|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 经冠状动脉造影证实的初次冠状动脉支架内血栓形成长期临床预后:431例临床分析显示文摘本研究(Dutch Stent Thrombosis Registry)为一项多中心研究,纳入了2004年1月至2007年2月期间经造影确认的ST病例。本研究ST的定义根据ARC分类为明确的血栓形成。根据事件发生的时间分为急性(24h之内)、亚急性(24h~30d)、晚期(30d~1年)和极晚期(1年以后)血栓形成。 | van Werkum JW Heestermans AA de Korte FI 张闻多 | 2009 | 中国心血管杂志2009，14，4： | 15 |
| 2 | Role of matrix metalloproteinase,tissue inhibitor of metalloproteinase and tumor necrosis factor-α single nucleotide gene polymorphisms in inflammatory bowel disease显示文摘AIM:To study the (functional) relevance of single nucleotide polymorphisms (SNPs) in genes encoding matrix metalloproteinases (MMP)-1,-2,-3,-9,tissue inhibitors of metalloproteinases (TIMP)-1,-2 and tumor necrosis factor (TNF)-α in the etiopathogenesis of inflammatory bowel diseases (IBD),that may enhance susceptibility and/or disease severity. METHODS:Genomic DNA from 134 Crohn's disease (CD),111 ulcerative colitis (UC) patients and 248 control subjects was isolated from resected intestinal tissue or blood. Allelic composition at SNP loci was determined by PCR-RFLP or tetra primer ARMS PCR. RESULTS:The TIMP-1 genotype TT in women and T in men at SNP +372 T/C was found to increase CD susceptibility (39% vs 23.8%,P=0.018 and 67.9% vs 51.6%,P=0.055,respectively),while women with this genotype were less prone to development of fistulae during follow-up (41.4% vs 68.3%,P=0.025). Male IBD or CD patients carrying the TIMP-1 +372 T-allele expressed lower levels of TIMP-1 in surgically resected macroscopically inflamed tissue (0.065 < P < 0.01). The 5T5T genotype at MMP-3 SNP -1613 5T/6T increased the chance of stenotic complications in CD during follow-up (91.2% vs 71.8%,P = 0.022) but seemed to protect against colonic involvement of this disease at first endoscopic/radiologic examination (35.3% vs 59.5%,P=0.017). CONCLUSION:Allelic composition at the examinedSNPs in genes coding for TIMP-1 and MMP-3 affect CD susceptibility and/or phenotype,i.e.,fistulizing disease,stricture pathogenesis and first disease localisation. These findings reinforce the important role of these proteins in IBD. | Martin JW Meijer Marij AC Mieremet-Ooms Ruud A van Hogezand Cornelis BHW Lamers Daniel W Hommes Hein W Verspaget | 2007 | World Journal of Gastroenterology2007，13，21： | 15 |
| 3 | m TOR signaling in liver regeneration: Rapamycin combined with growth factor treatment显示文摘AIM: To investigate the effects of mammalian target of rapamycin(mT OR) inhibition on liver regeneration and autophagy in a surgical resection model.METHODS: C57BL/6 mice were subjected to a 70% partial hepatectomy(PH) and treated intraperitoneally every 24 h with a combination of the m TOR inhibitor rapamycin(2.5 mg/kg per day) and the steroid dexamethasone(2.0 mg/kg per day) in phosphate bufferedsaline(PBS) or with PBS alone as vehicle control. In the immunosuppressant group, part of the group was treated subcutaneously 4 h prior to and 24 h after PH with a combination of human recombinant interleukin 6(IL-6; 500 μg/kg per day) and hepatocyte growth factor(HGF; 100 μg/kg per day) in PBS. Animals were sacrificed 2, 3 or 5 d after PH and liver tissue and blood were collected for further analysis. Immunohistochemical staining for 5-Bromo-2'-deoxyuridine(Brd U) was used to quantify hepatocyte proliferation. Western blotting was used to detect hepatic microtubule-associated protein 1 light chain 3(LC3)-Ⅱ protein expression as a marker for autophagy. Hepatic gene expression levels of proliferation-, inflammation- and angiogenesisrelated genes were examined by real-time reverse transcription-polymerase chain reaction and serum bilirubin and transaminase levels were analyzed at the clinical chemical core facility of the Erasmus MC-University Medical Center.RESULTS: m TOR inhibition significantly suppressed regeneration, shown by decreased hepatocyte proliferation(2% vs 12% Brd U positive hepatocyte nuclei at day 2, P < 0.01; 0.8% vs 1.4% at day 5, P = 0.02) and liver weight reconstitution(63% vs 76% of initial total liver weight at day 3, P = 0.04), and furthermore increased serum transaminase levels(aspartate aminotransferase 641 U/L vs 185 U/L at day 2, P = 0.02). Expression of the autophagy marker LC3-Ⅱ, which was reduced during normal liver regeneration, increased after mT OR inhibition(46% increase at day 2, P = 0.04). Hepatic gene expression showed an increased inflammation-related response [tumor necrosis factor(TNF)-α 3.2-fold upregulation at day 2, P = 0.03; IL-1Ra 6.0-fold upregulation at day 2 and 42.3-fold upregulation at day 5, P < 0.01] and a reduced expression of cell cycle progression and angiogenesis-related factors(HGF 40% reduction at day 2; vascular endothelial growth factor receptor 2 50% reduction at days 2 and 5; angiopoietin 1 60% reduction at day 2, all P ≤ 0.01). Treatmentwith the regeneration stimulating cytokine IL-6 and growth factor HGF could overcome the inhibitory effect on liver weight(75% of initial total liver weight at day 3, P = 0.02 vs immunosuppression alone and P = 0.90 vs controls) and partially reversed gene expression changes caused by rapamycin(TNF-α and IL-1Ra levels at day 2 were restored to control levels). However, no significant changes in hepatocyte proliferation, serum injury markers or autophagy were found.CONCLUSION: mT OR inhibition severely impairs liver regeneration and increases autophagy after PH. These effects are partly reversed by stimulation of the IL-6 and HGF pathways. | Suomi MG Fouraschen Petra E de Ruiter Jaap Kwekkeboom Ron WF de Bruin Geert Kazemier Herold J Metselaar Hugo W Tilanus Luc JW van der Laan Jeroen de Jonge | 2013 | World Journal of Transplantation2013，3，3： | 6 |
| 4 | New therapeutic opportunities for Hepatitis C based on small RNA显示文摘Hepatitis C virus (HCV) infection is one of the major causes of chronic liver disease, including cirrhosis and liver cancer and is therefore, the most common indication for liver transplantation. Conventional antiviral drugs such as pegylated interferon-alpha, taken in combination with ribavirin, represent a milestone in the therapy of this disease. However, due to different viral and host factors, clinical success can be achieved only in approximately half of patients, making urgent the requirement of exploiting alternative approaches for HCV therapy. Fortunately, recent advances in the understanding of HCV viral replication and host cell interactions have opened new possibilities for therapeutic intervention. The most recent technologies, such as small interference RNA mediated gene-silencing, anti-sense oligonucleotides (ASO), or viral vector based gene delivery systems, have paved the way to develop novel therapeutic modalities for HCV. In this review, we outline the application of these technologies in the context of HCV therapy. In particular, we will focus on the newly defined role of cellular microRNA (miR-122) in viral replication and discuss its potential for HCV molecular therapy. | Qiu-wei Pan Scot D Henry Bob J Scholte Hugo W Tilanus Harry LA Janssen Luc JW van der Laan | 2007 | World Journal of Gastroenterology2007，13，33： | 4 |
| 5 | Motor evoked potentials in predicting recovery from upper extremity paralysis after acute strooke显示文摘 | Hendricks HT Pasman JW van Limbeek J | 2003 | Cerebrovasc Dis2003，16，3： | 2 |
| 6 | Biallelic expression of the H19 and IGF2 genes in human testicular germ cell tumors显示文摘 | Oosterhuis JW Kalscheuer V | 1994 | J Natl Cancer Inst1994，86，14： | 1 |
| 7 | MR angiogra-phy of the intracranial vessels:technical aspects and clinical applications显示文摘 | Ozsarlak O Van Goethem JW Maes M | 2004 | Neuroradiology2004，46，： | 1 |
| 8 | Diagnosis andtreatment of ( disease - related ) in - hospital malnutrition : the performance of medical and nursing staff显示文摘 | Bavelaar JW Otter CD van Bodegraven AA | 2008 | Clinical Nutrition2008，27，3： | 1 |
| 9 | Hepatic adenoma and focal nodular hyperplasia:MR findings with superparamagnetic iron oxide-enhanced MRI 显示文摘 | Beets-Tan RG Van Engelshoven JM Greve JW | 1998 | Clin Imaging1998，22，3： | 1 |
| 10 | Two-year statin therapy does not alter the progression of intima-media thickness in patients with type 2 diabetes without manifest cardiovascular disease显示文摘 | Beishuizen ED van de Ree MA Jukema JW el al | 2004 | Diabetes Care2004，27，12： | 1 |
| 11 | Reduction of neural adhesions by biodegradable autocrossiinked hyaluronic acid gel after injury of peripheral nerves: an experimental study 显示文摘 | Smit X van Neck JW Afoke A | 2004 | Journalof neurosurgery2004，101，4： | 1 |
| 12 | Heliox re- duces respiratory system resistance in respiratory syncyti- al virus induced respiratory failure显示文摘 | Kneyber MC van Heerde M Twisk JW | 2009 | Critical care Med2009，13，3： | 1 |
| 13 | Exploratory MCDA for Handling DeepUncertaintiesiThe Case of Intelligent Speed Adaptation Im-plementation显示文摘 | Van DP JW GM | 2010 | Journal of Multi-criteria Decision Analy-sis2010，，17： | 1 |
| 14 | Feasibility of mitral valve surgery using minimal extracorporeal circu- lation 显示文摘 | Sjatskig J Yilmaz A van Boven JW | 2012 | Perfusion2012，27，4： | 1 |
| 15 | The highlyconserved cardiac glycoside binding site of Na, K-ATPase plays arole in blood pressure regulation显示文摘 | Dostanic-Larson I Van Huysse JW Lorenz JN | 2005 | Proc Natl Acad Sci USA2005，102，15： | 1 |
| 16 | Tracking of risk factors for coronary heart disease over a 14-year period:A comparison between lifestyle and biologic risk factors with data from the Amsterdam Growth and Health Study显示文摘 | TWISK JW KEMPER HC VAN MECHELEN W | 1997 | Am J Epidemic1997，14，5： | 1 |
| 17 | Argpyrimi- dine-modified Heat shock protein 27 in human non-smallcell lung cancer:a possible mechanism for evasion of ap- optosis 显示文摘 | van Heijst JW Niessen HW Musters RJ | 2006 | Cancer Lett2006，241，2： | 1 |
| 18 | The DD genotype of the ACE gene polymorphism is associated with progression of diabetic nephropathy to end stage renal failure in IDDM显示文摘 | Vleming LJ van der Pijl JW Lemkes HH | 1999 | Clin Nephrol1999，51，： | 1 |
| 19 | Excess mortality in women compared to men after PCI in STEMI: An anal- ysis of 11,931 patients during 2000-2009 显示文摘 | De Boer SP Roos-Hesselink JW van Leeuwen MA | 2014 | Int J Cardiol2014，176，2： | 1 |
| 20 | Predictors of coronary stent thrombosis:the Dutch Stent Thrombosis Registry显示文摘 | VAN WERKUM JW HEESTERMANS AA ZOMER AC | 2009 | J Am Coll Cardiol2009，53，16： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员