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| 1 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 2 | Carbon nitride: Ab initio investigation of carbon-rich phases 显示文摘 | HART J N CLEAYSSENS F ALLAN N L | 2009 | Phys Rev B2009，80，17： | 1 |
| 3 | Guaranteed Cost Control of Affine Nonlinear Systems via Partition of Unity Method 显示文摘 | Hart D F Shi L | 2013 | Automatica2013，49，2： | 1 |
| 4 | Stroke in the people's republic of China显示文摘 | Shi F L Hart RG Shemam DG | 1989 | Stroke1989，20，11： | 1 |
| 5 | Phosphorus Runoff From Agricultural Land and Direct Fertilizer Effects:A Review 显示文摘 | HART M R QUIN B F NGUYEN M L | 2004 | Jour- nal of Environmental Quality2004，33，6： | 1 |
| 6 | A somatic cell hybrid with a single human chromosome 22 corrects the defect in the CHO mutant (Ade- I )lacking adenylosuccinase activity 显示文摘 | Van Keuren M L Hart I M Kao F T | 1987 | Cytogenet Cell Genet1987，44，： | 1 |
| 7 | The mediating role of distributive,procedural,and interactional justice on the relationship between downsizing and organizational citizenship behavior显示文摘 | Hart A L Thomson N F Huning T M | 2016 | Journal of Organizational Culture Communications&Conflict2016，20，： | 1 |
| 8 | Phosphorus runoff from agricultural land and direct fertilizer effects:a review显示文摘 | HART M R QUIN B F NGUYEN M L | 2004 | Journal of Environmental Quality2004，33，： | 1 |
| 9 | Elevated endotoxin levels in non-alcoholic fatty liver disease显示文摘 | Harte A L Silva N F D Creely S J | 2010 | J Inflamm2010，7，： | 1 |
| 10 | Phosphorus runoff from agricultural land and direct fertilizer effects:A review显示文摘 | Hart M R Quin B F Nguyen M L | 2004 | Environment Quality2004，33，6： | 1 |
| 11 | Development of mental health first aid guidelines for Aboriginal and Tortes Strait Islander people experiencing problems with substance use: a Delphi study显示文摘 | HART L M BOURCHIER S J JORM A F | 2010 | BMC Psychiatry2010，10，： | 1 |
| 12 | Queen execution and caste conflict in the stingless bee Melipona beecheii 显示文摘 | WENSELEERS T HART A G RATNIEKS F L W | 2004 | Ethology2004，110，： | 1 |
| 13 | Fatigue显示文摘 | Hart L Freel M Milde F | 1990 | Nurs Clin N Am1990，25，4： | 1 |
| 14 | Chemical and strontium isotope characterization of rainwater in Beijing,China 显示文摘 | Xu Z F Hart G L | 2009 | Atmospheric Environment2009，43，： | 1 |
| 15 | Affective issues in library and information science systems work: A content analysis显示文摘 | Julien H McKechnie L E F Hart S | 2005 | Library & Information Science Research2005，，27： | 1 |
| 16 | The human intesti- nal cytochrome P450 'pie'显示文摘 | Paine M F Hart H L Ludington S S | 2006 | Drug Metab Dispos2006，34，5： | 1 |
| 17 | Immune cell functional assay inmoni- toting of adult liver trans plantati on recipients with infection 显示文摘 | Xue F Zhang J Hart L | 2010 | Transplantation2010，89，5： | 1 |
| 18 | Visfatin is regulated by rosiglitazone in type 2 diabetes mellitus and influenced by NFKB and JNK in human abdominal subcutaneous adipocytes 显示文摘 | MCGEE K C HARTE A L DA SILVA N F | 2011 | PLoS One2011，6，20： | 1 |
| 19 | A pilot study on a step-feeding anoxie/oxic activated sludge system 显示文摘 | Wang S P Yu L F Hart G H | 2006 | Water Science and Technology2006，53，9： | 1 |
| 20 | Low-fat set yogurt made from milk subjected to combinations of high hydrostatic pressure and thermal processing显示文摘 | Harte F Luedecke L Swanson B | 2003 | Journal of Dairy Science2003，86，4： | 1 |
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