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| 1 | Global burden, distribution, and interventions for infectious diseases of poverty显示文摘Infectious diseases of poverty(IDoP)disproportionately affect the poorest population in the world and contribute to a cycle of poverty as a result of decreased productivity ensuing from long-term illness,disability,and social stigma.In 2010,the global deaths from HIV/AIDS have increased to 1.5 million and malaria mortality rose to 1.17 million.Mortality from neglected tropical diseases rose to 152,000,while tuberculosis killed 1.2 million people that same year.Substantial regional variations exist in the distribution of these diseases as they are primarily concentrated in rural areas of Sub-Saharan Africa,Asia,and Latin America,with geographic overlap and high levels of co-infection.Evidence-based interventions exist to prevent and control these diseases,however,the coverage still remains low with an emerging challenge of antimicrobial resistance.Therefore,community-based delivery platforms are increasingly being advocated to ensure sustainability and combat co-infections.Because of the high morbidity and mortality burden of these diseases,especially in resource-poor settings,it is imperative to conduct a systematic review to identify strategies to prevent and control these diseases.Therefore,we attempted to evaluate the effectiveness of one of these strategies,that is community-based delivery for the prevention and treatment of IDoP.In this paper,we describe the burden,epidemiology,and potential interventions for IDoP.In subsequent papers of this series,we describe the analytical framework and the methodology used to guide the systematic reviews,and report the findings and interpretations of our analyses of the impact of community-based strategies on individual IDoPs. | Zulfiqar A Bhutta Johannes Sommerfeld Zohra S Lassi Rehana A Salam Jai K Das | 2014 | Infectious Diseases of Poverty2014，3，1： | 21 |
| 2 | The conceptual framework and assessment methodology for the systematic reviews of community-based interventions for the prevention and control of infectious diseases of poverty显示文摘This paper describes the conceptual framework and the methodology used to guide the systematic reviews of community-based interventions(CBIs)for the prevention and control of infectious diseases of poverty(IDoP).We adapted the conceptual framework from the 3ie work on the‘Community-Based Intervention Packages for Preventing Maternal Morbidity and Mortality and Improving Neonatal Outcomes’to aid in the analyzing of the existing CBIs for IDoP.The conceptual framework revolves around objectives,inputs,processes,outputs,outcomes,and impacts showing the theoretical linkages between the delivery of the interventions targeting these diseases through various community delivery platforms and the consequent health impacts.We also describe the methodology undertaken to conduct the systematic reviews and the meta-analyses. | Zohra S Lassi Rehana A Salam Jai K Das Zulfiqar A Bhutta | 2014 | Infectious Diseases of Poverty2014，3，1： | 5 |
| 3 | Impact of community-based interventions on HIV knowledge, attitudes, and transmission显示文摘In 2012,an estimated 35.3 million people lived with HIV,while approximately two million new HIV infections were reported.Community-based interventions(CBIs)for the prevention and control of HIV allow increased access and ease availability of medical care to population at risk,or already infected with,HIV.This paper evaluates the impact of CBIs on HIV knowledge,attitudes,and transmission.We included 39 studies on educational activities,counseling sessions,home visits,mentoring,women’s groups,peer leadership,and street outreach activities in community settings that aimed to increase awareness on HIV/AIDS risk factors and ensure treatment adherence.Our review findings suggest that CBIs to increase HIV awareness and risk reduction are effective in improving knowledge,attitudes,and practice outcomes as evidenced by the increased knowledge scores for HIV/AIDS(SMD:0.66,95%CI:0.25,1.07),protected sexual encounters(RR:1.19,95%CI:1.13,1.25),condom use(SMD:0.96,95%CI:0.03,1.58),and decreased frequency of sexual intercourse(RR:0.76,95%CI:0.61,0.96).Analysis shows that CBIs did not have any significant impact on scores for self-efficacy and communication.We found very limited evidence on community-based management for HIV infected population and prevention of mother-to-child transmission(MTCT)for HIV-infected pregnant women.Qualitative synthesis suggests that establishment of community support at the onset of HIV prevention programs leads to community acceptance and engagement.School-based delivery of HIV prevention education and contraceptive distribution have also been advocated as potential strategies to target high-risk youth group.Future studies should focus on evaluating the effectiveness of community delivery platforms for prevention of MTCT,and various emerging models of care to improve morbidity and mortality outcomes. | Rehana A Salam Sarah Haroon Hashim H Ahmed Jai K Das Zulfiqar A Bhutta | 2014 | Infectious Diseases of Poverty2014，3，1： | 3 |
| 4 | Impact of community-based interventions for the prevention and control of malaria on intervention coverage and health outcomes for the prevention and control of malaria显示文摘In this paper,we aim to evaluate the effectiveness of community-based interventions(CBIs)for the prevention and management of malaria.We conducted a systematic review and identified 42 studies for inclusion.Twenty-five of the included studies evaluated the impact of the community-based distribution of insecticide-treated nets(ITNs),indoor residual spraying(IRS),or impregnated bed sheets;14 studies evaluated intermittent preventive therapy(IPT)delivered in community settings;two studies focused on community-based education for malaria prevention;and one study evaluated environmental management through drain cleaning.Our analysis suggests that,overall,the community-based delivery of interventions to prevent and control malaria resulted in a significant increase in ITNs ownership(RR:2.16,95%CI:1.86,2.52)and usage(RR:1.77,95%CI:1.48,2.11).However,usage of ITNs was limited to two-thirds of the population who owned them.Community-based strategies also led to a significant decrease in parasitemia(RR:0.56,95%CI:0.42,0.74),malaria prevalence(RR:0.46,95%CI:0.29,0.73),malaria incidence(RR:0.70,95%CI:0.54,0.90),and anemia prevalence(RR:0.79,95%CI:0.64,0.97).We found a non-significant impact on splenomegaly,birth outcomes(low birth weight,prematurity,stillbirth/miscarriage),anthropometric measures(stunting,wasting,and underweight),and mortality(all-cause and malaria-specific).The subgroup analysis suggested that community-based distribution of ITNs,impregnated bed sheets and IRS,and IPT are effective strategies.Qualitative synthesis suggests that high coverage could be achieved at a lower cost with the integration of CBIs with existing antenatal care and immunization campaigns.Community-based delivery of interventions to prevent and control malaria are effective strategies to improve coverage and access and reduce malaria burden,however,efforts should also be concerted to prevent over diagnosis and drug resistance. | Rehana A Salam Jai K Das Zohra S Lassi Zulfiqar A Bhutta | 2014 | Infectious Diseases of Poverty2014，3，1： | 2 |
| 5 | Tackling the existing burden of infectious diseases in the developing world: existing gaps and the way forward显示文摘This series evaluates the effectiveness of community-based interventions(CBIs)to prevent and control infectious diseases of poverty(IDoP).Evidence from our reviews suggests that CBIs and school-based delivery platforms are effective in averting risk behaviors and reducing the disease burden.Co-implementation of interventions through existing community-based programs including immunization campaigns,antenatal care and maternal and child health programs have the potential to scale-up interventions for IDoP.Future research should focus on the process of developing and implementing efficient community-based programs through a comprehensive approach,and to gauge the effectiveness of various existing delivery models in order to improve morbidity and mortality outcomes. | Zulfiqar A Bhutta Rehana A Salam Jai K Das | 2014 | Infectious Diseases of Poverty2014，3，1： | 2 |
| 6 | In vitro and in vivo studies on the antioxidant activity of fish peptide isolated from the croaker (Otolithes ruber)muscle protein hydrolysate 显示文摘 | Nazeer R A Kumar N S Jai G R | 2012 | Peptides2012，35，2： | 1 |
| 7 | Rapid switch from intravenous epoprostenol to intravenous treprostinil in patients with pulmonary arterial hypertension显示文摘 | Sitbon O Manes A Jais X | 2007 | J Cardiovasc Pharmacol2007，49，： | 1 |
| 8 | Analytical description of the motion of an acoustic-driven atomic force microscope cantilever in liquid 显示文摘 | Jai C Cohen-Bouhacina T Maali A | 2007 | Applied Physics Letters2007，90，11： | 1 |
| 9 | Immunosuppressive therapy in lupus-and mixed connective tissue disease-associated pulmonary arterial hypertension:a retrospective analysis of twenty-three cases显示文摘 | Jais X Launay D Yaici A | 2008 | Arthritis Rheum2008，58，2： | 1 |
| 10 | Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins显示文摘 | Haissaguerre M Jais P Shall DC Takahashi A | 1998 | N Engl J Med1998，339，10： | 1 |
| 11 | Local electrogram-based criteria of cavotricuspid isthmus block显示文摘 | Shah DC Takahashi A Jais P | 1999 | J Cardiovasc Electrophysiol1999，10，： | 1 |
| 12 | Bosentan for treat- ment of inoperable chronic thromboembolic pulmonary hyper- tension: BENEFIT( Bosentan Effects in iNopErable Forms of chronic Thromboembolic pulmonary hypertension ), a ran- domized, placebo-controlled trial 显示文摘 | JAIS X D'ARMINI A M JANSA P | 2008 | J Am Coil Cardiol2008，52，： | 1 |
| 13 | Pregnancy outcomes in pulmonary arterial hypertension in the modern management era 显示文摘 | Jais X Olsson K M Barbera J A | 2012 | Eur Respir J2012，40，88： | 1 |
| 14 | Impact of different gases and pneumoperitoneum pressures on tumor growth during laparoscopy in a rat model显示文摘 | AGOSTINI A ROBIN F JAIS JP | 2002 | Surg Endosc2002，16，3： | 1 |
| 15 | Immunosuppressive therapy in lupus and mixed connective tissue disease associated pul- monary arterial hypertension: a retrospective analysis of twenty three cases显示文摘 | Jais X Launay D Yaici A | 2008 | Arthritis Rheum2008，58，2： | 1 |
| 16 | Hemoperitoneum secondary to rupture of cystic artery pseudoaneurysm显示文摘BACKGROUND:Spontaneous hemoperitoneum of hepato- biliary origin is commonly due to hemorrhage from a liver tumor.It is rarely caused by spontaneous rupture of aneurysm in visceral arteries. METHODS:We report an unusual case of hemoperitoneum caused by rupture of cystic artery pseudoaneurysm,and also outline the approach to its management through surgical and radiological methods. RESULTS:In our patient,the pseudoanurysm was initially treated with percutaneous thrombin injection.However this method of treatment failed after initial success.The pseudoanurysm was finally obliterated successfully using microcoil embolization. CONCLUSIONS:The mainstay of treatment of cystic artery pseudoaneurysm is cholecystectomy and ligation of the aneurysm.Recent publications showed success in using microcoil embolisation.In this case we also outline the use of percutaneous thrombin injection as a definitive treatment method and discuss its success or failure as a new method of treatment. | Ali Ghoz Ehab Kheir Anil Kotru Karim Halazun David Kessel Jai Patel J J Peter A Lodge | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，3： | 1 |
| 17 | lmmunosuppressive therapy in lu- pus-and mixed connective tissue disease-associated pulmonary arteri- al hypertension : a retrospective analysis of twenty-three cases 显示文摘 | Jais X Launay D Yaici A | 2008 | Arthritis Rheum2008，58，2： | 1 |
| 18 | Sensors and actuators in distributed systems显示文摘 | Jai A E Pritchard A J | 1987 | International Journal of Control1987，46，4： | 1 |
| 19 | The potential for macitentan,a new dual endothelin receptor antagonist,in the treatment of pulmonary arterial hypertension显示文摘 | Steriade A Seferian A Jais X | 2014 | Ther Adv Respir Dis2014，8，3： | 1 |
| 20 | Some high energy materials and their for-mulations for specialized applications显示文摘 | Jai P A | 2005 | Pro-pellants Explosives Pyrotechnics2005，30，5： | 1 |
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