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| 1 | Expression of tissue factor in pancreatic adenocarcinoma is associated with activation of coagulation显示文摘瞄准:在 thromboembolism 的开发在胰腺的癌症和它的角色学习织物因素(TF ) 的表示。方法:TF 表示被北污点和间接免疫荧光在八根人的胰腺的癌房间线学习。或者拼接的 TF (asTF ) 的表示被 RT-PCR 估计。另外, TF 表示被免疫荧光与胰腺的腺癌(PCa ) 在 19 个病人的胰腺的纸巾决定,有慢性胰炎(CP ) 的 9 个病人和 20 正常控制。血浆样品(30 PCa 病人, 13 CP 病人和 20 控制) 为可溶的 TF 层次和凝结激活标记被调查[thrombin-antithrombin III 建筑群(梭织) ,凝血素碎片 1 + 2 (F1 + 2 )] 。结果:所有胰腺的癌房间线表示了 TF (8/8 ) ,他们中的大多数表示了 asTF (6/8 ) 。在蛋白质水平的 TF 表示没与癌房间线的区别相关。几乎,二件胰腺的癌症组织样品染色了为 TF (17/19 ) 积极。在 CP 的所有样品,弱染色被限制为胰腺的管房间,而一些仅仅内皮下房间在正常控制的 9/20 是积极的。TF 并且在 PCa 病人梭织层次而 2 铺平的提高的 F1 + 没与控制相比到达统计意义,显著地与控制相比被提高。在病人们梭织的 CP 和 F1 + , 2 个层次证明了显著地与控制相比被提高,尽管梭织举起少些比在 PCa 病人被读。结论:我们结束那除了起来房间膜上的 TF 的调整表示,可溶的 TF 可能在胰腺的癌症贡献凝结系统的激活。 | Stephan L Haas Ralf Jesnowski Michael Steiner Frank Hummel Jrg Ringel Christine Burstein Horst Nizze Stefan Liebe J Matthias Lhr | 2006 | World Journal of Gastroenterology2006，12，30： | 9 |
| 2 | Cementomimetics——constructing a cementum-like biomineralized microlayer via amelogenin-derived peptides显示文摘Cementum is the outer-,mineralized-tissue covering the tooth root and an essential part of the system of periodontal tissue that anchors the tooth to the bone. Periodontal disease results from the destructive behavior of the host elicited by an infectious biofilm adhering to the tooth root and left untreated,may lead to tooth loss. We describe a novel protocol for identifying peptide sequences from native proteins with the potential to repair damaged dental tissues by controlling hydroxyapatite biomineralization. Using amelogenin as a case study and a bioinformatics scoring matrix,we identified regions within amelogenin that are shared with a set of hydroxyapatite-binding peptides (HABPs) previously selected by phage display. One 22-amino acid long peptide regions referred to as amelogenin-derived peptide 5 (ADP5) was shown to facilitate cell-free formation of a cementum-like hydroxyapatite mineral layer on demineralized human root dentin that,in turn,supported attachment of periodontal ligament cells in vitro. Our findings have several implications in peptide-assisted mineral formation that mimic biomineralization. By further elaborating the mechanism for protein control over the biomineral formed,we afford new insights into the evolution of protein-mineral interactions. By exploiting small peptide domains of native proteins,our understanding of structure-function relationships of biomineralizing proteins can be extended and these peptides can be utilized to engineer mineral formation. Finally,the cementomimetic layer formed by ADP5 has the potential clinical application to repair diseased root surfaces so as to promote the regeneration of periodontal tissues and thereby reduce the morbidity associated with tooth loss. | Mustafa Gungormus Ersin E Oren Jeremy A Horst Hanson Fong Marketa Hnilova Martha J Somerman Malcolm L Snead Ram Samudrala Candan Tamerler Mehmet Sarikaya | 2012 | International Journal of Oral Science2012，4，2： | 5 |
| 3 | Different characteristics of chronic dibutyltin dichloride-induced pancreatitis and cholangitis in mouse and rat显示文摘Background:Current animal models of chronic pancreatitis(CP)often provide only limited pathophysio-logical insights since they incompletely reflect the human disease.CP induced by injection of dibutyltin dichloride(DBTC-pancreatitis)shares with human CP the important feature of extended fibrosis and would be an even more attractive model if it could be transferred from rats to mice,as recently sug-gested in the context of combined ethanol and DBTC application.This study aimed to evaluate the effects of DBTC in pancreas and liver of C57BL/6 mice,a strain commonly used to engineer genetic mouse mod-els.Methods:C57BL/6 mice and Lewis rats were exposed to variable doses of DBTC.After an investigation period of up to 4 weeks,laboratory findings and histopathological changes of pancreas and liver were evaluated.Results:Chronic DBTC-pancreatitis in rats was characterized by acinar cell damage,ductal changes,fi-brosis,and inflammatory cell infiltrates.Mice treated with DBTC at 6–8 mg/kg body weight,the standard doses in rats,showed transient increases of lipase activities but no morphological signs of chronic DBTC-pancreatitis 4 weeks after injection of the drug.Increased doses of 10–12 mg/kg DBTC were intolerable due to their high toxicity.In contrast,mice and rats presented with a similar histopathology of the liver that can be characterized as a chronic-proliferative DBTC-cholangitis with predominating damage and proliferation of the small bile ducts as well as secondary portal inflammatory cell infiltrates and a begin-ning portal fibrosis.Conclusions:The DBTC-model cannot be transferred from rats to C57BL/6 mice with respect to chronic DBTC-pancreatitis,but might be of interest to study DBTC-cholangitis in both species. | Friederike Lütt Luise Ehlers Horst Nizze Robert Jaster | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，2： | 2 |
| 4 | In vitro growth characteristics of five candidate aquaculture probiotics and two fish pathogens grown in fish intestinal mucus显示文摘 | Niall G V Winston D L Horst K | 2004 | Microbiology Letters2004，231，： | 1 |
| 5 | Eeffect of the addition of potassium or sodium,but not calcium to prepartum rations on milk fever in dairy cows显示文摘 | Goff J P R L Horst | 1997 | Dairy Science1997，，80： | 1 |
| 6 | Bone morphogenetic proteins stimulate angiogenesis through osteoblast-derived vascular endothelial growth factor A显示文摘 | Deckers M M van Bezooijen R L van der Horst G | 2002 | Endocrinology2002，143，4： | 1 |
| 7 | Effects of the addition of potassium or so- dium, but not calcium, to prepartum rations on milk fever in dairy cattle 显示文摘 | GOFF J P HORST R L | 1997 | J Dairy Sci1997，80，1： | 1 |
| 8 | Relative Acidifying Activity of Anionic Salts Commonly Used to Prevent Milk Fever显示文摘 | Goff J P R Ruize R L Horst | 2004 | Joumal of Dairy Science2004，87，5： | 1 |
| 9 | Antiproliferative effects of the GnRH antagonist cetrorelix and of GnRH Ⅱ on human endometrial and ovarian cancer cells are not mediated through the GnRH type Ⅰ receptor显示文摘 | Grundker C Schlotawa L Viereck V Eicke N Horst A Kairies B | 2004 | Eur J Endocrinol2004，151，： | 1 |
| 10 | Addition of chloride to a prepartal diet high in cations increase 1,25-dihydroxyvitamin D response to hypotalcemia preventing milk fever显示文摘 | Horst R L F J Mueller J K Miller | 1991 | Dairy science1991，，70： | 1 |
| 11 | Experimental observation of the quantum Hall effect and Berry's phase ingrapheme 显示文摘 | Zhang Yuanbo Y Tan an Wen Stormer Horst L | 2005 | Nature2005，438，20： | 1 |
| 12 | The intratumoral distribution of nuclear beta-catenin is a prognostic marker in colon cancer显示文摘 | Horst D Reu S Kriegl L | 2009 | Cancer2009，115，10： | 1 |
| 13 | Strategies for preventing milk fever in dairy cattle显示文摘 | HORST R L GOFF J P REINHARDT T A | 1997 | Journal of Dairy Science1997，80，： | 1 |
| 14 | Accumulation of zinc and organic acids in roots of zinc tolerant and non-tolerant ecotypes of Deschampsia caespitosa显示文摘 | Godbold D L Horst W J Collins J C | 1984 | J Plant Physio1984，116，： | 1 |
| 15 | A human homologue of the rat metastas is-associated variant of CD44 is express ed in colorectal carcinomas and adenomat ous polyps显示文摘 | Heider K Hofmann M Horst E et a l | 1993 | J Cell Biol1993，120，： | 1 |
| 16 | Robust DNA Microarray Image Analysis显示文摘 | Nobert B Horst B Hilmar L | 2003 | Machine Vision and Applications2003，15，： | 1 |
| 17 | Microencapsulated cell-mediated treatment of inoperable pancreatic carcinoma显示文摘 | Matthias L?hr Anne Hoffmeyer Jens-Christian Kr?ger Mathias Freund Johannes Hain Albrecht Holle Peter Karle Wolfram T Kn?fel Stefan Liebe Petra Müller Horst Nizze Matthias Renner Robert M Saller Thomas Wagner Karlheinz Hauenstein Walter H Günzburg Brian Sa | 2001 | The Lancet2001，，9268： | 1 |
| 18 | Ca^2+-ATPase protein expression in mammary tissue 显示文摘 | John T P Horst R L | 2000 | Am J Physiol Cell Physiol2000，279，： | 1 |
| 19 | Effect of silver nitrate and gibberellic acid on gynoecious cucumber显示文摘 | Pharr D M Horst E K | 1978 | Cucubit Genet1978，2，： | 1 |
| 20 | Strategies for preventing milk fever in dairy cattle显示文摘 | HORST R L GAFF J P REINHARD T A | 1997 | J Dairy Sic1997，80，： | 1 |
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