|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Wind energy and wave energy resources assessment in the East China Sea and South China Sea显示文摘In this paper,the third-generation wave model WAVEWATCH-III(WW3) was used to simulate the wave field of the East China Sea and South China Sea from January 1988 to December 2009,with wind input of CCMP wind field.Then,the wind energy density and wave energy density were calculated by using the simulated 22-years' wave-field data and CCMP data.By synthetically considering the size of energy density,the frequency of energy level and the stability of energy density,the re-sources of wind energy and wave energy in the East China Sea and South China Sea were analyzed and regionalized.The re-sult can be a guide to searching location of wind & wave power plant. | ZHENG ChongWei ZHUANG Hui LI Xin LI XunQiang | 2012 | Science China(Technological Sciences)2012，55，1： | 122 |
| 2 | Effect of phosphorylation of MAPK and Stat3 and expression of c-fos and c-jun proteins on hepatocarcinogenesis and their clinical significance显示文摘AIM To study the effect of phosphorylation ofMAPK and Stat3 and the expression of c-fos andc-jun proteins on hepatocellular carcinogenesisand their clinical significance.METHODS SP immunohistochemistry was usedto detect the expression of p42/44MAPK, p-Stat3,c-fos and c-jun proteins in 55 hepatocellularcarcinomas (HCC) and their surrounding livertissues.RESULTS The positive rates and expressionlevels of p42/44MAPK, p-Stat3, c-fos and c-junproteins in HCCs were significantly higher thanthose in pericarcinomatous liver tissues (PCLT).A positive correlation was observed between theexpression of p42/44MAPK and c-fos proteins, andbetween p-Stat3 and c-jun, but there was nosignificant correlation between p42/44MAPK and p-Stat3 in HCCs and their surrounding livertissues.CONCLUSION The abnormalities of Ras/Rat/MAPK and JAKs/ Stat3 cascade reaction maycontribute to malignant transformation ofhepatocytes. Hepatocytes which are positive forp42/ 44MAPK, c-fos or c-jun proteins may bepotential malignant pre-cancerous cells.Activation of MAPK and Stat3 proteins may be anearly event in hepatocellular carcinogenesis. | De Yun Feng Hui Zheng Yi Tan Rui Xue Cheng Department of Pathology, Hunan Medical University, Changsha 410078, Hunan Province, China New England Biolab, MA, USA | 2001 | World Journal of Gastroenterology2001，7，1： | 75 |
| 3 | Mapping wetland changes in China between 1978 and 2008显示文摘Four wetland maps for all China have been produced,based on Landsat and CBERS-02B remote sensing data between 1978 and 2008 (1978,1990,2000 and 2008).These maps were mainly developed by manual interpretation and validated by substantial field investigation in 2009.Based on these maps,we analyzed the 2008 wetland distribution in China and discussed wetland changes and their drivers over the past 30 years.(i) There were about 324097 km 2 of wetlands in 2008,for which inland marshes or swamps were the most common wetland type (35%),with lakes (26%) second.Most of the wetlands were in Heilongjiang,Inner Mongolia,Qinghai and Tibet,occupying about 55% of the national wetland area.(ii) From 1978 to 2008,China's wetland area continually and significantly decreased,by about 33% based on changes in the wetland map.This was in sharp contrast to the increase in artificial wetlands,which increased by about 122%.Inland marshes accounted for the main loss of total wetlands from 1978 to 2000.From 2000 through 2008,riverine and lacustrine wetlands constituted the main wetland loss.Fortunately however,the rate of wetland loss decreased from 5523 to 831 km 2 /a.(iii) The change ratio of lost natural wetlands (including inland and coastal wetlands) to non-wetlands has decreased slightly over the past 30 years.From 1978 to 1990,nearly all natural wetlands (98%) lost were transformed into non-wetlands.However,the ratio declined to 86% from 1990 to 2000,and to 77% from 2000 to 2008.(iv) All Chinese provinces were divided into three groups according to patterns of wetland changes,which could relate to the driving forces of such changes.Tibet was completely different from other provinces,as it was one representative example in which there was a net wetland increase,because of global warming and decreased human activity since 1990.Increased economic development caused considerable wetland loss in most eastern provinces,and artificial wetlands increased. | NIU ZhenGuo ZHANG HaiYing WANG XianWei YAO WenBo ZHOU DeMin ZHAO KuiYi ZHAO Hui LI NaNa HUANG HuaBing LI CongCong YANG Jun LIU CaiXia LIU Shuang WANG Lin LI Zhan YANG ZhenZhong QIAO Fei ZHENG YaoMin CHEN YanLei SHENG YongWei GAO XiaoHong ZHU WeiHong WANG WenQing WANG Hong WENG YongLing ZHUANG DaFang LIU JiYuan LUO ZhiCai CHENG Xiao GUO ZiQi GONG Peng | 2012 | Chinese Science Bulletin2012，57，22： | 51 |
| 4 | Gallstone recurrence after successful percutaneous cholecystolithotomy:a 10-year follow-up of 439 cases显示文摘BACKGROUND: Stone recurrence is a major problem in the medication of gallstones with gallbladder preservation. The aim of this study was to determine the long-term recurrence rate of gallstones and the clinical outcome after successful percutaneous cholecystolithotomy (PCCL) treatment, and to investigate the possible risk factors for gallstone recurrence. METHODS: After successful PCCL for gallstones, 439 patients were followed up during a 10-year period. The long-term gallstone recurrence rate and clinical outcome were evaluated. Risk factors associated with stone recurrence were identified. RESULTS: Gallstone recurrence was detected in 182 of 439 PCCL patients, giving an overall recurrence rate of 41.46%. The cumulative gallstone recurrence rate for each of the 10 post-operative years was 9.57%, 18.91%, 27.33%, 34.14%, 37.59%, 39.86%, 41.90%, 42.73%, 42.85%, and 43.21%, respectively. Among these recurrent patients, 94 were asymptomatic, 80 suffered from nonspecific upper gastrointestinal symptoms and 8 suffered from abdominal pain or biliary colic. Thirty-eight of the 182 patients were retreated with cholecystectomy. The risk factors for stone recurrence included a family history of gallstones, preference for fatty food, accompanying liver disease, multiple stones and poor gallbladder function pre-PCCL. CONCLUSIONS: In this study, the overall recurrence rate of gallstone was 41.46% during a 10-year period. The highest frequency of gallstone recurrence was during the 5th to 6th postoperative years and then continued to slowly increase. Risk factors for stone recurrence varied.We suggest that the use of PCCL in patients with gallstones should be considered carefully because of stone recurrence. | Zou, Yi-Ping Du, Ji-Dong Li, Wei-Min Xiao, Yin-Qi Xu, Hong-Bin Zheng, Fang Huang, Hui Liu, Hao-Run Li, Hu-Cheng | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，2： | 43 |
| 5 | Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders: executive summary and 2019 update of clinical management of ischaemic cerebrovascular diseases显示文摘Aim Stroke is the leading cause of disability and death in China.Ischaemic stroke accounts for about 60%-80%of all strokes.It is of considerable significance to carry out multidimensional management of ischaemic cerebrovascular diseases.This evidence-based guideline aims to provide the latest detailed and comprehensive recommendations on the diagnosis,treatment and secondary prevention of ischaemic cerebrovascular diseases.Methods We had performed comprehensive searches of MEDLINE(via PubMed)(before 30 June 2019),and integrated the relevant information into charts and distributed to the writing group.Writing group members discussed and determined the recommendations through teleconference.We used the level of evidence grading algorithm of Chinese Stroke Association to grade each recommendation.The draft was reviewed by the Guideline Writing Committee of Chinese Stroke Association Stroke and finalised.This guideline is fully updated every 3 years.results This evidence-based guideline is based on the treatment,care and prevention of ischaemic cerebrovascular diseases,which emphasises on pathogenesis evaluation,intravenous thrombolysis,endovascular therapy,antiplatelet therapy,prevention and treatment of complications,and risk factor management.Conclusions This updated guideline presents a framework for the management of ischaemic cerebrovascular diseases.Timely first-aid measures,professional care in the acute stage,and proactive secondary prevention will be helpful to patients. | Liping Liu Weiqi Chen Hongyu Zhou Wanying Duan Shujuan Li Xiaochuan Huo Weihai Xu Li'an Huang Huaguang Zheng Jingyi Liu Hui Liu Yufei Wei Jie Xu Yongjun Wang | 2020 | Stroke & Vascular Neurology2020，5，2： | 42 |
| 6 | Mechanism of chain propagation for the synthesis of polyoxymethylene dimethyl ethers显示文摘Polyoxymethylene dimethyl ethers(PODE)were synthesized from the reaction of paraformaldehyde with dimethoxymethane(DMM)over different acid catalysts at different conditions.Products were found to follow the Schulz-Flory distribution law.The chain propagation proceeds through the insertion of an individual segment of CH2O one by one,while the simultaneous insertion of a few CH2O segments or their assembly is unlikely.Due to the restriction of this law,it is difficult to increase the selectivity to the desired products(e.g.,PODE3 4). | Yupei Zhao Zheng Xu Hui Chen Yuchuan Fu Jianyi Shen | 2013 | Journal of Energy Chemistry2013，22，6： | 36 |
| 7 | Developing the Science Product Algorithm Testbed for Chinese Next-Generation Geostationary Meteorological Satellites:Fengyun-4 Series显示文摘Fengyun-4A(FY-4A), the first of the Chinese next-generation geostationary meteorological satellites, launched in2016, offers several advances over the FY-2: more spectral bands, faster imaging, and infrared hyperspectral measurements. To support the major objective of developing the prototypes of FY-4 science algorithms, two science product algorithm testbeds for imagers and sounders have been developed by the scientists in the FY-4 Algorithm Working Group(AWG). Both testbeds, written in FORTRAN and C programming languages for Linux or UNIX systems, have been tested successfully by using Intel/g compilers. Some important FY-4 science products, including cloud mask, cloud properties, and temperature profiles, have been retrieved successfully through using a proxy imager, Himawari-8/Advanced Himawari Imager(AHI), and sounder data, obtained from the Atmospheric Infra Red Sounder, thus demonstrating their robustness. In addition, in early 2016, the FY-4 AWG was developed based on the imager testbed—a near real-time processing system for Himawari-8/AHI data for use by Chinese weather forecasters.Consequently, robust and flexible science product algorithm testbeds have provided essential and productive tools for popularizing FY-4 data and developing substantial improvements in FY-4 products. | Min MIN Chunqiang WU Chuan LI Hui LIU Na XU Xiao WU Lin CHEN Fu WANG Fenglin SUN Danyu QIN Xi WANG Bo LI Zhaojun ZHENG Guangzhen CAO Lixin DONG | 2017 | Journal of Meteorological Research2017，31，4： | 35 |
| 8 | Laparoscopic VS open hepatectomy for hepatolithiasis: An updated systematic review and meta-analysis显示文摘AIM To perform a meta-analysis on laparoscopic hepatectomy VS conventional liver resection for treating hepatolithiasis.METHODS We conducted a systematic literature search on Pub Med,Embase,Web of Science and Cochrane Library,and undertook a meta-analysis to compare the efficacy and safety of laparoscopic hepatectomy V S conventional open liver resection for local hepatolithiasis in the left or right lobe. Intraoperative and postoperative outcomes(time,estimated blood loss,blood transfusion rate,postoperative intestinal function recovery time,length of hospital stay,postoperative complication rate,initial residual stone,final residual stone and stone recurrence) were analyzed systematically.RESULTS A comprehensive literature search retrieved 16 publications with a total of 1329 cases. Meta-analysis of these studies showed that the laparoscopic approach for hepatolithiasis was associated with significantly less intraoperative estimated blood loss [weighted mean difference(WMD): 61.56,95% confidence interval(CI): 14.91-108.20,P = 0.01],lower blood transfusion rate [odds ratio(OR): 0.41,95%CI: 0.22-0.79,P = 0.008],shorter intestinal function recovery time(WMD: 0.98,95%CI: 0.47-1.48,P = 0.01),lower total postoperative complication rate(OR: 0.52,95%CI: 0.39-0.70,P < 0.0001) and shorter stay in hospital(WMD: 3.32,95%CI: 2.32-4.32,P < 0.00001). In addition,our results showed no significant differences between the two groups in operative time(WMD: 21.49,95%CI: 0.27-43.24,P = 0.05),residual stones(OR: 0.79,95%CI: 0.50-1.25,P = 0.31) and stone recurrence(OR: 0.34,95%CI: 0.11-1.08,P = 0.07). Furthermore,with subgroups analysis,our results proved that the laparoscopic approach for hepatolithiasis in the left lateral lobe and left side could achieve satisfactory therapeutic effects. CONCLUSION The laparoscopic approach is safe and effective,with less intraoperative estimated blood loss,fewer postoperative complications,reduced length of hospital stay and shorter intestinal function recovery time than with conventional approaches. | Hui Li Jun Zheng Jian-Ye Cai Shi-Hui Li Jun-Bin Zhang Xiao-Ming Wang Gui-Hua Chen Yang Yang Gen-Shu Wang | 2017 | World Journal of Gastroenterology2017，23，43： | 36 |
| 9 | Role of Epstein-Barr Virus Encoded Latent Membrane Protein 1 in the Carcinogenesis of Nasopharyngeal Carcinoma显示文摘Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP1) has been known to have oncogenic properties during latent infection in nasopharyngeal carcinoma (NPC). Our studies focused on the role of LMP1 in NPC, and showed that LMP1 triggers the NF-κB, AP-1 and STAT signaling pathways. Strikingly, LMP1 was found to mediate the formation of a new heterodimer between c-Jun and JunB. Also, we have identified JAK/STAT and PI-PLC-PKC activation triggered by LMP1 through upregulating the expression of JAK3 and enhancing the phosphorylation of STAT. The constitutive activation of these signaling cascades explains LMP1’s ability to induce such a diverse array of morphological and phenotypic effects in cells and provides insight into how LMP1 may induce cell transformation, in which multihit targeted genes in the downstream play an essential role. All signaling cascades triggered by LMP1 ultimately lead to the disruption of the cell cycle: the acceleration of G1/S phase and the arrest of G2/M phase. We also found that LMP1 induced the expression of hTERT and promoted cell immortalization. Importantly, by intervening physical intracellular signal transduction pathways and disturbing the progression of the cell cycle, LMP1, an important oncoprotein encoded by EBV, is thought to be a key modulator in the pathogenesis of NPC. Interfering LMP1 signaling could be a promising strategy to target the malignant phenotype of NPC. | Hui Zheng Lili Li Duosha Hu Xiyun Deng Ya Cao | 2007 | Cellular & Molecular Immunology2007，4，3： | 34 |
| 10 | Characterization and distribution of polycyclic aromatic hydrocarbon in sediments of Haihe River, Tianjin, China显示文摘在这学习沉积,样品从 Haihe 河 inTianjin 城市的 13 个地点被收集,中国,十六优先级多不的芳香的烃(哼)借助于 GC-MS.The 全部的集中在 USEPA wereanalyzed 列出了哼从 774.81~255371.91 ng/gdw ,并且二~四响哼在沉积 samples.Molecular 比率,如此的 asphenanthrene/anthracene , fluoranthene/pyrene 和 low-molecular-weight PAH/high-molecular-weightPAH 是主导的,被用来学习 pollutio | JIANG Bin ZHENG Hai-long HUANG Guo-qiang DING Hui LI Xin-gang SUO Hong-tu LI Rui | 2007 | Journal of Environmental Sciences2007，19，3： | 29 |
| 11 | Inhibition of Excitatory Amino Acid Efflux Contributes to Protective Effects of Puerarin Against Cerebral Ischemia in Rats显示文摘Objective To investigate whether the protective effects of puerarine(Pur)against cerebral ischemia is associated with depressing the extracellular levels of amino acid transmitters in brain of rats.Methods Male Sprague-Dawley rats were subjected to transient middle cerebral artery occlusion(MCAO)for 60 min followed by 24 h reperfusion.Pur(50,100 mg/kg,i.p.)was administered at the onset of MCAO.The infarct rate and edema rate were detected on TTC(2,3,5-triphenyltetrazolium chloride)-stained coronal sections.The extracellular levels of amino acid transmitters were monitored in striatum of rats with ischemic/reperfusion injury using in vivo microdialysis technique.Furthermore,the protective effects of Pur against glutamate-induced neurotoxicity were detected.Glutamate-induced apoptotic and necrotic cells in hippocampus were estimated by flow cytometric analysis of Annexin-V and PI labeling cells.Results Pur(100 mg/kg)significantly decreased infarct size by 31.6%(P<0.05),reduced edema volume(P<0.05),and improved neurological functions(P<0.05)following MCAO.In these rats,the ischemia-induced extracellular levels of aspartate(Asp),glutamate(Glu),γ-aminobutyric acid(GABA),and taurine(Tau)were significantly reduced in striatum of vehicle-treated animals by 54.7%,56.7%,75.8%,and 68.1%(P<0.01 and P<0.05).Pur reduced the peak values of Glu and Asp more obviously than those of GABA and Tau,and the rate of Glu/GABA during MCAO markedly decreased in Pur-treated MCAO rats,compared with the vehicle-treated MCAO rats.Meanwhile,apoptosis and necrosis induced by Glu in cultured hippocampal neurons were significantly reduced after Pur treatment.Conclusion Acute treatment with Pur at the onset of occlusion significantly depresses ischemia-induced efflux of amino acids,especially,excitotoxicity in the striatum,a mechanism underlying the neuroprotective effect on cellular survival. | XIAO-HONG XU XIAO-XIANG ZHENG QIONG ZHOU HUI LI | 2007 | Biomedical and Environmental Sciences2007，20，4： | 30 |
| 12 | Endogenous danger signals trigger hepatic ischemia/reperfusion injury through toll-like receptor 4/nuclear factor-kappa B pathway显示文摘到 ischemic 肝脑叶的血流动的背景恢复可以似非而是地加重织物损害,它被称为肝的 ischemia/reperfusion 损害(IRI ) 。像使用费的受体 4 (TLR4 ) ,在几种肝房间类型,和表明小径的原子 factor-kappa B (NF-B ) 上表示了对调停关键肝的煽动性的反应。因为 IRI 是,实质上,许多种危险唤起的一种深刻尖锐煽动性的反应发信号,我们调查了在部分肝的 IRI.Methods 野类型的鼠标的一个鼠科的模型表明小径激活的 TLR4/NF-B ( Wr , C3H/HeN )或 TLR4 变异的鼠标( C3H/HeJ )受到 45 分钟到 1 个小时跟随的部分肝的局部缺血, 3 小时灌注。没有血供应的阻塞,假冒的组接受了一样的过程。在灌注的结束,肝功能的妥协和肝节的组织学的变化作为肝损害的严厉被测量。在门静脉的内毒素的水平被 limulus 试金测量。NF-B 激活被 electrophoretic 活动性移动试金(EMSA ) 决定。肿瘤坏死因素的层次 --(TNF-) 并且在在肝的 IRI 以后的全身的血的 interleukin-1 (IL-1 ) 被连接酶的 immunosorbent 估计试金(ELISA ).Results 在变异的老鼠的肝功能和词法损害的妥协在部分肝的 IRI 以后在 WT 老鼠比那些更显著地被减轻。在 WT 老鼠的 NF-B 激活在 TLR4 变异的老鼠是比那强壮的,并且两个是比在假冒的操作老鼠(P0.01 ) 的那些强壮的。在每个组的内毒素是无法发现的。在全身的血的 TNF-1 和 IL-1 的层次在两紧张被提高,但是在假冒的操作的组降低。这些调停人显著地在 WT 鼠标(P0.01 ) 与那些相比在 TLR4 变异的鼠标被减少 .Conclusions 表明小径的 TLR4/NF-B 可以调停 TLR4/NF-B 小径的内长的危险 signals.Inhibition 触发的肝的 IRI 可以是为在一些临床的设置的 attenuating ischemia/reperfusion-induced 织物损坏的一个潜在的治疗学的目标。 | WANG Hui LI Zhuo-ya WU He-shui WANG Yang JIANG Chun-fang ZHENG Qi-chang ZHANG Jin-xiang | 2007 | Chinese Medical Journal2007，，6： | 25 |
| 13 | Effect of HCV NS_3 protein on P53 protein expression in hepatocarcinogenesis显示文摘NTRODUCTIONHepatocelularcarcinoma(HCC)isoneofthemostcommonhumancancersintheworld.Recently,theHCVinfectionwasfoundtobeanetiolo... | FENG De Yun, CHEN Rui Xue, PENG Yong, ZHENG Hui and YAN Ya Hui | 1999 | World Journal of Gastroenterology1999，5，1： | 25 |
| 14 | Distribution of polycyclic aromatic hydrocarbons in sediments from Yellow River Estuary and Yangtze River Estuary,China显示文摘Surface sediment samples collected from twenty-one sites of Yellow River Estuary and Yangtze River Estuary were determined for sixteen priority polycyclic aromatic hydrocarbons (PAHs) by isotope dilution GC-MS method. The total PAH contents varied from 10.8 to 252 ng/g in Yellow River Estuary sediment, and from 84.6 to 620 ng/g in Yangtze River Estuary sediment. The mean total PAH content of Yangtze River Estuary was approximately twofold higher than that of Yellow River Estuary. The main reasons for the difference may be the rapid industrial development and high population along Yangtze River and high silt content of Yellow River Estuary. The evaluation of PAH sources suggested that PAHs in two estuaries sediments estuaries were derived primarily from combustion sources, but minor amounts of PAHs were derived from petroleum source in Yellow River Estuary. PAHs may be primary introduced to Yellow River Estuary via dry/wet deposition, wastewater effuents, and accidental oil spills, and Yangtze River Estuary is more prone to be affected by wastewater discharge. | HUI Yamei ZHENG Minghui LIU Zhengtao GAO Lirong | 2009 | Journal of Environmental Sciences2009，21，12： | 24 |
| 15 | Coupled Fluid-structure Flutter Analysis of a Transonic Fan显示文摘A coupled 液体结构方法被开发为拍翅在 turbomachinery 的片颤动的分析。途径基于空气动力学、结构的方程及时同时在被行进的液体结构相互作用的时间领域答案。三维(3D ) 不稳定的雷纳兹一般水准海军司烧(RANS ) 方程与 multiblock 被解决动态使空气动力学的力量变形上的有限体积计划评估的格子。有 multigrid 的双走时间的技术和一个有效含蓄的计划被采用及时行进答案。片颤动与片运动被每个模式的回答的线性联合在不稳定的负担下面在计算的一个气动弹性变形模型一起被建模。代码在不稳定的流动的预言被验证拍翅震荡的串联的行为并且被使用拍翅以设计速度的一把接近音速的扇子的分析。 | ZHENG Yun YANG Hui | 2011 | Chinese Journal of Aeronautics2011，24，3： | 22 |
| 16 | 2016 Chinese expert consensus and guidelines for the diagnosis and treatment of papillary thyroid microcarcinoma显示文摘The incidence of papillary thyroid carcinoma(PTC)has exponentially increased in recent years.Papillary thyroid microcarcinoma(PTMC)accounts for the majority of the reported cases of PTC.The debates and crucial issues in PTMC management have received researchers'attention.To further improve the clinical management of PTMC in China, | Ming Gao Minghua Ge Qinghai Ji Ruochuan Cheng Hankui Lu Haixia Guan Li Gao Zhuming Guo Tao Huang Xiaoming Huang Xiaoming Li Yansong Lin Qinjiang Liu Xin Ni Yi Pan Jianwu Qin Zhongyan Shan Hui Sun Xudong Wang Zhengang Xu Yang Yu Daiwei Zhao Naisong Zhang ShengZhang Ying Zheng Jingqiang Zhu Dapeng Li Xiangqian Zheng 无 | 2017 | Cancer Biology & Medicine2017，14，3： | 23 |
| 17 | Intraoperative radiofrequency ablation combined with ^(125)iodine seed implantation for unresectable pancreatic cancer显示文摘AIM: To evaluate the feasibility, efficacy and safety of intraoperative radiofrequency ablation (RFA) combined with 125 iodine seed implantation for unresectable pancreatic cancer. METHODS: Thirty-two patients (21 males and 11 females) at the age of 68 years (range 48-90 years) with unresectable locally advanced pancreatic cancer admitted to our hospital from January 2006 to May 2008 were enrolled in this study. The tumor, 4-12 cm in diameter, located in pancreatic head of 23 patients and in pancreatic body and tail of 9 patients, was found to be unresectable during operation. Diagnosis of pancreatic cancer was made through intraoperative biopsy. Patients were treated with FRA combined with 125 iodine seed implantation. In brief, a RFA needle was placed, which was confirmed by intraoperative ultrasound to decrease the potential injury of surrounding vital structures, a 125 iodine seed was implanted near the blood vessels and around the tumor border followed by bypass palliative procedure (cholangio-jejunostomy and/or gastrojejunostomy) in 29 patients.RESULTS: The serum CA 19-9 level was decreased from 512 ± 86 U/mL before operation to 176 ± 64 U/mL, 108 ± 42 U/mL and 114 ± 48 U/mL, respectively, 1, 3 and 6 mo after operation (P < 0.05). The pain score on day 7 after operation, 1 and 3 mo after combined therapy was decreased from 5.86 ± 1.92 before operation to 2.65 ± 1.04, 1.65 ± 0.88 and 2.03 ± 1.16, respectively, after operation (P < 0.05). The rate of complete response (CR), partial response (PR), stable disease (SD), progressive disease (PD) in 32 patients was 21.8% (7/32), 56.3% (18/32), 15.6% (5/32) and 6.3% (2/32), respectively, 6 mo after operation, with a median overall survival time of 17. 5 mo. The median survival time of patients at stage Ⅲ was longer than that of those at stage Ⅳ (19 mo vs 10 mo, P = 0.0026). The median survival time of patients who received and did not receive chemotherapy after operation was 20 mo and 16 mo, respectively (P = 0.0176). Of the 32 patients, 3 (10.6%) experienced postoperative complications including transient biliary leaks in 2 patients and acute pancreatitis in 1 patient. All the patients recovered well after conservative support treatment. CONCLUSION: Intraoperative RFA combined with 125 iodine seed implantation is a feasible and safe procedure for unresectable pancreatic cancer with acceptable minor complications, and can prolong the survival time of patients, especially those at stage Ⅲ. | Yi-Ping Zou Wei-Min Li Fang Zheng Fu-Cheng Li Hui Huang Ji-Dong Du Hao-Run Liu | 2010 | World Journal of Gastroenterology2010，16，40： | 21 |
| 18 | Hepatocellular carcinoma and macrophage interaction induced tumor immunosuppressionvia Treg requires TLR4 signaling显示文摘AIM: To investigated the interaction between toll-like receptor 4 (TLR4)-activated hepatoma cells and macrophages in the induction of tumor-immune suppression mediated by CD4+CD25high family of transcription factor P3 (FOXP3) regulatory T cells (Tregs). METHODS: The proportion of FOXP3+ Tregs was identified in peripheral blood and tumor tissues of 60 hepatocellular carcinoma (HCC) patients. TLR4 expression was examined in tumor tissues and cell lines. The correlation was examined between FOXP3+ Tregs in peripheral blood and TLR4 expression of HCC tissues. Following activation of TLR4 in H22 murine hepatoma cells pre-incubated with lipopolysaccharide (LPS) and co-cultured with macrophage cell line RAW246.7, the synthesis of cytokines tumor necrosis factor-α, CCL22, and interleukin (IL)-10 by the two cell lines was detected and analyzed. RESULTS: FOXP3+ Tregs were enriched in tumor sites, and circulating FOXP3+ Tregs were increased in HCC patients in correlation with multiple tumor foci and up-regulated TLR4 expression in HCC tissues. Semi-quantitative analysis indicated that TLR4 was over-expressed in HCC compared with the matched normal tissues. Cell cultivation experiments indicated that the mRNAs of IL-10 and CCL22 were significantly up-regulated in the RAW246.7 cell line when co-cultured with LPS preincubated H22 cells. CONCLUSION: In hepatoma cell lines, TLR4 may indirectly facilitate the recruitment of Tregs to the tumor site and promote intrahepatic metastasis through its interaction with macrophages. | Jing Yang Jin-Xiang Zhang Hui Wang Guo-Liang Wang Qing-Gang Hu Qi-Chang Zheng | 2012 | World Journal of Gastroenterology2012，18，23： | 20 |
| 19 | The Role of Fibrocyte in the Pathogenesis of Silicosis显示文摘Exposure to free silica induces silicosis and myofibroblasts are regarded as primary effector cells.Fibrocytes can differentiate into myofibroblast.Therefore,the present study was designed to investigate whether | LI Juan YAO Wu HOU Jian Yong ZHANG Lin BAO Lei CHEN Hui Ting WANG Di YUE Zhong Zheng LI Yi Ping ZHANG Miao YU Xing Hao ZHANG Jian Hui QU Ya Qian HAO Chang Fu | 2018 | Biomedical and Environmental Sciences2018，31，4： | 20 |
| 20 | Protective effect of probiotics on intestinal barrier function in malnourished rats after liver transplantation显示文摘BACKGROUND: Most patients waiting for liver transplantation have end-stage liver diseases with malnutrition, which is prone to induce intestinal barrier dysfunction after liver transplantation. We aimed to study the effect of probiotics on intestinal barrier function in malnourished rats following liver transplantation with long-term antibiotics. METHODS: Twelve Lewis rats were selected as donors. Twelve BN rats, which served as recipients, were subjected to malnutrition by semi-starvation for 4-5 weeks. They were randomly divided into two groups: a control group which received phosphate-buffered saline and a probiotics group which received Bifidobacterium and Lactobacillus. All recipients were injected with intramuscular imipenem and subcutaneous cyclosporine A. Furthermore, six normal BN rats without any drugs or operations served as a normal group. Eight days after operation, all rats were sacrificed for examination of the following parameters: serum levels of endotoxin and TNF-α, bacterial translocation, intestinal microflora, ileocecal sIgA, lymphocyte numbers, and phenotypes (CD4, CD8, αβTCR, γδTCR)ofPeyer'spatches. RESULTS: In recipients subjected to malnutrition, weight decreased by 20% and they survived until 8 days after operation. Compared with the normal group, all recipients on postoperative day 8 showed increased levels of serum endotoxin and TNF-α as well as increased counts oftranslocated bacteria. Meanwhile, there were decreases in counts of Bifidobacterium and Lactobacillus in the ileocecum, sIgA concentration, and lymphocytes of Peyer's patches. Moreover, partial alteration in lymphocyte phenotypes was evidenced by elevated ratios of CD8 + and γδTCR + lymphocytes. In contrast, compared to the control group, supplementation with probiotics reduced the levels of serum endotoxin, TNF-α and bacterial translocation, increased the counts of Bifidobacterium and Lactobacillus, the concentration of sIgA and lymphocytes of Peyer's patches, and also slightly restored the alteration of lymphocyte phenotypes. CONCLUSION: Supplementation with probiotics including Bifidobac-terium and Lactobacillus promoted partial restoration of intestinal microflora and improved intestinal barrier function in malnourished rats after liver transplantation with long-term use of antibiotics. | Zhi-Gang Ren, Hui Liu, Jian-Wen Jiang, Li Jiang, Hui Chen, Hai-Yang Xie, Lin Zhou and Shu-Sen Zheng Key Laboratory of Combined Multi-organ Transplan- tation, Ministry of Public Health, and Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China and Institute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，5： | 20 |
您所在的机构暂未开通此部分的功能，请联系管理员