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| 1 | Global gene expression analysis of gastric cancer by oligonucleotide microarrays显示文摘 | HIPPO Y TANIGUCHI H TSUTSUMI S | 2002 | Cancer Research2002，62，1： | 1 |
| 2 | Multi-sensor obstacle detec- tion and tracking显示文摘 | STILLER C HIPPO J | 2000 | Image and Vision Computing2000，，： | 1 |
| 3 | Differential gene expression profiles of scirrhous gastric cancer cells with high metastatic potential to peritoneum or lymph nodes显示文摘 | Hippo Y Yashiro M Ishii M | 2001 | Cancer Res2001，，61： | 1 |
| 4 | Differential gene expression profiles of scirrhous gastric cancer cells with high metastatic poten- tial to peritoneum or lymph nodes显示文摘 | Hippo Y Yashiro M Ishii M | 2001 | Cancer Res2001，61，3： | 1 |
| 5 | splicing-factor oncoprotein SF2/ASF activates mTORC1 显示文摘 | Kami R Hippo Y Lowe SW | 2008 | Proc Natl Acad Sci U S A2008，105，15： | 1 |
| 6 | Identification of soluble NH2-terminal fragment of glypican-3 as a serological marker for early-stage hepatocellular carcinoma显示文摘 | Hippo Y Watanabe K Watanabe A | 2004 | Cancer Res2004，64，12： | 1 |
| 7 | Activated carbon produce from anillinois basin coal显示文摘 | SUN JIAN HIPPO E J MARSH H | 1997 | Carbon1997，35，： | 1 |
| 8 | Increased tumor necrosis factor receptor 1 expression in human colorectal adenomas显示文摘AIM: To determine the expression statuses of tumor necrosis factor (TNF)-α, its receptors (TNF-R) and downstream effector molecules in human colorectal adenomas. METHODS: We measured the serum concentrations of TNF-α and its receptors in 62 colorectal adenoma patients and 34 healthy controls. The protein expression of TNF-α, TNF-R1, TNF-R2 and downstream signals of the TNF receptors, such as c-Jun N-terminal kinase (JNK), nuclear factor-κ B and caspase-3, were also investigated in human colorectal adenomas and in normal colorectal mucosal tissues by immunohistochemistry. Immunofluorescence confocal microscopy was used to investigate the consistency of expression of TNF-R1 and phospho-JNK (p-JNK). RESULTS: The serum levels of soluble TNF-R1 (sTNF-R1) in adenoma patients were significantly higher than in the control group (3.67 ± 0.86 ng/mL vs 1.57 ± 0.72 ng/mL, P < 0.001). Receiver operating characteristic analysis revealed the high diagnostic sensitivity of TNF-R1 measurements (AUC was 0.928) for the diagnosis of adenoma, and the best cut-off level of TNF-R1 was 2.08 ng/mL, with a sensitivity of 93.4% and a specificity of 82.4%. There were no significant differences in the serum levels of TNF-α or sTNF-R2 between the two groups. Immunohistochemistry showed high levels of TNF-R1 and p-JNK expression in the epithelial cells of adenomas. Furthermore, a high incidence of co-localization of TNF-R1 and p-JNK was identified in adenoma tissue. CONCLUSION: TNF-R1 may be a promising biomarker of colorectal adenoma, and it may also play an important role in the very early stages of colorectal carcinogenesis. | Kunihiro Hosono Eiji Yamada Hiroki Endo Hirokazu Takahashi Masahiko Inamori Yoshitaka Hippo Hitoshi Nakagama Atsushi Nakajima | 2012 | World Journal of Gastroenterology2012，18，38： | 1 |
| 9 | Identification of soluble NH2-terminal fragment of glypican-3 as a serological marker for early-stage hepatocellular carcinoma显示文摘 | Hippo Y Watanabe K Watanabe A | 2004 | Cancer Res2004，64，7： | 1 |
| 10 | Identification ofsoluble NH2-terminal fragment of glypican-3 as a serologicalmarker for early-stage hepatocellular carcinoma显示文摘 | Hippo Y Watanabe K Watanabe A | 2004 | Cancer Res2004，64，7： | 1 |
| 11 | An opposing view on WWOX protein function as a tumor suppressor显示文摘 | Watanabe A Hippo Y Taniguchi H | 2003 | Cancer Res2003，63，24： | 1 |
| 12 | Identification of soluble NH2-terminal fragment of glypican-3 as a serological marker for early-stage hepatocellular carcinoma显示文摘 | Hippo Y Watanabe K Watanabe A | 2004 | Cancer Res2004，64，9： | 1 |
| 13 | Global gene expression analysis of gastric cancer by oligonucleotide microarrays 显示文摘 | Hippo Y Taniguchi H Tsutsumi S | 2002 | Cancer Res2002，62，1： | 1 |
| 14 | Identification of soluble NH2-terminal fragment of glypican-3 as a serological marker for earlystage hepatocellular carcinoma 显示文摘 | Hippo Y Watanabe K Watanabe A | 2004 | Cancer Res2004，64，9： | 1 |
| 15 | Glypican-3 as a serum marker for hepatocellular carcinoma显示文摘 | CAPURRO M FILMUS J HIPPO Y | 2005 | Cancer Res2005，65，1： | 1 |
| 16 | Co-conversion of coal waste plastic mixtures under various pyrolysis and liquefaction conditions 显示文摘 | PALMER S R HIPPO E L TANDAN D | 1995 | Prepr Am Chem Soc Div Fuel Chem1995，40，1： | 1 |
| 17 | Identification of soluble NH2-terminal fragment of glypican-3 as a serological Inarker for early-stage hepateceHular carcinoma显示文摘 | HIPPO Y WATANABE K WATANABE A T | 2004 | Cancer Res2004，64，7： | 1 |
| 18 | Identification of soluble NH2 - terminal fragment of glypican - 3 as a sero- logical marker for early - stage hepat ocellular carcinoma 显示文摘 | Hippo Y Watanabe K Watanabe A | 2004 | Cancer Res2004，64，7： | 1 |
| 19 | Reduction of iron oxide in carbon monoxide atmosphere - reaction controlled kinetics 显示文摘 | Mondal K Lorethova H Hippo E | 2004 | Fuel Processing Technology2004，86，1： | 1 |
| 20 | Reduction of Iron Oxide in Carbon Monoxide Atmosphere-Reaction Controlled Kinetics 显示文摘 | Mondal K Lorethova H Hippo E | 2004 | Fuel Processing Technology2004，86，： | 1 |
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