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| 1 | Cementomimetics——constructing a cementum-like biomineralized microlayer via amelogenin-derived peptides显示文摘Cementum is the outer-,mineralized-tissue covering the tooth root and an essential part of the system of periodontal tissue that anchors the tooth to the bone. Periodontal disease results from the destructive behavior of the host elicited by an infectious biofilm adhering to the tooth root and left untreated,may lead to tooth loss. We describe a novel protocol for identifying peptide sequences from native proteins with the potential to repair damaged dental tissues by controlling hydroxyapatite biomineralization. Using amelogenin as a case study and a bioinformatics scoring matrix,we identified regions within amelogenin that are shared with a set of hydroxyapatite-binding peptides (HABPs) previously selected by phage display. One 22-amino acid long peptide regions referred to as amelogenin-derived peptide 5 (ADP5) was shown to facilitate cell-free formation of a cementum-like hydroxyapatite mineral layer on demineralized human root dentin that,in turn,supported attachment of periodontal ligament cells in vitro. Our findings have several implications in peptide-assisted mineral formation that mimic biomineralization. By further elaborating the mechanism for protein control over the biomineral formed,we afford new insights into the evolution of protein-mineral interactions. By exploiting small peptide domains of native proteins,our understanding of structure-function relationships of biomineralizing proteins can be extended and these peptides can be utilized to engineer mineral formation. Finally,the cementomimetic layer formed by ADP5 has the potential clinical application to repair diseased root surfaces so as to promote the regeneration of periodontal tissues and thereby reduce the morbidity associated with tooth loss. | Mustafa Gungormus Ersin E Oren Jeremy A Horst Hanson Fong Marketa Hnilova Martha J Somerman Malcolm L Snead Ram Samudrala Candan Tamerler Mehmet Sarikaya | 2012 | International Journal of Oral Science2012，4，2： | 5 |
| 2 | A comparison of the relative efficiency of ICSI and extended culture with epididymal sperm versus testicular sperm in patients with obstructive azoospermia显示文摘This is a retrospective cohort study comparing blastocyst transfer outcomes following intracytoplasmic sperm injection utilizing epididymal versus testicular sperm for men with obstructive azoospermia.All cases at a single center between 2012 and 2016 were included.Operative approach was selected at the surgeon’s discretion and included microepididymal sperm aspiration or testicular sperm extraction.Blastocyst culture was exclusively utilized prior to transfer.The primary outcome was live birth rate.Secondary outcomes included fertilization rate,blastulation rate,euploidy rate,and implantation rate.A mixed effects model was performed.Seventy-six microepididymal sperm aspiration cases and 93 testicular sperm extraction cases were analyzed.The live birth rate was equivalent(48.6%vs 50.5%,P=0.77).However,on mixed effects model,epididymal sperm resulted in a greater likelihood of fertilization(adjusted OR:1.37,95%CI:1.05–1.81,P=0.02)and produced a higher blastulation rate(adjusted OR:1.41,95%CI:1.1–1.85,P=0.01).As a result,the epididymal sperm group had more supernumerary blastocysts available(4.3 vs 3,P<0.05).The euploidy rate was no different.Pregnancy rates were no different through the first transfer cycle.However,intracytoplasmic sperm injection following microepididymal sperm aspiration resulted in a greater number of usable blastocysts per patient.Thus,the true benefit of epididymal sperm may only be demonstrated via a comparison of cumulative pregnancy rates after multiple transfers from one cohort. | Scott J Morin Brent M Hanson Caroline R Juneau Shelby A Neal Jessica N Landis Richard T Scott Jr James M Hotaling | 2020 | Asian Journal of Andrology2020，22，2： | 2 |
| 3 | Is the Occurrence of Avian Influenza Virus in Charadriiformes Species and Location Dependent显示文摘 | B A Hanson M P Luttrell V H Goekjian | 2008 | Journal of Wildlife Diseases2008，44，2： | 1 |
| 4 | On sufficiency of the Kuhn Tucker condition 显示文摘 | | 1981 | J Math Anal Appl1981，80，： | 1 |
| 5 | Focal adhesion kinase: in command and control of cell motility 显示文摘 | Mitra S K Hanson D A Schlaepfer D D | 2005 | Nat Rev Mol Cell Biol2005，6，1： | 1 |
| 6 | Generalized parallel- perspective stereo mosaics from airborne video 显示文摘 | Zhu Z G Hanson A R Riseman E M | 2004 | IEEE Transactions on Pattern Analysis and Machine Intelligence2004，26，2： | 1 |
| 7 | Cavity flame-holders for ignition and flame stabilization in seramjets: An Overview 显示文摘 | Ben-Yakar A Hanson R K | 2001 | JPP2001，14，4： | 1 |
| 8 | Prokayotic osmoregulation:Genetics and physiology 显示文摘 | Csonka L N Hanson A D | 1991 | Annu Rev Microbiol1991，45，： | 1 |
| 9 | Nanostructured Oxides in Chemistry显示文摘 | Fernandez G M Martinez A A Hanson J C | 2004 | Chem Rev2004，104，： | 1 |
| 10 | Isolation and purifica- tion of immunoglobulins from chicken egs using thiophilic interaction chromatography 显示文摘 | HANSEN P SCOBLE J A HANSON B | 1998 | J Immunol Met1998，215，12： | 1 |
| 11 | Fluorometric assay for bacterial primase 显示文摘 | Koepsell S A Hanson S Hinrichs S H | 2005 | Analytical Biochemistry2005，339，2： | 1 |
| 12 | Concentration Economics in the Food Industry显示文摘 | Renshaw T A Sapakie S F Hanson M C | | 0，，05： | 1 |
| 13 | A contextual postprocess- ing system for error correction using binary n-grams显示文摘 | Rieseman E M Hanson A R | 1974 | IEEE Transactions on Computers1974，23，： | 1 |
| 14 | Synergistic Activity of Recombinant Human Endostatin in Combination with Adriamycin: Analysis of in Vitro Activity on Endothelial Cells and in Vivo Tumor Progression in an Orthotopic Murine Mammary Carcinoma Model 显示文摘 | Plum S M Hanson A D Volker K M el al | 2003 | Clin Cancer Res2003，9，12： | 1 |
| 15 | Relative humidity around apple fruit influences its accumulation of calcium显示文摘 | Cline J A Hanson E J | 1992 | J Amer Soc Hort Sci1992，117，： | 1 |
| 16 | Active Metal Brazing of Zirconia显示文摘 | W B Hanson K I Ironside J A Fernie | 2000 | Acta Materialia2000，48，： | 1 |
| 17 | Current trcnds in Rwanda's HIV/AIDS epidemic显示文摘 | Kayirangwa E Hanson J Mlmyakazi L Kabeja A | 2006 | Sex Transm Infect2006，82，1： | 1 |
| 18 | Spillovers, Foreign In- vestment and Export Behaviour 显示文摘 | Aitken B G Hanson A Harrison | 1997 | Journal of International Economics1997，43，12： | 1 |
| 19 | Influence of Pavement Surface Type on Tire/Pavement Generated Noise 显示文摘 | Bennert T Hanson D Maher A | 2005 | Journal of Testing and Evaluation2005，33，2： | 1 |
| 20 | Standardization of a fluconazole bioassay and correlation of results with those obtained by high-pressure liquid chromatography显示文摘 | REX J H HANSON L H AMANTEA M A | 1991 | Antimicrob Agents Chemother1991，35，： | 1 |
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