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| 1 | Role of matrix metalloproteinase,tissue inhibitor of metalloproteinase and tumor necrosis factor-α single nucleotide gene polymorphisms in inflammatory bowel disease显示文摘AIM:To study the (functional) relevance of single nucleotide polymorphisms (SNPs) in genes encoding matrix metalloproteinases (MMP)-1,-2,-3,-9,tissue inhibitors of metalloproteinases (TIMP)-1,-2 and tumor necrosis factor (TNF)-α in the etiopathogenesis of inflammatory bowel diseases (IBD),that may enhance susceptibility and/or disease severity. METHODS:Genomic DNA from 134 Crohn's disease (CD),111 ulcerative colitis (UC) patients and 248 control subjects was isolated from resected intestinal tissue or blood. Allelic composition at SNP loci was determined by PCR-RFLP or tetra primer ARMS PCR. RESULTS:The TIMP-1 genotype TT in women and T in men at SNP +372 T/C was found to increase CD susceptibility (39% vs 23.8%,P=0.018 and 67.9% vs 51.6%,P=0.055,respectively),while women with this genotype were less prone to development of fistulae during follow-up (41.4% vs 68.3%,P=0.025). Male IBD or CD patients carrying the TIMP-1 +372 T-allele expressed lower levels of TIMP-1 in surgically resected macroscopically inflamed tissue (0.065 < P < 0.01). The 5T5T genotype at MMP-3 SNP -1613 5T/6T increased the chance of stenotic complications in CD during follow-up (91.2% vs 71.8%,P = 0.022) but seemed to protect against colonic involvement of this disease at first endoscopic/radiologic examination (35.3% vs 59.5%,P=0.017). CONCLUSION:Allelic composition at the examinedSNPs in genes coding for TIMP-1 and MMP-3 affect CD susceptibility and/or phenotype,i.e.,fistulizing disease,stricture pathogenesis and first disease localisation. These findings reinforce the important role of these proteins in IBD. | Martin JW Meijer Marij AC Mieremet-Ooms Ruud A van Hogezand Cornelis BHW Lamers Daniel W Hommes Hein W Verspaget | 2007 | World Journal of Gastroenterology2007，13，21： | 15 |
| 2 | Critical appraisal ofthe current practice in murine TNBS-induced colitis显示文摘 | te VeIde A A Verstege M I Hommes D W | 2006 | Inflamm Bowel Dis2006，12，10： | 1 |
| 3 | Kinetics of hydrolysis of fructooligosaccharides in mineral buffered aqueous solutions:influence of pH and temperature显示文摘 | L'HOMME C ARBELOT M PUIGSERVER A | 2003 | Journal of Agricultural and Food Chemistry2003，51，1： | 1 |
| 4 | Heterogeneous Beliefs and Routes to Chaos in a Simple Asset Pricing Model显示文摘 | BROCK W A HOMMES C H | 1998 | Jour- nal of Economic Dynamics and Control1998，22，： | 1 |
| 5 | Indication of sclerotherapy in the treatment of ischiatic pressure sore: about 13 cases显示文摘 | Bahe L Prud homme A Penaud A | 2012 | Ann Chir Plast Esthet2012，57，6： | 1 |
| 6 | Heterogeneous beliefs and routes to chaos in a simple asset pricing model 显示文摘 | Brock W A Hommes C H | 1998 | Journal of Economic Dynamics and Control1998，22，89： | 1 |
| 7 | Heterogeneous beliefs androutes to chaos in a simple asset pricing model显示文摘 | BROCK W A HOMMES C H | 1998 | Journalof Economic Dynamics&Control1998，22，89： | 1 |
| 8 | Packing for control of hemorrhage in major liver trauma 显示文摘 | Nicol A J Hommes M Primrose R | 2007 | World J Surg2007，31，3： | 1 |
| 9 | Structural and functional properties of membrane and secreted IgD 显示文摘 | Preud'homme JL Petit I Barra A | 2000 | Molec Immunol2000，37，15： | 1 |
| 10 | Structural and functional properties of membrane and secreted IgD 显示文摘 | Preud' homme J L Petit I Barra A | 2000 | Mol Immunol2000，37，： | 1 |
| 11 | Breast cancerstem-like cells are inhibited by a non-toxic aryl hydrocarbonreceptor agonist显示文摘 | Prud'homme G J Glinka Y Toulina A | 2010 | PLoS One2010，5，13： | 1 |
| 12 | Functionalized single graphene sheets derived from splitting graphite oxide 显示文摘 | Schniepp H C Li J L McAllister M J Sai H Herrera Alonso M Adamson D H Prud'Homme R K Car R Saville D A Aksay I A | 2006 | J Phys Chem B2006，110，17： | 1 |
| 13 | Heterogeneous beliefs and routes to chaos in a simple asset pricing model显示文摘 | Brock W A Hommes C H | 1988 | Journal of Economic Dynamics and Control1988，22，8： | 1 |
| 14 | Block copolymer nanoparticles as nanobeads for the polymerase chain reaction 显示文摘 | Zhang S Y Prud'homme R K Link A J | 2011 | Nano Lett2011，11，： | 1 |
| 15 | Heterogeneous beliefs and routes to chaos in a simple asset pricing model显示文摘 | Brock W A Hommes C H | 1998 | Journal of Econominc Dynamics & Control1998，22，8： | 1 |
| 16 | Statins and their potential targets in muliple sclerosis therapy显示文摘 | Stwe O Prod Homme T Slavin A | 2003 | Expert Opin Ther Targets2003，7，5： | 1 |
| 17 | A Rational Route to Randomness 显示文摘 | BROCK W A HOMMES C H | 1997 | Econometrica1997，65，5： | 1 |
| 18 | Improved vision after intravenous immunoglobulin in stable demyelinating optic neuritis显示文摘 | Van Engelen B G Hommes O R Pincker A | 1992 | Ann Nenrol1992，32，： | 1 |
| 19 | Evolu-tionary dynamics in markets with many trader types显示文摘 | BROCK W A HOMMES C H WAGENER F | 2005 | Journal of Mathematical Economics2005，41，12： | 1 |
| 20 | A locus for simple pure febrile seizures maps to chromosome 6q22-q24显示文摘 | Nabbout R Prud' homme JF Herman A | 2002 | Brain2002，125，12： | 1 |
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