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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Irritable bowel syndrome显示文摘 | Alexander C Ford Nicholas J Talley | 2012 | BMJ (sep )2012，，041： | 4 |
| 3 | Helicobacer pylori initiate or perpetuate immune thrombocytopenic purpura? 显示文摘 | Marc M Nichola C Christelle J | 2004 | Blood2004，103，3： | 1 |
| 4 | Ediacaran-Cambrian Sirab Formation of the A1 Huqf region, Sultanate of Oman 显示文摘 | Nicholas C J Gold S E P | 2012 | Geo Arabia Journal of the Middle East Petroleum Geosciences2012，17，1： | 1 |
| 5 | Structural and mechanistic investigation of a phosphatemodified HZSM-5 catalyst for methanol conversion显示文摘 | Abubakar S M Marcus D M Lee J C Ehresmann J O Chen C Y Kletnieks P W Guenther D R Hayman M J Pavlova M Nicholas J B Haw J F | | 0，，10： | 1 |
| 6 | Quality of life and depression following childbirth : impact of social support 显示文摘 | Webster J Nicholas C Velacott C | 2011 | Midwifery2011，27，5： | 1 |
| 7 | Increased number of coagulation products in relationship to red blood cell products transfused improves mortality in trauma patients显示文摘 | Shaz BH Dente C J Nicholas J | 2010 | Transfusion2010，50，2： | 1 |
| 8 | Prediction and evaluation of sintering aids for cerium gadolinium oxide显示文摘 | Nicholas J D de Jonghe L C | | 0，，： | 1 |
| 9 | Stable isotopic evidence for methane seeps in Neoproterozoic postglacial cap carbonates显示文摘 | GANQING JIANG KENNEDY M J NICHOLAS C B | | Nature0，426，6968： | 1 |
| 10 | The electrochemistry of monobutyltin and mixtures of b-utyltin compounds at mercury electrodes inaqueous media显示文摘 | BOND A M NICHOLAS J RODNEY J C | 1995 | Analytica Chimica Acta1995，32，2： | 1 |
| 11 | Microfluidic chip for low-flow push-pull perfusion sampling in vivo with on-line analysis of amino acids 显示文摘 | NICHOLAS A C SCOTT T B MEINERS J C | 2005 | Analytical Chemistry2005，77，21： | 1 |
| 12 | Effect of residual shaft bow on unbalance response and balancing of a single mass flexible rotor - part 1 显示文摘 | Nicholas J C Gunter E J Allaire P E | 1976 | Journal of Engineering for Power ASME1976，98，2： | 1 |
| 13 | Voulganing a new generalized battery management system 显示文摘 | CHATZAKIS J KALAITZAKIS K NICHOLAS C | 2003 | IEEE Transactions2003，50，5： | 1 |
| 14 | Glycerol geneartes tugor in rice blast显示文摘 | Joke C Babara J M Nicholas S | 1977 | Nature1977，389，： | 1 |
| 15 | Variation of proline rich cell wail proteins in soybean lines with anthocyanin mutations 显示文摘 | Nicholas C D Lindstrom J T Vodkin L O | 1993 | Plant Mol Bio11993，21，： | 1 |
| 16 | A comparison of the stable and student distributions as statistical models for stock prices 显示文摘 | Blattberg R C Nicholas J G | 1974 | Journal of Business1974，47，2： | 1 |
| 17 | Relationships within the aldehyde dehydrogenase extended family显示文摘 | Perozich J Nicholas H Wang B C | 1999 | Protein Science1999，8，： | 1 |
| 18 | Part Ⅱ: Ventricular size and extracerebral space 显示文摘 | MeArdle CB Richardson C J Nicholas DA Developmental features of the neonatal brain: MR imaging | 1987 | Radiology1987，162，11： | 1 |
| 19 | Observer bias and sub-sampling efficiencies for estimating the number of migrating fish in rivers using dual-frequency identification sonar(DIDSON)显示文摘 | Pertremana I C Nicholas E J Scott W M | 2014 | Fisheries Research2014，，155： | 1 |
| 20 | Effect of residual shaft bow on unbalance response and balancing of a single mss flexible rotor: PartI-Unbalancing response: Part Ⅱ-Balancing显示文摘 | Nicholas J C Gunter E J Allaire P E | 1976 | J Eng Power1976，98，2： | 1 |
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