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| 1 | Fecal immunochemical test accuracy in average-risk colorectal cancer screening显示文摘AIM:To assess the fecal immunochemical test(FIT)accuracy for colorectal cancer(CRC)and advanced neoplasia(AN)detection in CRC screening.METHODS:We performed a multicentric,prospective,double blind study of diagnostic tests on asymptomatic average-risk individuals submitted to screening colonoscopy.Two stool samples were collected and the fecal hemoglobin concentration was determined in the first sample(FIT1)and the highest level of both samples(FITmax)using the OC-sensor.Areas under the curve(AUC)for CRC and AN were calculated.The best FIT1and FITmax cut-off values for CRC were determined.At this threshold,number needed to scope(NNS)to detect a CRC and an AN and the cost per lesion detected were calculated.RESULTS:About 779 individuals were included.An AN was found in 97(12.5%)individuals:a CRC in 5(0.6%)and an advanced adenoma(≥10 mm,villous histology or high grade dysplasia)in 92(11.9%)subjects.For CRC diagnosis,FIT1 AUC was 0.96(95%CI:0.95-0.98)and FITmax AUC was 0.95(95%CI:0.93-0.97).For AN,FIT1 and FITmax AUC were similar(0.72,95%CI:0.66-0.78 vs 0.73,95%CI:0.68-0.79,respectively,P=0.34).Depending on the number of determinations and the positivity threshold cut-off used sensitivity for AN detection ranged between 28%and 42%and specificity between 91%and 97%.At the best cut-off point for CRC detection(115 ng/mL),the NNS to detect a CRC were 10.2 and 15.8;and the cost per CRC was 1814€and 2985€on FIT1 and FITmax strategies respectively.At this threshold the sensitivity,NNS and cost per AN detected were 30%,1.76,and 306€,in FIT1 strategy,and 36%,2.26€and 426€,in FITmax strategy,respectively.CONCLUSION:Performing two tests does not improve diagnostic accuracy,but increases cost and NNS to detect a lesion. | Vicent Hernandez Joaquin Cubiella M Carmen Gonzalez-Mao Felipe Iglesias Concepción Rivera M Begoa Iglesias Lucía Cid Ines Castro Luisa de Castro Pablo Vega Jose Antonio Hermo Ramiro Macenlle Alfonso Martínez-Turnes David Martínez-Ares Pamela Estevez Estela Cid M Carmen Vidal Angeles López-Martínez Elisabeth Hijona Marta Herreros-Villanueva Luis Bujanda Jose Ignacio Rodriguez-Prada the COLONPREV study investigators | 2014 | World Journal of Gastroenterology2014，20，4： | 4 |
| 2 | Multimodality functional imaging using DW-MRI and 18F-FDG-PET/CT during radiation therapy for human papillomavirus negative head and neck squamous cell carcinoma: Meixoeiro Hospital of Vigo Experience显示文摘AIM To noninvasively investigate tumor cellularity measured using diffusion-weighted magnetic resonance imaging(DW-MRI) and glucose metabolism measured by 18 Flabeled fluorodeoxyglucose positron emission tomography/computed tomography(18F-FDG-PET/CT) during radiation therapy(RT) for human papillomavirus negative(HPV-) head and neck squamous cell carcinoma(HNSCC).METHODS In this prospective study, 6 HPV- HNSCC patients underwent a total of 34 multimodality imaging examinations(DW-MRI at 1.5 T Philips MRI scanner [(n = 24) pre-, during-(2-3 wk), and post-treatment(Tx), and 18F-FDG PET/CT pre- and post-Tx(n = 10)]. All patients received RT. Monoexponential modeling of the DW-MRI data yielded the imaging metric apparent diffusion coefficient(ADC) and the mean of standardized uptake value(SUV) was measured from 18F-FDG PET uptake. All patients had a clinical follow-up as the standard of care and survival status was documented at 1 year.RESULTS There was a strong negative correlation between the mean of pretreatment ADC(ρ =-0.67, P = 0.01) and the pretreatment 18F-FDG PET SUV. The percentage(%) change in delta(?) ADC for primary tumors and neck nodal metastases between pre- and Wk2-3 Tx were as follows: 75.4% and 61.6%, respectively, for the patient with no evidence of disease, 27.5% and 32.7%, respectively, for those patients who were alive with disease, and 26.9% and 7.31%, respectively, for those who were dead with disease.CONCLUSION These results are preliminary in nature and are indicative, and not definitive, trends rendered by the imaging metrics due to the small sample size of HPV- HNSCC patients in a Meixoeiro Hospital of Vigo Experience. | David Aramburu Núnez Antonio Lopez Medina Moisés Mera Iglesias Francisco Salvador Gomez Abhay Dave Vaios Hatzoglou Ramesh Paudyal Alfonso Calzado Joseph O Deasy Amita Shukla-Dave Victor M Munoz | 2017 | World Journal of Radiology2017，9，1： | 2 |
| 3 | Temperature-and salinity-decoupled overproduction of hydroxyectoine by Chromohalobacter salexigens 显示文摘 | Rodríguez M J Argando?a M Iglesias G F | 2013 | Applied and Environmental Microbiology2013，79，3： | 1 |
| 4 | Compositional and structural changes during aerial oxidation of coal and their relations with technological properties 显示文摘 | Iglesias M J de la Puente G Fuente E | 1998 | Vibrational Spectroscopy1998，17，1： | 1 |
| 5 | Metabolic endotoxemia initiates obesity and insulin resistance 显示文摘 | CANI P D AMAR J IGLESIAS M A | 2007 | Diabetes2007，56，7： | 1 |
| 6 | AMP- activated protein kinase activation by AICAR increases both muscle fatty acid and glucose uptake in white muscle of insulin-resistant rats in vivo显示文摘 | Iglesias M A Furler S M Cooney G J | 2004 | Diabetes2004，53，7： | 1 |
| 7 | Extraction and characterization of sunflower pectin显示文摘 | IGLESIAS M T LOZANO J E | 2004 | Journal of Food Engineering2004，62，： | 1 |
| 8 | Control of the chemical structure of perhydrous coals : FTIR and Py-GC/MS investigation显示文摘 | IGLESIAS M J del RIIO J C LAGGOUN-D FARGE F CUESTA M J SU REZ-RUIZ I | 2002 | J Anal Appl Pyrolysis2002，62，1： | 1 |
| 9 | A model for the study of meshing stiffness in spur gear transmissions 显示文摘 | Rincon A F D Viadero F Iglesias M | 2013 | Mechanism and Machine Theory2013，61，3： | 1 |
| 10 | Br(o)snsted ionic liquids:study of physico-chemicai properties and catalytic activity in aldol condensations显示文摘 | IGLESIAS M GONZALEZ-OLMOS R MEDINA 1 C F | | 0，，02： | 1 |
| 11 | Evaluation of an ICP collision/reaction cell-MS system for the sensitive determination of speetrally interfered and non-inter-fered elements using the same gas conditions显示文摘 | Iglesias M Gilon N Poussel E | 2002 | Jour nal of Analytical Atomic Spectrometry2002，17，10： | 1 |
| 12 | Serum concentrations of leptin, adiponectin and resistin, and their relationship with cardiovascular disease in patients with end-stage renal disease 显示文摘 | DIEZ JJ IGLESIAS P FERNANDEZ- REYES M J | 2005 | Clin Endocrinol(Oxf)2005，62，2： | 1 |
| 13 | Diagenesis and reservoir quality evolution of palaeocene deep-water,marine sandstones,the Shetland-Faroes Basin,British continental shelf显示文摘 | Mansurbeg H Morad S Salem A Marfil R El-ghali M A K Nystuen J P Caja M A Amorosi A Garcia D A Iglesia La | 2008 | Marine and Petroleum Geology2008，25，： | 1 |
| 14 | Structure of Tars Derived from Low-Temperature Pyrolysis of Pure Vitrinites: Influence of Rank and Composition of Vitrinites 显示文摘 | Iglesias M J Cuesta M J Suarez-Rui I | 2001 | J Anal Appl Pyrol2001，59，2： | 1 |
| 15 | Collagen I upregulates extracellular matrix gene expression and secretion of TGF-beta 1 by cultured human mesangial cells显示文摘 | Ortega-Velazquez R Gonzalez-Rubio M Ruiz-Torres MP Diez-Marques ML Iglesias MC Rodriguez-Puyol M | 2004 | Am J Physiol Cell Physiol2004，286，6： | 1 |
| 16 | Caveolin-1 loss of function accelerates glucose transporter 4 and insulin receptor deg- radation in 313-L1 adipocytes 显示文摘 | Gonzalez Munoz E Lopez Iglesias C Calvo M | 2009 | Endocrinology2009，150，8： | 1 |
| 17 | Mitogen-activated protein kinase phosphatase-l(MKP-1) impairs the response to anti-epidermal growth factor receptor (EGFR) antibody cetuximab in metastatic colorectal cancer patients显示文摘 | Montagut C Iglesias M Arumi M | 2010 | Br J Cancer2010，102，7： | 1 |
| 18 | Analysis of tantalum implants used for avascular necrosis of the femoral head:a review of five retrieved specimens显示文摘 | Fernández-Fairen M Murcia A Iglesias R | 2012 | J Appl Biomater Funct Mater2012，10，1： | 1 |
| 19 | High temperature reduces apple fruit colour via modulation of the anthocyanin regulatory complex显示文摘 | Wang L K Micheletti D Palmer J Volz R Lozano L Espley R Hellens R P Chagn6 D Rowan D D Troggio M Iglesias I Allan A C | 2011 | Plant Cell & Environment2011，34，： | 1 |
| 20 | An evaluation of the basis and consequences of a Stay-Green mutation in the navel negra Citrus Mutant Using transcriptomic and proteomic profling and metabolite analysis显示文摘 | ALOS E ROCA M IGLESIAS D J | 2008 | Plant Physiology2008，147，： | 1 |
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