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| 1 | Nature brings new avenues to the therapy of central nervous system diseases——an overview of possible treatments derived from natural products显示文摘Natural products(NPs), including traditional Chinese medicine(TCM), have been long and widely used in the prevention and treatment of central nervous system(CNS) diseases by virtue of their abundant sources, diverse structures, and novel activities.In this review article, we intend to summarize and discuss the situation or status of the clinical employments or trials of the NPs and their derivatives with CNS activities. NPs that have been extensively studied in preclinical research in recent years are also included. The compounds presented in this review are classified according to their indications and followed by details such as natural sources, possible biological mechanisms, and development status, while a considerable proportion of them are found in TCM. In addition, some drug combinations with synergistic effects are also mentioned. According to their impressive therapeutic effects and novel chemical structures, NPs are not only effective therapeutic remedies in clinic, but also lead compounds for structural modification, which indicate that nature brings new avenues to the therapy of CNS diseases. | Junchi Zhang Yang He Xiangrui Jiang Hualiang Jiang Jingshan Shen | 2019 | Science China(Life Sciences)2019，62，10： | 30 |
| 2 | Expression of Epstein-Barr virus genes in EBV-associated gastric carcinomas显示文摘AIM: To understand the expression of latent and lytic genes of Epstein-Barr virus (EBV) in EBV-associated gastric carcinoma (EBVaGC) and to explore the relationship between EBV-encoded genes and development of EBVaGC at molecular level.METHODS: One hundred and seventy-two gastric carcinoma tissues and 172 corresponding para-carcinoma tissues were tested for EBV genome by polymerase chain reaction (PCR)-Southern blotting. EBV-encoded small RNA (EBER)1 of the PCR positive specimens was detected by in situ hybridization (ISH). Gastric carcinomas with positive EBER1signals were classified as EBVaGCs. RT-PCR and Southern hybridization were applied to the detection of expression of nuclear antigen (EBNA) promoters (Qp, Wp and Cp),EBNA 1 and EBNA 2, latent membrane proteins (LMP) 1,2A and 2B and lytic genes (immediate early genes BZLF1and BRLF1, early genes BARF1 and BHRF1, late genes BcLF1and BLLF1) in EBVaGCs.RESULTS: Eleven EBV positive samples existed in gastric carcinoma tissues (6.39%). No EBV positive sample was found in corresponding para-carcinoma tissues. The difference between EBV positivity in carcinoma tissues and corresponding para-carcinoma tissues was significant(x2 = 9.0909, P = 0.0026). Transcripts of Qp and EBNA1were detected in all the 11 EBVaGCs, while both Wp and Cp were silent. EBNA2, LMP1 and LMP2B mRNA were absent in all the cases, while LMP2A mRNA was detected in 4 of the 11 cases. Of the 11 EBVaGCs, 7 exhibited BcLF1 transcripts and 2 exhibited BHRF1 transcripts. The transcripts of BZLF1and BARF1 were detected in 5 cases, respectively. No BLLF1and BRLF mRNA were detected.CONCLUSION: The latent pattern of EBV in gastric carcinoma corresponds to the latency Ⅰ/Ⅱ. Some lyric infection genes are expressed in EBVaGCs tissues. BARF1 and BHRF1genes may play an important role in tumorigenesis of gastric carcinoma. | BingLuo YunWang Xiao-FengWang HuaLiang Li-PingYan Bao-huaHuang PengZhao | 2005 | World Journal of Gastroenterology2005，11，5： | 16 |
| 3 | Rational construction of graphene oxide with MOF- derived porous NiFe@C nanocubes for high-performance microwave attenuation显示文摘与强壮、悦耳的宽带微波吸收探索小微波变细材料是高度合乎需要的,但是仍然是重要挑战。此处,三维(3D ) 由在碳 nanocubes 以内嵌入的 NiFe nanoparticles 组成的多孔的混合 composites 在 graphene 氧化物上装饰了(去) 表(NiFe@C nanocubes@GO ) 同样高效的微波变细材料讲道理地被综合了。3D 多孔的混合 composites 被一个简单方法制作,它包含 NiFe 普鲁士的蓝类似物 nanocubes 的一步舞热分解面对去表。得益于展出好磁性、绝缘的损失以及一根合适的阻抗火柴的唯一的结构的特征,产生 NiFe@C nanocubes@GO composites 表演优秀微波变细能力。与最小的思考损失(RL ) 在在 2.8 公里的厚度和为 RL 的 38.6% 的最大的百分比带宽的 7.7 GHz 的 of-51 | Zhihong Yang Hualiang Lv Renbing WU | 2016 | Nano Research2016，9，12： | 16 |
| 4 | Design and development of an oral remdesivir derivative W116 against SARS-CoV-2显示文摘Dear Editor,Since the declaration of COVID-19 as a global pandemic on March 11,2020,this pandemic has been circulating for 17 months throughout the world,leading to more than 200 million infections and nearly 4.4 million deaths as of August 15,2021.The pathogen of COVID-19 is a novel coronavirus named SARS-CoV-2,which shares-79%genome sequence identity with SARS-CoV.1 At the early stage of the COVID-19 outbreak,5ARS-CoV-2 caused great panic in the hardest-hit areas due to its high transmissibility and pathogenicity.To fight the COVID-19 crisis,drug repurposing was immediately pursued in order to find potential therapeutics. | Yuanchao Xie Wanchao Yin Yumin Zhang Weijuan Shang Zhen Wang Xiaodong Luan Guanghui Tian Haji A.Aisa Yechun Xu Gengfu Xiao Jia Li Hualiang Jiang Shuyang Zhanq Leike Zhang H.Eric Xu Jingshan Shen | 2021 | Cell Research2021，31，11： | 12 |
| 5 | Artificial intelligence in drug design显示文摘Thanks to the fast improvement of the computing power and the rapid development of the computational chemistry and biology,the computer-aided drug design techniques have been successfully applied in almost every stage of the drug discovery and development pipeline to speed up the process of research and reduce the cost and risk related to preclinical and clinical trials.Owing to the development of machine learning theory and the accumulation of pharmacological data, the artificial intelligence(AI) technology, as a powerful data mining tool, has cut a figure in various fields of the drug design, such as virtual screening,activity scoring, quantitative structure-activity relationship(QSAR) analysis, de novo drug design, and in silico evaluation of absorption, distribution, metabolism, excretion and toxicity(ADME/T) properties. Although it is still challenging to provide a physical explanation of the AI-based models, it indeed has been acting as a great power to help manipulating the drug discovery through the versatile frameworks. Recently, due to the strong generalization ability and powerful feature extraction capability,deep learning methods have been employed in predicting the molecular properties as well as generating the desired molecules,which will further promote the application of AI technologies in the field of drug design. | Feisheng Zhong Jing Xing Xutong Li Xiaohong Liu Zunyun Fu Zhaoping Xiong Dong Lu Xiaolong Wu Jihui Zhao Xiaoqin Tan Fei Li Xiaomin Luo Zhaojun Li Kaixian Chen Mingyue Zheng Hualiang Jiang | 2018 | Science China(Life Sciences)2018，61，10： | 10 |
| 6 | Hierarchical composite of biomass derived magnetic carbon framework and phytic acid doped polyanilne with prominent electromagnetic wave absorption capacity显示文摘To solve the electromagnetic pollution,herein,a CoFe_(2)O_(4)/C/PANI composite was developed by a green route,which was constructed with spinel of metal oxide,graphitized carbon and conductive polymer composites.Benefiting from the designable interfaces and increased dipoles,the microwave dielectric response capability can be boosted significantly and resulted in the enhanced microwave absorbing performance.As revealed by the reflection loss curve,the minimum reflection loss(RLmin) reached-51.81 dB at 12.4 GHz under a matched thickness of 2.57 mm.At 2.5 mm,the effective absorbing band covered 8.88 GHz,suggesting the desirable wideband feature.In our case,the method of utilization of a novel green way to fabricate multiple-component EM absorber can be a promising candidate for high-performance EM absorber. | Tianqi Hou Zirui Jia Ailing Feng Zehua Zhou Xuehua Liu Hualiang Lv Guanglei Wu | 2021 | Journal of Materials Science & Technology2021，，9： | 8 |
| 7 | Achieving excellent bandwidth absorption by a mirror growth process of magnetic porous polyhedron structures显示文摘对称的 Fe 2 O 3/BaCO3 有 10 m 和 ~ 的边长度的高度的六角形的锥结构 4 m 被报导,使用一个普通 solvothermal 过程和镜子生长获得过程。集中的离子横梁和高分辨率的传播电子显微镜学技术表明 -Fe2O3 是在场的单个水晶特征。Ba 离子贡献了在最后的 composites 展出的对称的结构的形成。随后,多孔的磁性的对称的六角形的锥结构被用来学习观察强烈电磁波干扰。在 2-18 GHz 的电磁的吸收表演研究作为与象锭子,范围,立方体,和杆那样的另外的形状相比显示了更强壮的变细电磁波能力。最大的吸收频率带宽在有涂层厚度 d = 的 7.2 GHz 1.5 公里。特殊结构和 BaCO 3 的缺席多半在在这研究描述的优秀电磁的吸收性质起了一个重要作用。 | Hualiang Lv Haiqian Zhang Jun Zhao Guangbin Ji Youwei Du | 2016 | Nano Research2016，9，6： | 8 |
| 8 | The gating charge pathway of an epilepsy-associated potassium channel accommodates chemical ligands显示文摘电压门钾(Kv ) 隧道在电压传感器领域(VSD ) 从 gating 费用的运动导出他们的电压敏感。gating 在 VSD 通过一条物理小径控告 translocate 打开或关门隧道。以前的研究证明 gating 控告 Shaker 的小径, Kv1.2-2.1 妄想的隧道被堵塞,形成集中的电场和 gating 费用转移中心的结构的基础。这里,我们证明 gating 控告电压门 KCNQ2 钾隧道的小径,哪个引起癫痫的活动减小,能提供各种各样的小分子 ligands。记录的联合 mutagenesis,分子的模拟和 electrophysiological,为探查使活跃之物的一个有约束力的模型, ztz240,在 gating 费用,小径被定义。这个信息被用来建立指向定义 ligand 有约束力的衣袋的基于船坞的虚拟屏蔽试金。有五新 chemotypes 的九使活跃之物被识别,并且在 vivo,实验显示出那三 ligands 绑定到 gating 费用小径展览重要反癫痫活动。由指向衣袋的虚拟屏蔽的各种各样的新奇使活跃之物的鉴定在 gating 费用小径支持一个 ligand 有约束力的地点的存在。gating 费用小径的能力提供新卓见提供小分子 ligands 进治疗学地相关的 KCNQ2 隧道的 gating 费用小径。 | Ping Li Zhuxi Chen Haiyan Xu Haifeng Sun Hao Li Hong Liu Huaiyu Yang Zhaobing Gao Hualiang Jiang Min Li | 2013 | Cell Research2013，23，9： | 8 |
| 9 | Computational drug discovery显示文摘计算的药发现是为加速和节俭的药发现和发展过程的有效策略。因为生物大分子和小分子信息的可获得性的戏剧的增加,计算的药发现的适用性被扩大了并且广泛地适用于将近在药发现和发展工作流的每个阶段包括目标鉴定和确认,带发现和优化和现出症状之前的潜的测试。极大地在过去的十年,象分子的停靠那样的计算的药发现方法,当模特儿并且印射的 pharmacophore, de novo 设计,分子的类似计算并且基于顺序的虚拟屏蔽被改进了。在这评论,我们在场这域里的这些重要计算方法,平台和成功的应用程序的概述。 | Si-sheng OU-YANG Jun-yan LU Xiang-qian KONG Zhong-jie LIANG Cheng LUO Hualiang JIANG | 2012 | Acta Pharmacologica Sinica2012，33，9： | 7 |
| 10 | SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target显示文摘Cytokine storm and multi-organ failure are the main causes of SARS-CoV-2-related death.However,the origin of excessive damages caused by SARS-CoV-2 remains largely unknown.Here we show that the SARS-CoV-2 envelope(2-E)protein alone is able to cause acute respiratory distress syndrome(ARDS)-like damages in vitro and in vivo. | Bingqing Xia Xurui Shen Yang He Xiaoyan Pan Feng-Liang Liu Yi Wang Feipu Yang Sui Fang Yan Wu Zilei Duan Xiaoli Zuo Zhuqing Xie Xiangrui Jiang Ling Xu Hao Chi Shuangqu Li Qian Meng Hu Zhou Yubo Zhou Xi Cheng Xiaoming Xin Lin Jin Hai-Lin Zhang Dan-Dan Yu Ming-Hua Li Xiao-Li Feng Jiekai Chen Hualiang Jiang Gengfu Xiao Yong-Tang Zheng Lei-Ke Zhang Jingshan Shen Jia Li Zhaobing Gao | 2021 | Cell Research2021，31，8： | 7 |
| 11 | Low dose of hydroxychloroquine reduces fatality of critically ill patients with COVID-19显示文摘Coronavirus disease 2019(COVID-19)is a pandemic with no specific drugs and high fatality.The most urgent need is to find effective treatments.We sought to determine whether hydroxychloroquine(HCQ)application may reduce the death risk of critically ill COVID-19 patients.In this retrospective study,we included 550 critically ill COVID-19 patients who need mechanical ventilation in Tongji Hospital,Wuhan,from February 1,2020 to April 4,2020.All 550 patients received comparable basic treatments including antiviral drugs and antibiotics,and 48 of them were treated with oral HCQ treatment(200 mg twice a day for 7–10 days)in addition to the basic treatments.Primary endpoint is fatality of patients,and inflammatory cytokine levels were compared between HCQ and non-hydroxychloroquine(NHCQ)treatments.We found that fatalities are 18.8%(9/48)in HCQ group,which is significantly lower than 47.4%(238/502)in the NHCQ group(P<0.001).The time of hospital stay before patient death is 15(10–21)days and 8(4–14)days for the HCQ and NHCQ groups,respectively(P<0.05).The levels of inflammatory cytokine IL-6 were significantly reduced from 22.2(8.3–118.9)pg mL–1 at the beginning of the treatment to 5.2(3.0–23.4)pg mL–1(P<0.05)at the end of the treatment in the HCQ group but there is no change in the NHCQ group.These data demonstrate that addition of HCQ on top of the basic treatments is highly effective in reducing the fatality of critically ill patients of COVID-19 through attenuation of inflammatory cytokine storm.Therefore,HCQ should be prescribed as a part of treatment for critically ill COVID-19 patients,with possible outcome of saving lives. | Bo Yu Chenze Li Peng Chen Ning Zhou Luyun Wang Jia Li Hualiang Jiang Dao-Wen Wang | 2020 | Science China(Life Sciences)2020，63，10： | 7 |
| 12 | Effects of Shuanghuanglian oral liquids on patients with COVID-19:a randomized,open-label,parallel-controlled,multicenter clinical trial显示文摘We conducted a randomized,open-label,parallel-controlled,multicenter trial on the use of Shuanghuanglian(SHL),a traditional Chinese patent medicine,in treating cases of COVID-19.A total of 176 patients received SHL by three doses(56 in low dose,61 in middle dose,and 59 in high dose)in addition to standard care.The control group was composed of 59 patients who received standard therapy alone.Treatment with SHL was not associated with a difference from standard care in the time to disease recovery.Patients with 14-day SHL treatment had significantly higher rate in negative conversion of SARS-CoV-2 in nucleic acid swab tests than the patients from the control group(93.4%vs.73.9%,P=0.006).Analysis of chest computed tomography images showed that treatment with high-dose SHL significantly promoted absorption of inflammatory focus of pneumonia,which was evaluated by density reduction of inflammatory focus from baseline,at day 7(mean difference(95%CI),−46.39(−86.83 to−5.94)HU;P=0.025)and day 14(mean difference(95%CI),−74.21(−133.35 to−15.08)HU;P=0.014).No serious adverse events occurred in the SHL groups.This study illustrated that SHL in combination with standard care was safe and partially effective for the treatment of COVID-19. | Li Ni Zheng Wen Xiaowen Hu Wei Tang Haisheng Wang Ling Zhou Lujin Wu Hong Wang Chang Xu Xizhen Xu Zhichao Xiao Zongzhe Li Chene Li Yujian Liu Jialin Duan Chen Chen Dan Li Runhua Zhang Jinliang Li Yongxiang Yi Wei Huang Yanyan Chen Jianping Zhao Jianping Zuo Jianping Weng Hualiang Jiang Dao Wen Wang | 2021 | Frontiers of Medicine2021，15，5： | 7 |
| 13 | Why are oseltamivir and zanamivir effective against the newly emerged influenza A virus (A/HIN1)?显示文摘 | Kunqian Yu Cheng Luo Guangrong Qin Zhijian Xu Ning Li Hong Liu Xu Shen Jianpeng Ma Qinghua Wang Caiguang Yang Weiliang Zhu Hualiang Jiang | 2009 | Cell Research2009，19，10： | 6 |
| 14 | Study on typical hole defects in AZ91D magnesium alloy prepared by low pressure lost foam casting显示文摘The hole defects can easily occur in magnesium alloy castings that are prepared by low pressure lost foam casting(LP-LFC)process when the process parameters such as vacuum,pouring temperature and f illing velocity are not properly selected.In this study,the forming mechanism of the hole defects in AZ91D magnesium castings by LP-LFC process was investigated.The shape,location and surface appearance of the hole defects were observed using optical microscopy and scanning electron microscopy,and the chemical composition on the surface of the holes was analyzed using energy spectrometer.The result indicates that there are two types of hole defects,i.e.,the pyrolysis products related hole defects,including concentrative hole and blow hole defects,and slag related hole defects.The concentrative hole and the blow-hole defects were formed either by the liquidEPS degradation products entrapped in the molten metal under the condition that the pouring temperature is equal to or lower than 730℃,or by the hindered transport of EPS pyrolysis products.Some irregular shape hole defects were caused by slag or by coating slough entrapment when the pouring temperature is equal to 750℃and the f illing velocity is equal to or greater than 100 mm·s-1.To reduce or eliminate the hole defects,the vacuum and f illing velocity must be properly chosen to ensure that the metal front prof ile exhibits convex shape and in laminar current state,and the pouring temperature should be just high enough to ensure that the molten melt has adequate heat energy to complete the foam pyrolysis and to fully occupy the mould.For AZ91D magnesium castings in this study,the parameters should be 730℃pouring temperature,0.02-0.03 MPa vacuum and 80mm·s-1f illing velocity. | Li Jiqiang Zhao zhong Fan Zitian Dong Xuanpu Shi Hualiang | 2013 | China Foundry2013，10，4： | 5 |
| 15 | Potential treatment of COVID-19 by inhibitors of human dihydroorotate dehydrogenase显示文摘The ongoing pandemic of severe acute respiratory syn・drome coronavirus 2(SARS・CoV・2),referred to as coronavirus disease 2019(COVID-19),has caused over 13 million infections and over 560,000 deaths worldwide(http://gffzz36b398b81f8a4a4csck9cukb5bf6n699c.ffgz.tsg.suse.edu.cn/emergencies/diseases/novel・coron avirus-2019/sit uation-reports),posing a significant threat to globally public health and economics.At present,no efficacious antiviral drugs and vaccines have been approved for the prophylaxis or treatment of COVID-19.Tremendous efforts have been made to develop drug and vaccine against SARS-CoV-2.The main protease(Mpro,also called 3CLpro)is an attractive drug target among coronaviruses,and several potent inhibitors of the SARS-CoV-23CLpro together with their crystal structures in complex with the protease have been reported(Dai et al.,2020;Jin et al.,2020;Zhang et al.,2020). | Yechun Xu Hualiang Jiang | 2020 | Protein & Cell2020，11，10： | 5 |
| 16 | Combined Effects of Chronic Obstructive Pulmonary Disease and Depression on Spatial Memory in Old Rats显示文摘Objective To investigate the combined effects of chronic obstructive pulmonary disease(COPD)and depression on spatial memory in old rats,aiming to better understand the comorbidity of the two diseases in geriatric patients.Methods The SD rats were assigned into five groups:adult control group(n=6),elderly control group(n=6),elderly COPD group(n=6),elderly depression group(n=6)and elderly COPD with depression group(n=6).Smoking and chronic unpredictable mild stress(CUMS)with solitary support were used to induce COPD model,depression model,respectively,and the both were applied for the comorbidity model.Learning and memory deficits were assessed by Morris water maze(MWM)test.The activity of superoxide dismutase(SOD)and the content of malondialdehyde(MDA)in serum and hippocampus tissue were determined by Xanthinoxidase method and Thiobarbituric acid reaction(TBAR)method,respectively.Results The results of pulmonary histology,lung function,open-field test and sucrose consumption demonstrated the comorbidity models of COPD and depression in elderly rats were successfully established using smoking and CUMS with solitary support.Compared with the elderly control group,the group of COPD with depression had obviously longer time of latency and longer travel distance to reach the platform in MWM test(LSD-t=-10.116,P=0.000;LSD-t=-6.448,P=0.000).The SOD activity in serum and hippocampus decreased significantly(LSD-t=2.629,P=0.014;LSD-t=2.215,P=0.044)and the MDA content in serum and hippocampus increased significantly(LSD-t=-2.140,P=0.042;LSD-t=-2.070,P=0.049)in elderly COPD with depression group.Conclusions COPD in comorbidity of depression could induce spatial memory deficit in old rats.The mechanisms might be related to the overloaded and free radical metabolic imbalance.These results suggest a potential therapeutic target for comorbidity of COPD and depression in geriatric patients. | Cui Cai Changqing Xu Hualiang Jin Bei Li | 2018 | Chinese Medical Sciences Journal2018，33，4： | 4 |
| 17 | One-Dimensional Magnetic FeCoNi Alloy Toward Low-Frequency Electromagnetic Wave Absorption显示文摘Rational designing of one-dimensional(1D)magnetic alloy to facilitate electromagnetic(EM)wave attenuation capability in low-frequency(2-6 GHz)microwave absorption field is highly desired but remains a significant challenge.In this study,a composite EM wave absorber made of a FeCoNi medium-entropy alloy embedded in a 1D carbon matrix framework is rationally designed through an improved electrospinning method.The 1D-shaped FeCoNi alloy embedded composite demonstrates the high-density and continuous magnetic network using off-axis electronic holography technique,indicating the excellent magnetic loss ability under an external EM field.Then,the in-depth analysis shows that many factors,including 1D anisotropy and intrinsic physical features of the magnetic medium-entropy alloy,primarily contribute to the enhanced EM wave absorption performance.Therefore,the fabricated EM wave absorber shows an increasing effective absorption band of 1.3 GHz in the low-frequency electromagnetic field at an ultrathin thickness of 2 mm.Thus,this study opens up a new method for the design and preparation of high-performance 1D magnetic EM absorbers. | Bintong Yang Jiefeng Fang Chunyang Xu Hui Cao Ruixuan Zhang Biao Zhao Mengqiu Huang Xiangyu Wang Hualiang Lv Renchao Che | 2022 | Nano-Micro Letters2022，14，10： | 4 |
| 18 | Silicon-coated fibrous network of carbon nanotube/iron towards stable and wideband electromagnetic wave absorption显示文摘Materials that can absorb electromagnetic(EM)wave have garnered increased attention in recent years due to their potential to mitigate the ever increasing environmental pollution by EM waves.Thanks to recent advances in micro/nanofabrication,a variety of magnetic metal-based EM absorbers have been reported.The design and synthesis of EM absorbers that exhibit efficient and wide-band absorption at small thicknesses,however,remains elusive.Here we report the design of fibrous nanostructures consisting of magnetic iron(Fe)nanoparticles and carbon nanotubes(CNTs),which exhibits a wide-band EM absorption(3.8 GHz)while maintain the thickness at 1.2 mm.In our work,we created a novel core-shell structure by immersing the highly fibrous CNT-Fe structure into solid-state silicon(SiO)matrix.Finally,the SiO-coated CNT-Fe structures exhibit good stability against air-induced oxidation and acid corrosion while maintaining high EM absorption.Overall,the results reported in this study present new avenues to absorb EM from ambient air.We believe that our work elevates the utility of EM absorbers to real-world applications such as anti-acid and oxidation ability. | Xiaodi Zhou He Han Yuchao Wang Cheng Zhang Hualiang Lv Zhichao Lou | 2022 | Journal of Materials Science & Technology2022，，26： | 4 |
| 19 | High-resolution mapping of brain vasculature and its impairment in the hippocampus of Alzheimer’s disease mice显示文摘Accumulating evidence indicates the critical importance of cerebrovascular dysfunction in the pathogenesis of Alzheimer’s disease(AD).However,systematic comparative studies on the precise brain vasculature of wild-type and AD model mice are still rare.Using an image-optimization method for analysing Micro-Optical Sectioning Tomography(MOST)data,we generated cross-scale whole-brain 3 D atlases that cover the entire vascular system from large vessels down to smallest capillaries at submicron resolution,for both wild-type mice and a transgenic(APP/PS1)mouse model of AD.In addition to distinct vascular patterns in different brain regions,we found that the main vessels of the molecular layer of the hippocampal dentate gyrus(DG-ml)undergo abrupt changes in both diameter and branch angle,spreading a unique comb-like pattern of capillaries.By using a quantitative analysis workflow,we identified in the hippocampus of AD mice an overall reduction of the mean vascular diameter,volume fraction and branch angle,with most significant impairment in the DG-ml.In addition,virtual endoscopy revealed irregular morphological features in the vessel lumen of the AD mice,potentially contributing to the impairment of blood flow.Our results demonstrate the capability of high-resolution cross-scale evaluation of brain vasculature and underscore the importance of studying hippocampal microcirculation for understanding AD pathogenesis. | Xiaochuan Zhang Xianzhen Yin Jingjing Zhang Anan Li Hui Gong Qingming Luo Haiyan Zhang Zhaobing Gao Hualiang Jiang | 2019 | National Science Review2019，6，6： | 4 |
| 20 | Biomass-Derived Carbon Heterostructures Enable Environmentally Adaptive Wideband Electromagnetic Wave Absorbers显示文摘Although advances in wireless technologies such as miniature and wearable electronics have improved the quality of our lives,the ubiquitous use of electronics comes at the expense of increased exposure to electromagnetic(EM)radiation.Up to date,extensive efforts have been made to develop high-performance EM absorbers based on synthetic materials.However,the design of an EM absorber with both exceptional EM dissipation ability and good environmental adaptability remains a substantial challenge.Here,we report the design of a class of carbon heterostructures via hierarchical assembly of graphitized lignocellulose derived from bamboo.Specifically,the assemblies of nanofibers and nanosheets behave as a nanometer-sized antenna,which results in an enhancement of the conductive loss.In addition,we show that the composition of cellulose and lignin in the precursor significantly influences the shape of the assembly and the formation of covalent bonds,which affect the dielectric response-ability and the surface hydrophobicity(the apparent contact angle of water can reach 135°).Finally,we demonstrate that the obtained carbon heterostructure maintains its wideband EM absorption with an effective absorption frequency ranging from 12.5 to 16.7 GHz under conditions that simulate the real-world environment,including exposure to rainwater with slightly acidic/alkaline pH values.Overall,the advances reported in this work provide new design principles for the synthesis of high-performance EM absorbers that can find practical applications in real-world environments. | Zhichao Lou Qiuyi Wang Ufuoma IKara Rajdeep SMamtani Xiaodi Zhou Huiyang Bian Zhihong Yang Yanjun Li Hualiang Lv Solomon Adera Xiaoguang Wang | 2022 | Nano-Micro Letters2022，14，1： | 3 |
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