | Carotenoids and egg quality in the lesser black-backed gull Larus fuscus : a supplemental feeding study of maternal effects显示文摘 | Blount Jonathan D. Surai Peter F. Nager Ruedi G. Houston David C. M? ller Anders Pape Trewby Michael L. Kennedy Malcolm W | 2002 | Proceedings of the Royal Society B: Biological Sciences . 2002 (1486)2002，，： | 1 |
| 16 | Management of severe head injury显示文摘 | Jonathan W Graham M | 1996 | Contemporary Neurosurgery1996，18，： | 1 |
| 17 | Product platform design: Method and application 显示文摘 | Simpson T W Jonathan R M Mistree F | 2001 | Research in Engineering Design2001，13，1： | 1 |
| 18 | Managenment of severe head injury 显示文摘 | Jonathan W Grahaam M | 2010 | Contemp Neurosurg2010，1815，： | 1 |
| 19 | Side resistance of large diameter bored piles socketed into decomposed rock显示文摘 | Charles W W N Terence L Y Y Jonathan H M L | 2001 | Journal of Geotechnical and Geoenvironmental Engineering ASCE2001，127，8： | 1 |
| 20 | A survey of active network research显示文摘 | David L T Jonathan M S David J W | 2002 | IEEE Communications Magazine2002，35，22： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员