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| 1 | Estrogen deficiency leads to telomerase inhibition, telomere shortening and reduced cell proliferation in the adrenal gland of mice显示文摘雌激素缺乏调停变老,但是内在的机制尚待充分坚定。我们这里报导 aromatase 的指向的混乱在老鼠引起的雌激素缺乏在 vivo 在肾上腺导致 telomerase 活动的重要抑制。基因表示分析证明当雌激素不在时, telomerase 颠倒 transcriptase (TERT ) 基因表示在肾上腺外皮和肾的萎缩与损害房间增长联合被减少。在 c 工具包积极的干细胞被识别在肾的外皮的实质占据。telomeres 的分析表明那雌激素缺乏比那在肾的外皮导致显著地更短的 telomeres 在野类型(WT ) 控制鼠标。为了推进,建立雌激素的原因的效果,我们在这些雌激素缺乏的动物进行了雌激素代替治疗。为 3 个星期的雌激素的管理在雌激素缺乏的老鼠恢复 TERT 基因表示, telomerase 活动和房间增长。因此,我们第一次,那雌激素缺乏在 vivo 在鼠标的肾上腺引起 TERT 基因表示, telomerase 活动, telomere 维护,和房间增长的抑制的数据表演,建议那 telomerase 抑制并且 telomere 弄短可以调停在肾上腺的房间增长拘捕,因此贡献雌激素在生理的条件下面的导致缺乏的老化。 | Sharyn Bayne Margaret EE Jones He Li Alex R Pinto Evan R Simpson Jun-Ping Liu | 2008 | Cell Research2008，18，11： | 6 |
| 2 | AGE与RAGE相互作用通过活性氧引起足细胞凋亡显示文摘目的:探讨晚期糖基化终末产物(AGE)对足细胞凋亡的影响,及氧化应激在其中的作用。方法:小鼠足细胞株由美国纽约西奈山医学院Peter Mundel教授馈赠。用钙磷脂结合蛋白Ⅴ-荧光异硫氰酸盐(FITC)和碘化物(PI)标记细胞,采用荧光激活细胞分类(FACS)法来计数凋亡和坏死的足细胞。Dharmacon On TargetPlus SMARTpool si RNA试剂和Amaxa RNAi nucleofection试剂盒成功转染si RNA到足细胞。绿荧光蛋白载体证明转染的有效性,分别采用Western Blot和实时定量PCR(RT-PCR)方法来检测si RNA转染足细胞后AGE受体蛋白(RAGE)靶基因蛋白质和mRNA的表达。用LS50B型荧光分光光度计测活性氧,根据波长485nm在530nm发射的荧光来判断活性氧(ROS)的产生。观察活性氧的清除剂N-乙酰基-半胱氨酸(NAC)能否减少AGE-BSA诱导的足细胞凋亡。结果:AGE引起足细胞的凋亡呈剂量依赖性,随AGE浓度的增大,凋亡的发生率逐渐升高;RAGE siRNA能减少60%~70%RAGE mRNA和蛋白质的表达;ROS的清除剂NAC可明显减少AGE-BSA引起的ROS的产生和足细胞凋亡。结论:AGE与RAGE作用后活性氧产生增加,活性氧的增加可能是AGE引起足细胞凋亡的途径之一,可通过抗氧化减少ROS的产生延缓糖尿病肾病的进展。 | 刘智辉 于青 袁伟杰 Jone Cijiang He | 2008 | 中国中西医结合肾病杂志2008，9，10： | 5 |
| 3 | Notch signaling:Its essential roles in bone and craniofacial development显示文摘Notch is a cellecell signaling pathway that is involved in a host of activities including development,oncogenesis,skeletal homeostasis,and much more.More specifically,recent research has demonstrated the importance of Notch signaling in osteogenic differentiation,bone healing,and in the development of the skeleton.The craniofacial skeleton is complex and understanding its development has remained an important focus in biology.In this review we briefly summarize what recent research has revealed about Notch signaling and the current understanding of how the skeleton,skull,and face develop.We then discuss the crucial role that Notch plays in both craniofacial development and the skeletal system,and what importance it may play in the future. | Mikhail Pakvasa Pranav Haravu Michael Boachie-Mensah Alonzo Jones Elam Coalson Junyi Liao Zongyue Zeng Di Wu Kevin Qin Xiaoxing Wu Huaxiu Luo Jing Zhang Meng Zhang Fang He Yukun Mao Yongtao Zhang Changchun Niu Meng Wu Xia Zhao Hao Wang Linjuan Huang Deyao Shi Qing Liu Na Ni Kai Fu Michael J.Lee Jennifer Moriatis Wolf Aravind Athiviraham Sherwin S.Ho Tong-Chuan He Kelly Hynes Jason Strelzow Mostafa El Dafrawy Russell R.Reid | 2021 | Genes & Diseases2021，8，1： | 4 |
| 4 | Differing Prevalence and Diversity of Bacterial Species in Fetal Membranes from Very Preterm and Term Labor显示文摘 | Jones HE Harris KA Azizia M | 2009 | PLoS One2009，4，12： | 1 |
| 5 | Putomycin-purified rat brain microvascular endothelial cell cultures exhibit improved barrier properties in response to glucocorticoid induction显示文摘 | Calabria AR Weidenfeller C Jones AR de Vries HE Shusta EV | | 0，，： | 1 |
| 6 | Influence oflikelihood function choice foe estimating crop model parameters usingthe generalized likelihood uncertainty estimation method显示文摘 | Jianqiang He James W Jones Wendy D Graham | 2010 | Agricul-tural Systems2010，103，： | 1 |
| 7 | Biatrial approach to cardiac myxomas:30-year clinical experience 显示文摘 | Jones DR Warden HE Murroy FG | 1995 | Ann Thorac Surg1995，50，： | 1 |
| 8 | Fluid mechanics of heart valves显示文摘 | Yoganathan A P He Z Casey Jones S | 2004 | Annu Rev Biomed Eng2004，6，： | 1 |
| 9 | Differing preva- lence and diversity of bacterial species in fetal membranesfrom very preterm and term labor显示文摘 | Jones HE Harris KA Azizia M | 2009 | PLoS One2009，4，12： | 1 |
| 10 | Insulin-like growth factor-Ⅰ receptor signalling and acquired resistance to gefitinib (ZD1839;Iressa) in human breast and prostate cancer cells显示文摘 | Jones HE Goddard L Gee JM | | 0，，04： | 1 |
| 11 | Rapid identification of JAK2 exon,12 mutations using high resolution melting analysis显示文摘 | Jones AV Cross NC White HE | | 0，，10： | 1 |
| 12 | GM wheat development in China:current status and challenges to commercialization显示文摘 | Xia L Q Ma Y Z He Y Jones H D | 2012 | Journal of Experimental Botany2012，63，5： | 1 |
| 13 | Cell-mediated immunity inthe immunopa-thogenesis of dermatophytosis显示文摘 | Jone HE | 1986 | Acta Derm-venercol suppl (stockh)1986，121，： | 1 |
| 14 | Growth factor receptor interplay and resistance in cancer显示文摘 | Jones HE Gee JM Hutcheson IR | | 0，，1： | 1 |
| 15 | Influence of likelihood function choice for estimating crop model parameters using the generalized likelihood uncertainty estimation method显示文摘 | He J Jones J W Graham W D | 2010 | Agricultural Systems2010，103，： | 1 |
| 16 | Insulin resistance,the metabolic syndrome,and risk of incident cardiovascular disease in nondiabetic American indians:The strong heart study显示文摘 | RESNICK HE JONES K RUOTOLO G | 2003 | Diabetes Care2003，26，3： | 1 |
| 17 | A role for 13- cell-expressed G protein-coupled receptor 119 in glyce- mic control by enhancing glucose-dependent insulin re-lease显示文摘 | CHU Z L JONES R M HE H M | 2007 | Endocrinology2007，148，6： | 1 |
| 18 | Comparative effects on lipid levels of combination therapywith a statin and extended-release niacin or ezetimibe versus a statin alone (the COMPELL study) 显示文摘 | MCKENNEY JM JONES PH BAYS HE | 2007 | Atherosclerosis2007，192，2： | 1 |
| 19 | Insulin resistance ,the metabolic syndrome, and the risk of incident cardiovascular disease in nondiabetic American Indians显示文摘 | Resnick HE Jones K Ruotolo G | 2003 | Diabetes Care2003，26，： | 1 |
| 20 | Insulin receptor substrate-1 involvement in epidermal growth factor receptor and insulin-like growth factor receptor signalling:implication for Gefitinib (' Iressa') response and resistance显示文摘 | Knowlden JM Jones HE Barrow D | | 0，，01： | 1 |
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