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| 1 | Machine learning models compared to existing criteria for noninvasive prediction of endoscopic retrograde cholangiopancreatography-confirmed choledocholithiasis显示文摘Background and aims:Noninvasive predictors of choledocholithiasis have generally exhibited marginal performance characteristics.We aimed to identify noninvasive independent predictors of endoscopic retrograde cholangiopancreatography(ERCP)-confirmed choledocholithiasis and accordingly developed predictive machine learning models(MLMs).Methods:Clinical data of consecutive patients undergoing first-ever ERCP for suspected chol-edocholithiasis from 2015 to 2019 were abstracted from a prospectively-maintained database.Multiple logistic regression was used to identify predictors of ERCP-confirmed choledocholithiasis.MLMs were then trained to predict ERCP-confirmed choledocholithiasis using pre-ERCP ultrasound(US)imaging only as well as using all available noninvasive imaging(US,computed tomography,and/or magnetic reso-nance cholangiopancreatography).The diagnostic performance of American Society for Gastrointestinal Endoscopy(ASGE)“high-likelihood”criteria was compared to MLMs.Results:We identified 270 patients(mean age 46 years,62.2%female,73.7%Hispanic/Latino,59%with noninvasive imaging positive for choledocholithiasis)with native papilla who underwent ERCP for suspected choledocholithiasis,of whom 230(85.2%)were found to have ERCP-confirmed chol-edocholithiasis.Logistic regression identified choledocholithiasis on noninvasive imaging(odds ratio(OR)¼3.045,P¼0.004)and common bile duct(CBD)diameter on noninvasive imaging(OR¼1.157,P¼0.011)as predictors of ERCP-confirmed choledocholithiasis.Among the various MLMs trained,the random forest-based MLM performed best;sensitivity was 61.4%and 77.3%and specificity was 100%and 75.0%,using US-only and using all available imaging,respectively.ASGE high-likelihood criteria demonstrated sensitivity of 90.9%and specificity of 25.0%;using cut-points achieving this specificity,MLMs achieved sensitivity up to 97.7%.Conclusions:MLMs using age,sex,race/ethnicity,presence of diabetes,fever,body mass index(BMI),total bilirubin,maximum CBD diameter,and choledocholithiasis on pre-ERCP noninvasive imaging predict ERCP-confirmed choledocholithiasis with good sensitivity and specificity and outperform the ASGE criteria for patients with suspected choledocholithiasis. | Camellia Dalai John M Azizian Harry Trieu Anand Rajan Formosa C Chen Tien Dong Simon W Beaven James H.Tabibian | 2021 | Liver Research2021，5，4： | 3 |
| 2 | 腹腔镜、开腹和机器人手术切除直肠癌的肿瘤学和围手术期结果:一项多中心、倾向评分加权队列研究显示文摘目的:尽管进行了多个随机对照试验,但微创和传统开腹直肠癌手术的短期和长期结果仍不清楚。本研究的目的是比较腹腔镜、开腹和机器人直肠癌切除术的成功率和术后结果。方法:这是一项使用倾向评分加权的多中心、准实验队列研究。数据源于2016年'美国外科医生学院国家外科手术质量改善计划(NSQIP)'中所有年龄在18~89岁的接受开腹、腹腔镜或机器人直肠癌切除术的成年患者。主要结果是代表肿瘤切除术成功的复合指标,包括远端切缘阴性、环周切缘阴性、至少评估12枚淋巴结。次要结果是全身和手术部位的并发症,以及再入院、再手术、手术时间和住院时间。 | 孙凌宇 KETHMAN W C HARRIS A H S MORRIS A M | 2020 | 结直肠肛门外科2020，26，1： | 2 |
| 3 | A comparison of several vector quantization codebook generation approaches显示文摘 | Huang C M Harris R W | 1993 | IEEE Transactions on Image Processing1993，2，1： | 1 |
| 4 | In vitro techniques for the assessment of neurotoxicity 显示文摘 | Harry GJ Billingsley M Bruinink A Campbell IL Classen W Dorman DC | 1998 | Environ Health Perspect1998，106，1： | 1 |
| 5 | Osthole stimulates osteoblast differentiation and bone formation by activation of beta-catenin-BMP signaling显示文摘 | Tang DZ Hou W Zhou Q Zhang M Holz J Sheu TJ Li TF Cheng SD Shi Q Harris SE Chen D Wang YJ | 2010 | J Bone Miner Res2010，25，6： | 1 |
| 6 | Bmi1 transgene induces lymphomas and collaborates with myc in tumorigenesis显示文摘 | Haupt Y Bath M L Harris A W | 1993 | Oncogene1993，8，11： | 1 |
| 7 | Physical properties of near Earth asteroids from thermal infrared observations and thermal modeling显示文摘 | Delbo M Harris A W | 2002 | Meteoritics & Planetary Science2002，37，12： | 1 |
| 8 | Phosphate-induced metal immobilization in a contaminated site 显示文摘 | CAO R X MA L Q CHEN M SINGH S P HARRIS W G | 2003 | Environmental Pollution2003，122，： | 1 |
| 9 | Bmi1 transgene induces lymphomas and collaborates with myc in tumorigenesis显示文摘 | Haupt Y Bath M L Harris A W | 1993 | Oncogene1993，8，11： | 1 |
| 10 | Directed evolution of ionizing radiation resistance in Escherichia coli 显示文摘 | Harris D R Pollock S V Wood E A Goiffon R J Klingele A J Cabot E L Schackwitz W Martin J Eggington J Durfee T J Middle C M Norton J E Popelars M C Li H Klugman S A Hamilton L L Bane L B Pennacchio L A Albert T J Perna N T Cox M M Battista J R | 2009 | Journal of Bacteriology2009，191，16： | 1 |
| 11 | A biomarker panel for peripheral arterial disease显示文摘 | Fung E T Wilson A M Zhang F Harris N Edwards K A Olin J W | 2008 | Vasc Med2008，13，： | 1 |
| 12 | Psy-chometrically equivalent Russian speech audiometrymaterials by male and female talkers显示文摘 | HARRIS R W NISSEN S L POLA M G | 2007 | Int J Audiol2007，46，： | 1 |
| 13 | Direct in- fusion of a variant of insulin - like growth factor - I into the skin of sheep and effects on local blood flow, amino acid utilization and cell reolication显示文摘 | HARRIS P M MCBRIDE B W GURNSEY M P | 1993 | J Endocrinol1993，139，3： | 1 |
| 14 | Synthesis and characterization of imide oligomers end-capped with 4- ( phenylethynyl ) phthalic anhydrides 显示文摘 | JOHNSTONE J A LI F M HARRIS F W | 1994 | Polymer1994，35，22： | 1 |
| 15 | Ratoon stunting disease of sugarcane: isolation of the causal bacterium显示文摘 | Davis M J Gillaspie A G Harris R W | 1980 | Science1980，210，4476： | 1 |
| 16 | Bmi1 transgene induces lymphomas and collaborates with myc in tumorigenesis显示文摘 | Haupt Y Bath M L Harris A W | 1993 | Oncogene1993，8，11： | 1 |
| 17 | Genome, transcriptome, and secretome analysis of wood decay fungus Postia placenta supports unique mechanisms of lignocellulose conversion 显示文摘 | Martinez D Challacombe J Morgenstern 1 Hibbett D Schmoll M Kubicek CP Ferreira P Ruiz-Duenas FJ Martinez AT Kersten P Hammel KE Wymelenberg AV Gaskell J Lindquist E Sabat G BonDurant SS Larrondo LF Canessa P Vicuna R Yadav J Doddapaneni H Subramanian V Pisabarro AG Lavin JL Oguiza JA Master E Henrissat B Coutinho PM Harris P Magnuson JK Baker SE Bruno K Kenealy W Hoegger PJ Kties U Ramaiya P kucas S Salamov A Shapiro H Tu H Chee CL Misra M Xie G Teter S Yaver D James T Mokrejs M Pospisek M Grigoriev IV Brettin T Rokhsar D Berka R Cullen D | 2009 | PNAS2009，106，6： | 1 |
| 18 | Metabolic syndrome and its components as predictors of incident type 2 diabetes mellitus in an Aboriginal community显示文摘 | Ley Sylvia H Harris Stewart B Mamakeesick Mary Noon Tina Fiddler Edith Gittelsohn Joel Wolever Thomas M S Connelly Philip W Hegele Robert A Zinman Bernard Hanley Anthony J G | 2009 | Canadian Medical Association. Journal2009，，6： | 1 |
| 19 | New route to smart core-shell polymeric microgels: Synthesis and properties显示文摘 | Lenung M F Zhu J Harris F W | 2004 | Macromol Rapid Commun2004，25，： | 1 |
| 20 | PVT after splenectomy显示文摘 | Harris W Marcaccio M | 2006 | Can J Surg2006，49，2： | 1 |
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