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| 1 | Colonoscopic yield of colorectal neoplasia in daily clinical practice显示文摘AIM:To assess the prevalence and location of ad-vanced neoplasia in patients undergoing colonoscopy,and to compare the yield per indication.METHODS:In a multicenter colonoscopy survey (n = 18 hospitals) in the Amsterdam area (Northern Holland),data of all colonoscopies performed during a three month period in 2005 were analyzed. The location and the histological features of all colonic neoplasia were recorded. The prevalence and the distribution ofadvanced colorectal neoplasia and differences in yield between indication clusters were evaluated. Advanced neoplasm was defi ned as adenoma > 10 mm in size,with > 25% villous features or with high-grade dyspla-sia or cancer.RESULTS:A total of 4623 eligible patients underwent a total colonoscopy. The prevalence of advanced neo-plasia was 13%,with 281 (6%) adenocarcinomas and 342 (7%) advanced adenomas. Sixty-seven percent and 33% of advanced neoplasia were located in the distal and proximal colon,respectively. Of all patients with right-sided advanced neoplasia (n = 228),51% had a normal distal colon,whereas 27% had a syn-chronous distal adenoma. Ten percent of all colono-scopies were performed in asymptomatic patients,7% of whom had advanced neoplasia. In the respective procedure indication clusters,the prevalence of right-sided advanced neoplasia ranged from 11%-57%. CONCLUSION:One out of every 7-8 colonoscopies yielded an advanced colorectal neoplasm. Colonoscopy is warranted for the evaluation of both symptomatic and asymptomatic patients. | Jochim S Terhaar sive Droste Mike E Craanen Rene WM van der Hulst Joep F Bartelsman Dick P Bezemer Kim R Cappendijk Gerrit A Meijer Linde M Morsink Pleun Snel Hans ARE Tuynman Roy LJ van Wanrooy Eric IC Wesdorp Chris JJ Mulder | 2009 | World Journal of Gastroenterology2009，15，9： | 6 |
| 2 | ABCA1 and ABCG1 synergize to mediate cholesterol export to apoA-1 显示文摘 | Gelissen IC Harris M Rye KA | 2006 | Arterioscler Thromb Vasc Biol2006，26，3： | 1 |
| 3 | Protein kinase B/Akt activity is involved in renal TGF-β1 driven epithelialmesenchymal transition in vitro and in vivo显示文摘 | KATTLA J J CAREW R M HELJ IC M | 2008 | Am J Physiol Renal Physiol2008，295，1： | 1 |
| 4 | Functional assays testing pathogenicity of 14 cystathionine- beta synthase mutations 显示文摘 | Rurreizt IC Asteggiano M Cozar | 2006 | Hum Mutat2006，27，3： | 1 |
| 5 | Enhanced expression of the CD71 mesangial IgA1 receptor in Berger disease and Henoch-Schonlein nephritis:Association between CD71 expression and IgA deposits显示文摘 | Haddad E Moura IC Arcos-Fajardo M | 2003 | Am SocNephro2003，14，2： | 1 |
| 6 | Th1/Th2 patterns and balance in cytokine production in the parents and infants of a large birth cohort显示文摘 | Halonen M Lohman IC Stern DA | 2009 | J Immunol2009，182，5： | 1 |
| 7 | Genotoxic and reproductive effects of an industrially contaminated soil on the earthworm Eisenia fetida显示文摘 | Bonnard M Eom IC Morel JL | 2009 | Environmental and Molecular Mutagenesis2009，50，1： | 1 |
| 8 | Characterization and evolutionary relationship of methionine-rich legumin-like protein from buckwheat 显示文摘 | Samard(z)ic' J T Milisavljevic' M D Brlljacic' J M Konstantinovic' M M Maksimovic' V R | 2003 | Plant Physiology and Biochemistry2003，42，： | 1 |
| 9 | Maintenance therapy with certolizumab pegol for Crohn's disease 显示文摘 | Schreiber S Khaliq-Kareemi M Lawrance IC | 2007 | N Engl J Med2007，357，： | 1 |
| 10 | American College of Radi- ology Appropriateness Criteria-locally advanced ( high-risk ) prostate cancer显示文摘 | Ciezki JP Hsu IC Abdel-Wahab M | 2012 | Clin Oncol( R Coil Radiol)2012，24，1： | 1 |
| 11 | Enhanced expression of the CD71 mesangial IgA1 receptor in Berger and Henoch-Schonlein nephritis:association between CD71 expression and IgA deposits显示文摘 | Haddad E Moura IC Arcos-Fajardo M | 2003 | J Am Soc Nephrology2003，14，2： | 1 |
| 12 | A polymorphism in the 5'flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobuline显示文摘 | Baldini M Lohman IC Halonen M | 1999 | Am J Respir Cell Mol Biol1999，20，： | 1 |
| 13 | Metformin improves cardiac function in a nondiabetic rat model ofpost-MI heart failure显示文摘 | Yin M van der Horst IC van Melle Jp | | 0，，02： | 1 |
| 14 | Self-assembly of π-conjugated discs on heterogeneous surfaces:Effect of the micro-and nano-scale dewetting显示文摘 | Palermo V Palma M Tomov(ic) (Z) | | 0，，1： | 1 |
| 15 | Experience with registered mucosal vaccines显示文摘 | Dietrich G Griot Wenk M Metcalfe IC | 2003 | Vaccine2003，21，78： | 1 |
| 16 | Quantitative detection of human complement factor H-related protein in transitional cell carcinoma of the urinary bladder显示文摘 | Heicappell R Wettig IC Schostak M | 1999 | Eur Urol1999，35，： | 1 |
| 17 | Treatment of landfill leachate by ozonation,ultrafihration nanofiltration and membrane bioreactor 显示文摘 | Jakopovic H K Mato~ic M Muftic M | 2008 | Fresenius Environment Bulletin2008，17，6： | 1 |
| 18 | Comparison of pharmacokinetics and toxicity after high-dose methotrexate treatments in children with acute lymphoblastic leukemia显示文摘 | Csordas IC Hegyi M Eipel O T | 2013 | Anticancer Drugs2013，24，2： | 1 |
| 19 | p16(INK4a) is selectively silenced in the tumoral progression of mycosis fungoides显示文摘 | Navas IC Algara P Mateo M | | 0，，： | 1 |
| 20 | Central se- rous chorioretinopathy 显示文摘 | Wang M Munch IC Hasler PW Prtinte C Larsen M | 2008 | Acta Ophthalmol2008，86，2： | 1 |
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