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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 3 | Carburization behavior of HK40 steel in furnaces used for ethylene production 显示文摘 | D J Hall M K Hossain and R F Atkinson | 1982 | High Temperature High Pressure1982，14，： | 1 |
| 4 | Objective methods for registration landmarks and determining cloud motions from satellite data显示文摘 | Endlich R M Wolf D E and Brain A E | 1972 | IEEE Trans1972，21，： | 1 |
| 5 | Diagnostic assay recommended by the World Health Organization for swine origin influenza A (H1N1) virus cross-reacts with H5N1 influenza virus显示文摘 | Peacey M Hall R J Bocacao J | 2009 | J Clin Microbiol2009，47，： | 1 |
| 6 | Freezing point de- pression of NaC1-KCI-H20 solutions 显示文摘 | Hall D L Sterner S M and Bodner R J | 1988 | Economic Geology1988，100，5： | 1 |
| 7 | Effects of seawater ozonation on biofilm development in aquaculture tanks显示文摘 | Wietz M Hall M R Hj L | 2009 | Systematic and Applied Microbiology2009，32，4： | 1 |
| 8 | Performance on a measure of category fluency in cognitively impaired elderly 显示文摘 | Hall J R Harvey M Vo H T | 2011 | Neuropsychol Dev Cogn B Aging Neuropsychol Cogn2011，18，3： | 1 |
| 9 | Risk Analysis Techniques and Their Application to Software Development 显示文摘 | BENNETT J C BOHORIS G A ASHNWALL E M HALL R C | 1996 | European Journal of Operational Research1996，95，： | 1 |
| 10 | Freezing point depression of NaCl-KCl-H2O solutions显示文摘 | Hall D L Sterner S M Bodnar R J | 1988 | Economic Geology1988，83，： | 1 |
| 11 | Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast 显示文摘 | Heitman J Movva N R Hall M N | 1991 | Science1991，253，5022： | 1 |
| 12 | Freezing point depression of NaC1-KCI-HzO solutions显示文摘 | HALL D L STERNER S M BODNAR R J | 1988 | Economic Geology1988，83，： | 1 |
| 13 | An ecologi- cal risk assessment for the use of Irgarol 1051 as an algae- cide for antifouling paints 显示文摘 | Hall LW Jr Gidding J M Solomon K R | 1999 | Crit Rev Toxicol1999，29，： | 1 |
| 14 | A human XY female with a frame shift mutation in the candidate testis-determining gene S R Y显示文摘 | Jager R J Anvret M Hall K | 1990 | Nature1990，348，6300： | 1 |
| 15 | Targets for cell cycle arrest by the immunosuppressant rapamycin in yesar 显示文摘 | HEITMAN J MOVVA N R HALL M N | 1991 | Sci- nece1991，253，5022： | 1 |
| 16 | The fractional inhibitory concentration (FIC) index as a measure of syn- ergy显示文摘 | Hall M J Middleton R F Westmacott D | 1983 | J Antimierob Chemother1983，11，5： | 1 |
| 17 | Freezing point de- pression of NaC1-KC1-H20 solutions 显示文摘 | Hall D L Sterner S M Bodnar R J | 1988 | Econ Geol1988，83，： | 1 |
| 18 | The 1995 Kikwit Ebola out- break :lessons hospitals and physicians 显示文摘 | Hall R C Hall R C Chapman M J | 2008 | C en Hosp Psychiatry2008，30，5： | 1 |
| 19 | Barley mutants lacking chloroplast glutamine synthetase-biochemical and genetic analysis显示文摘 | Wallsgrove R M Turner J C Hall N P | 1987 | Plant Physiol1987，83，： | 1 |
| 20 | Osseous healing using injectable calcium sulfate-based putty for the delivery of demineralized bone matrix and cancellous bone chips显示文摘 | Turner T M Urban R M Hall D J | 2003 | Orthopedics2003，26，5： | 1 |
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