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| 1 | Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer显示文摘Inflammatory bowel diseases are characterised by inflammation that compromises the integrity of the epithelial barrier. The intestinal epithelium is not only a static barrier but has evolved complex mechanisms to control and regulate bacterial interactions with the mucosal surface. Apical tight junction proteins are critical in the maintenance of epithelial barrier function and control of paracellular permeability. The characterisation of alterations in tight junction proteins as key players in epithelial barrier function in inflammatory bowel diseases is rapidly enhancing our understanding of critical mechanisms in disease pathogenesis as well as novel therapeutic opportunities. Here we give an overview of recent literature focusing on the role of tight junction proteins, in particular claudins, in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer. | Jonathan Landy Emma Ronde Nick English Sue K Clark Ailsa L Hart Stella C Knight Paul J Ciclitira Hafid Omar Al-Hassi | 2016 | World Journal of Gastroenterology2016，22，11： | 39 |
| 2 | History of the infantile hepatic hemangioma:From imaging to generating a differential diagnosis显示文摘We aim to provide an up-to-date summary of infantile hepatic hemangioma(IHH) and its misnomers and to dialectically present the differential diagnosis of these rare entities of the liver.Eligible peer-reviewed articles on hepatic infantile hemangiomas,published between 2000 and 2015,were reviewed for this study.IHH is the most common hepatic vascular tumor in children.Once a liver mass is identified in an infant,the differential diagnosis ranges from vascular malformations to benign and malignant tumors including mesenchymal hamartoma,hepatoblastoma,metastatic neuroblastoma,so careful physical examination,imaging studies,and,if indicated,tumor markers and biopsy,are of pivotal importance to ascertain the correct diagnosis.Despite the benign nature of IHHs,some of these lesions may demand medical and/or surgical intervention,especially for multiple and diffuse IHH.Complications can include hepatomegaly,hypothyroidism and cardiac failure.Therefore,a close follow-up is required until complete involution of the lesions.We propose an algorithm to guide the physicians towards the proper management of hepatic lesions. | Maria Gnarra Gerald Behr Alison Kitajewski June K Wu Sudha A Anupindi Carrie J Shawber Nick Zavras Dimitrios Schizas Chris Salakos Konstantinos P Economopoulos | 2016 | World Journal of Clinical Pediatrics2016，5，3： | 27 |
| 3 | Cognitive performance in patients with COPD显示文摘 | Jeroen J.W Liesker Dirkje S Postma Rypko J Beukema Nick H.T ten Hacken Thys van der Molen Roland A Riemersma Ed H van Zomeren Huib A.M Kerstjens | 2003 | Respiratory Medicine2003，，4： | 3 |
| 4 | A spectral response approach for detecting dominant phytoplankton size class from satellite remote sensing显示文摘An important goal in ocean colour remote sensing is to accurately detect different phytoplank- ton groups with the potential uses including the validation of multi-phytoplankton carbon cycle models; synoptically monitoring the health of our oceans, and improving our understanding of the bio-geochemical interactions between phytoplankton and their environment. In this paper a new algorithm is developed for detecting three dominant phytoplankton size classes based on distinct differences in their optical signatures. The technique is validated against an independent cou- pled satellite reflectance and in situ pigment dataset and run on the 10-year NASA Sea viewing Wide Field of view Sensor (SeaWiFS) data series. Results indicate that on average 3.6% of the global oceanic surface layer is dominated by microplankton, 18.0% by nanoplankton and 78.4% by picoplankton. Results, however, are seen to vary depending on season and ocean basin. | Robert J W Brewin Samantha J Lavender Nick J Hardman-Mountford Takafumi Hirata | 2010 | Acta Oceanologica Sinica2010，29，2： | 2 |
| 5 | Systems biology approaches for studying the pathogenesis of non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD) is a progressive disease of increasing public health concern.In western populations the disease has an estimated prevalence of 20%-40%,rising to 70%-90% in obese and type Ⅱ diabetic individuals.Simplistically,NAFLD is the macroscopic accumulation of lipid in the liver,and is viewed as the hepatic manifestation of the metabolic syndrome.However,the molecular mechanisms mediating both the initial development of steatosis and its progression through non-alcoholic steatohepatitis to debilitating and potentially fatal fibrosis and cirrhosis are only partially understood.Despite increased research in this field,the development of non-invasive clinical diagnostic tools and the discovery of novel therapeutic targets has been frustratingly slow.We note that,to date,NAFLD research has been dominated by in vivo experiments in animal models and human clinical studies.Systems biology tools and novel computational simulation techniques allow the study of large-scale metabolic networks and the impact of their dysregulation on health.Here we review current systems biology tools and discuss the benefits to their application to the study of NAFLD.We propose that a systems approach utilising novel in silico modelling and simulation techniques is key to a more comprehensive,better targeted NAFLD research strategy.Such an approach will accelerate the progress of research and vital translation into clinic. | Ciarán P Fisher Andrzej M Kierzek Nick J Plant J Bernadette Moore | 2014 | World Journal of Gastroenterology2014，20，41： | 2 |
| 6 | Mutifactorial analysis of risk factors for reduced bone mineral density in patients with Crohn’s disease显示文摘AIM: To determine the prevalence of osteoporosis in a cohort of patients with Crohn’s disease (CD) and to identify the relative significance of risk factors for osteoporosis. METHODS: Two hundred and fifty-eight unselected patients (92 M, 166 F) with CD were studied. Bone mineral density (BMD) was measured at the lumbar spine and hip by dual X-ray absorptiometry. Bone formation was assessed by measuring bone specific alkaline phosphatase (BSAP) and bone resorption by measuring urinary excretion of deoxypyridinoline (DPD) and N-telopeptide (NTX). RESULTS: Between 11.6%-13.6% patients were osteoporotic (T score < -2.5) at the lumbar spine and/or hip. NTX levels were significantly higher in the patients with osteoporosis (P < 0.05) but BSAP and DPD levels were not significantly different. Independent risk factors for osteoporosis at either the lumbar spine or hip were a low body mass index (P < 0.001), increasing corticosteroid use (P < 0.005), and male sex (P < 0.01). These factors combined accounted for 23% and 37% of the reduction in BMD at the lumbar spine and hip respectively. CONCLUSION: Our results confirm that osteoporosis is common in patients with CD and suggest that increased bone resorption is the mechanism responsible for thebone loss. However, less than half of the reduction in BMD can be attributed to risk factors such as corticosteroid use and low BMI and therefore remains unexplained. | Sarah A Bartram Robert T Peaston David J Rawlings David Walshaw Roger M Francis Nick P Thompson | 2006 | World Journal of Gastroenterology2006，12，35： | 2 |
| 7 | Cognitive performance in patients with COPD显示文摘 | Jeroen J.W Liesker Dirkje S Postma Rypko J Beukema Nick H.T ten Hacken Thys van der Molen Roland A Riemersma Ed H van Zomeren Huib A.M Kerstjens | 2003 | Respiratory Medicine2003，，4： | 2 |
| 8 | Grid services, for distributed system integration显示文摘 | Foster I Kesselman C Nick J M | 2002 | Compute2002，35，6： | 1 |
| 9 | Grid services for distributed systems integration显示文摘 | FOSTER I KESSELMAN C NICK J | 2002 | IEEE Comput2002，35，6： | 1 |
| 10 | Grid services for distributed system integration 显示文摘 | FOSTER I KESSELMAN C NICK J | 2002 | Computer2002，35，6： | 1 |
| 11 | Grid services for distributed system integration 显示文摘 | FOSTER I KESSELMAN C NICK J | 2002 | IEEE Computer2002，35，6： | 1 |
| 12 | Phytomining 显示文摘 | BR()( )KS R R CHAMBERS M F NICKS J | 1998 | Trends in Plan* Sci1998，3，9： | 1 |
| 13 | Grid services for the distributed system integration 显示文摘 | FOSTER I KESSELMAN C NICK J | 2002 | Computer2002，35，6： | 1 |
| 14 | Farming for metals显示文摘 | Nicks L J Chambers M F | 1995 | Mining Environmental Management1995，3，3： | 1 |
| 15 | Using soil erosion models for global change studies 显示文摘 | Williams J Nearing M Nicks A | 1996 | Journal of Soil and Water Conservation1996，51，38： | 1 |
| 16 | A randomized, pharmacokinetic and pharmacodynamic, cross-over study of duodenal or jejunal administration compared to nasogastric administration of omeprazole suspension in patients at risk for stress ulcers显示文摘 | Jeffrey O Phillips Keith M Olsen Jill A Rebuck Nick J Rangnekar Brent W Miedema Michael H Metzler | 2001 | The American Journal of Gastroenterology2001，，： | 1 |
| 17 | Selective activation and functional significance of p38a mitogen-activated protein kinase in lipopolysaccharide-stimulated neutrophils显示文摘 | NICK J A AVDI N J YOUNG S K | 1999 | J Clin Invest1999，103，6： | 1 |
| 18 | The relationship of weather types to dust storm generation in Arizona显示文摘 | Brazel A J Nicking W C | 1986 | J Climatol1986，6，3： | 1 |
| 19 | Current Directions in the Practice of Environmental Risk Assessment in the United Kingdom 显示文摘 | Simon J Pollard Roger Yearsley Nick Reynard | 2002 | Environmental Science & Technology2002，36，4： | 1 |
| 20 | Recombinant human ac-tivated protein C reduces human endotoxin-induced pulmonary in-flammation via inhibition of neutrophil chemotaxis显示文摘 | Nick J A Coldren C D Geraci M W | 2004 | Blood2004，104，13： | 1 |
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