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| 1 | Source mechanism of strong aftershocks (M_s≥5.6) of the 2008/05/12 Wenchuan earthquake and the implication for seismotectonics显示文摘Dozens of >M5, hundreds of >M4, and much more >M3 aftershocks occurred after the 2008/05/12 Wenchuan earthquake, which were well recorded by permanent and portable seismic stations. After relocated with P arrival, the >M3 aftershocks show two trends of distribution, with most of the aftershocks located along the north-east strike consistent with Longmenshan fault system, yet there is a north-west trend around the epicenter. It seems that substantially more aftershocks occur in regions with crystalline bedrocks. Then we collected waveform data from National Digital Seismograph Network and regional seismograph network of China, and employed 'Cut and Paste' method to obtain focal mechanisms and depths of the big aftershocks (M≥5.6). While most of those aftershocks show thrust mechanism, there are some strike slip earthquakes in the northern-most end of the rupture. Focal mechanisms show that the events located on the southern part of central Beichuan-Yingxiu Fault (BY) are mainly thrust earthquakes, which is consistent with initial mechanism of the main shock rupture. In the north part the aftershocks along the BY are also dominated by thrust slip, which is quite different from the right slip rupture of the main shock. Around Qingchuan-Pingwu Fault, the focal mechanisms are dominated by right-slip rupture with large depths (~18 km). So we suspected that in the north part the main shock might rupture on two faults: Beichuan Fault and Qingchuan-Pingwu Fault. The complex pattern of aftershock mechanisms argues for presence of a complicated fault system in the Longmenshan area. | ZHENG Yong1,2,MA HongSheng3,Lü Jian4,NI SiDao5,LI YingChun6 & WEI ShengJi2 1 Institute of Geodesy and Geophysics,Chinese Academy of Sciences,Wuhan 430077,China 2 Institute of Geophysics,Chinese Earthquake Administration,Beijing 100086,China 3 Institute of Earthquake Science,Chinese Earthquake Administration,Beijing 100086,China 4 Earthquake Administration of Jiangxi Province,Nanchang 330039,China 5 School of Earth and Space Science,University of Science and Technology of China,Hefei 230026,China 6 Earthquake Administration of Jiangsu Province,Nanjing 210014,China | 2009 | Science China Earth Sciences2009，52，6： | 100 |
| 2 | RESEARCH OF QUANTUM GENETIC ALGORITH AND ITS APPLICATION IN BLIND SOURCE SEPARATION显示文摘This letter proposes two algorithms: a novel Quantum Genetic Algorithm (QGA)based on the improvement of Han's Genetic Quantum Algorithm (GQA) and a new Blind Source Separation (BSS) method based on QGA and Independent Component Analysis (ICA). The simulation result shows that the efficiency of the new BSS method is obviously higher than that of the Conventional Genetic Algorithm (CGA). | Yang Junan Li Bin Zhuang Zhenquan (Department of Electronic Science & Technology, USTC, Hefei 230026) | 2003 | Journal of Electronics(China)2003，20，1： | 60 |
| 3 | Decoupling of surface and subsurface sutures in the Dabie orogen and a continent-collisional lithospheric-wedging model: Sr-Nd-Pb isotopic evidences of Mesozoic igneous rocks in eastern China显示文摘There are significant differences of Nd and Pbisotopic compositions between Mesozoic mafic igneous rocks from the North China Block (NCB) and the South ChinaBlock (SCB). Mesozoic mantle-derived igneous rocks fromthe North China Block have very low e Nd values (-15 to -21), and 206Pb/204Pb ratios (< 17.9), while those in the SCB are characterized by e Nd > -10 and 206Pb/204Pb > 18.3. The verylow e Nd values (-16 to -20) and 206Pb/204Pb ratios (< 17.3) of the early Cretaceous mafic-ultramafic intrusions developedin the north part of the Dabie orogen (NDZ) suggest that the deep lithosphere underneath the NDZ belongs to the NCBbut not the SCB. Therefore, although the surface suture be-tween the NCB and SCB is located on the north side of theNDZ, the subsurface suture between the NCB and SCBshould be located to the south side of the NDZ. This is con-sistent with the previous suggestion that the subsurface su-ture in the Sulu terrane east of the Tanlu fault was the south displacement, but contradictory to northward continentalsubduction of the SCB. A continent-collisional lithospheric-wedging model can interpret the decoupling of the surface and subsurface sutures in the Dabie-Sulu orogen. After slabbreak-off, the continuing convergence of two continental blocks must increase the compression force acting on the suture zone, which might induce the lithosphere splitting of SCB. Thus, the lower crust and lithospheric mantle on thesouth margin of the NCB can wedge into the north margin of the lithosphere of the SCB along the Dabie-Sulu collisionzone. This process caused the overthrust of the mid-upper continental crust with exhumed ultrahigh pressure meta-morphic (UHPM) rocks and underthrust of the deep litho-sphere of the SCB. It could be an important mechanism re-sponsible for the second rapid cooling and uplifting of theUHPM rocks and lithospheric delamination as well as thecorresponding magmatism in Jurassic in the Dabie orogen.The southward movement of subsurface suture in theDabie-Sulu orogen may also provide a tectonic setting indepth for the large-scale Mesozoic magmatic-metallogenesis along the middle-lower reaches of the Yangtse River in east-ern China. | LI Shuguang & YANG Wei School of Earth and Space Sciences, University of Science and Tech-nology of China, Hefei 230026, China | 2003 | Chinese Science Bulletin2003，48，8： | 37 |
| 4 | Construction, expression and characterization of the engineered antibody against tumor surface antigen, p185^(c-erbB-2)显示文摘The c-erbB-2 proto-oncogene encodes a 185kDa protein p185, which belongs to epidermal growth factorreceptor family. Amplification of this gene has been shown to correlate with poor clinical prognosis forcertain cancer patients. The monoclonal antibody A21 which directed against p185 specifically inhibitsproliferation of tumor cells overexpressing p185, hence allows it to be a candidate for targeted therapy. Inorder to overcome several drawbacks of murine MAb, we cloned its VH and VL genes and constructed thesingle-chain Fv (scFv) through a peptide linker. The recombinant scFvA21 was expressed in Escherichiacoli and purified by the affinity column. Subsequently it was characterized by ELISA, Western blot, cellimmunohistochemistry and FACS. All these assays showed the binding activity to extracellular domain(ECD) of p185. Based on those properties of scFvA21, we further constructed the scFv-Fc fusion moleculewith a homodimer form and the recombinant product was expressed in mammalian cells. In a series ofsubsequent analysis this fusion protein showed identical antigen binding site and activity with the parentantibody. These anti-p185 engineered antibodies have promised to be further modified as a tumor targetingdrugs, with a view of application in the diagnosis and treatment of human breast cancer. | LIAN SHENG CHENG, AI PING LIU, JIA HONG YANG, YAN QIU DONG, LIANG WEI LI, JING WANG, CHAO CHEN WANG, JING LIUSchool of Life Science, University of Science and Technology of China, Hefei 230027, China | 2003 | Cell Research2003，13，1： | 24 |
| 5 | A promising new class of irradiation tolerant materials:Ti_2ZrHfV_(0.5)Mo_(0.2) high-entropy alloy显示文摘Recently, high-entropy alloys(HEAs) or multi-principal-element alloys with unprecedented physical,chemical, and mechanical properties, have been considered as candidate materials used in advanced reactors due to their promising irradiation resistant behavior. Here, we report a new single-phase bodycentered cubic(BCC) structured Ti_2 ZrHfV_(0.5)Mo_(0.2) HEA possessing excellent irradiation resistance, i.e.,scarcely irradiation hardening and abnormal lattice constant reduction after helium-ion irradiation,which is completely different from conventional alloys. This is the first time to report the abnormal XRD phenomenon of metallic alloys and almost no hardening after irradiation. These excellent properties make it to be a potential candidate material used as core components in next-generation nuclear reactors. The particular irradiation tolerance derives from high density lattice vacancies/defects. | Yiping Lu Hefei Huang Xuzhou Gao Cuilan Ren Jie Gao Huanzhi Zhang Shijian Zheng Qianqian Jin Yonghao Zhao Chenyang Lu Tongmin Wang Tingju Li | 2019 | Journal of Materials Science & Technology2019，35，3： | 23 |
| 6 | Timing and geochemical characters of the Sanchazi magmatic arc in Mianlüe tectonic zone,South Qinling显示文摘The Sanchazi mafic-ultramafic complex in Mianlüe tectonic zone,South Qinling can be subdivided into two blocks,I.e.Sanchazi paleo-magmatic arc and Zhuangkegou paleo-oceanic crust fragment (ophiolite).The Sanchazi paleo-magmatic arc is mainly composed of ande-site,basaltic and basalt-andesitic gabbro(or diorite),andesitic dyke,plagiogranite and minor ul-tramafric rocks,which have typical geochemical features of island arc volcanic rocks,such as high field strength element(e.g.Nb,Ti)depletions and lower Cr,Ni contents.The Light rare earth element (LREE) and K enrichments of these rocks and zircon xenocrystals of 900 Ma from plagiogranite suggest that this magmatic arc was developed on the South active continental margin of the South Qinling micro-continent.The U-Pb age of (300±61) Ma for zircons from plagiogranite in-dicates that the Mianlüe paleo-oceanic crust was probably subducted underneath the South Qinling micro-continent in Carboniferous.This is consistent with the formation time (309Ma) of the Huwan eclogite originating form oceanic subduction in Dabie Mountains,suggesting that the Mianlüe paleo-ocean probably extended eastward to the Dabie Mountains in Carboniferous.The high-Mg adakitic rocks in Sanchazi paleo-magmatic arc suggest thet the subducted oceanic crust was relatively young (<25Ma) and hot. | LI Shuguang1, HOU Zhenhui1, YANG Yongcheng2, SUN Weidong1,1), ZHANG Guowei3, & LI Qiuli1 1. School of Earth and Space Sciences,University of Science and Technology of China ,Hefei 230026,China 2. Regional Geological Survey Team of Shaanxi Province,Xianyang 712000, China 3. Department of Geology, Northwest University,Xi抋n 710069, China | 2004 | Science China Earth Sciences2004，47，4： | 16 |
| 7 | Cellular automata pedestrian movement model considering human behavior显示文摘The pedestrian movement is more complex than vehicular flow for the reason that people are more flexible and intelligent than car. Without the limit of 搇anes?pedestrian movement is loose and free. Furthermore, they are easily affected by other walkers as well as the environ-ment around. In this paper some special technique is intro-duced considering human behavior to make the rules more reasonable. By simulating the two-dimension pedestrian movement, the phase transition phenomena of pedestrian movement, including the up walkers moving from the bottom to the upper boundary and the right walkers moving from the left to the right boundary, are presented. Studying on the effect of the system size on the critical density shows that the critical density is independent of the system size in the scope studied in this paper. | YANG Lizhong, FANG Weifeng, LI Jian, HUANG Rui & FAN Weicheng State Key Laboratory of Fire Science, University of Science and Tech-nology of China, Hefei 230026, China Correspondence should be addressed to Yang Lizhong (e-mail:zxd@ustc. edu.cn) | 2003 | Chinese Science Bulletin2003，48，16： | 16 |
| 8 | A reconstruction method of porous media integrating soft data with hard data显示文摘The three-dimensional reconstruction of porous media is of great significance to the research of mechanisms of fluid flow. The real three-dimensional structural data of porous media are helpful to describe the irregular topologic structures in porous media. The reconstruction of porous media will be inaccurate while only hard data or no conditional data are available. Reconstructed results can be more accurate, using soft data during reconstruction. Integrating soft data with hard data, a method based on multiple-point geostatistics (MPS) is proposed to reconstruct three-dimensional structures of porous media. The variogram curves and permeability, computed by lattice Boltzmann method (LBM), of the reconstructed images and the target image obtained from real volume data were compared, showing that the structural characteristics of reconstructed porous media using both soft data and hard data as conditional data are most similar to those of real volume data. | LU DeTang1,2,3, ZHANG Ting1,2,3, YANG JiaQing1,2,3, LI DaoLun1,2,3 & KONG XiangYan1,2,3 1 Department of Modern Mechanics, University of Science and Technology of China, Hefei 230027, China 2 Research Center of Oil and Natural Gas, University of Science and Technology of China, Hefei 230027, China 3 Key Laboratory of Software in Computing and Communication of Anhui Province, University of Science and Technology of China, Hefei 230027, China | 2009 | Chinese Science Bulletin2009，54，11： | 16 |
| 9 | The April 14th, 2010 Yushu earthquake, a devastating earthquake with foreshocks显示文摘In the early morning of April 14th, 2010, a strong earth- quake (Ms7.1, http://gffzz49cbc139c294479ahoc59b6bov9f9690b.ffgz.tsg.suse.edu.cn; Mw6.9, http://neic. usgs.gov) occurred in Yushu district, Qinghai Province, China. More than 2000 lives were lost and over 100000 injured, | NI SiDao1, WANG WeiTao2 & LI Li3 1 School of Earth and Space Sciences, University of Science and Technology of China, Hefei 230026, China 2 Institute of Geophysics, China Earthquake Administration, Beijing 100081, China 3 National Earthquake Infrastructure Service, China Earthquake Administration, Beijing 100036, China | 2010 | Science China Earth Sciences2010，53，6： | 15 |
| 10 | Progress in research and application of water mist fire suppression technology显示文摘Water mist technology in fire suppression has been a subject of many investigations over the last decade. This paper introduces the concept of water mist technology and discusses its extinguishment mechanisms in comparison with other fire suppression systems briefly. A survey is made on the recent applications of water mist for (1) Class B spray and pool fires in machinery spaces, gas turbine enclosures, combat vehicles, and flammable liquid storage rooms; (2) Class A fires in residential occupancies, marine accommoda-tions and public spaces, heritage buildings and libraries; (3) Class C fires in electronic equipment and computer rooms; and (4) the fires in aircraft onboard cabin and cargo com-partments. The paper proceeds to review some new applica-tions of water mist for the Class K fires in commercial cook rooms. Use of water mist for total-ship protection as well as the fire protection of heavy goods vehicle shuttle trains is also investigated. At last, the up-to-date development of corresponding test to evaluate the capabilities and limitaions of water mist is discussed. | LIU Jianghong, LIAO Guangxuan, LI Peide, FAN Weicheng & LU Qiang State Key Laboratory of fire Science, University of Science and Tech-nology of China, Hefei 230026, China Correspondence should be addressed to Liu Jianghong (e-mail: ljh@ ustc.edu.cn) | 2003 | Chinese Science Bulletin2003，48，8： | 15 |
| 11 | PREPARATION OF ULTRAFINE METAL PARTICLES BY COMBINED METHOD γ-RAY RADIATION—HYDROTHERMAL CRYSTALLIZATION显示文摘The γ-ray radiation technique combined with hydrothermal crystallization was firstlyused to prepare ultrafine metallic particles of An,Cu and Au-Cu alloy.Particle sizefor Au in average is about 10 nm.The morphologies were observed by TEM.Thenucleation mechanism of metal particles and their stability are discussed. | CHEN Zuyao CHEN Bo QIAN Yitai ZHANG Manwei YANG Li FAN Chenggao University of Science and Technology of China,Hefei,China | 1992 | Acta Metallurgica Sinica(English Letters)1992，5，11： | 13 |
| 12 | Sorption of Eu(Ⅲ) on GMZ bentonite in the absence/presence of humic acid studied by batch and XAFS techniques显示文摘Bentonite has been extensively studied because of its strong sorption ability and low permeability.In this work,the Na-bentonite from Gaomiaozi County (China) has been characterized by XRD,FTIR and acid-base titration.The sorption of Eu(III) on Na-bentonite in the absence/presence of humic acid (HA) was studied at T = 25 ± 2 °C and in 0.01 mol/L NaClO4 solution.The effects of pH,HA,contact time and initial Eu(III) concentrations were also investigated.The results indicate that the sorption of Eu(III) on Na-bentonite was dependent on pH values.The presence of HA had little effect on Eu(III) sorption at low pH values,but decreased Eu(III) sorption at high pH values.X-ray absorption fine structure spectroscopy (XAFS) was applied to characterize the local structural environment of the adsorbed Eu(III) on bare Na-bentonite and HA-bentonite hybrids.The re- sults indicate that Eu(III) was bound to O atoms at a distance of about 2.39 at pH 4.15.The results are crucial for the evalua- tion of the sorption and migration of other trivalent lanthanides and actinides in bentonite as backfill materials. | HU Jun1,2,XIE Zhi3,HE Bo3,SHENG GuoDong1,CHEN ChangLun1,LI JiaXing1,CHEN YiXue2 & WANG XiangKe1 1Key Laboratory of Novel Thin Film Solar Cells Institute of Plasma Physics,Chinese Academy of Sciences,Hefei 230031,China 2School of Nuclear Science and Engineering,North China Electric Power University,Beijing 102206,China 3National Synchrotron Radiation Laboratory,University of Science & Technology of China,Hefei 230029,China | 2010 | Science China Chemistry2010，53，6： | 12 |
| 13 | 2-Cocycles of original deformative Schrdinger-Virasoro algebras显示文摘Both original and twisted Schrdinger-Virasoro algebras, and also their deformations were introduced and investigated in a series of papers by Henkel, Roger and Unterberger. In the present paper we aim at determining the 2-cocycles of original deformative Schrdinger-Virasoro algebras. | LI JunBo1, 2 , SU YuCai3 & ZHU LinSheng21 Department of Mathematics, Shanghai Jiao Tong University, Shanghai, 200240, China 2 Department of Mathematics, Changshu Institute of Technology, Changshu 215500, China 3 Department of Mathematics, University of Science and Technology of China, Hefei 230026, China | 2008 | Science China Mathematics2008，51，11： | 12 |
| 14 | Improving thermoelectric properties of p-type Bi_2Te_3-based alloys by spark plasma sintering | Di LI,Rui-rui SUN,Xiao-ying QIN Key Laboratory of Materials Physics,Institute of Solid State Physics,Chinese Academy of Sciences, Hefei 230031,China | 2011 | Progress in Natural Science:Materials International2011，21，4： | 10 |
| 15 | Research on the reconstruction method of porous media using multiple-point geostatistics显示文摘The pore structural characteristics have been the key to the studies on the mechanisms of fluids flow in porous media. With the development of experimental technology, the modern high-resolution equipments are capable of capturing pore structure images with a resolution of microns. But so far only 3D volume data of millimeter-scale rock samples can be obtained losslessly. It is necessary to explore the way of virtually reconstructing larger volume digital samples of porous media with the representative structural characteristics of the pore space. This paper proposes a reconstruction method of porous media using the structural characteristics captured by the data templates of multiple-point geostatistics. In this method, the probability of each structural characteristic of a pore space is acquired first, and then these characteristics are reproduced according to the probabilities to present the real structural characteristics in the reconstructed images. Our experimental results have shown that: (i) the deviation of LBM computed permeability respectively on the virtually reconstructed sandstone and the original sample is less than 1.2%; (ii) the reconstructed sandstone and the original sample have similar structural characteristics demonstrated by the variogram curves. | ZHANG Ting 1,2,3, LI DaoLun 1,2 , LU DeTang 1,2 & YANG JiaQing 1,2 1 Department of Modern Mechanics, University of Science and Technology of China, Hefei 230027, China 2 Research Center of Oil and Natural Gas, University of Science and Technology of China, Hefei 230027, China 3 The 28th Research Institute, China Electronics Technology Group Corporation, Nanjing, 210007, China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，1： | 10 |
| 16 | Sm-Nd and zircon SHRIMP U-Pb dating of Huilanshan mafic granulite in the Dabie Mountains and its zircon trace element geochemistry显示文摘The mafic granulites from Huilanshan are outcropped on the center of the Luotian dome in the northern Dabie Mountains. The Sm-Nd isochron defined by granulite-facies meta-morphic minerals (garnet + clinopyroxene + hypersthene) yields an age of 136 ± 18 Ma indicating the early Cretaceous granulite-facies metamorphism. The cathodoluminescence (CL) images of zircons from the granulite show clearly core-mantle-rim structures. The zircon cores are charac-terized by typical oscillatory zoning and highly HREE enriched patterns, which suggests their magma origin. Some zircon cores among them with little Pb loss give SHRIMP U-Pb ages rang-ing from 753 to 780 Ma, which suggests that the protolith of Huilanshan granulite is Neopro-terozoic mafic rocks. The zircon mantles usually cut across the oscillatory zone of the zircon cores have 3―10 times lower REE, Th, U, Y, Nb and Ta contents than the igneous zircon cores but have high common Pb contents. These characteristics suggest that they were formed by hydrothermal alteration of the igneous zircons. The part of zircon mantles with little Pb loss give a similar SHRIMP U-Pb age (716―780 Ma) to the igneous zircon cores, which implies that the hydrothermal events occurred closely to the magmatic emplacement. In view of the strong early Cretaceous magmatism in the Luotian dome, consequently, the Huilanshan mafic granulite was formed by heating of the Neoproterozoic mafic rocks in mid-low crust, which caused the granu-lite-facies metamorphism underneath the Dabie Mountains. The similarity between the granulite metamorphic age (136 ± 18 Ma) defined by Sm-Nd isochron and K-Ar age of 123―127 Ma given by amphible from the gneiss in Luotian dome suggests a rapid uplifting of the Luotian dome, which may result in further exhumation of the ultrahigh pressure metamorphic rocks in the Dabie Mountains. | HOU Zhenhui1, LI Shuguang1, CHEN Nengsong2, LI Qiuli1 & LIU Xiaoming3 1. School of Earth and Space Sciences, University of Science and Technology of China, Hefei 230026, China 2. The Key Laboratory of Continental Dynamics of the Ministry of Education, Northwest University, Xi’an 710069, China 3. Faculty of Earth Sciences, China University of Geosciences, Wuhan 430074, China | 2005 | Science China Earth Sciences2005，48，12： | 10 |
| 17 | Mesozoic-Cenozoic tectonic transition in Kuqa Depression-Tianshan,Northwest China:Evidence from sandstone detrital and geochemical records显示文摘Similar to compositional evolution of sandstone modes and detrital heavy minerals from different profiles in the Kuqa Depression, Northwest China, major element analysis of whole sandstones from the same profiles shows four discontinuous depositional interfaces or periods, respectively corresponding to Lower Triassic\Middle Triassic, Upper Jurassic\Lower Cretaceous, Lower Cretaceous\Paleogene and Miocene\Pliocene, and indicates five-phase evolution during Mesozoic-Cenozoic: (1) From the first to fifth phase, a depositional suite changes from maroon and coarse clastic, through grey-dark grey and fine, red and coarse, red-mottled, interlayered by gypsum, to brown and coarse clastic assemblages, accompanying detrital component evolution in unstable-stable-unstable-very unstable-very unstable assem- blages. It is indicated that carbonate and complex detritus gradually dominate in sandstones in post-Late Jurassic, with rapid reduction of compositional maturity. (2) For major element geo- chemical parameters of whole sandstones, CaO and Fe2 O * 3+MgO contents show a change sequence in high-low-high-higher-highest values, with rapid increasing in post-Late Jurassic. (3) Contra some aggregative indicators for weathering indexes of sandstone detrital component, Al2O3/(CaO+Na2O) and ln(Q/(L+CE)), show a change sequence in low-high-low-lower-lowest ratios, with rapid decreasing in post-Late Jurassic. It is found that sandstone samples of the first, second and later three phases may be distinguished from the A-CN-K and A-CNK-FM diagrams respectively. Therefore, in the Kuqa Depression-Tianshan, the most important discontinuous depositional interface recording paleotectonic and paleoclimatic transition occurred in Early Triassic\Middle Triassic and Late Jurassic\Early Cretaceous, respectively, and, however, tec- tonic differentiations of basin-range system finally result in distinct depositional systems but similar detrital weathering indexes across the Lower Cretaceous\Paleogene and Miocene\ Plio- cene interfaces, respectively. | LI Zhong1, GUO Hong2, WANG Daoxuan3 & LIN Wei1 1. Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, China 2. Tarim Oilfield Branch, CNPC, Korla 841000, China 3. Hefei University of Industry, Tunxilu 193, Hefei 230009, China | 2005 | Science China Earth Sciences2005，48，9： | 9 |
| 18 | Blocking effects of siRNA on VEGF expression in human colorectal cancer cells显示文摘AIM:To investigate the expression of vascular endothelial cell growth factor (VEGF) and its receptors Fmslike tyrosine kinase 1 (FLT-1) and fetal liver kinase 1 (FLK-1) in colorectal carcinoma (CRC),and the blocking effects of small interfering RNAs (siRNAs) on VEGF expression in human colorectal cancer HCT116 cells.METHODS:Immunohistochemical staining for VEGF,FLT-1 and FLK-1 proteins was performed in 82 cases of CRC and 14 normal colorectal mucosae.A siRNA targeting VEGF was synthesized and transfected into HCT116 cells using lipofectamine 2000.Immunocytochemical staining and Western blotting analyses were performed to detect the expression of VEGF protein.The suppressive effect of the siRNA on cell proliferation was detected using the 3-(4,5-dimethylthiazol-2-yl)2,5-diphenyltertrazolium bromide (MTT) assay.Cellular apoptosis was detected using flow cytometry (FCM).RESULTS:The expression of VEGF,FLT-1 and FLK-1 in tumor tissues was significantly higher than that in normal tissues (P=0.008,P=0.000,P=0.000).The expression of VEGF was positively correlated with both lymph node metastasis and clinical stage (P=0.009 and P=0.025,respectively).Immunocytochemistry showed that the expression of VEGF was weakly positive and Western blotting indicated a significant reduction in VEGF-siRNA cell protein levels.VEGF-siRNA cell growth inhibition was assessed by the MTT assay,and the tumor cell proliferation rate was significantly different at 24,48,and 72 h after transfection.FCM results showed that the VEGF-siRNA group had an apparent aneuploid peak.CONCLUSION:VEGF,FLT-1 and FLK-1 are associated with colorectal carcinogenesis.siRNA silencing of the VEGF gene suppresses proliferation,and induces apoptosis in HCT116 cells.The results suggest that VEGF may be a new gene therapy target for colorectal cancer. | Yu Yin,Li-Yu Cao,Wen-Qing Wu,Hao Li,Yan Jiang,Hong-Fu Zhang,Department of Pathology,Anhui Medical University,Hefei 230032,Anhui Province,China Wen-Qing Wu,Department of Pathology,Anhui Provincial Hospital,Hefei 230001,Anhui Province,China | 2010 | World Journal of Gastroenterology2010，16，9： | 9 |
| 19 | Hybrid of comprehensive learning particle swarm optimization and SQP algorithm for large scale economic load dispatch optimization of power system显示文摘Economic load dispatch (ELD) is an important optimization task in power systems. In the previous works, various researchers attempted to address this problem by both mathmatical and heuristic optimization algorithms. However, there are still two practically important issues that have not attracted sufficient attention: 1) the stability of these algorithms cannot be effectively ensured; 2) the performance of these algorithms on large scale ELD optimization tasks remains to be unsatisfactory. CLPSO is an effective global optimization algorithm. To strengthen the convergence ability of CLPSO, the sequential quadratic programming (SQP) is introduced into it. This results in a new algorithm hybrid of comprehensive learning particle swarm optimization and sequential quadratic programming (SQP-CLPSO). To assess the performance of SQP-CLPSO, it is compared with several state-of-the-art evolutionary algorithms (EAs) on the classical ELD optimization problems. Experimental results show that SQP-CLPSO has very good abilities of convergence, diversity maintainence and scalability, which make it suitable for complex ELD problems. | WANG Yu , LI Bin & YUAN Bo Department of Electronic Science and Technology, School of Information Science and Technology, University of Science and Technology of China, Hefei 230027, China | 2010 | Science China(Information Sciences)2010，53，8： | 9 |
| 20 | Paleotemperature changes over the past 3000 years in eastern Beijing, China: A reconstraction based on Mg/Sr records in a stalagmite显示文摘The Mg/Sr ratio in a stalagmite, which is di-rectly proportional to DMg/Ca, the solid-liquid distribution coefficient of Mg, is proposed as a geochemical thermometer to estimate paleotemperature changes. The paleotempera-ture change in eastern Beijing over the past 3000 years has been reconstructed by using this thermometer in the stalag-mite ZFFS-1 from Jingdong Cave. The records can be di-vided into two periods: 3000—2000 aBP, cool and wet, the air temperature averaging 9.8℃; and 2000 aBP—present, hot and dry, the air temperature being 1℃ higher than the mean value (11.7℃) of the past 3000 years. During 500—200 aBP, the air temperature was about 1.2℃ lower than that of the present, corresponding to the Little Ice Age in Europe. Like d 18O and d 13C, Mg/Sr (or DMg/Ca) reflects an obviously warming trend of the past 200 years. These results are sup-ported by historic records. | MA Zhibang1, LI Hongchun2, XIA Ming1, KU Tehlung2, PENG Zicheng3, CHEN Yushu4 & ZHANG Zhaofeng3 1. Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, China 2. Department of Earth Sciences, University of Southern California, Los Angeles, CA90089-0740, USA 3. Department of Earth and Space Science, University of Science and Technology of China, Hefei 230026, China 4. Beijing Foshan Tourist Service Centre, Beijing 101201, China | 2003 | Chinese Science Bulletin2003，48，4： | 8 |
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