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| 1 | 国际胃袖状切除专家共识:基于>12000手术病例的最佳操作指南显示文摘腹腔镜胃袖状切除术(1aparoscopic sleeve gastrectomy,LSG)系相对较新的减重手术方式。因其操作相对简单、治疗肥胖合并疾病及减重效果明显,逐步得以广泛接受。目前美国代谢与减重手术协会将其推荐为肥胖症治疗的单独标准术式。2011年3月25~26日, | 苏远涛 徐安安 朱江帆 Diaz AA Arvidsson D Baker RS Basso N Bellanger D Boza C El Mourad H France M Gagner M Galvao-Neto M Higa KD Himpens J Hutchinson CM Jacobs M Jorgensen JO Jossart G Lakdawala M Nguyen NT Nocca D Prager G Pomp A Ramos AC Rosenthal RJ Shah S Vix M Wittgrove A Zundel N | 2013 | 中国微创外科杂志2013，13，9： | 12 |
| 2 | INT-767 improves histopathological features in a dietinduced ob/ob mouse model of biopsy-confirmed nonalcoholic steatohepatitis显示文摘AIM To characterize the efficacy of the dual FXR/TGR5 receptor agonist INT-767 upon histological endpoints in a rodent model of diet-induced and biopsy-confirmed non-alcoholic steatohepatitis(NASH).METHODS The effects of INT-767 on histological features of NASH were assessed in two studies using Lep^(ob/ob)(ob/ob) NASH mice fed the AMLN diet(high fat with transfat, cholesterol and fructose). In a proof-of-conceptstudy, Lep^(ob/ob)(ob/ob) NASH mice were first dosed with INT-767(3 or 10 mg/kg for 8 wk). A second ob/ob NASH study compared INT-767(3 and 10 mg/kg) to obeticholic acid(OCA)(10 or 30 mg/kg; 16 wk). Primary histological endpoints included qualitative and quantitative assessments of NASH. Other metabolic and plasma endpoints were also assessed. A comparative assessment of INT-767 and OCA effects on drug distribution and hepatic gene expression was performed in C57 Bl/6 mice on standard chow. C57 Bl/6 mice were orally dosed with INT-767 or OCA(1-30 mg/kg) for 2 wk, and expression levels of candidate genes were assessed by RNA sequencing and tissue drug levels were measured by liquid chromatography tandem-mass spectrometry.RESULTS INT-767 dose-dependently(3 and 10 mg/kg, PO, QD, 8 wk) improved qualitative morphometric scores on steatohepatitis severity, inflammatory infiltrates and fibrosis stage. Quantitative morphometric analyses revealed that INT-767 reduced parenchymal collagen area, collagen fiber density, inflammation(assessed by Galectin-3 immunohistochemistry) and hepatocyte lipid droplet area following INT-767 treatment. In a comparative study(16 wk), the FXR agonists OCA(10 and 30 mg/kg) and INT-767(3 and 10 mg/kg) both improved NASH histopathology, with INT-767 exerting greater therapeutic potency and efficacy than OCA. Mechanistic studies suggest that both drugs accumulate similarly within the liver and ileum, however, the effects of INT-767 may be driven by enhanced hepatic, but not ileal, FXR function. CONCLUSION These findings confirm the potential utility of FXR and dual FXR/TGR5 activation as disease intervention strategies in NASH. | Jonathan D Roth Michael Feigh Sanne S Veidal Louise KD Fensholdt Kristoffer T Rigbolt Henrik H Hansen Li C Chen Mathieu Petitjean Weslyn Friley Niels Vrang Jacob Jelsing Mark Young | 2018 | World Journal of Gastroenterology2018，24，2： | 7 |
| 3 | Mesh Saliency显示文摘 | LEE C H VARSHNEY A JACOBS D W | 2005 | ACM Transaction on Graph2005，24，3： | 1 |
| 4 | Comparisons of the Outcome Prediction Performance of Injury Severity Scoring Tools Using the Abbreviated Injury Scale 90 Update 98 (AIS 98) and 2005 Update 2008 (AIS 2008) 显示文摘 | Tohira H Jacobs I Mountain D | 2011 | Ann Adv Automot Med2011，55，： | 1 |
| 5 | The effects of supply chain integration on customer satisfaction and financial performance : An organizational learning perspective 显示文摘 | YU W T JACOBS M A SALISBURY W D ENNS H | 2013 | International Journal of Production Economies2013，146，1： | 1 |
| 6 | First -trimester or second-trimester screening, or both, for Down syndrome显示文摘 | Fergal D Malone Canick Jacob A Robert H | 2005 | N Engl Med2005，353，19： | 1 |
| 7 | Report of the conference on low blood cholesterol;mortality associations显示文摘 | Jacobs D Blackburn H Higgins M | 1992 | Circulation1992，86，3： | 1 |
| 8 | Mesh Saliency 显示文摘 | Lee C H Varshney A Jacobs D W | 2005 | ACM Transaction on Graph2005，24，3： | 1 |
| 9 | Structure Determination ofγ'-Fe4N andε-Fe3N显示文摘 | Jacobs H Rechenbach D Zachwieja U | 1995 | J Alloys Compounds1995，227，1： | 1 |
| 10 | Shape classification using the inner-distance显示文摘 | Ling H B Jacobs D W | | 0，，02： | 1 |
| 11 | OMEGA EP high-energy petawatt laser: progress and prospects显示文摘 | D N Maywar J H Kelly L J Waxer S F B Morse I A Begishev J Bromage C Dorrer J L Edwards L Folnsbee M J Guardalben S D Jacobs R Jungquist T J Kessler R W Kidder B E Kruschwitz S J Loucks J R Marciante R L McCrory D D Meyerhofer A V Okishev J B Oliver G Pien | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 12 | A multi-center, randomized, double blind placebo-controlled trial of estrogens to prevent Alzheimer's disease and loss of memory in women: design and baseline characteristics 显示文摘 | Sano M Jacobs D Andrews H | 2008 | Clin TriMs2008，5，5： | 1 |
| 13 | Dynamicsand structure formation in thin polymer melt films 显示文摘 | Seemann R Herminghaus S Neto C Schlagowski S Podzimek D Konrad R Mantz H Jacobs K | 2005 | Journal of Physics2005，17，9： | 1 |
| 14 | Dietary fat and incidence of type 2 diabetes in older women显示文摘 | Meyer K A Jacobs D R Kushi L H | 2011 | Diabetes Care2011，24，2： | 1 |
| 15 | Water deficiency induces evolutionary tradeoff between stress tolerance and chemical defense allocation that may help explain range limits in plants显示文摘 | SIEMENS D H DUVALL-JISHA J JACOBS J | 2012 | Oikos2012，121，5： | 1 |
| 16 | H R C T of fibrosing lung disease显示文摘 | Jacob J H ansell D M | | R espirology0，20，6： | 1 |
| 17 | 难治性类风湿关节炎的临床特点:一项国际问卷调查研究显示文摘目的尽管按照目前欧洲抗风湿联盟(EULAR)的推荐对类风湿关节炎(rheumatoid arthritis,RA)患者进行治疗,难治性RA患者的临床症状却仍然没有得到完全控制,目前EULAR指南主要关注的是RA的早期治疗和药物治疗。本研究的目的在于分析难治性RA患者的临床特点,以及在患者管理中需要探索然而现有EULAR指南并未涉及的问题。方法对多个国家的风湿科医生进行问卷调查,分析难治性RA的临床特点。问卷包括多选题以及开放性问题,从开放性问题的回答中发现需要进一步阐明的问题以及现有EULAR指南需要增加的内容。结果410名受访者完成了调查问卷,关于难治性RA的特点:50%受访者认为基于28个关节评估的疾病活动评分(disease activity score assessing 28 joints,DAS28)>3.2或存在疾病活动的征象;42%受访者认为疲劳是其特点;48%认为至少两种传统合成改变病情抗风湿药(DMARDs)以及使用至少两种生物制剂或靶向合成DMARDs治疗失败;89%认为糖皮质激素不能减量到5 mg/天或泼尼松不能减量到10 mg/天或同等剂量的其他激素。另外,现有EULAR指南中应增加合并症和关节外表现的干预以及多种药物联合治疗等重要内容。结论目前风湿科医生对难治性RA的定义有很大争议。难治性RA患者的很多重要问题目前EULAR指南中均没有涉及。 | Nadia MT Roodenrijs Maria J H de Hair Marlies C van der Goes Johannes WG Jacobs Paco MJ Welsing Désirée van der Heijde Daniel Aletaha Maxime Dougados Kimme L Hyrich Iain B McInnes Ulf Mueller-Ladner Ladislav Senolt Zoltan Szekanecz Jacob Mvan Laar Nagy Gyorgy 黄艳荣(译) 张卓莉(审校) | 2019 | 英国医学杂志中文版2019，22，2： | 1 |
| 18 | A generalization of the conjugate-gradient method to solve complex systems 显示文摘 | Jacobs D A H | 1986 | IMA Journal of Numerical Analysis1986，，6： | 1 |
| 19 | Low temperature water-gas shift: in situ DRIFTS-reaction study of ceria surface area on the evolution of formats on Pt/CeO2 fuel processing catalysts for fuel cell applications 显示文摘 | Gary Jacobs Leann Williams Uschi Graham Gerald A Pennis E Burtron H D | 2003 | Applied Catalysis A: General2003，252，： | 1 |
| 20 | Gas-particle partitioning of atmospheric Hg (11) and its effect on global mercury deposition显示文摘 | Amos H M Jacob D J Holmes C D | 2012 | Atmospheric Chemistry and Physics2012，12，1： | 1 |
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