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| 1 | Comparative effectiveness of i-SCAN^(TM) and high-definition white light characterizing small colonic polyps显示文摘AIM:To evaluate accuracy of in vivo diagnosis of adenomatous vs non-adenomatous polyps using i-SCAN digital chromoendoscopy compared with high-definition white light.METHODS:This is a single-center comparative effectiveness pilot study.Polyps(n = 103) from 75 averagerisk adult outpatients undergoing screening or surveillance colonoscopy between December 1,2010 and April 1,2011 were evaluated by two participating endoscopists in an academic outpatient endoscopy center.Polyps were evaluated both with high-definition white light and with i-SCAN to make an in vivo prediction of adenomatous vs non-adenomatous pathology.We determined diagnostic characteristics of i-SCAN and highdefinition white light,including sensitivity,specificity,and accuracy,with regards to identifying adenomatous vs non-adenomatous polyps.Histopathologic diagnosis was the gold standard comparison.RESULTS:One hundred and three small polyps,detected from forty-three patients,were included in the analysis.The average size of the polyps evaluated in the analysis was 3.7 mm(SD 1.3 mm,range 2 mm to 8 mm).Formal histopathology revealed that 54/103(52.4%) were adenomas,26/103(25.2%) were hyperplastic,and 23/103(22.3%) were other diagnoses include 'lymphoid aggregates','non-specific colitis,' and 'no pathologic diagnosis.' Overall,the combined accuracy of endoscopists for predicting adenomas was identical between i-SCAN(71.8%,95%CI:62.1%-80.3%) and high-definition white light(71.8%,95%CI:62.1%-80.3%).However,the accuracy of each endoscopist differed substantially,where endoscopist A demonstrated 63.0% overall accuracy(95%CI:50.9%-74.0%) as compared with endoscopist B demonstrating 93.3% overall accuracy(95%CI:77.9%-99.2%),irrespective of imaging modality.Neither endoscopist demonstrated a significant learning effect with i-SCAN during the study.Though endoscopist A increased accuracy using i-SCAN from 59%(95%CI:42.1%-74.4%) in the first half to 67.6%(95%CI:49.5%-82.6%) in the second half,and endoscopist B decreased accuracy using i-SCAN from 100%(95%CI:80.5%-100.0%) in the first half to 84.6%(95%CI:54.6%-98.1%) in the second half,neither of these differences were statistically significant.CONCLUSION:i-SCAN and high-definition white light had similar efficacy predicting polyp histology.Endoscopist training likely plays a critical role in diagnostic test characteristics and deserves further study. | Johanna L Chan Li Lin Michael Feiler Andrew I Wolf Diana M Cardona Ziad F Gellad | 2012 | World Journal of Gastroenterology2012，18，41： | 3 |
| 2 | Non-orthogonal stagnation-point flow towards a stretching surfacein a non-New tonian fluid w ith heat transfer显示文摘 | Labropulu F Li D Pop I | 2010 | International Journal of Thermal Sciences2010，49，6： | 1 |
| 3 | Overexpressing glutamine synthetase gene modifies nitrogen metabolism and abiotic steress responses in rice 显示文摘 | Cai H G Zhong Y Xiao J H Li X /-I Zhang Q F Lian X M | 2009 | Plant Cell Reports2009，28，3： | 1 |
| 4 | Study on sensorless control model based on a model reference adaptive system with parameter optimization 显示文摘 | YANG J G ZHOU F LI B I | 2011 | Applied Mechanics and Materials2011，，121126： | 1 |
| 5 | A minimax portfolio selection strategy with equilibrium显示文摘 | I Deng X T Li Z F Wang S Y | 2005 | European Journal of Operational Research2005，166，： | 1 |
| 6 | Repair of Damaged DNA by Arabidopsis Cell Extract显示文摘 | Li A Schuermann D Gallego F Kovalchuk I Tinland B | 2002 | Plant Cell2002，14，1： | 1 |
| 7 | Shrimp zircon geochronological and geochemical evidence for Neo - Proterozoic arc - related magmatism along the western of the Yangtze Block, South China 显示文摘 | Zhou M F Yah D P Kennedy A K Li Q I and Ding J | 2002 | Earth Planet Sci Lett2002，196，： | 1 |
| 8 | P upi l - spa r i ng,painless compression of the oculomotor nerve byexpanding basilar artery aneurysm: a case of ocularpseudomyasthenia显示文摘 | Ajt a i B Fi ne EJ Li ncof f N | 2004 | Arch Neurol2004，61，： | 1 |
| 9 | Detection of human telomerase RNA gene in cervical cancer and precancerous lesions: comparison with cytological and human papillomavirus DNA test findings显示文摘 | Li Y Ye F L~i WG | 2010 | Int J Gynee01 Cancer2010，20，4： | 1 |
| 10 | Ordered Nanop- orous Membranes Based on Block Copolymers with High Chemical Stability and Tunable Separation Properties显示文摘 | Li X F Fustin C A Vankelecorn I F J | 2010 | J Mater Chem2010，20，： | 1 |
| 11 | Elastic-plastic spherical contact modeling including roughness effects 显示文摘 | Li L Etsion I Talke F E | 2010 | Tribology Letters2010，40，3： | 1 |
| 12 | Core-shell assembly of natural polymers for adjusting release performance of dielofenac显示文摘 | Li W Z l i G F Wang J L | 2013 | International Jour- al of Polymeric Malerials and Polymeric Biomaterials2013，62，6： | 1 |
| 13 | 查看详情显示文摘 | Li Y F Xu D H Oh J I Shen W Z Li X Yu Y | | 0，，： | 1 |
| 14 | Structural Basis for Double- Stranded RNA Processing by Dicer显示文摘 | MacRae I J Zbou K Li F | 2006 | Science2006，311，5758： | 1 |
| 15 | High-speed chiral separation on microchip electrophoresis devices 显示文摘 | RODRIGUEZ I JIN L J LI S F Y | 2000 | Electrophoresis2000，21，： | 1 |
| 16 | The concentration of serum transforming growth factor-beta1 is decreased in cervical carcinoma natients显示文摘 | Wu H S Li Y F Chon C I | 2002 | Cancer Invest2002，20，1： | 1 |
| 17 | 显示文摘 | Gamez-Polo C Li Y F Perez-Landazabal J I | 2003 | Sen A2003，106，： | 1 |
| 18 | Genome sequence and analysis of the tuber crop potato显示文摘 | Xu X Pan S Cheng S Zhang B Mu D Ni P Zhang G Yang S Li R Wang J Orjeda G Guzman F Tones M Lnzano R Ponce O Martinez D De la Cruz G Chakrabarti S K Patil V U Skryabin K G Kuznetsov B B Ravin N V Kolganova T V Beletsky A V Mardanov A V Di Genova A Bolser D M Martin D M Li G Yang Y Kuang H Hu Q Xiong X Bishop G J Sagredo B Mejia N Zagorski W Gromadka R Gawor J Szczesny P Huang S Zhang Z Liang C He J Li Y He Y Xu J Zhang Y Xie B Du Y Qu D Bonierbale M Ghislain M Herrera Mdel R Giuliano G Pietrella M Perrotta G Faeella P O 'Brien K Feingold S E Barreiro L E Massa G A Diambra L Whitty B R Vaillancourt B Lin H Massa A N Geoffroy M Lundback S DellaPenna D Buell C R Sharma S K Marshall D F Waugh R Bryan G J Destefanis M Nagy I Milbourne D Thomson S J Fiefs M Jacobs J M Nielsen K L Sonderkaer M Iovene M Tortes G A Jiang J Veilleux R E Bachem C W de Boer J Bonn T Kloosterman B van Eck H Datema E Hekkert B Goverse A van Ham R C Visser R G | 2011 | Nature2011，475，7355： | 1 |
| 19 | Comparison and evaluation of methods for liver segmentation from CT datasets显示文摘 | Heimann T van Ginneken B Styner MA Arzhaeva Y Aurich V Bauer C Beck A Becket C Beichel R Bekes G Bello F Binnig G Bischof H Bornik A Cashman PM Chi Y Cordova A Dawant BM Fidrich M Furst JD Furukawa D Grenacher L Hornegger J Kainmuller D Kitney RI Kobatake H Lamecker H Lange T Lee J Lennon B Li R Li S Meinzer HP Nemeth G Raicu DS Rau AM van Rikxoort EM Rousson M Rusko L Saddi KA Schmidt G Seghers D Shimizu A Slagmolen P Sorantin E Soza G Susomboon R Waite JM Wimmer A Wolf I | 2009 | IEEE Transactions on Medical Imaging2009，28，8： | 1 |
| 20 | VEGF receptor 2/- 3 het- erodimers detected in situ by proximity ligation on angiogenic sprouts显示文摘 | Nilsson I Bahram F Li X | 2010 | EMBO J2010，29，8： | 1 |
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