|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病源性轻度认知障碍诊断标准推荐显示文摘美国国立老化研究所(NIA)和阿尔茨海默病协会(ADA)组织了一个工作组,负责阿尔茨海默病(AD)痴呆前症状阶段——即本文所称的AD源性轻度认知障碍(MCI)的诊断标准的制订及完善。该工作组制订了以下两套标准:(1)在缺乏相应条件进行先进影像技术及脑脊液检查时,医务人员适用的核心临床标准;(2)适用于包括临床试验在内的科学研究的研究标准。后者纳入了基于影像技术及脑脊液检查的生物标志物的应用。并根据所出现的生物标志物的性质,将最终MCI诊断的确定性程度分为4个级别。而要使生物标志物有效应用于诊断,并在社区医疗服务中规范使用,尚需做大量的工作。 | McKhann GM Knopman DS Chertkow H Hyman BT Jack CR Jr Kawas CH Klunk WE Koroshetz WJ Manly JJ Mayeux R Mohs RC Morris JC Rossor MN Schehens P Carrillo MC Thies B Weintraub S Phelps CH 贾建平(译) 陆璐(译) 张逸驰(译) 黄丽黄(译) 礼媛(译) | 2012 | 中华神经科杂志2012，45，5： | 51 |
| 2 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病痴呆诊断标准的推荐显示文摘由美国国立老化研究所(NIA)和阿尔茨海默病(AD)协会组织了一个工作组,负责修订1984年版AD痴呆的诊断标准。旨在确保修订后的标准具有足够的灵活性,既可供缺乏神经心理学测验、先进的影像技术和脑脊液检查措施的普通医务人员使用,也可供具备上述措施的科研、临床试验的专业研究者使用。新的标准广泛适用于各种原因的痴呆以及专门针对AD痴呆的标准,保留了1984年版标准中的“很可能的AD痴呆”的总体框架。在过去27年的经验基础上,工作组对临床诊断标准做了一些修改,保留了“可能的AD痴呆”的术语,但对其进行了更有针对性的重新定义。在科研用的“很可能的和可能的AD痴呆”的诊断标准中纳入了生物标志物证据。AD痴呆的核心临床标准仍将是临床实践中诊断的基础,但用生物标志物证据来提高AD痴呆诊断的病理生理学特异性也被人们寄予厚望。要实现AD痴呆的生物标志物诊断,还有许多工作摆在面前。 | McKhann GM Knopman DS Chertkow H Hyman BT Jack CR Jr Kawas CH Klunk WE Koroshetz WJ Manly J J Mayeux R Mohs RC Morris JC Rossor MN Scheltens P Carrillo MC Thies B Weintraub S Phelps CH 贾建平(译) 陆璐(译) 张逸驰(译) 黄丽(译) 韩阅(译) | 2012 | 中华神经科杂志2012，45，5： | 52 |
| 3 | Down-regulation of Hsp90 could change cell cycle distribution and increase drug sensitivity of tumor cells显示文摘:AIM To construct Hsp90 antisense RNAeukaryotic expression vector, transfect it intoSGC7901 and SGC7901/VCR of MDR-type humangastric cancer cell lines, HCC7402 of humanhepatic cancer and Eel09 of human esophagealcancer cell lines, and to study the cell cycledistribution of the gene transected cells andtheir response to chemotherapeutic drugs.METHODS A I .03kb cDNA sequence of Hsp90Pwas obtained from the primary plasmid phHsp90by EcoR 1 and BamH I nuclease digestion andwas cloned to the EcoR 1 and BamH 1 site ofthe pcDNA by T4DNA ligase and an antisenseorientation of Hsp900 expression vector wasconstructed. The constructs were transfectedwith lipofectamine and positive clones wereselected with G418. The expression of RNA wasdetermined with dot blotting and RNaseprotection assay, and the expression of Hsp90protein determined with Western blot. Cell cycledistribution of the transfectants was analyzedwith flow cytometry, and the drug sensitivity ofthe transfectants to adriamycin (ADR ),vincrinstine (VCR ), mitomycin (MMC ) andcyclophosphamide (CTX ) with MTT andintracellular drug concentration of thetransfectants was determined with flowcytometry.RESULTS In EcoR 1 and BamH I restrictionanalysis, the size and the direction of the clonedsequence of Hsp900 remained what had beendesigned and the gene constructs were namedpcDNA-Hsp90. AH^SGC7901, AH^SGC7901/ VCR,AH-HCC7402 and AH-Eel09 cell clones allexpressed Hsp90 anti--sense RNA. Theexpression of Hsp90 was down--regulated in AHSGC7901, AH--SGC7901/ VCR, AH-HCC7402 andAH--Eel09 cell clones. Cell cycle distribution waschanged differently. In AH-SGC7901/ VCR andAH-Ec109 cells, G, phase cells were increased; Sphase and G, phase cells were decreased ascompared with their parental cell lines. In AHSGC7901 cell, G, phase cells were decreased, Qphase cells increased and S phase cells were notchanged, and in AH-HCC7402 cells G,, S and qphase cells remained unchanged as comparedwith their parental cell lines. The sensitivity ofAH--SGC7901, AH--SGC7901/ VCR, AH-HCC7402 andAH-Ec109 to chemotherapeutic drugs, thesensitivity ot AH--SGC7901/ VCR to ADR, VCR,MMC and CTX the sensitivity of AH-HCC7402 toADR and VCR, and the sensitivity of Eel09 toADR, VCR and CTX all increased as comparedwith their parental cell lines. The meanfluorescence intensity of ADR in AH--SGC7901,AH-SGC7901/ VCR, AH--HCC7402 and AH-Ec109was also significantly elevated (P< 0. 05).CONCLUSION Down-regulation of HsP90 couldchange cell cycle distribution and increase thedrug sensitivity of tumor cells. | Liu XL Xiao B Yu ZC Guo JC Zhao QC Xu L Shi YQ Fan DM | 1999 | World Journal of Gastroenterology1999，5，3： | 21 |
| 4 | 在有类型 2 糖尿病的病人的 nephropathy 的管理。 | Critchley JA Zhao HL Tomlinson B Leung W Thomas GN Chan JC Cockram CS | 2002 | Chinese Medical Journal2002，，1： | 12 |
| 5 | 急性脊髓损伤患者治疗的临床操作指南:关于MRI基线在临床治疗决策与结果预测中作用的几点建议(英文)显示文摘The objective of this guideline is to outline the role of magnetic resonance imaging(MRI) in clinical decision making and outcome prediction in patients with traumatic spinal cord injury(SCI).Methods A systematic review of the literature was conducted to address key questions related to the use of MRI in patients with traumatic SCI.This review focused on longitudinal studies that controlled for baseline neurologic status.A multidisciplinary Guideline Development Group(GDG) used this information,their clinical expertise,and patient input to develop recommendations on the use of MRI for SCI patients.Based on GRADE(Grading of Recommendation,Assessment,Development and Evaluation),a strong recommendation is worded as ' we recommend,' whereas a weaker recommendation is indicated by 'we suggest.' Results Based on the limited available evidence and the clinical expertise of the GDG,our recommendations were:(1) 'We suggest that MRI be performed in adult patients with acute SCI prior to surgical intervention,when feasible,to facilitate improved clinical decision-making'(quality of evidence,very low) and(2) 'We suggest that MRI should be performed in adult patients in the acute period following SCI,before or after surgical intervention,to improve prediction of neurologic outcome '(quality of evidence,low).Conclusions These guidelines should be implemented into clinical practice to improve outcomes and prognostication for patients with SCI. | Fehlings MG Martin AR Tetreault LA Aarabi B Anderson P Arnold PM Brodke D Burns AS Chiba K Dettori JR Furlan JC Hawryluk G Holly LT Howley S Jeji T Kalsi-Ryan S Kotter M Kurpad S Kwon BK Marino RJ Massicotte E Merli G Middleton JW Nakashima H Nagoshi N Palmieri K Singh A Skelly AC Tsai EC Vaccaro A Wilson JR Yee A Harrop JS | 2017 | 中华神经外科疾病研究杂志2017，16，6： | 8 |
| 6 | The prevention of osteoporosis using sequential low - dose hormone replacement therapy with estradiol - 17 beta and dydrogesterone 显示文摘 | Lees B Stevenson JC | 2001 | Osteoporosis International2001，12，4： | 1 |
| 7 | Sensidvity to choli-nevgic drug treatments of aged rats with variable degrees of spatial memory impairment显示文摘 | Stemmelin J Cassel JC Will B | 1999 | Behav Brain Res1999，98，： | 1 |
| 8 | Power and weakness of spontaneous reporting:a probabilistic approach显示文摘 | Begaud B Pere JC | 1992 | J Clin Epidemiol1992，45，3： | 1 |
| 9 | Apoptosis in the trophoblastrole of apoptosis in placental morphogenesis显示文摘 | HUPPERTZ B KINGDOM JC | 2004 | J Soc Gynecol Investig2004，11，6： | 1 |
| 10 | Acute cervical traumatic spinal cord injury:MR imaging findings correlated with neurologic outcome-prospective study with 100 consecutive patients显示文摘 | Miyanji F Furlan JC Aarabi B | 2007 | Radiology2007，243，3： | 1 |
| 11 | Heat - shnek protein 60 - reactive CD4^+ CD28 null T cells in patients with acute coronary syndromes 显示文摘 | Zal B Kaski JC Arno G | 2004 | Circulation2004，109，10： | 1 |
| 12 | TLR signaling by tumor and immune cells: a double edged sword 显示文摘 | Huang B Zhao J Unkeless JC | 2008 | Oncogeue2008，27，2： | 1 |
| 13 | Ubiquitous expression of the calcitonin - i gene in multiple tissues in response to sepsis 显示文摘 | Muller B White JC Nylen ES | 2001 | J Clin Endocrinol Metab2001，86，： | 1 |
| 14 | Divergent trophoblast invasion and apoptosis in placental bed spiral arteries from pregnancies cnmplicared by maternal anemia and early - onset preeclampsia/intrauterine growth restriction 显示文摘 | Kadyrov M Kingdom JC Huppertz B | 2006 | Am J Obstet Cynecol2006，194，2： | 1 |
| 15 | yon Willebrand factor in cardiovascular disease :focus on acute coronary syndromes 显示文摘 | Spiel AO Gilbert JC Jilma B | 2008 | Circulation2008，117，11： | 1 |
| 16 | Influence of an enriched environment and cortical grafting on functional out- come in brain infarcts of adult rats 显示文摘 | Grabowski M Sorensen JC Mattsson B | 1995 | Exp Neurol1995，133，： | 1 |
| 17 | New concepts on the mechanism of action ,of fibrates and therapeutic prospeetives in atherosclerosis显示文摘 | Fruchart JC Staels B Duriez P | 2001 | Bull Acad Natl Med2001，185，1： | 1 |
| 18 | The thyrotropin-releasing hormone receptor:interaction with TSH and autoantibodies 显示文摘 | Rapopart B Chazenbalk GD Jaume JC | 1998 | Endoer Rev1998，19，： | 1 |
| 19 | Peroxisome proliferatoractivated receptor alpha activators regulate genes governing lipoprotein metabolism, vascular inflammation and atherosclerosis显示文摘 | Fruchart JC Duriez P Staels B | 1999 | Curr Opin Lipidol1999，10，： | 1 |
| 20 | Extensive screening for hereditary non-polyposis colorectal cancer显示文摘 | Dieumegard B Grandjouan S Sabourin JC | 2000 | Br J Cancer2000，82，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员