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| 1 | Safety and efficacy of Hansenula-derived PEGylated-interferon alpha-2a and ribavirin combination in chronic hepatitis C Egyptian children显示文摘AIM:To investigate the safety and efficacy of a Hansenula-derived PEGylated(polyethylene glycol)interferon(IFN)-alpha-2a(Reiferon Retard)plus ribavirin customized regimen in treatment-na?ve and previously treated(non-responders and relapsers)Egyptian children with chronic hepatitis C infection.METHODS:Forty-six children with chronic hepatitis C virus(HCV)infection were selected from three tertiary pediatric hepatology centers.Clinical and laboratory evaluations were undertaken.Quantitative polymerase chain reaction(PCR)for HCV-RNA was performed before starting treatment,and again at 4,12,24,48,72wk during treatment and 6 mo after treatment cessation.All patients were assigned to receive a weekly subcutaneous injection of PEG-IFN-alpha-2a plus daily oral ribavirin for 12 wk.Thirty-four patients were treatment-na?ve and 12 had a previous treatment trial.Patients were then divided according to PCR results into two groups.GroupⅠincluded patients who continued treatment on a weekly basis(7-d schedule),while groupⅡincluded patients who continued treatment on a 5-d schedule.Patients from either group who were PCR-negative at week 48,but had at least one PCRpositive test during therapy,were assigned to have an extended treatment course up to 72 wk.The occurrence of adverse effects was assessed during treatment and follow up.The study was registered at www.ClinicalTrials.gov(NCT02027493).RESULTS:Only 11 out of 46(23.9%)patients showed a sustained virological response(SVR),two patients were responders at the end of treatment;however,they were lost to follow up at 6 mo post treatment.Breakthrough was seen in 18(39.1%)patients,one patient(2.17%)showed relapse and 14(30.4%)were non-responders.Male gender,short duration of infection,low viral load,mild activity,and mild fibrosis were the factors related to a better response.On the other hand,patients with high viral load and absence of fibrosis failed to respond to treatment.Before treatment,liver transaminases were elevated.After commencing treatment,they were normalized in all patients at week 4 and were maintained normal in responders till the end of treatment,while they increased again significantly in non-responders(P=0.007 and 0.003 at week 24 and 72 respectively).The 5-d schedule did not affect the response rate(1/17 had SVR).Treatment duration(whether 48 wk or extended course to 72 wk)gave similar response rates(9/36 vs 2/8 respectively;P=0.49).Type of previous treatment(short acting IFN vs PEG-IFN)did not affect the response to retreatment.On the other hand,SVR was significantly higher in previous relapsers than in previous non-responders(P=0.039).Only mild reversible adverse effects were observed and children tolerated the treatment well.CONCLUSION:Reiferon Retard plus ribavirin combined therapy was safe.Our customized regimen did not influence SVR rates.Further trials on larger numbers of patients are warranted. | Suzan El Naghi Tawhida Y Abdel-Ghaffar Hanaa El-Karaksy Elham F Abdel-Aty Mona S El-Raziky Aleef A Allam Heba Helmy Hanaa A El-Araby Behairy E Behairy Mohamed A El-Guindi Hatem El-Sebaie Aisha Y Abdel-Ghaffar Nermin A Ehsan Ahmed M El-Hennawy Mostafa M Sira | 2014 | World Journal of Gastroenterology2014，20，16： | 2 |
| 2 | The effect of an-esthesia and surgery on plasma cytokine production显示文摘 | Helmy S A Wahby M A El-Nawaway M | 1999 | Anesthesia1999，54，8： | 1 |
| 3 | Traumatic brain injury: in- tensive care management显示文摘 | Helmy A Vizcaychipi M Gupta AK | 2007 | Br J Anaesth2007，99，1： | 1 |
| 4 | Modeling path duration distributions in MANETs and their impact on reactive routing protocols 显示文摘 | Bai F N Sadagopan B Krishnamachari A Helmy | 2004 | IEEE Journal on Selected Areas in Communications: (S0733-8716)2004，22，7： | 1 |
| 5 | Brain aging in normal egyptians:neuropsychological,electrophysiological and caranial tomographic assessment显示文摘 | Elwan O Helmy A Abdel-Naseer M | 1996 | J Neurol Sci1996，136，： | 1 |
| 6 | Mobility-assisted resolution of queries in large- scale mobile sensor network (MARQ) 显示文摘 | HELMY A | 2003 | Computer Net- works Journal2003，43，4： | 1 |
| 7 | Small worlds in wireless networks 显示文摘 | HELMY A | 2003 | IEEE Communication Letters2003，7，10： | 1 |
| 8 | The effect of the preemptive use of the NMDA receptor antagonist dextromethorphan on postoperative analgesic requirements显示文摘 | Helmy SA Bali A | 2001 | Anesth Analg2001，92，： | 1 |
| 9 | Randomised controlled trial of long term portographic follow up versus variceal band ligation following transjugular intrahepatic portosystemic stent shunt for preventing oesophageal variceal rebleeding显示文摘 | Tripathi D Lui HF Helmy A | 2004 | Gut2004，53，3： | 1 |
| 10 | User's Profile Ontology-based Semantic Framework for Personalized Food and Nutrition Recommendation 显示文摘 | A1-Nazer A Helmy T Al-Mulhem M | 2014 | Procedia Computer Science2014，32，： | 1 |
| 11 | The important framework foranalyzing the impact of mobility on performance of routing for Ad hocnetworks显示文摘 | BAI Fan SADAGOPAN N HELMY A | 2003 | Ad hoc Networks Journal2003，1，4： | 1 |
| 12 | Human papillomavirus-16 (HPV-16) infection association with CIAP-2 expression in head and neck cancer显示文摘 | Mansour A All M Helmy H | 2012 | Med Oncol2012，，： | 1 |
| 13 | Cytokines and innate inflammation in the pathogenesis of human traumatic brain injury显示文摘 | Helmy A De Simoni MG Guilfoyle MR | 2011 | Prog Neurobiol2011，95，3： | 1 |
| 14 | Matrix metalloproteinase expression in contusional traumatic brain injury: a paired microdialysis study显示文摘 | Guilfoyle MR Carpenter KL Helmy A | 2015 | J Neurotrauma2015，32，20： | 1 |
| 15 | Prophylatic anti-emetic efficacy of ondansetron in laparoscpic cholecytectomy under total intravenous anaesthesia显示文摘 | | 1999 | Anaesthesia1999，54，： | 1 |
| 16 | Active query forwarding in sensor networks 显示文摘 | SADAGOPAN N KRISHNAMACHARI B HELMY A | 2005 | Ad Hoc Networks2005，3，1： | 1 |
| 17 | The important framework for analyzing the impact of mobility on performance of routing for Ad hoc networks显示文摘 | BAI Fan SADAGOPAN N HELMY A | 2003 | Ad hoe Networks Journal2003，1，4： | 1 |
| 18 | CMOS distributed amplifiers with extended flat bandwidth and improved input matching using gate line with coupled inductors 显示文摘 | Entesari K Tavakoli A R Helmy A | 2009 | IEEE Transactions on Microwave Theory and Techniques2009，57，12： | 1 |
| 19 | Synoptic and local scale atmospheric circulation associated with air pollution episodes in an urban Mediterranean area显示文摘 | Flocas H Kelessis A Helmis C | 2009 | Theoretical and Applied Climatology2009，95，34： | 1 |
| 20 | Traumatic brain injury:intensive care management显示文摘 | Helmy A Vizcaychipi M Gupta AK | 2007 | Br J Anaesth2007，99，1： | 1 |
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