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| 1 | Coexpression of receptor-tyrosine-kinases in gastric adenocarcinoma-a rationale for a molecular targeting strategy?显示文摘AIM: To define the (co-)expression pattern of target receptor-tyrosine-kinases (RTK) in human gastric adenocarcinoma. METHODS: The (co-)expression pattern of VEGFR1-3,PDGFRα/b and EGFR1 was analyzed by RT-PCR in 51 human gastric adenocarcinomas. In addition,IHC staining was applied for confirmation of expression and analysis of RTK localisation. RESULTS: The majority of samples revealed a VEGFR1 (98%),VEGFR2 (80%),VEGFR3 (67%),PDGFRα (82%) and PDGFRβ(82%) expression,whereas only 62% exhibited an EGFR1 expression. 78% of cancers expressed at least four out of six RTKs. While VEGFR1-3 and PDGFRα revealed a predominantly cytoplasmatic staining in tumor cells,accompanied by an additional nuclear staining for VEGFR3 ,EGFR1 was almost exclusively detected on the membrane of tumor cells. PDGFRβ was restricted to stromal pericytes,which also depicted a PDGFRα expression.receptor-tyrosine-kinases coexpression in gastric adenocarcinoma and might therefore encourage an application of multiple-target RTK-inhibitors within a combination therapy. | Daniel Drescher Markus Moehler Ines Gockel Kirsten Frerichs Annett Müller Friedrich Dünschede Thomas Borschitz Stefan Biesterfeld Martin Holtmann Thomas Wehler Andreas Teufel Kerstin Herzer Thomas Fischer Martin R Berger Theodor Junginger Peter R Galle Carl C Schimanski | 2007 | World Journal of Gastroenterology2007，13，26： | 4 |
| 2 | Killing of p53-deficient hepatoma cells by parvovirus H-1 and chemotherapeutics requires promyelocytic leukemia protein显示文摘AIM: To evaluate the synergistic targeting and killing of human hepatocellular carcinoma (HCC) cells lacking p53 by the oncolytic autonomous parvovirus (PV) H-1 and chemotherapeutic agents and its dependence on functional promyelocytic leukemia protein (PML). METHODS: The role of p53 and PML in regulating cy-totoxicity and gene transfer mediated by wild-type (wt) PV H-1 were explored in two pairs of isogenic human hepatoma cell lines with different p53 status. Further-more,H-1 PV infection was combined with cytostatic drug treatment. RESULTS: While the HCC cells with different p53 status studied were all susceptible to H-1 PV-induced apoptosis,the cytotoxicity of H-1 PV was morepronounced in p53-negative than in p53-positive cells. Apoptosis rates in p53-negative cell lines treated by genotoxic drugs were further enhanced by a treatment with H-1 PV. In flow cytometric analyses,H-1 PV infection resulted in a reduction of the mitochondrial transmembrane potential. In addition,H-1 PV cells showed a significant increase in PML expression. Knocking down PML expression resulted in a striking reduction of the level of H-1 PV infected tumor cell death. CONCLUSION: H-1 PV is a suitable agent to circumvent the resistance of p53-negative HCC cells to genotoxic agents,and it enhances the apoptotic process which is dependent on functional PML. Thus,H-1 PV and its oncolytic vector derivatives may be considered as therapeutic options for HCC,particularly for p53-negative tumors. | Maike Sieben Kerstin Herzer Maja Zeidler Vera Heinrichs Barbara Leuchs Martin Schuler Jan J Cornelis Peter R Galle Jean Rommelaere Markus Moehler | 2008 | World Journal of Gastroenterology2008，14，24： | 2 |
| 3 | Grain size dependence of coercivity and permeability in nanocrystalline ferromagnets显示文摘 | Herzer G | 1990 | IEEE Trans Magn1990，26，5： | 1 |
| 4 | Grain size dependence of coercivity and permeability in nanocrystalline ferromagnets显示文摘 | Herzer G | 1990 | Magnetics lEEE Transactions1990，26，5： | 1 |
| 5 | Rescue of death receptor and mitochondrial apoptosis signaling in resistant human NSCLC in vivo 显示文摘 | Okouoyo S Herzer K Ucur E | 2004 | Int J Cancer2004，108，4： | 1 |
| 6 | Onset of heart failure determines the hepatic cell death pattern 显示文摘 | Herzer K Kneiseler G Bechmann LP | 2011 | Ann Hepatol2011，10，2： | 1 |
| 7 | Grain - structure and magnetism of nanocrystalline ferromagnets显示文摘 | Herzer G | 1989 | IEEE Trans Mag1989，25，： | 1 |
| 8 | Grain structure and magnetism of nanocrystalline ferromagnets 显示文摘 | Herzer G | 1989 | IEEE Trans Magn1989，25，： | 1 |
| 9 | The long-run relationship between outward FDI and total factor productivity:evidence for developing countries显示文摘 | HERZER D | 2010 | Journal of Development Studies2010，47，5： | 1 |
| 10 | Outward FDI,total factor productivity and domestic output:evidence from Germany显示文摘 | HERZER D | 2012 | International Economic Journal2012，26，1： | 1 |
| 11 | Transforming growth factor beta can mediate apoptosis via the expression of TRAIL in human hepatoma cells显示文摘 | Ganten TM Schulze-Bergkamen H | 2005 | Hepatology2005，42，1： | 1 |
| 12 | 显示文摘 | Hubert A Herzer G | 1991 | J Appl Phys1991，，69： | 1 |
| 13 | Soft magnetic nanocrystalline materials显示文摘 | HERZER G | 1995 | Scripta Metall Mater1995，33，1011： | 1 |
| 14 | The long-run relationship between outward foreign direct investment and total factor productivity:Evidence for developing countries显示文摘 | Dierk Herzer | 2011 | The Journal of Development Studies2011，47，5： | 1 |
| 15 | The causal relationship between domestic and outward foreign investment:evidence for Italy显示文摘 | Dierk Herzer | 2008 | Applied Financial Economics Letters2008，，4： | 1 |
| 16 | Glucocorticoid corteatment induces apoptosis resistance toward cancer therapy in carcinomas显示文摘 | Herr I Ucur E Herzer K | 2003 | Cancer Res2003，63，12： | 1 |
| 17 | Grain structure and magnetism of nanocrystalline ferromagnets显示文摘 | Herzer G | 1989 | IEEE Trans Magn1989，25，5： | 1 |
| 18 | Grain size dependence of coercivity and permeability in nanocrystalline ferromagnets 显示文摘 | Herzer G | 1990 | IEEE Transactions on Magnetics1990，26，5： | 1 |
| 19 | Rescue of death receptor andmitochondrial apoptosis signaling in resistant human NSCLC invivo显示文摘 | Okouoyo S Herzer K Ucur E | 2004 | Int J Cancer2004，108，4： | 1 |
| 20 | Surface crystallisation and magnetic properties in amorphous iron rich alloys 显示文摘 | Herzer G Hilzinger H R | 1986 | Journal of Magnetism and Magnetic Materials1986，62，23： | 1 |
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