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| 1 | Evaluation of protective effect of cactus pear seed oil(Opuntia ficusincida L. MILL.) against alloxan-induced diabetes in mice显示文摘Objective: To evaluate the in vitro antioxidant power of cactus pear seed oil [Opuntia ficusincida L. MILL.(CPSO)] and its protective effect against chemically induced diabetes mellitus in mice. Methods: The in vitro antioxidant effect of CPSO was evaluated using 2,2-diphenyl-1-picrylhydrazyl(DPPH) scavenging assay. The preventive effect was conducted on Swiss albino mice treated with CPSO(2 m L/kg, per os), before and after a single intraperitoneal alloxan administration(100 mg/kg). Survival rate, body weight and fasting blood glucose were measured and histopathological analysis of pancreas was performed to evaluate alloxaninduced tissue injuries. Results: CPSO exhibited an antioxidant effect in DPPH scavenging assay. Moreover, the administration of CPSO(2 m L/kg) significantly attenuated alloxaninduced death and hyperglycemia(P<0.001) in treated mice. Morphometric study of pancreas revealed that CPSO significantly protected islets of langerhans against alloxan induced-tissue alterations. Conclusions: Based on theses results, CPSO can prevent alloxan-induced-diabetes by quenching free radicals produced by alloxan and inhibiting tissue injuries in pancreatic β-cells. | Berraaouan Ali Ziyyat Abderrahim Mekhfi Hassane Legssyer Abdelkhaleq Aziz Mohammed Bnouham Mohamed | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，7： | 6 |
| 2 | Gastric precancerous lesions are associated with gene variants in Helicobacter pylori -susceptible ethnic Malays显示文摘AIM: To identify genes associated with gastric pre-cancerous lesions in Helicobacter pylori (H. pylori )susceptible ethnic Malays. METHODS: Twenty-three Malay subjects with H. pylori infection and gastric precancerous lesions identified during endoscopy were included as 'cases'. Thirtyseven Malay subjects who were H. pylori negative and had no precancerous lesions were included as 'controls'. Venous blood was collected for genotyping with Affymetrix 50K Xba1 kit. Genotypes with call rates < 90% for autosomal single nucleotide polymorphisms (SNPs) were excluded. For each precancerous lesion, associated SNPs were identified from Manhattan plots, and only SNPs with a χ2 P value < 0.05 and Hardy Weinberg Equilibrium P value > 0.5 was considered as significant markers. RESULTS: Of the 23 H. pylori -positive subjects recruited, one sample was excluded from further analysis due to a low genotyping call rate. Of the 22 H. pylori positive samples, atrophic gastritis only was present in 50.0%, complete intestinal metaplasia was present in 18.25%, both incomplete intestinal metaplasia and dysplasia was present in 22.7%, and dysplasia only was present in 9.1%. SNPs rs9315542 (UFM1 gene), rs6878265 (THBS4 gene), rs1042194 (CYP2C19 gene) and rs10505799 (MGST1 gene) were significantly associated with atrophic gastritis, complete intestinal metaplasia, incomplete metaplasia with foci of dysplasia and dysplasia, respectively. Allele frequencies in 'cases' vs 'controls' for rs9315542, rs6878265, rs1042194 and rs10505799 were 0.4 vs 0.06, 0.6 vs 0.01, 0.6 vs 0.01 and 0.5 vs 0.02, respectively. CONCLUSION: Genetic variants possibly related to gastric precancerous lesions in ethnic Malays susceptible to H. pylori infection were identified for testing in subsequent trials. | Sathiya Maran Yeong Yeh Lee Shuhua Xu Nur-Shafawati Rajab Norhazrini Hasan Syed Hassan Syed Abdul Aziz Noorizan Abdul Majid Bin Alwi Zilfalil | 2013 | World Journal of Gastroenterology2013，19，23： | 5 |
| 3 | Effect of Establishment Methods and Weed Management Practices on Some Growth Attributes of Rice显示文摘Studies were carried out for two years to evaluate the effect of methods of sowing and weed control practices on the productivity of transplanted and direct wet-seeded rice in Dera Ismail Khan, NWFP, Pakistan. The experiment was laid out in a randomized complete block design with a split plot arrangement. The planting techniques viz. transplanting and direct seeding were maintained in main plots while weed control practices included the use of granular herbicide Sunstar 15WG (ethoxy sulfuron), Machete 60EC (butachlor), conventional hand weeding, and the weedy check (control) were assigned to the sub-plots. Data were recorded on weed parameters like weed density and dry weed biomass 60 and 90 days after sowing (DAS); agronomic parameters including plant population, number of panicles and paddy yield and physiological parameters like leaf area index and net assimilation rate 45 and 90 DAS. The planting methods and weed management significantly influenced most of the parameters studied. The data revealed that the paddy yield and its components were significantly higher in the transplanted method than that in direct-seeded method, while the weed density and biomass were lower in the transplanted plots than the direct-seeded plots. Among weed management tools, the maximum paddy yield was obtained in hand weeding, closely followed by herbicide application Machete 60EC during both cropping seasons. | Mohammad Safdar BALOCH Inayat Ullah AWAN Gul HASSAN Abdul Aziz KHAKWANI | 2006 | Rice science2006，13，2： | 2 |
| 4 | Insecticide susceptibility of the dengue vector Aedes aegypti (Diptera: culicidae) in Makkah City, Saudi Arabia显示文摘 | Al Thbiani Aziz Hamady Dieng Ahmad Abu Hassan Tomomitsu Satho Fumio Miake Md Rawi Che Salmah Sazaly AbuBakar | 2011 | Asian Pacific Journal of Tropical Disease2011，，2： | 2 |
| 5 | Earthquake induced pounding between adjacent buildings considering soil-structure interaction显示文摘Many closely located adjacent buildings have suffered from pounding during past earthquakes because they vibrated out of phase.Furthermore,buildings are usually constructed on soil;hence,there are interactions between the buildings and the underlying soil that should also be considered.This paper examines both the interaction between adjacent buildings due to pounding and the interaction between the buildings through the soil as they affect the buildings' seismic responses.The developed model consists of adjacent shear buildings resting on a discrete soil model and a linear viscoelastic contact force model that connects the buildings during pounding.The seismic responses of adjacent buildings due to ground accelerations are obtained for two conditions:fixed-based(FB) and structure-soil-structure interaction(SSSI).The results indicate that pounding worsens the buildings' condition because their seismic responses are amplified after pounding.Moreover,the underlying soil negatively impacts the buildings' seismic responses during pounding because the ratio of their seismic response under SSSI conditions with pounding to those without pounding is greater than that of the FB condition. | Sadegh Naserkhaki Farah N.A.Abdul Aziz Hassan Pourmohammad | 2012 | Earthquake Engineering and Engineering Vibration2012，11，3： | 2 |
| 6 | Computed Tomography(CT) Imaging of Inju- ries from Blunt Abdominal Trauma: A Pictorial Essay 显示文摘 | Hassan R Abd Aziz A | 2010 | Malays J Med Sci2010，17，2： | 1 |
| 7 | Heparin-induced thrombocytopenia and recent advances in its therapy显示文摘 | Hassan Y Awaisu A Aziz NA | | 0，，06： | 1 |
| 8 | Intraoperative OCT of bilateral macular coloboma in a child with down syndrome显示文摘 | Hassan A Aziz MD Marco Ruggeri | 2011 | J Pediatr 0phthalml Strabismus2011，48，： | 1 |
| 9 | Hepatoprotective effect of Opuntia dillenii seed oil on CCl_4 induced acute liver damage in rat显示文摘Objective:To investigate the hepatoprotective effect of Opuntia dillenii seed oil(ODSO)on CCl_4 provoked liver injury in rat.Methods:Animals were treated orally with ODSO at a concentration of 2 mL/kg,once daily for one week before the first intraperitoneal injection of CCl_4,and thereafter the administration of the oil was continued for 7 days until the introduction of the second injection of CCl_4.Fourteen hours after the last dose of CCl_4,rats were sacrificed,and the relative liver weight,weight gain,alkaline phosphatase,aspartate amino transferase,alanine aminotransferase,direct bilirubin,total bilirubin,triglycerides,total cholesterol,very low density lipoprotein,low density lipoprotein,high density lipoprotein,plasmatic glucose,urea,creatinine,acid uric and malondialdehyde were determined.Results:The significant increase was found in relative liver weight and plasma levels of alanine aminotransferase,aspartate amino transferase,alkaline phosphatase,total bilirubin,direct bilirubin,triglycerides,very low-density lipoprotein,urea,uric acid and malondialdehyde.Likewise,the significant decrease was indicated in the weight gain and the level of glucose plasmatic,and high-density lipoprotein levels in CCl_4 produced liver injury in rats were re-established to normal levels when treated with ODSO.While,no change was observed in the total cholesterol,low-density lipoprotein and creatinine in all animals.Conclusions:We conclude that the ODSO has a protective effect on CCl_4-mediated liver injury.Hence,we suggest its inclusion as a preventive control of liver disorders. | Mohamed Bouhrim Hayat Ouassou Mohamed Choukri Hassane Mekhfi Abderrahim Ziyyat Abdelkhaleq Legssyer Mohammed Aziz Mohamed Bnouham | 2018 | Asian Pacific Journal of Tropical Biomedicine2018，8，5： | 1 |
| 10 | An analysis of clinical pharmcist interventions in an intensive care unit显示文摘 | Hassan Y Aziz NA Awang J | 1992 | J Clin Pharm Ther1992，17，6： | 1 |
| 11 | Comprehension of antibiotic instructions in an outpatient Malaysian practice显示文摘 | Hassan Y Abd Aziz N Sarriff A | 1994 | Hosp Pharm1994，29，1： | 1 |
| 12 | The complexity of achie ving anticoagulation control in the face of warfarin-phenytoin in teraction: an Asian case report显示文摘 | Hassan Y Awaisu A Aziz NA | 2005 | Pharm World Sci2005，27，1： | 1 |
| 13 | The Effects of Urbanization towards social and culturalchanges among Malaysian Settlers in the Federal Land DevelopmentSchemes (FELDA),Johor Darul Takzim 显示文摘 | Noreen Noor Abd Aziz Wan Haslin Aziah Wan Hassan NurAdilah Saud | 2012 | Procedia -Social andBehavioral Sciences2012，68，： | 1 |
| 14 | Carotid artery occlusion for the treatment of symptomatic giant carotid aneurysms: a proposal of classification and surgical protocol 显示文摘 | Rashad S Hassan T Aziz W | 2014 | Neurosurg Rev2014，37，3： | 1 |
| 15 | Does the duration of smok- ing cessation have an impact on hospital admission and health-related quality of life amongst COPD patients 显示文摘 | Hassan HA Aziz NA Hassan Y | 2014 | Int J Chron Obstruct Pulmon Dis2014，14，9： | 1 |
| 16 | Retrocaval ure- ter: the importance of intravenous urography显示文摘 | HASSAN R AZIZ A A MOHAMED S K | 2011 | The Malay sian Journal of Medical Sciences2011，18，4： | 1 |
| 17 | The Effects of Urbanization towards Social and Cultural Changes among Malaysian Settlers in the Federal Land Development Schemes (FELDA), Johor Darul Takzim显示文摘 | Noreen Noor Abd Aziz Wan Haslin Aziah Wan Hassan Nur Adilah Saud | 2012 | Procedia - Social and Behavioral Sciences2012，，： | 1 |
| 18 | Impact of a renal drug dosing service on dose adjustment in hospitalized patients with chronic kidney disease 显示文摘 | HASSAN Y AL-RAMAHI R J AZIZ N A | 2009 | Ann Pharmacother2009，43，10： | 1 |
| 19 | Intraoperative OCT of Bilateral Macular Coloboma in a Child With Down Syndrome显示文摘 | Aziz Hassan A. Ruggeri Marco Berrocal Audina M | 2011 | Journal of Pediatric Ophthalmology and Strabismus2011，，： | 1 |
| 20 | Prevalence of factor V Leiden mutation and other hereditary thrombophilic factors in Egyptian children with portal vein thrombosis: results of a single-center case-control study显示文摘 | Hanaa El-Karaksy Nehal El-Koofy Manal El-Hawary Azza Mostafa Mona Aziz Mortada El-Shabrawi Nabil A. Mohsen Magd Kotb Mona El-Raziky Marwa Abu El-Sonoon Hassan A-Kader | 2004 | Annals of Hematology2004，，11： | 1 |
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