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| 1 | Effects of Tetrandrine and QYT on ICAM-1 and SOD gene expression in pancreas and liver of rats with acute pancreatitis显示文摘AIM: Available experimental evidence from both clinical andanimal models shows that both Chinese medicines tetrandine(Tet) and Qing Yi Tong (QYT) have positive treatment effectson acute pancreatitis (AP). This investigation was conductedto explore the treatment mechanisms of Tet and QYT on APat the molecular level and thereby explain their therapeuticaffects. It included an invest igation of the effects of thesedrugs on gene expression of both intercellular adhesionmolecule 1 (ICAM-1) and superoxide dismutase (Mn-SODand Cu, Zn-SOD) in a rat model with ARMETHODS: AP in the test rats was induced by subjectingthem to laparotomy followed by a retrograde injection of 4 %sodium taurocholate into the bilio-pancreatic duct. The testrats with AP were divided into three groups. One was treatedwith Tet, one with QYT, and one with normal saline solution.The sham-operated control group (SO) rats were only subjectedto laparotomy. They were given no further treatment. For theTet group, Tet was injected intraperitoneally, and for the QYTgroup, QYT was given with a nose-gastric catheter. Theseprocedures were done at both 10 min and 5 h after APinduction. The levels of ICAM-1 mRNA expression and ofSOD (Mn-SOD and Cu, Zn-SOD) mRNA expression in thepancreas and liver tissues were measured by RT-PCR at 1,5, and 10 h after AP induction.RESULTS: When compared with the SO group during theobservation time, rats with AP showed a higher expressionof ICAM and a lower expression of Mn-SOD in both pancreasand liver tissues, and a lower expression of Cu, Zn-SOD inthe pancreas. Tet treatment attenuated changes in theexpression of both ICAM-1, and SOD (Mn-SOD and Cu, Zn-SOD) to a significant degree. A similar effect on theexpression of SOD (Mn-SOD and Cu, Zn-SOD) was also foundin the QYT group, but no obvious suppressive effect onICAM-1 expression was observed.CONCLUSION: The results of this study suggest that oneof the main mechanisms of Tet and QYT in treating AP is toenhance anti-oxidation of the body. The results also suggestthat the anti-inflammatory effect of Tet is involved in thereduction of ICAM-1 expression. This explains why Tet andQYT are beneficial in treating AP. | Yong-YuLi Xue-LiLi Cui-XiangYang HongZhong HongYao LingZhu | 2003 | World Journal of Gastroenterology2003，9，1： | 13 |
| 2 | Comprehensive profiling reveals mechanisms of SOX2-mediated cell fate specification in human ESCs and NPCs显示文摘SOX2 是干细胞,特别胚胎的干细胞(转换字符) 和神经祖先房间(NPC ) 的多重类型的一个关键管理者。理解位于 SOX2 的功能下面的机制为认识到转换字符和 NPC 的完整的潜力是很重要的。通过染色体宽的比较研究,这里,我们证明 SOX2 在人的转换字符(hESCs ) 执行它的不同函数,通过房间类型依赖者和阶段依赖者抄写的导出 hESC 的 NPC (hNPCs ) 编程序。重要地, SOX2 在 hESCs 压制非神经的系并且由禁止正规 Wnt 发信号从 hNPCs 调整神经发生。在 hESCs, SOX2 由表明调节的人, WLS 和 SFRP2 的重要 Wnt 的直接 transcriptional 规定完成如此的抑制。而且, SOX2 经由与 histone 变体 H2A.Z 交往并且招募保证 pluripotent epigenetic 风景到体态的 polycomb 抑压者建筑群 2 在 hESCs 的发展基因。一起,我们的结果推进我们由房间,类型特定的抄写因素控制系特定的基因表达式程序并且指定房间命运的机制的理解。 | Chenlin Zhou Xiaoqin Yang Yiyang Sun Hongyao Yu Yong Zhang Ying Jin | 2016 | Cell Research2016，26，2： | 9 |
| 3 | WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells显示文摘POU 抄写因素 OCT4 不仅在维持 pluripotent 和房间而且幕作为通过基因剂量的一个房间命运决定因素完成的胚胎的茎(ES ) 的自我更新的状态起一个必要作用。然而,控制细胞内部的 OCT4 蛋白质水平的分子的机制留下逃犯。这里,我们报导那人的 WWP2, E3 ubiquitin (Ub ) 蛋白质 ligase,通过它的 WW 领域明确地与 OCT4 交往并且在 vitro 并且在 vivo 提高 OCT4 的 Ub 修正。我们首先证明在人的 ES 房间的内长的 OCT4 能被 Ub post-translationally 修改。而且,我们发现 WWP2 以一种剂量依赖者方式,和 WWP2 的活跃地点半胱氨酸残余通过 26S proteasome 支持了 OCT4 的降级在 OCT4 上为它的酶的活动和解朊的效果被要求。显著地,我们当 WWP2 表示是由特定的 RNA 干扰(RNAi ) 的 downregulated 时,内长的 OCT4 蛋白质水平显著地被提高的数据表演,建议那 WWP2 是为在人的 ES 房间维持合适的 OCT4 蛋白质水平的一个重要管理者。而且,北污点分析证明 WWP2 抄本在多样的人的织物 / 器官是广泛地在场的并且高度在无差别的人的 ES 房间表示了。然而,它的表示水平快速在区分的人的 ES 房间以后被减少,显示 WWP2 表示力量发展地被调整。我们的调查结果证明 WWP2 是在人的 ES 房间的 OCT4 蛋白质水平的一个重要管理者。 | Huiming Xu Weicheng Wang Chunliang Li Hongyao Yu Acong Yang Beibei Wang Ying Jin | 2009 | Cell Research2009，19，5： | 8 |
| 4 | Realization of non-equilibrium process for high thermoelectric performance Sb-doped Ge Te显示文摘Pristine GeTe shows inferior thermoelectric performance around unit due to the large carrier concentration induced by the presence of intrinsic high concentration of Ge vacancy. In this study, we report a thermoelectric figure of merit ZT of 1.56 at 700 K, realized in Sb-doped GeTe based thermoelectric(TE)materials via combined effect of suppression of intrinsic Ge vacancy and Sb doping. The nonequilibrium nature during melt spinning process plays very important role. For one thing, it promotes the homogeneity in Ge_(1-x)Sb_xTe samples and refines the grain size of the product. Moreover the persistent Ge precipitated as impurity phase in the traditional synthesis process is found to be dissolved back into the GeTe sublattice, accompanying with a drastic suppression of Ge vacancies concentration which in combination with Sb electron doping significantly reduced the inherent carrier concentration in GeTe.Low carrier concentration, approaching the optimum carrier concentration ~3.74 × 10^(-20) cm^(-3) and a high power factor of 4.01 × 10^(-3) W m^(-1)K^(-2) at 750 K are achieved for Ge_(0.98)Sb_(0.02) Te sample. In addition,the enhanced grain boundary phonon scattering by refining the grain size through melt spinning(MS)process, coupled with the intensified alloying phonon scattering via Sb doping leads to low thermal conductivity of 1.53 W m^(-1) K^(-1) at 700 K for Ge_(0.94) Sb_(0.06) Te sample. All those contribute to a high ZT value,representing over 50% improvement in the ZT value compared to the Sb free samples, which provides an alternative way for ultrafast synthesis of high performance GeTe based thermoelectric material. | Evariste Nshimyimana Xianli Su Hongyao Xie Wei Liu Rigui Deng Tingting Luo Yonggao Yan Xinfeng Tang | 2018 | Science Bulletin2018，63，11： | 6 |
| 5 | Strengthening effect of Cu-rich phase precipitation in 18Cr9Ni3CuNbN austenitic heat-resisting steel显示文摘The Cu-containing austenitic heat-resistant steel 18Cr9Ni3CuNbN, which is being used as superheater and reheater tube material for modern ultra-super-critical (USC) power plants all over the world, has been investigated at 650 ℃ long time aging till 10 000 h. SEM, TEM and 3DAP (three dimensional atom probe) have been used to follow microstructural changes with mechanical property variations. Experimental results show that Cu-rich phase and MX precipitate in the grains as well as M 23 C 6 precipitates at grain boundaries are the main precipitation strengthening phases in this steel. Among them Cu-rich phase is the most important strengthening phase. Homogeneous distribution of very fine nano-size Cu-rich phase has been formed at very early stage of 650 ℃ aging (less than 1 h). Cu atoms gradually concentrate to Cu-rich particles and the other elements (such as Fe, Cr, Ni etc) diffuse away from Curich particles to γ-matrix with the increasing of aging time at 650 ? C. The growth rate of Cu-rich phase at 650 ℃ long time aging is very slow and the average diameters of Cu-rich phase have been determined by TEM method. Cu-rich phase keeps in about 30 nm till 650 ℃ aging for 10 000 h. It shows that nano-size Cu-rich phase precipitation strengthening can be kept for long time aging at 650 ℃ because of its excellent stability at high temperatures. According to structure stability study and mechanical properties determination results the Cu-rich phase precipitation sequence and its strengthening mechanism model have been suggested and discussed. | Chengyu CHI Hongyao YU Jianxin DONG Xishan XIE Zhengqiang CUI Xiaofang CHEN Fusheng LIN | 2011 | Acta Metallurgica Sinica(English Letters)2011，24，2： | 6 |
| 6 | Identifying changes in the wheat kernel proteome under heat stress using iTRAQ显示文摘Wheat(Triticum aestivum L.) is one of the three major global food crops. Hightemperature stress can affect its yield and quality. Studies of the effect of hightemperature stress on wheat kernel development are important because they can reveal the stability of wheat quality and lead to the genetic improvement of wheat quality traits. In this study, the isobaric tags for relative and absolute quantitation(iTRAQ)method was adopted to analyze changes in the protein expression profile of wheat cultivars under high temperature stress. The protein content of wheat grain increased under heat stress, while the SDS-sedimentation value and starch content decreased.Grain filling was deficient under high temperature stress, which reduced thousandkernel weight but did not affect wheat kernel length. The 207 differentially expressed proteins identified in Gaocheng 8901 under heat stress were associated with energy metabolism, growth and development, and stress response. Gene Ontology enrichment analysis showed that the annotated proteins that were differentially expressed in Gaocheng 8901 under heat stress were involved mainly in stimulus response, abiotic stress response, stress response, and plasma membrane. A set of 78 differentially expressed proteins were assigned to 83 KEGG signaling/metabolic pathways. KEGG pathway enrichment analysis showed that this set of proteins was significantly enriched in members of 51 pathways, and the proteins participated mainly in protein synthesis in the endoplasmic reticulum, starch and sucrose metabolism, and reaction on ribosomes. Five differentially expressed proteins were involved in protein–protein interaction networks that may greatly influence the yield and quality of wheat grain. In wheat, high-temperature stress leads to a variety of effects on protein expression and may ultimately cause changes in yield and quality. | Yufeng Zhang Hongyao Lou Dandan Guo Ruiqi Zhang Meng Su Zhenghong Hou Haiying Zhou Rongqi Liang Chaojie Xie Mingshan You Baoyun Li | 2018 | The Crop Journal2018，6，6： | 5 |
| 7 | Application and testing of a vertical angle control for a boom-type road header显示文摘Automatic profiling control using a boom-type roadheader requires an understanding of horizontal and vertical swing angles of the cutting boom. In this study the vertical angle of the cutting boom is discussed. First, a vertical swing detection model for the cutting boom is established. Then, a kinematic analysis of the vertical swing mechanism is made and formulae describing the geometrical relationship between the vertical swing of the cutting boom and the telescopic length of vertical hydraulic lift cylinders and vertical swing angle of the boom are presented. Various factors such as complexity of the calculation model, the difficulty of installing the sensor and the cost are compared for two methods. Finally, directly measuring the vertical swing angle of the cutting boom with a tilt sensor is decided to be the more simple and effective method. The detection sensitivity and the vertical cutting error of a tilt sensor are studied. Vibration tests on an EBZ160 roadheader were performed in a coal mine. The characteristic vibration frequencies are analyzed. A design of a vibration isolation mount for the tilt sensor is presented. It makes the detection device work more reliably under conditions where vibration is present and lays a foundation for the implementation of an automatic roadhead cutter. A tilt sensor is installed on an EBZ160 and an EBZ200, and experiments have been done in a coal mine. The results show that the experimental result is favorable and achieves the goal of automatic control of the vertical swing of the cutting boom. | TIAN Jie CHEN Guoqiang YANG Yang WANG Hongyao LIU Jiangong WU Miao | 2010 | Mining Science and Technology2010，20，1： | 4 |
| 8 | 3D urchin like V-doped CoP in situ grown on nickel foam as bifunctional electrocatalyst for efficient overall water-splitting显示文摘Cobalt phosphide (CoP) is considered to be a potential candidate in the field of electrocatalysis due to its low-cost, abundant resources and high electrochemical stability. However, there is a great space for further improvement of its electrocatalytic performance since its charge transfer rate and catalytic activity have not reached a satisfactory level. Herein, we design and fabricate a three dimensional urchins like V-doped CoP with different amounts of V-doping on nickel foam electrode. The V-doped CoP/NF electrode with optimized amounts of V-doping (10%) exhibits outstanding hydrogen evolution reaction (HER) performance under universal-pH conditions and preeminent oxygen evolution reaction (OER) performance in alkaline media. Notably, the assembled water-splitting cell displays a cell voltage of only 1.53 V at 10 mA·cm−2 and has excellent durability, much better than many reported related bifunctional catalysts. The experiment results and theoretical analysis revealed that vanadium atoms replace cobalt atoms in CoP lattice. Vanadium doping can not only raise the density of electronic states near the Fermi level enhancing the conductivity of the catalyst, but can also optimize the free energy of hydrogen and oxygen-containing intermediates adsorption over CoP, thus promoting its catalytic activity. Moreover, the unique nanostructure of the catalyst provides the various shortened channels for charge transfer and reactant/electrolyte diffusion, which accelerates the electrocatalytic process. Also, the in situ growth strategy can improve the conductivity and stability of the catalyst. | Hongyao Xue Alan Meng Haiqin Zhang Yusheng Lin Zhenjiang Li Chuansheng Wang | 2021 | Nano Research2021，14，11： | 4 |
| 9 | Bioinspired hybrid patches with self-adhesive hydrogel and piezoelectric nanogenerator for promoting skin wound healing显示文摘Wound management is a crucial measure for skin wound healing and is significantly important to maintaining the integrity of skins and their functions.Electrical stimulation at the wound site is a compelling strategy for skin wound repair.However,there has been an urgent need for wearable and point-of-care electrical stimulation devices that have self-adhesive and mechanical properties comparable to wound tissue.Herein,we develop a bioinspired hybrid patch with self-adhesive and piezoelectric nanogenerator(HPSP)for promoting skin wound healing,which is composed of a mussel-inspired hydrogel matrix and a piezoelectric nanogenerator based on aligned electrospun poly(vinylidene fluoride)nanofibers.The device with optimized modulus and permeability for skin wear can self-adhere to the wound site and locally produce a dynamic voltage caused by motion.We show that the HPSP not only promotes fibroblast proliferation and migration in vitro,but also effectively facilitates the collagen deposition,angiogenesis,and re-epithelialization in vivo with the increased expressions of crucial growth factors.The HPSP reduces the wound closure time of full-thickness skin defects by about 1/3,greatly accelerating the healing process.This patch can serve as wearable and real-time electrical stimulation devices,potentially useful in clinical applications of skin wound healing. | Shuo Du Nuoya Zhou Yujie Gao Ge Xie Hongyao Du Hao Jiang Uanbin Zhang Juan Tao Jintao Zhu | 2020 | Nano Research2020，13，9： | 3 |
| 10 | Correlation Between Phase Stability and Tensile Properties of the Ni-Based Superalloy MAR-M247显示文摘Phase stability and its effect on tensile properties of MAR-M247 alloy have been investigated during thermal exposure at 800–900°C for up to 10,000 h.Detailed investigations reveal that the larger secondaryγ′phase has no obvious growth,but the smaller tertiaryγ′phase obviously coarsens and the coalescence occurs during thermal exposure at 850°C and below.γ′coarsening behavior is consistent with the description of Ostwald ripening theory beforeγ′coalescence.Hf-rich blocky MC carbide shows excellent thermal stability,but Ta-rich script-type MC carbide gradually degenerates via reaction,MC+γ→M_(23)C_(6)+γ′and finally formsγ film around MC and M_(23)C_(6) carbides.With increasing thermal exposure time,the tensile strength decreases.The ductility first increases and then decreases during exposure at 800°C,but it decreases continuously at 900°C.In addition,the ductility keeps almost constant when the exposure time is longer than 5000 h. | Linxu Li Xiufang Gong Changshuai Wang Yunsheng Wu Hongyao Yu Haijun Su Lanzhang Zhou | 2021 | Acta Metallurgica Sinica(English Letters)2021，34，6： | 2 |
| 11 | Site selection and data processing of GNSS receiver calibration networks based on TEQC and GAMIT显示文摘This study introduces the site selection and data processing of GNSS receiver calibration networks. According to the design requirements and relevant specifications, the authors investigate the observation conditions of the potential sites and collect the experimental GNSS observation data. TEQC is used to evaluate the data availability rate and multipath effects of the observation data to determine the appropriate site. After the construction and measurement of the calibration network, the baseline processing of the medium and long baseline network is conducted by GAMIT. The accuracy indexes including NRMS, difference between repeated baselines, and closure of independent observation loops all meet the specified criteria. | ZHOU Changjie MAO Jiuchang WANG Hongyao WU Qiong | 2019 | Global Geology2019，22，2： | 2 |
| 12 | HOW TO EMPHASIZE THE STUDY OF ENGLISH ROOTS AND WORD-BUILDING FOR IMPROVING VOCABULARY TEACHING AT COLLEGE显示文摘Guiding college students to acquire an adequate vocabularyis an important task that is often neglected. The morevocabulary hat is mastered, the higher level a learner of Englishwill have. But in China, the traditional method of teachingvocabulary is learning by rote, and learners of foreign languagesare inclined to learn as much vocabulary as possible this wayregardless of whether these vocabulary is useful or not. Indeed,there are some disadvantageous factors hindering the studentsfrom expanding vocabulary rapidly and efficiently. We have todevelop a scientific method of teaching vocabulary exploringmethods of which is the key to this article. | Li Hongyao | 2001 | Chinese Journal of Applied Linguistics2001，24，4： | 2 |
| 13 | High-throughput 16S rDNA sequencing of the pulmonary microbiome of rats with allergic asthma显示文摘A decrease in microbial infection in adolescents is implicated with an increase in the incidence of asthma and allergic diseases in adulthood,indicating that the microbiome plays a critical role in asthma.However,the microbial composition of the lower respiratory tract remains unclear,hindering the further exploration of the pathogenesis of asthma.This study aims to explore the microbial distribution and composition in the lungs of normal rats and rats with allergic asthma via 16S rDNA sequencing.The DNA of the pulmonary microbiome was extracted from the left lungs collected from normal control group(NC),saline control group(SC),and allergic asthma group(AA)under aseptic conditions.After the 16s rDNA V4eV5 region was amplified,the products were sequenced using Illumina high-throughput technology and subjected to operational taxonomic unit(OTU)cluster and taxonomy analysis.The OTU values of AA increased significantly compared with those of NC and SC.Microbiome structure analysis showed that the dominant phylum of the pulmonary microbiome changed from Proteobacteria in NC to Firmicutes in AA.Linear discriminant analysis indicated that the key microbiomes involved in the three groups varied. | Yang Xiong Sen Hu Hongyao Zhou Hui Zeng Xuan He Dongni Huang Xiaoyu Li | 2020 | Genes & Diseases2020，7，2： | 2 |
| 14 | WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells显示文摘 | Huiming Xu Weicheng Wang Chunliang Li Hongyao Yu Acong Yang Beibei Wang Ying Jin | 2009 | Cell Research2009，19，6： | 1 |
| 15 | Ternary nano-CaCO3/poly(ethylene terephthalate) fiber/polypropylene composites: Increased impact strength and reinforcing mechanism显示文摘 | Ke Fuyou Jiang Xingwen Xu Hongyao | 2012 | Composites Science and Technology2012，72，5： | 1 |
| 16 | 显示文摘 | Yin Shouchun Xu Hongyao Fang Min | 2005 | Macromol Chem Phys2005，206，： | 1 |
| 17 | 显示文摘 | Yin Shouchun Xu Hongyao Shi Wenfang | 2005 | Polymer2005，46，18： | 1 |
| 18 | CO2 - respon- sive anionic wormlike micelles based on natural erucic acid 显示文摘 | ZHANG YONGMIN YIN HONGYAO FENG YUJUN | 2014 | Green Materials2014，2，2： | 1 |
| 19 | Calibration ruler for CW-EPR distance measurement using diradical molecule of rigid structure显示文摘许多试验性的因素和控制不了的因素可以由连续波浪电子在距离测量介绍错误顺磁的回声。处理这个问题,几 C 60 nitroxide diradical 与僵硬结构和明确的分子的尺寸使内收被用作距离刻度统治者。经由增加试验性的系列和偶极的拓宽功能的模拟节目基于距离计算节目的改进分别地,距离刻度方法在象不同溶剂,答案集中,测量温度,和微波力量那样的不同条件下面被开发。作为结果,稳定的距离刻度统治者在 813 的范围以内被建立 ? 。距离刻度效果被评估导致 0.84 的相应距离测量精确 ? 。结果建议非偶极的光谱的拓宽因素的影响能被克服,并且建立试验性并且计算方法对大量状况合适。发达方法将在 biomacromolecular 分析保证更精确、客观的距离测量。 | Guofu Dong Hongyao Wang Jianbo Cong Changzhen Wang Junwang Guo Tong Zhang Jingkui Yang Guoshan Yang Ke Wu | 2015 | Acta Biochimica et Biophysica Sinica2015，47，5： | 1 |
| 20 | Connexin 43 Reverses Malignant Phenotypes of Glioma Stem Cells by Modulating E‐Cadherin显示文摘 | Shi‐CangYu Hua‐LiangXiao Xue‐FengJiang Qing‐LiangWang YanLi Xiao‐JunYang Yi‐FangPing Jiang JieDuan Jian‐YongJiang Xian‐ZongYe Sen‐LinXu Yang‐HongXin Xiao‐HongYao Jian‐HongChen Wei‐HuaChu WeiSun BingWang Ji MingWang XiaZhang Xiu‐WuBian | 2012 | STEM CELLS2012，，2： | 1 |
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