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| 1 | Clinical features and management of postural tachycardia syndrome in children: a single-center experience显示文摘 | Li Jiawei Zhang Qingyou Hao Hongjun Jin Hongfang Du Junbao | 2014 | Chinese Medical Journal2014，，21： | 11 |
| 2 | In vivo evaluation of urokinase-loaded hollow nanogels for sonothrombolysis on suture embolization-induced acute ischemic stroke rat model显示文摘The urokinase-type plasminogen activator(uPA)loaded hollow nanogels(nUK)were synthesized by a one-step reaction of glycol chitosan and aldehyde capped poly(ethylene oxide).The resultant formulation is sensitive to diagnostic ultrasound(US)of 2 MHz.Herein,we evaluated the in vivo sonothrombolysis performance of the nUK on acute ischemic stroke rat model which was established by suture embolization of middle cerebral artery(MCA).Via intravenous(i.v.)administration,the experimental data prove a controlled release of the therapeutic protein around the clots under ultrasound stimulation,leading to enhanced thrombolysis efficiency of the nUK,evidenced from smaller infarct volume and better clinical scores when compared to the i.v.dose of free uPA no matter with or without US intervention.Meanwhile,the preservation ability of the nanogels not only prolonged the circulation duration of the protein,but also resulted in the better blood-brain barrier protection of the nUK formulation,showing no increased risk on the hemorrhagic transformation than the controls.This work suggests that the nUK is a safe sonothrombolytic formulation for the treatment of acute ischemic stroke. | Yuming Teng Haiqiang Jin Ding Nan Mengnan Li Chenghe Fan Yuanyuan Liu Pu Lv Wei Cui Yongan Sun Hongjun Hao Xiaozhong Qu Zhenzhong Yang Yining Huang | 2018 | Bioactive Materials2018，3，1： | 7 |
| 3 | Identification of marine natural gases with different origin sources显示文摘Kinetic experiments of gas generation for typical samples of marine gas precursors including low-maturity kerogen,residual kerogen and oil as well as dispersed liquid hydrocarbon(DLH)in source rocks were performed by closed system,and the evolution trends of molecular and isotopic compositions of natural gases from different precursors against the maturity(R0%)at laboratory conditions were analyzed.Several diagrams of gas origin were calibrated by using the experimental data.A diagram based on the ratio of normal and isomerous butane and pentane(i/nC4-i/nC5)was proposed and used to identify the origins of the typical marine natural gases in the Sichuan Basin and the Tarim Basin, China.And the maturities of natural gases were estimated by using the statistical relationships between the gaseous molecular carbon isotopic data and maturities(δ13C-R 0 %)with different origins.The results indicate that the molecular and isotopic compositions of simulated gases from different precursors are different from each other.For example,the dryness index of the oil-cracking gas is the lowest;the dryness indices of gases from DLH and kerogen in closed system are almost the same;and the dryness index of gases from residual kerogen is extremely high,indicating that the kerogen gases are very dry;the contents of non-hydrocarbon gases in kerogen-cracking gases are far higher than those in oil-cracking and DLH-cracking gases.The molecular carbon isotopes of oil-cracking gases are the lightest,those of kerogen in closed system and GLH-cracking gases are the second lightest,and those of cracking gases from residual kerogen are the heaviest.The calibration results indicate that the diagrams of ln(C1/C2)-ln(C2/C3)andδ13C2-δ13C3-ln(C2/C3)can discriminate primary and secondary cracking gases,but cannot be used to identify gas origin sources,while the diagram of i/nC4-i/nC5 can differentiate the gases from different precursors.The application results of these diagrams show that gas mixtures extensively exist in China,which involved the gases from multiple precursors and those from different maturity stages.For example,marine gases in the Sichuan Basin involve the mixture of oil-cracking gases and high-over-maturated kerogen gases,while those in the Tarim Basin involve not only the mixture of gases from multiple precursors,but also those from different maturity gases and post-reservoir alternations such as oxidized degradation and gas intrusion processes. | WANG YunPeng 1 ,ZHAO ChangYi 2 ,WANG ZhaoYun 2 ,WANG HongJun 2 ,TIAN Jin 1 ,ZOU YanRong 1 &LIU JinZhong1 1State Key Laboratory of Organic Geochemistry,Guangzhou Institute of Geochemistry,Chinese Academy of Sciences,Guangzhou 510640,China 2Institute of Geology,Research Institute of Petroleum Exploration and Development,PetroChina,Beijing 100083,China | 2008 | Science China Earth Sciences2008，51，S1： | 4 |
| 4 | Copy number variants of ABCF1, IL17REL, and FCGR3A are associated with the risk of gout显示文摘 | Dong, Zheng Li, Yuan Zhou, Jingru Jiang, Shuai Wang, Yi Chen, Yulin Zhao, Dongbao Yang, Chengde Qian, Qiaoxia Ma, Yanyun He, Hongjun Ji, Hengdong Yang, Yajun Wang, Xiaofeng Xu, Xia Pang, Yafei Zou, Hejian Jin, Li Zhang, Feng Wang, Jiucun | 2017 | Protein & Cell2017，8，6： | 3 |
| 5 | Development of a CLDN18.2-targeting immuno-PET probe for non-invasive imaging in gastrointestinal tumors显示文摘Claudin18.2(CLDN18.2)is a tight junction protein that is overexpressed in a variety of solid tumors such as gastrointestinal cancer and oesophageal cancer.It has been identified as a promising target and a potential biomarker to diagnose tumor,evaluate efficacy,and determine patient prognosis.TST001 is a recombinant humanized CLDN18.2 antibody that selectively binds to the extracellular loop of human Claudin18.2.In this study,we constructed a solid target radionuclide zirconium-^(89)(^(89)Zr)labled-TST001 to detect the expression of in the human stomach cancer BGC823CLDN18.2 cell lines.The[^(89)Zr]Zr-desferrioxamine(DFO)-TST001 showed high radiochemical purity(RCP,>99%)and specific activity(24.15±1.34 GBq/mmol),and was stable in 5%human serum albumin,and phosphate buffer saline(>85%RCP at 96 h).The EC_(50) values of TST001 and DFO-TST001 were as high as 0.413±0.055 and 0.361±0.058 nM(P>0.05),respectively.The radiotracer had a significantly higher average standard uptake values in CLDN18.2-positive tumors than in CLDN18.2-negative tumors(1.11±0.02 vs.0.49±0.03,P=0.0016)2 days post injection(p.i.).BGC823CLDN18.2 mice models showed high tumor/muscle ratios 96 h p.i.with[^(89)Zr]Zr-DFO-TST001 was much higher than those of the other imaging groups.Immunohistochemistry results showed that BGC823CLDN18.2 tumors were highly positive(+++)for CLDN18.2,while those in the BGC823 group did not express CLDN18.2().The results of ex vivo biodistribution studies showed that there was a higher distribution in the BGC823CLDN18.2 tumor bearing mice(2.05±0.16%ID/g)than BGC823 mice(0.69±0.02%ID/g)and blocking group(0.72±0.02%ID/g).A dosimetry estimation study showed that the effective dose of[^(89)Zr]Zr-DFO-TST001 was 0.0705 mSv/MBq,which is within the range of acceptable doses for nuclear medicine research.Taken together,these results suggest that Good Manufacturing Practices produced by this immuno-positron emission tomography probe can detect CLDN18.2-overexpressing tumors. | Yan Chen Xingguo Hou Dapeng Li Jin Ding Jiayue Liu Zilei Wang Fei Teng Hongjun Li Fan Zhang Yi Gu Steven Yu Xueming Qian Zhi Yang Hua Zhu | 2023 | Journal of Pharmaceutical Analysis2023，13，4： | 2 |
| 6 | Application of phasor measurement unit on locating disturbance source for low-frequency oscillation显示文摘 | Jin Ma Pu Zhang FU Hongjun | 2010 | IEEE Transactions on Smart Grid2010，1，3： | 1 |
| 7 | Quality criteria of acrylonitrile for the protection of aquatic life in China显示文摘 | Zhang Tong Jin Hongjun Zhu Huailan | 1996 | Chemosphere1996，，10： | 1 |
| 8 | Comprehensive Investigation of Submarine Slide Zones and Mass Movements at the Northern Continental Slope of South China Sea显示文摘Multi-beam bathymetry and seismic sequence surveys in the northern slope of the South China Sea reveal detailed geomorphology and seismic stratigraphy characteristics of canyons, gullies, and mass movements. Modern canyons and gullies are roughly elongated NNW–SSW with U-shaped cross sections at water depths of 400–1000 m. Mass movements include slide complexes, slide scars, and debris/turbidity flows. Slide complexes and slide scars are oriented in the NE–SW direction and cover an area of about 1790 and 926 km^2, respectively. The debris/turbidity flows developed along the lower slope. A detailed facies analysis suggests that four seismic facies exist, and the late Cenozoic stratigraphy above the acoustic basement can be roughly subdivided into three sequences separated by regional unconformities in the study area. The occurrence of gas hydrates is marked by seismic velocity anomalies, bottom-simulating reflectors, gas chimneys, and pockmarks in the study area. Seismic observations suggest that modern canyons and mass movements formed around the transition between the last glacial period and the current interglacial period. The possible existence and dissociation of gas hydrates and the regional tectonic setting may trigger instability and mass movements on the seafloor. Canyons may be the final result of gas hydrate dissociation. Our study aims to contribute new information that is applicable to engineering construction required for deep-water petroleum exploration and gas hydrate surveys along any marginal sea. | CHEN Hongjun LIANG Jin GONG Yuehua | 2018 | Journal of Ocean University of China2018，17，1： | 1 |
| 9 | Application of phasor meas-urement unit on locating disturbance source for low-frequency oscil-lation显示文摘 | Jin Ma Pu Zhang Fu Hongjun | 2010 | IEEE Transctions on Smart Grid2010，1，3： | 1 |
| 10 | Ethylene oligomerization by salen-type zirconium complexes to low-carbon linear α-oldins显示文摘 | Wang Mei Zhu Hongjun Jin Kun | 2003 | Catalysis2003，220，： | 1 |
| 11 | Real-time yaw rate prediction based on nonlinear model and feedback compensation for vehicle dynamic control显示文摘 | ZHU Hongjun LI Liang JIN M | | 0，，10： | 1 |
| 12 | Real-time yaw rate prediction based on nonlinear model and feedback compensation for vehicle dynamic control显示文摘 | ZHU Hongjun LI Liang JIN M | | 0，，： | 1 |
| 13 | Whole genome sequencing and biological characterization of Duck/JS/10, a new lentogenic class I Newcastle disease virus显示文摘 | Chunchun Meng Xvsheng Qiu Shiqiang Jin Shengqing Yu Hongjun Chen Chan Ding | 2012 | Archives of Virology2012，，5： | 1 |
| 14 | Application of phasor measurement unit on locating disturbance source for low-frequency oscillation显示文摘 | Jin Ma Pu Zhang Hongjun Fu | 2010 | IEEE Transac- tions on Smart Grid2010，1，3： | 1 |
| 15 | Relationship between bioaccumulation,distribution of MET and lipid content of aquatic organisms显示文摘The studies on bioaccumulation and distribution of the plant growth regulator multi - effect triazole( MET) in the fish (Carassias auratus) and Daphnia (D. magna) showed that the bioaccumulation factor(BCF) was in positive correlation to the lipid content | Liu Zhengtao Zhou Fengfan Jin Hongjun(Department of Environmental Sciences , Nanjing University , Nanjing 210093 , China) | 1995 | Journal of Environmental Sciences1995，7，2： | 1 |
| 16 | Quality criteria of acrylonitrile for the protection of aquatic in China显示文摘 | Zhang Tong Jin Hongjun Zhu Huailan | 2002 | Chemosphere2002，32，10： | 1 |
| 17 | Whole genome sequencing and biological characterization of Duck/JS/10, a new lentogenic class I Newcastle disease virus显示文摘 | Chunchun Meng Xvsheng Qiu Shiqiang Jin Shengqing Yu Hongjun Chen Chan Ding | 2012 | Archives of Virology2012，，5： | 1 |
| 18 | Application of phasormeasurement unit on locating disturbance source for low-fre-quency oscillation显示文摘 | Ma Jin Zhang Pu Fu Hongjun | 2010 | IEEE Transactions on Smart Grid2010，，3： | 1 |
| 19 | Application of phasormeasurement unit on locating disturbance source for low-frequencyoscillation显示文摘 | Ma Jin Zhang Pu Fu Hongjun | 2010 | IEEE Trans on Smart Grid*2010，1，3： | 1 |
| 20 | An experimental study on the drying kinetics of lignite in high temperature nitrogen atmosphere 显示文摘 | Zheng Hongjun Zhang Shouyu Guo Xi Lü Junfu Dong Aixia Deng Wenxiang Tang Wenjiao Zhao Menghao Jin Tao | 2014 | Fuel Processing Technology2014，126，： | 1 |
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