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| 1 | High-fat-induced intestinal permeability dysfunction associated with altered fecal bile acids显示文摘AIM:To investigate whether high-fat-feeding is associated with increased intestinal permeability via alterations in bile acid metabolism.METHODS:Male C57Bl/6J mice were fed on a high-fat (n=26) or low-fat diet (n=24) for 15 wk.Intestinal permeability was measured from duodenum,jejunum,ileum and colon in an Ussing chamber system using 4 kDa FITC-labeled dextran as an indicator.Fecal bile acids were analyzed with gas chromatography.Segments of jejunum and colon were analyzed for the expression of farnesoid X receptor (FXR) and tumor necrosis factor (TNF).RESULTS:Intestinal permeability was significantly increased by high-fat feeding in jejunum (median 0.334 for control vs 0.393 for high-fat,P=0.03) and colon (0.335 for control vs 0.433 for high-fat,P=0.01),but not in duodenum or ileum.The concentration of nearly all identified bile acids was significantly increased by high-fat feeding (P<0.001).The proportion of ursodeoxycholic acid (UDCA) in all bile acids was decreased (1.4%±0.1% in high-fat vs 2.8%±0.3% in controls,P<0.01) and correlated inversely with intestinal permeability (r=-0.72,P=0.01).High-fat feeding also increased jejunal FXR expression,as well as TNF expression along the intestine,especially in the colon.CONCLUSION:High-fat-feeding increased intestinal permeability,perhaps by a mechanism related to bile acid metabolism,namely a decreased proportion of fecal UDCA and increased FXR expression. | Lotta K Stenman Reetta Holma Riitta Korpela | 2012 | World Journal of Gastroenterology2012，18，9： | 19 |
| 2 | Effects of the viability of Lactobacillus rhamnosus GG on rotavirus infection in neonatal rats显示文摘AIM:To study the effects of live and dead Lactobacillus rhamnosus GG(GG) on rotavirus infection in a neonatal rat model.METHODS:At the age of 2 d,suckling Lewis rat pups were supplemented with either live or dead GG and the treatment was continued daily throughout the experi-ment.At the age of 5 and 6 d the pups received oral rotavirus(RV) SA-11 strain.The pups were sacrificed at the age of 7 or 8 d by decapitation.The gastrointestinal tract was removed and macroscopic observations were done.The consistency of feces in the colon was classified using a four-tier system.RV was detected from the plasma,small intestine,colon and feces by real-time quantitative polymerase chain reaction(PCR).RESULTS:In this neonatal rat model,RV induced a mild-to-moderate diarrhea in all except one pup of the RV-inoculated rats.RV moderately reduced body weight development from day 6 onwards.On day 7,after 2 d of RV infection,live and dead GG groups gained significantly more weight than the RV group without probiotics [36%(P = 0.001) and 28%(P = 0.031),respectively].In addition,when compared with the RV control group,both live and dead GG reduced the weight ratio of colon/animal body weight to the same level as in the healthy control group,with reductions of 22%(P = 0.002) and 28%(P < 0.001),respectively.Diarrhea increased moderately in both GG groups.However,the diarrhea incidence and severity in the GG groups were not statistically significantly different as compared with the RV control group.Moreover,observed diarrhea did not provoke weight loss or death.The RV control group had the largest amount of RV PCR-positive samples among the RV-infected groups,and the live GG group had the smallest amount.Rats receiving live GG had significantly less RV in the colon(P = 0.027) when compared with the RV control group.Live GG was also more effective over dead GG in reducing the quantity of RV from plasma(P = 0.047).CONCLUSION:Both live and dead GG have beneficial effects in RV infection.GG may increase RV clearance from the body and reduce colon swelling. | Hanna Ventola Liisa Lehtoranta Mari Madetoja Marja-Leena Simonen-Tikka Leena Maunula Merja Roivainen Riitta Korpela Reetta Holma | 2012 | World Journal of Gastroenterology2012，18，41： | 2 |
| 3 | A theoretical study of olivine LiMPO4 cathodes显示文摘 | Osorio-Guillen J M Holma B Ahuja R | 2004 | Solid State Ionics2004，167，： | 1 |
| 4 | The prototype inductive adder with droop compensation for the CLIC kicker systems显示文摘 | Holma J Barnes M J | 2014 | IEEE Transactions on ma Science2014，42，23： | 1 |
| 5 | Increased enterocyte production in gnotobiotic rats mono -associated with Lactobacillus rhamnosus GG显示文摘 | Banasaz M Norin E Holma R | 2002 | Appl Environ Microbiol2002，68，： | 1 |
| 6 | Regulation and pricing of pharmaceuticals, reference pricing or price cap regulation? 显示文摘 | K Brekke A Grasdal T Holmas | 2009 | European Economic Review2009，53，： | 1 |
| 7 | The use of time-integrated NOAA NDVI data and rainfall to assess landscape degradation in the arid shrubland of Western Australia显示文摘 | Alexander McR Holma Shane W Cridlandb Michael L Roderick | 2003 | Remote Sensing of Environment2003，85，： | 1 |
| 8 | Computed tomography data based rapid prototyping model of the temporal bone before cochlear implant surgery显示文摘 | Lopponen H Holma T Sorri M | 1997 | Acta Otolaryngol Suppl1997，529，： | 1 |
| 9 | Treatment of primary hypogonadism in men by the transdermal administration of testosterone显示文摘 | Findlay J C Hamilton J B Holma J | 1989 | J Clin Endocrinol Metab1989，69，1： | 1 |
| 10 | Primary angioplasty for acute myocardial infarction in the elderly 显示文摘 | Lane GE Holmas DR Jr | 2000 | Coron Artary Dis2000，113，： | 1 |
| 11 | Keeping nurses at work: a duration analysis 显示文摘 | Holmas Tot Helge | 2002 | Health Economics2002，11，6： | 1 |
| 12 | WCDMA for UMTS 显示文摘 | Harri Holma Antti Toskala | 2004 | 2004，，： | 1 |
| 13 | Intraspecific variation in sensitivity to UV-B radiation in rice显示文摘 | Barnes PW Maggard S Holma S R | 1993 | Crop Science1993，，： | 1 |
| 14 | A theoretical study of olivine LiMPO4 cathodes显示文摘 | Holma B Ahuja R | 2004 | Solid State Ionics2004，，167： | 1 |
| 15 | Computed tomography data based rapid prototyping model of the temporal bone before cochlear implant surgery 显示文摘 | Lopponen H Holma T Sorri M | 1997 | Acta Otolaryngol Suppl Stockh1997，529，： | 1 |
| 16 | The use of time-integrated NOAA NDVI data and rainfall to assess landscape degradation in the arid scrubland of Western Australia显示文摘 | Alexander McR Holma Shane W Cridlandb Michael L Roderick | 2003 | Remote Sensing of Environment2003，85，： | 1 |
| 17 | Ref- erence pricing, competition, and pharmaceutical expen- ditures: theory and evidence from a natural experiment 显示文摘 | Brekke K R Holmas T H Straume O R | 2011 | Journal of public economics2011，95，78： | 1 |
| 18 | Assessment of offshore platforms under extreme waves by probabilistic incremental wave analysis显示文摘 | Golafshani All Akbar Ebrahimian Hossein Bagheri Vahid Holmas Tore | 2011 | Journal of Constructional Steel Research2011，67，： | 1 |
| 19 | The use of time-integrated NOAA NDVI data and rainfall to assess landscape degradation in the arid shrubland of Western Australia显示文摘 | Alexander McR Holma Shane W Cridlandb Michael L Roderick | 2003 | Remote Sensing of Environment2003，85，： | 1 |
| 20 | Predictors for switch fromunipolar major depressive disorder to bipolar disorder type I or II: a 5-year prospective study显示文摘 | Hohna KM Melartin TK Holma IA | 2008 | J Clin Psychiatry2008，69，8： | 1 |
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