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| 1 | 伊立替康+卡铂或口服伊托泊苷+卡铂治疗广泛期小细胞肺癌的随机临床Ⅲ期对照研究显示文摘研究背景:顺铂联合伊托泊苷(EP方案)是目前小细胞肺癌的标准治疗方案,但广泛期小细胞肺癌的预后极差,即使总体健康状况良好的患者完成EC方案治疗后中位生存期仅约10个月。一项旨在研究伊立替康联合顺铂(即IP方案)对照EP方案疗效的Ⅲ期临床研究结果显示,接受IP方案者的中位生存期达12.8个月,优于接受EP方案治疗者的9.4个月(P=0.002)。 | Hermes A Bergman B Bremnes R 陆嘉德 | 2009 | 中国癌症杂志2009，19，2： | 9 |
| 2 | 早发性先兆子痫,迟发性先兆子痫和妊娠高血压后的心血管疾病危险因素显示文摘研究表明,有妊娠高血压病史的妇女心血管疾病(cardiovasculardisease,CVD)终生风险增加。这种风险与妊娠相关高血压疾病的严重程度及发病孕周有关。然而,cVD危险因素的差异是否在产后心血管筛查时就已经存在尚不清楚。研究人员将妊娠期高血压疾病患者分为3个亚组,分析CVD危险因素的产后差异。 | 刘莉 叶鹏 Veerbeek JH Hermes W Breimer AY van Rijn BB Koenen SV Mol BW Franx A de Groot CJ Koster MP | 2015 | 中华高血压杂志2015，23，2： | 5 |
| 3 | Antifungal activity and antidiarrheal activity via antimotility mechanisms of (-)-fenchone in experimental models显示文摘BACKGROUND(-)-Fenchone is a bicyclic monoterpene present in essential oils of plant species,such as Foeniculum vulgare and Peumus boldus,used to treatment of gastrointestinal diseases.Pharmacological studies report its anti-inflammatory,antioxidant,and antinociceptive activity.AIM To investigate antidiarrheal activity related to gastrointestinal motility,intestinal secretion and antimicrobial activity.METHODS A castor oil-induced diarrhea model was used to evaluate antidiarrheal activity.Intestinal transit and gastric emptying protocols were used to assess a possible antimotility effect.Muscarinic receptors,presynaptic α2-adrenergic and tissue adrenergic receptors,KATP channels,nitric oxide were investigated to uncover antimotility mechanisms of action and castor oil-induced enteropooling to elucidate antisecretory mechanisms.The antimicrobial activity was evaluated in the minimum inhibitory concentration model,the fractional inhibitory concentration index using the(-)-fenchone association method with standard antifungal agents.RESULTS(-)-Fenchone(75,150 and 300 mg/kg)showed antidiarrheal activity,with a significant decrease in the evacuation index.This activity is possibly related to a percentage of reduced intestinal transit(75,150 and 300 mg/kg).The antimotility effect of(-)-fenchone decreased in the presence of pilocarpine,yohimbine,propranolol,L-NG-nitroarginine methyl ester or glibenclamide.In the enteropooling model,no reduction in intestinal fluid weight was observed.(-)-Fenchone did not show antibacterial activity;on the other hand,inhibits the growth of strains of fungi with a minimum fungicide concentration of 32μg/mL.However,when it was associated with amphotericin B,no synergism was observed.CONCLUSION The antidiarrheal effect of(-)-fenchone in this study involves antimotility effect and not involve antisecretory mechanisms.(-)-Fenchone presents antifungal activity;however,it did not show antibacterial activity. | Michelle Liz de Souza Pessoa Leiliane Macena Oliveira Silva Maria Elaine Cristina Araruna Catarina Alves de Lima Serafim Edvaldo Balbino Alves Junior Alessa Oliveira Silva Matheus Marley Bezerra Pessoa Hermes Diniz Neto Edeltrudes de Oliveira Lima Leonia Maria Batista | 2020 | World Journal of Gastroenterology2020，26，43： | 2 |
| 4 | Financial liberalization and economic growth: A meta-analysis显示文摘 | Silke Bumann Niels Hermes Robert Lensink | 2013 | Journal of International Money and Finance2013，，： | 2 |
| 5 | Children's Response to Serious Illness: Perceptions of Benefit and Burden in a Pediatric Cancer Population显示文摘 | Currier J Hermes S Phipps S | | Journal of Pediatric Psychology0，，： | 1 |
| 6 | Measuring reaction kinetics in a lab-on-a-chip by microcoil NMR 显示文摘 | BENITO-LOPEZ F HERMES D C | 2005 | Lab on A Chip2005，5，： | 1 |
| 7 | Aente hespes zoster neualgia retrospective analysis of clinical aspects and therapeutic responsiveness显示文摘 | HAAS N HOLLE E HERMES B | 2001 | Dematology2001，202，4： | 1 |
| 8 | Microglial expression of the prion protein显示文摘 | Brown DR Besinger A Herms JW | 1998 | Neuroreport1998，9，： | 1 |
| 9 | Influence of an altered methylation potential on mRNA methylation and gene expression in HepG2 cells显示文摘 | Hermes M Osswald H Mattar J | 2004 | Eacp Cell Res2004，294，32： | 1 |
| 10 | CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells 显示文摘 | Herm V Slupsky JR Grafe M | 1998 | Nature1998，391，6667： | 1 |
| 11 | The cellular prion protein binds copper in vivo显示文摘 | Brown D R Qin Kefeng Herms J W | 1997 | Nature1997，390，6661： | 1 |
| 12 | The short term effects of foreign bank entry on domestic bank behavior: does economic development matter?显示文摘 | Lensink R Hermes N | 2004 | Journal of Banking and Finance2004，，： | 1 |
| 13 | An improved corre- lation for two-phase pressure drop of R-22 and R-410A in 180° return bends 显示文摘 | DOMANSKI P A HERMES C J L | 2008 | Applied Thermal Engineering2008，28，7： | 1 |
| 14 | Recent advances on the development of wound dressings for diabetic foot ulcer treatment—A review显示文摘 | Liane I.F. Moura Ana M.A. Dias Eugénia Carvalho Hermínio C. de Sousa | 2013 | Acta Biomaterialia2013，，7： | 1 |
| 15 | Heavy metal species,mobility and availability in soils显示文摘 | Brümmer G W Gerth J Herms U | 2007 | Zeitschrift für Pflanzenern hrung und Bodenkunde2007，149，4： | 1 |
| 16 | Hydrogen embrittlement susceptibility of tempered 9%Cr–1%Mo steel显示文摘 | L. Marchetti E. Herms P. Laghoutaris J. Chêne | 2011 | International Journal of Hydrogen Energy2011，，24： | 1 |
| 17 | The electrochemical determination of ammonium based on the selective inhibition of the low-spin iron (Ⅱ)/(Ⅲ) system of Prussian blue显示文摘 | HERMES M SCHOLZ F | 1997 | J Solid State Electrochem1997，1，： | 1 |
| 18 | Foreign Direct Investment, Financial Development and Economic Growth显示文摘 | Hermes N Lensink R | 2003 | The Journal of Development Studies2003，，38： | 1 |
| 19 | Loading of MOF-5 with Cu and ZnO nanoparticles by gas-phase infiltration with organometallic precursors:Properties of Cu/ZnO@MOF-5 as catalyst for methanol synthesis显示文摘 | Muller M Hermes S Kahler K | 2008 | Chemistry of Materials2008，20，14： | 1 |
| 20 | Pro- and Anti-inflammatory Cytokines in Steatosis and Steatohepatitis显示文摘 | Fabiola Rabelo Claudia P. M. S. Oliveira Joel Faintuch Daniel F. C. Mazo Vicencia M. R. Lima Jose Tadeu Stefano Hermes V. Barbeiro Francisco G. Soriano Venancio A. Ferreira Alves Flair J. Carrilho | 2010 | Obesity Surgery2010，，7： | 1 |
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