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| 1 | Aeration optimization through operation at low dissolved oxygen concentrations:Evaluation of oxygen mass transfer dynamics in different activated sludge systems显示文摘In wastewater treatment plants(WWTPs)using the activated sludge process,two methods are widely used to improve aeration efficiency — use of high-efficiency aeration devices and optimizing the aeration control strategy. Aeration efficiency is closely linked to sludge characteristics(such as concentrations of mixed liquor suspended solids(MLSS)and microbial communities)and operating conditions(such as air flow rate and operational dissolved oxygen(DO)concentrations). Moreover,operational DO is closely linked to effluent quality. This study,which is in reference to WWTP discharge class A Chinese standard effluent criteria,determined the growth kinetics parameters of nitrifiers at different DO levels in small-scale tests. Results showed that the activated sludge system could meet effluent criteria when DO was as low as 0.3 mg/L,and that nitrifier communities cultivated under low DO conditions had higher oxygen affinity than those cultivated under high DO conditions,as indicated by the oxygen half-saturation constant and nitrification ability. Based on nitrifier growth kinetics and on the oxygen mass transfer dynamic model(determined using different air flow rate(Q′_(air))and mixed liquor volatile suspended solids(MLVSS)values),theoretical analysis indicated limited potential for energy saving by improving aeration diffuser performance when the activated sludge system had low oxygen consumption; however,operating at low DO and low MLVSS could significantly reduce energy consumption. Finally,a control strategy coupling sludge retention time and MLVSS to minimize the DO level was discussed,which is critical to appropriate setting of the oxygen point and to the operation of low DO treatment technology. | Haitao Fan Lu Qi Guoqiang Liu Yuankai Zhang Qiang Fan Hongchen Wang | 2017 | Journal of Environmental Sciences2017，29，5： | 9 |
| 2 | Microbial diversity in cold seep sediments from the northern South China Sea显示文摘华南海(SCS ) 是最大的西方的和平的边缘的海。然而,微生物引起的研究从来没在寒冷被执行过渗出在 SCS 的沉积。在 2004, SONNE 177 巡航发现二冷渗出有在北 SCS 的不同的水深度的区域。在水深度在 3000 m 附近的地方, Haiyang 4 区域已经为在 seafloor 上的活跃渗出被证实了,例如微生物引起的地席, authigenic 碳酸盐外壳和瓣鳃类。我们在从这感冒收集的一个 5.55-m 沉积核心调查了微生物引起的丰富和差异渗出区域。一条综合途径包括地球化学和 16S rRNA 基因被采用种系发生的分析。这里,我们证明与沉积核心的地球化学侧面一起的微生物引起的丰富和差异揭示了在硫酸盐减小和甲烷氧化之间的 a coupled 反应。直接计数结果显示出的氮蒽橘子那微生物引起的丰富从 105 ~ 106 cells/g 沉积(湿重量)。丰富的深度相关的变化显示出象甲烷集中侧面的一样的趋势。种系发生的分析显示了减少硫酸盐的细菌和厌氧的氧化甲烷的 archaea 的存在。差异在表面是高得多的,但是处于沉积的 geochemical 条件响应变化与深度严厉地减少了,例如甲烷,硫酸盐集中和全部的器官的碳。海洋的 Benthic 组 B, Chloroflexi 和 JS1 分别地是 archaeal 和细菌的图书馆的占优势的 phylotypes。 | Yong Zhang Xin Su Fang Chen Yuanyuan Wang Lu Jiao Hailiang Dong Yongyang Huang Hongchen Jiang | 2012 | Geoscience Frontiers2012，3，3： | 9 |
| 3 | Microbial diversity in the hydrate-containing and-free surface sediments in the Shenhu area, South China Sea显示文摘Microbial diversity in the hydrate-containing(sites SH3B and SH7B)and-free(sites SH1B,SH5B,SH5C)sediments collected from the Shenhu area of the South China Sea(SCS)was investigated using 16S r RNA gene phylogenetic analysis.The phylogenetic results indicate difference in microbial communities between hydrate-containing and-free sediments.At the gas hydrate-containing sites,bacterial communities were dominated by Deltaproteobacteria(30.5%),and archaeal communities were dominated by Miscellaneous Crenarchaeotic Group(33.8%);In contrast,Planctomycetes was the major group(43.9%)in bacterial communities,while Marine Benthic Group-D(MBG-D)(32.4%)took up the largest proportion in the archaeal communities.Moreover,the microbial communities have characteristics different from those in other hydrate-related sediments around the world,indicating that the presence of hydrates can affect the microbial distribution.In addition,the microbial community composition in the studied sediments has its own uniqueness,which may result from co-effect of geochemical characteristics and presence/absence of hydrate. | Lu Jiao Xin Su Yuanyuan Wang Hongchen Jiang Yong Zhang Fang Chen | 2015 | Geoscience Frontiers2015，6，4： | 9 |
| 4 | Analysis of key microbial community during the start-up of anaerobic ammonium oxidation process with paddy soil as inoculated sludge显示文摘A sequencing batch reactor(SBR)-anaerobic ammonium oxidation(anammox) system was started up with the paddy soil as inoculated sludge. The key microbial community structure in the system along with the enrichment time was investigated by using molecular biology methods(e.g., high-throughput 16 S r RNA gene sequencing and quantitative PCR). Meanwhile,the influent and effluent water quality was continuously monitored during the whole start-up stage. The results showed that the microbial diversity decreased as the operation time initially and increased afterwards, and the microbial niches in the system were redistributed. The anammox bacterial community structure in the SBR-anammox system shifted during the enrichment, the most dominant anammox bacteria were Candidatus Jettenia. The maximum biomass of anammox bacteria achieved 1.68 × 10~9 copies/g dry sludge during the enrichment period, and the highest removal rate of TN achieved around 75%. | Xianglong Xu Guohua Liu Yuanyuan Wang Yuankai Zhang Hao Wan Lu Qi Hongchen Wang | 2018 | Journal of Environmental Sciences2018，30，2： | 8 |
| 5 | High-Temperature Metamorphism, Anataxis and Tectonic Evolution of a Mafic Granulite from the Eastern Himalayan Orogen显示文摘The Himalayan Orogen, resulting from the Tertiary collision of Indian and Asian continents, is a natural laboratory for studying metamorphism, partial melting and granite formation of collisional orogens. However, metamorphic and anatectic conditions and timescales of meta-mafic rocks in the Greater Himalayan Sequences(GHS) in the east-central Himalaya remain controversial. In this paper, we conduct a study of petrology and geochronology of mafic granulite from the Eastern Himalayan Syntaxis(EHS). The mafic granulite with abundant leucosome bands occurs as layers within felsic granulites and is well deformed. The granulite consists of garnet, plagioclase, amphibole and quartz with minor clinopyroxene, orthopyroxene, biotite, rutile, titanite and ilmenite. The garnet has growth compositional zoning and contains abundant mineral inclusions in its core. Peak metamorphic mineral assemblage of the granulite is garnet, amphibole, plagioclase, quartz, clinopyroxene and rutile, recording a high-pressure(HP) and high-temperature(HT) peak-metamorphism under conditions of 14–15.5 kbar and 780–790℃ in the presence of melt. The reconstructed clockwise P-T path is characterized by an early heating and burial prograde metamorphism, and late isothermal and cooling decompression retrogression. The granulite witnessed a long lasting HT metamorphism, partial melting and melt crystallization process which began at ca. 39 Ma and lasted to ca. 11 Ma. The present study shows that various high-grade rocks of the GHS in the EHS core experienced similar metamorphic conditions and P-T-t paths, indicating that they occurred as a coherent slab during the subduction and exhumation of Indian lithosphere. The significant melts generated during the prograde metamorphism of the GHS rocks not only contributed to the formation of the Himalayan leucogranite, but also resulted in the rheological weakening and ductile flow of the thickened lower crust of the Himalayan Orogen. | Zeming Zhang Huixia Ding Xin Dong Zuolin Tian Dongyan Kang Hongchen Mu Shengkai Qin Yuanyuan Jiang Mengmei Li | 2018 | Journal of Earth Science2018，29，5： | 7 |
| 6 | A 12-kyr record of microbial branched and isoprenoid tetraether index in Lake Qinghai,northeastern Qinghai-Tibet Plateau:Implications for paleoclimate reconstruction显示文摘Branched and Isoprenoid Tetraether(BIT) index was considered as a proxy for terrestrial organic matter input in lake sediments, based on the assumption that branched glycerol dialkyl glycerol tetraethers(b GDGTs) are mainly derived from terrestrial soils. However, mounting evidences have showed that the in situ production of b GDGTs is widespread in lakes, challenging BIT as a reliable terrestrial input proxy. Recently, BIT has been proven to be a reliable proxy for paleohydrology in a small crater lake(Lake Challa) in accordance with a different mechanism. However, the response of BIT to paleohydrology variation may differ for different lakes. In this study, we investigate the variations in the BIT index and the concentrations of its related GDGTs in a 12-ka sediment core from Lake Qinghai, in combination with our previous results for surface sediments. We find that variations in BIT strongly depend on the concentration of crenarchaeol in both surface and ancient sediments of this lake, whereas b GDGT concentration varies much less remarkably. Considering that crenarchaeol production is positively correlated with water depth in Lake Qinghai, water depth may exert negative control on the BIT index in this lake. This case is inconsistent with the positive relationship between BIT and lake levels or rainfall intensity reported for Lake Challa, suggesting that the response of BIT to local paleohydrology is site specific in lacustrine systems. Hence, the application of sedimentary BIT as a paleohydrological proxy in a specific lake requires caution before confirming the environmental controls on BIT in that lake. | WANG HuanYe DONG HaiLiang ZHANG ChuanLun JIANG HongChen LIU WeiGuo | 2016 | Science China Earth Sciences2016，59，5： | 6 |
| 7 | Current state and future perspectives of sewer networks in urban China显示文摘中国当局和公众大部分忽略了下水道网络;然而,各种各样的问题与新下水道的增加构造全国正在出现。在中国的下水道网络建设,管理,和维护的当前的国家包括地在这研究被考察。为大约 4.44 亿个人,服务下水道线的 511,200 km 位于城市的区域。在 2014, 70 亿美元在下水道网络建设被投资。然而,下水道扩散率和人均的下水道长度是比在发达国家的那些显著地低的。在本地政府的下水道行政机构是不协调的。法律,规定,和标准是不完全的,并且一些惯例是非科学的。因为下水道腐蚀控制措施没被发射,下水道维护的未来状况是极其冷酷的。而且,检查和康复主要依靠传统的途径。相反,创新技术的全面市场份额由于高费用,资金缺乏,和技术限制是很低的。象班机倒置 cured-in-place 那样的途径尖叫,开车进入用餐的餐厅紫外轻治好的班机,和螺线创伤衬里主要在经济地发达的区域被使用。根据地位和问题分析,瓷器最高的优先级将是以后在下水道网络进行好攻击的维护工作。新技术线路,腐蚀控制 - 周期的设想的检查 - 无沟的康复,能是为在中国的未来下水道维护的最好的选择。为使用这条技术线路的指令和机会在这研究详细被讨论。最后,在在中国的下水道网络的开发的另外的因素被建议。 | Dong Huang Xiuhong Liu Songzhu Jiang Hongchen Wang Junyan Wang Yuankai Zhang | 2018 | Frontiers of Environmental Science & Engineering2018，12，3： | 5 |
| 8 | Osteogenic and antibacterial dual functions of a novel levofloxacin loaded mesoporous silica microspheres/nano-hydroxyapatite/ polyurethane composite scaffold显示文摘Lev/MSNs/n-HA/PU has been proved to be a novel scaffold material to treat bone defect caused by chronic osteomyelitis.We have previously identified that this material can effectively treat chronic osteomyelitis caused by Staphylococcus aureus in vivo.However,the potential mechanisms of antibacterial and osteogenic induction properties remain unclear.Thus,for osteogenesis property,immunohistochemistry,PCR,and Western blot were performed to detect the expression of osteogenic markers.Furthermore,flow cytometry and TUNEL were applied to analyze MC3T3-E1 proliferation and apoptosis.For antibacterial property,the material was co-cultivated with bacteria,bacterial colony forming units was counted and the release time of the effective levofloxacin was assayed by agar disc-diffusion test.Moreover,scanning electron microscope was applied to observe adhesion of bacteria.In terms of osteogenic induction,we found BMSCs adherently grew more prominently on Lev/MSNs/n-HA/PU.Lev/MSNs/n-HA/PU also enhanced the expression of osteogenic markers including OCN and COL1a1,as well as effectively promoted the transition from G1 phase to G2 phase.Furthermore,Lev/MSNs/n-HA/PU could reduce apoptosis of MC3T3-E1.Besides,both Lev/MSNs/n-HA/PU and n-HA/PU materials could inhibit bacterial colonies,while Lev/MSNs/n-HA/PU possessed a stronger antibacterial activities,and lower bacterial adhesion than n-HA/PU.These results illustrated that Lev/MSNs/n-HA/PU composite scaffold possess favorable compatibility in vitro,which induce osteogenic differentiation of MSCs,promote proliferation and differentiation of MC3T3-E1,and inhibit apoptosis.Moreover,clear in vitro antibacterial effect of Lev/MSNs/n-HA/PU was also observed.In summary,this study replenishes the potential of Lev/MSNs/n-HA/PU composite scaffold possess dual functions of anti-infection and enhanced osteogenesis for future clinical application. | Zhiping Kuang Guangming Dai Ruijie Wan Dongli Zhang Chen Zhao Cheng Chen Jidong Li Hongchen Gu Wei Huang | 2021 | Genes & Diseases2021，8，2： | 4 |
| 9 | Diversity of microbial plankton across the Three Gorges Dam of the Yangtze River,China显示文摘长江的三个峡水坝(TGD ) ,中国,在世界上是最大的灌溉和水力发电的工程工程之一。效果巨大人造象动物志和 macrophyte 上的 TGD 一样的工程是明显的,主要通过水动力学和流动模式的变化;然而,微生物怎么对如此的变化作出回应,是不太清楚的。这研究被瞄准在不同季节和地点在微生物引起的差异检验差别(在前面并且在 TGD 后面) 。另外,依附粒子、免费生活的社区之间的差别也被检验。在水列在后面并且在 TGD 前面的全部、潜在地活跃的微生物的社区结构与基于 DNA 、基于 RNA 的 16S rRNA 基因被分析在三个不同季节的种系发生的途径。16S rRNA 基因的克隆图书馆从提取 DNA 在扩大以后被准备并且为一些样品,在从提取 rRNA 准备 cDNA 以后。差别在不同季节并且在免费生活、依附粒子的社区之间在地点之间被观察。细菌并且 archaeal 社区比在冬季在夏天是更多样的,由于在夏天的更高滋养的层次和更温暖的温度比在冬季。依附粒子的微生物比免费生活的社区更多样,可能因为在粒子的更高滋养的层次和异构的 geochemical 微型环境。在细菌的社区结构的空间变化被观察,即,在 TGD 后面的水水库(在上游) 比在水坝前面招待了更多样的细菌的人口(下游) ,因为沉积和水从的多样的来源对水库在上游。这些结果在水坝建设影响的河生态系统为我们对环境变化的微生物引起的社区的回答的理解有重要含意。 | Shang Wang Raymond M. Dong Christina Z. Dong Liuqin Huang Hongchen Jiang Yuli Wei Liang Feng Deng Liu Guifang Yang Chuanlun Zhang Hailiang Dong | 2012 | Geoscience Frontiers2012，3，3： | 4 |
| 10 | Simple model of sludge thickening process in secondary settlers显示文摘在废水处理植物(WWTP ) ,一个第二等的定居者充当 clarifier,污泥 thickener,和污泥存储坦克在期间山峰流动因此在激活的污泥进程的性能起一个重要作用。变厚的污泥在他们的操作期间发生在第二等的 clarifiers 的更低的部分。在这研究,由从激活的污泥的完全的变厚过程检测妨碍的地区,为污泥的一个简单模型变厚的速度, u s =斧子 b (= 0.9925SSVI 3.5, b = 3.541ln (描述在妨碍的地区变厚的激活的污泥的潜力和表演的 SSVI 3.5)+12.973),被开发。然而,因为在压缩地区的污泥显示出有限变厚,在压缩地区变厚的污泥没被学习。这个实验模型用解决从四 WWTP 获得并且从第五 WWTP 用测量数据验证了更好学习污泥变厚的数据的批被开发。探索不同污泥安定和变厚的机制,污泥变厚和污泥安定的曲线被比较。最后,包括温度,激动人心的、起始的深度,和聚合物调节的几个因素能在一个生物学的反应堆导致高度集中的回来污泥和生物资源,这被发现。 | Yuankai ZHANG Hongchen WANG Lu QI Guohua LIU Zhijiang HE Songzhu JIANG | 2016 | Frontiers of Environmental Science & Engineering2016，10，2： | 3 |
| 11 | Seasonal Interaction of River Water-Groundwater-Salt Lake Brine and Its Influence on Water-Salt Balance in the Nalenggele River Catchment in Qaidam Basin,NW China显示文摘Identifying interactions among river water,groundwater and salt lake brine is important for sustainable exploitation of brine mineral resources.In this study,we investigated the water exchange rate in dry and wet seasons,and assessed the influence of seasonal water exchange on brine concentration and crystallization process in the Nalenggele(NLGL)catchment of Qaidam Basin,China.The results show that the surface water infiltration and groundwater recharge rates in the wet season were 2.81×10^(-3)and 1.15×10^(-3)m^(3)/(s·m)in upstream,1.63×10^(-2)and 1.53×10^(-2)m^(3)/(s·m)in midstream,and 2.83×10^(-4)and 6.82×10^(-5)m^(3)/(s·m)in downstream,respectively;while their counterparts in the dry season were 9.81×10^(-4)and 5.05×10^(-4)m^(3)/(s·m)in upstream,and 8.34×10^(-3)and 7.78×10^(-3)m^(3)/(s·m)in midstream,respectively.The water exchange strongly influenced brine concentration and crystallinzation process,with brine chemistry belonging to 3K_(2)SO_(4)·Na_(2)SO_(4) and KCl types in wet and dry seasons,respectively.The strong water exchange in wet season destroyed the water-salt balance,while the low water exchange rate in dry season facilitated preparation of KCl products. | Jibin Han Jianxin Xu Lei Yi Zheng Chang Jianping Wang Haizhou Ma Baoyun Zhang Hongchen Jiang | 2022 | Journal of Earth Science2022，33，5： | 3 |
| 12 | Shape description matrix and its applications to color-image retrieval and recognition显示文摘Shape description matrix (SDM) describing regional pixel distribution characteristics of images is defined, with both radial and angular distribution messages taken into account to offer a comprehensive and exact description of the shape characteristics even upon a blurred edge. Using this SDM, a general color histogram (GCH) is developed. Both theoretical and experimental results show that the GCH can be applied to color-image retrievals and recognitions with a high efficiency. | WANG Yi,ZHAI Hongchen,LIANG Yanmei,ZHANG Siyuan & MU Guoguang Institute of Modern Optics,Nankai University,Tianjin 300071,China Key Laboratory of Information Sci-ence and Technology MOE,Tianjin 300071,China | 2004 | Science China(Technological Sciences)2004，47，2： | 3 |
| 13 | Identification and characterization of soybean dreg soluble dietary fibre by combination of extrusion pre-treatment and enzymatic modification显示文摘OBJECTIVES:Soybean dreg is a by-product of soy milk processing,which contains high levels of soluble dietary fibre(SDF).In this study,we aimed to provide comprehensive processes of pre-treated extrusion for the improving structure and properties of soybean dreg soluble dietary fibre(SDSDF),which would be a valuable approach to enhance physiological activity.METHODS:Here,we characteristic the functional role of SDSDF employing to extrusion pretreatment.Soybean dregs were pre-treated using the twin screw extrusion method followed by enzymatic modification using neutral protease,α-amylase,glucoamylase,and cellulose to produce SDSDF.The physical properties and antioxidant activity of SDSDF were investigated.RESULTS:The morphology and crystal structure of SDSDF were observed that,through extrusion processing and enzymatic modification,the SDSDF yield increased by 106.28%.Moreover,the surface structure showed block-shaped or reticular formations in the extruded SDSDF,and the size of block-shaped cells was about 10μm.Infrared spectroscopic analysis showed that a characteristic absorption peak of polysaccharide appeared at 1631 cm−1 during extrusion processing.However,after extrusion processing,decreased absorption peaks were observed for the extruded SDSDF.Furthermore,XRD analysis showed that the 2θdiffraction peak changed at 24.16°for the extruded SDSDF.CONCLUSIONS:The overall findings suggest that the water holding capacity(WHC),oil holding capacity(OHC),expansibility,and the water solubility were significantly decreased in extruded SDSDF.In addition,the scavenging ability of 1,1-diphenyl-2-picrylhydrazyl(DPPH),-OH,O_(2)^(-),and the total reducing power were significantly improved,indicating that beneficial changes had taken place in the crystal structure of cellulose or hemicellulose to improve the physiological activity in extruded SDSDF. | Min Qu Yujia Liu Guang Zhang Sophia Jun Xue Hongchen Fan Yan Wang Shiyou Yu | 2017 | Food Quality and Safety2017，1，2： | 3 |
| 14 | A Correntropy-based Affine Iterative Closest Point Algorithm for Robust Point Set Registration显示文摘The iterative closest point(ICP)algorithm has the advantages of high accuracy and fast speed for point set registration,but it performs poorly when the point set has a large number of noisy outliers.To solve this problem,we propose a new affine registration algorithm based on correntropy which works well in the affine registration of point sets with outliers.Firstly,we substitute the traditional measure of least squares with a maximum correntropy criterion to build a new registration model,which can avoid the influence of outliers.To maximize the objective function,we then propose a robust affine ICP algorithm.At each iteration of this new algorithm,we set up the index mapping of two point sets according to the known transformation,and then compute the closed-form solution of the new transformation according to the known index mapping.Similar to the traditional ICP algorithm,our algorithm converges to a local maximum monotonously for any given initial value.Finally,the robustness and high efficiency of affine ICP algorithm based on correntropy are demonstrated by 2D and 3D point set registration experiments. | Hongchen Chen Xie Zhang Shaoyi Du Zongze Wu Nanning Zheng | 2019 | IEEE/CAA Journal of Automatica Sinica2019，6，4： | 3 |
| 15 | Methane formation route in the conversion of methanol to hydrocarbons显示文摘The influence factors and paths of methane formation during methanol to hydrocarbons(MTH) reaction were studied experimentally and thermodynamically. The fixed-bed reaction results show that the formation of methane was favored by not only high temperature, but also high feed velocity, low pressure, as well as weak acid sites dominated on deactivated catalyst. The thermodynamic analysis results indicate that methane would be formed via the decomposition reactions of methanol and DME, and the hydrogenolysis reactions of methanol and DME. The decomposition reactions are thermal chemistry processes and easily occurred at high temperature. However, they are influenced by catalyst and reaction conditions through DME intermediate. By contrast, the hydrogenolysis reactions belong to catalytic processes. Parallel experiments suggest that, in real MTH reactions, the hydrogenolysis reactions should be mainly enabled by surface active H atom which might come from hydrogen transfer reactions such as aromatization. But H2will be involved if the catalyst has active components like NiO. | Wenping Zhao Baozhu Zhang Guiru Wang Hongchen Guo | 2014 | Journal of Energy Chemistry2014，23，2： | 3 |
| 16 | Applications of hollow nanomaterials in environmental remediation and monitoring: A review显示文摘因为他们的高化学、热的稳定性,高特定的表面区域,高孔,低密度,和好 biocompatibility,空 nanomaterials 吸引了重要注意。这些最先进的 nanomaterials 被显示了高效地吸附重金属,和不稳定的危险物质, photodegrade 坚持的器官的污染物质,和另外的混合物,并且使细菌失去活性。如此的性质为环境补习启用了这些材料的使用,例如在水 / 废水处理,土壤补习,空气纯化,并且物质监视等等。没有空结构,空 nanomaterials 由于他们的高活跃的表面区域比那些显示出更高的 photocatalytic 活动,减少了散开抵抗,并且改进了可接近性。并且,做的方法能在可见的光下面进一步改进空 nanomaterials 的 photocatalytic 表演。而且,因为他们的尺寸和形态学帮助决定他们的精确性质,这些材料的合成机制和方法是重要的。这篇文章考察环境应用和这些材料的潜在的风险,除了他们的综合体。最后,进这些材料的发展的眼界被提供。 | Yuankai ZHANG Zhijiang HE Hongchen WANG Lu QI Guohua LIU Xiaojun ZHANG | 2015 | Frontiers of Environmental Science & Engineering2015，9，5： | 2 |
| 17 | Extraction, detection, and profiling of serum biomarkers using designed Fe3O4@SiO2@HA core-shell particles显示文摘 | Chandrababu Rejeeth Xuechao Pang Ru Zhang Wei Xu Xuming Sun Bin Liu Jiatao Lou Jingjing Wan Hongchen Gu Wei Yan Kun Qian | 2018 | Nano Research2018，11，1： | 2 |
| 18 | A critical review of mineral–microbe interaction and co-evolution:mechanisms and applications显示文摘Mineral–microbe interactions play important roles in environmental change,biogeochemical cycling of elements and formation of ore deposits.Minerals provide both beneficial(physical and chemical protection,nutrients,and energy)and detrimental(toxic substances and oxidative pressure)effects to microbes,resulting in mineral-specific microbial colonization.Microbes impact dissolution,transformation and precipitation of minerals through their activity,resulting in either genetically controlled or metabolism-induced biomineralization.Through these interactions,minerals and microbes co-evolve through Earth history.Mineral–microbe interactions typically occur at microscopic scale but the effect is often manifested at global scale.Despite advances achieved through decades of research,major questions remain.Four areas are identified for future research:integrating mineral and microbial ecology,establishing mineral biosignatures,linking laboratory mechanistic investigation to field observation,and manipulating mineral–microbe interactions for the benefit of humankind. | Hailiang Dong Liuqin Huang Linduo Zhao Qiang Zeng Xiaolei Liu Yizhi Sheng Liang Shi Geng Wu Hongchen Jiang Fangru Li Li Zhang Dongyi Guo Gaoyuan Li Weiguo Hou Hongyu Chen | 2022 | National Science Review2022，9，10： | 2 |
| 19 | Sustained local delivery of insulin for potential improvement of peri-implant bone formation in diabetes显示文摘Dental implantation is an effective standard treatment modality to restore missing teeth and maxillofacial defects. However, in diabetics there is an increased risk for implant failure due to impaired peri-implant osseous healing. Early topical insulin treat- ment was recently shown to normalize diabetic bone healing by rectifying impairments in osteoblastic activities. In this study, insulin/poly(lactic-co-glycolic acid) (PLGA) microspheres were prepared by a double-emulsion solvent evaporation method. Microspheres were then incorporated in fibrin gel to develop a local drug delivery system for diabetic patients requiring im- plant treatment. In vitro release of insulin from fibrin gel loaded with these microspheres was assessed, and sustained prolonged insulin release over 21 days ascertained. To assess the bioactivity of released insulin and determine whether slow release might improve impaired diabetic bone formation, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), alkaline phosphatase (ALP) activity, mineralized nodule formation, and ELISA (enzyme-linked immunosorbent assay) assays were performed. The insulin released from the drug delivery system stimulated cell growth in previously inhibited cells, and ameliorated the impaired bone-forming ability of human MG-63 cells under high glucose conditions. Fibrin gel loaded with insulin/PLGA microspheres shows potential for improving peri-implant bone formation in diabetic patients. | HAN Yong ZHANG XueYan E LingLing WANG DongSheng LIU HongChen | 2012 | Science China(Life Sciences)2012，55，11： | 2 |
| 20 | The AIDER system and its clinical applications显示文摘Spinal cord injury(SCI)significantly affects thousands of individuals every year.SCI is due to various pathogenic factors such as trauma,inflammation,and tumors.SCI caused spinal neurological dysfunction below the injury plane,e.g.,it affects motor,sensory nerve,sphincter,and vegetative nerve function.A robotic exoskeleton system is an emerging rehabilitation therapy for SCI worldwide.For patients with SCI,correction of gait and improvement of the function of the lower limbs during walking are particularly important. | Yilin WANG Hong CHENG Jing QIU Anren ZHANG Hongchen HE | 2021 | Science China(Information Sciences)2021，64，8： | 2 |
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