|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Clinical use of bone-targeting radiopharmaceuticals with focus on alpha-emitters显示文摘Various single or multi-modality therapeutic options are available to treat pain of bone metastasis in patients with prostate cancer.Different radionuclides that emitβ-rays such as 153Samarium and 89Strontium and achieve palliation are commercially available.In contrast toβ-emitters,223Radium as a a-emitter has a short path-length.The advantage of the a-emitter is thus a highly localized biological effect that is caused by radiation induced DNA double-strand breaks and subsequent cell killing and/or limited effectiveness of cellular repair mechanisms.Due to the limited range of the a-particles the bone surface to red bone marrow dose ratio is also lower for 223Radium which is expressed in a lower myelotoxicity.The a emitter 223Radium dichloride is the first radiopharmaceutical that significantly prolongslife in castrate resistant prostate cancer patients with wide-spread bone metastatic disease.In a phaseⅢ,randomized,double-blind,placebo-controlled study 921patients with castration-resistant prostate cancer and bone metastases were randomly assigned.The analysis confirmed the 223Radium survival benefit compared to the placebo(median,14.9 mo vs 11.3 mo;P<0.001).In addition,the treatment results in pain palliation and thus,improved quality of life and a delay of skeletal related events.At the same time the toxicity profile of223Radium was favourable.Since May 2013,223Radium dichloride(Xofigo?)is approved by the US Food and Drug Administration. | Hinrich A Wieder Michael Lassmann Martin S Allen-Auerbach Johannes Czernin Ken Herrmann | 2014 | World Journal of Radiology2014，6，7： | 4 |
| 2 | Modeling slow deformation of polygonal particles using DEM显示文摘We introduce two improvements in the numerical scheme to simulate collision and slow shearing of irregular particles. First, we propose an alternative approach based on simple relations to compute the frictional contact forces. The approach improves efficiency and accuracy of the Discrete Element Method (DEM) when modeling the dynamics of the granular packing. We determine the proper upper limit for the integration step in the standard numerical scheme using a wide range of material parameters. To this end, we study the kinetic energy decay in a stress controlled test between two particles. Second, we show that the usual way of defining the contact plane between two polygonal particles is, in general, not unique which leads to discontinuities in the direction of the contact plane while particles move. To solve this drawback, we introduce an accurate definition for the contact plane based on the shape of the overlap area between touching particles, which evolves continuously in time. | Andrés A. Pea Pedro G. Lind Hans J. Herrmann | 2008 | Particuology2008，6，6： | 2 |
| 3 | Label-retaining liver cancer cells are relatively resistant to sorafenib显示文摘 | Hong-Wu Xin Chenwi M Ambe Danielle M Hari Gordon W Wiegand Tyler C Miller Jin-Qiu Chen Andrew J Anderson Satyajit Ray John E Mullinax Tomotake Koizumi Russell C Langan Douglas Burka Michelle A Herrmann Paul K Goldsmith Alexander Stojadinovic Udo Rudloff S | 2013 | Gut2013，，12： | 2 |
| 4 | Functional and neuroanatomic correlations in poststroke depression: the sunnybrook stroke study显示文摘 | Singh A Black S E Herrmann N | 2000 | Stroke2000，31，3： | 1 |
| 5 | Pathophysiology of HCN channels显示文摘 | Herrmann S Stieber J Ludwig A | | 0，，04： | 1 |
| 6 | Thypedin, the multi copy precursor for the hydra peptide pedin, is a beta-thymosin repeat- like domain containing protein显示文摘 | Herrmann D Hatta M Hoffmeister-Ullerich S A | 2005 | Mech Dev2005，122，11： | 1 |
| 7 | A model of buyer regret: Selected prepurchase and postpurchase antecedents with consequences for the brand and the channel显示文摘 | Keaveney S M Huber F Herrmann A | 2007 | Journal of Business Research2007，60，： | 1 |
| 8 | Persistent infection with small colony variant strains of Staphylococcus aureus in patients with cystic fibrosis显示文摘 | Kahl B Herrmann M Everding A S | 1998 | J Infect Dis1998，177，： | 1 |
| 9 | Persistent infection with small colony variant strains of Staphy- lococcus aureus in patients with cystic fibrosis显示文摘 | Kahl B Herrmann M Everding A S | 1998 | J Infect Dis1998，177，4： | 1 |
| 10 | Novel insights into the distribution of cardiac HCN channels:an expression study in the mouse heart 显示文摘 | Herrmann S Layh B Ludwig A | 2011 | J Mol Cell Cardiol2011，51，6： | 1 |
| 11 | Differential effect of experimental hypertension and hypercholesterolemia on advential remodeling显示文摘 | SAMEE S CHADE A | 2005 | Arterioscler Thromb Vasc Biol2005，25，2： | 1 |
| 12 | Recent trends in vegeta- tinn dynamics in the African Sahel and their relationship to climate 显示文摘 | Herrmann S M Anyamba A Tucker C J | 2005 | Global Environmental Change2005，15，4： | 1 |
| 13 | Differential effect ofexperimental hypertension and hypercholesterolemia onadvenfitial remedeling显示文摘 | Herrmann J Samee S Chede A | 2005 | Arterioscler Thromb Vasc Biol2005，25，2： | 1 |
| 14 | Aminotroponiminate alkyl and alkoxide complexes of zinc 显示文摘 | Herrmann J S Luinstra G A Roesky P W | 2004 | Journal of Organometallic Chemistry2004，689，： | 1 |
| 15 | Berechnung des Spannungsund Verschiebungsfeldes anisotroper Scheiben mit elliptischem Ausschnitt显示文摘 | HUFENBACH W SCHAFER M HERRMANN A S | 1990 | Ingenieur-Archiv1990，60，8： | 1 |
| 16 | Functional and neuroanatomic correlations in poststreke depression:the sunnybrook stroke study显示文摘 | Singh A Black S E Herrmann N | 2000 | Stroke2000，54，31： | 1 |
| 17 | Functional and neuroanatomic correlations in poststroke depression: The sunnybrook stroke study 显示文摘 | Singh A Black S Herrmann N | 2000 | Stroke2000，31，3： | 1 |
| 18 | Radiation drive capsules for fast ignition fusion显示文摘 | Slutz S A Herrmann M C | 2003 | Phys Plasmas2003，10，1： | 1 |
| 19 | Recent trends in vegetation dynamics in the African Sahel and their rela- tionship to climate显示文摘 | Herrmann S M Anyamba A Tucker C J | 2005 | Global Environmental Change2005，15，： | 1 |
| 20 | Insulin resistance, dyslipidaemia, inflammation and endothelial function in nephrotic syndrome显示文摘 | Dogra G K Herrmann S Irish A B | 2002 | Nephrol Dial Transplant2002，17，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员