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| 1 | Effect of nutritional counselling on hepatic,muscle and adipose tissue fat content and distribution in non-alcoholic fatty liver disease显示文摘AIM: To assess the effectiveness of the current UK clinical practice in reducing hepatic fat (IHCL). METHODS: Whole body MRI and 1H MRS were obtained, before and after 6 mo nutritional counselling, from liver, soleus and tibialis muscles in 10 subjects with non-alcoholic fatty liver disease (NAFLD). RESULTS: A 500 Kcal-restricted diet resulted in an average weight loss of 4% (-3.4 kg,) accompanied by significant reductions in most adipose tissue (AT) depots, including subcutaneous (-9.9%), abdominal subcutaneous (-10.2%) and intra-abdominal-AT (-11.4%). Intramyocellular lipids (IMCL) were significantly reduced in the tibialis muscle (-28.2%). Decreases in both IHCL (-39.9%) and soleus IMCL (-12.2%) content were also observed, although these were not significant. Several individuals showed dramatic decreases in IHCL, while others paradoxically showed increases in IHCL content. Changes in body composition were accompanied by improvements in certain liver function tests: serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Significant correlations were found between decreases in IHCL and reductions in both intra-abdominal and abdominal subcutaneous AT. Improvements in liver function tests were associated with reductions in intra-abdominal AT, but not with changes in IHCL. CONCLUSION: This study shows that even a very modest reduction in body weight achieved through lifestyle modification can result in changes in body fat depots and improvements in LFTs. | E Louise Thomas Audrey E Brynes Gavin Hamilton Nayna Patel Adam Spong Robert D Goldin Gary Frost Jimmy D Bell Simon D Taylor-Robinson | 2006 | World Journal of Gastroenterology2006，12，36： | 13 |
| 2 | Structure and function of epididymal protein cysteine-rich secretory protein-1显示文摘充满半胱氨酸的能分泌的 protein-1 (CRISP-1 ) 是 theepididymal 上皮分泌的糖蛋白。它是二个保存领域和一套 16 保存半胱氨酸残余描绘的蛋白质的一个大家庭的一个成员。在哺乳动物, CRISP-1 禁止精子鸡蛋熔化和罐头压制精子 capacitation。未知的哺乳动物的 CRISPproteins 遗体的行动的分子的机制,而是某些非哺乳动物的松脆的蛋白质能堵住离子隧道。在 ther 在, CRISP-1 包括叫作蛋白质 D 和 E 的二种形式。在我们的实验室的最近的工作证明 CRISP-1 的 D 形式与精子表面短暂地联系,而 Eform 紧绑。当精子被洗时,在所有 D 形式分裂了以后, CRISP-1 的 E 形式在精子表面上坚持。Cross-linking 研究为 D 和 E 表明 differentprotein 蛋白质相互作用模式,尽管为任何一个蛋白质的有约束力的搭挡还都没被识别。集体度谱的分析在不是 D 形式上的现在的 E 形式上揭示了潜在的 post-translationalmodification。这是蛋白质 D 和 E 之间的唯一的可辨别的差别,并且大概为在老鼠 CRISP-1 的这二种形式的行为的差别负责。这些研究证明更丰富的 D 形式短暂地与精子交往,可能与精子上的特定的受体出现,与 压制capacitation 功能一致在在附睾的精子运输和存储期间,并且也证实一紧绑能在女繁殖的道行动的 E 形式的人口。 | Kenneth P. Roberts Daniel S. Johnston Michael A. Nolan Joseph L. Wooters Nicole C. Waxmonsky Laura B. Piehl Kathy M. Ensrud-Bowlin David W. Hamilton | 2007 | Asian Journal of Andrology2007，9，4： | 4 |
| 3 | Shear Strength of Beams with Corrugated Webs显示文摘 | Mohamed Elgaaly Robert W. Hamilton Anand Seshadri | 1996 | Journal of Structural Engineering1996，，4： | 3 |
| 4 | 儿童房室结折返性心动过速患者经冷冻消融和射频消融的结果比较显示文摘目的 比较经导管冷冻消融和射频消融治疗儿童房室结折返性心动过速(AVNRT)的临床效果。方法 73例年龄在18岁以下,诊断为AVNRT的患者入选本研究,根据治疗方法分为冷冻消融组(冷冻组)和射频消融组(射频组),记录并分析比较两组的临床特点、冷冻标测次数、消融次数、X线曝光时间、消融术总时间、成功率、并发症发生率以及复发率。结果 共73例患者入选,冷冻组33例,男性16例,女性17例,平均年龄(12.4±2.8)岁;射频组40例,男性18例,女性22例,平均年龄(13.6±2.2)岁。冷冻组和射频组的消融次数分别为(2.7±1.7)次和(11±6.3)次(P〈0.001),X线曝光时间分别为(20±7)min和(25±9)min(P〈0.05),消融术总时间分别为(214±33)min和(164±36)min(P〈0.05),消融成功率88%(29/33)对100%(40/40)(P〈0.01),一过性房室阻滞的并发症发生率为12%对2.5%(P〈0.01)。冷冻组所有术中发生的传导阻滞均在5min内恢复。两组的复发率差异无统计学意义(6%与2.5%,P=NS)。结论 经导管冷冻消融治疗儿童AVNRT安全有效,但成功率低于射频消融,目前可作为后者的一种补充。 | 高东升 Christine Chiu-man Joel Kirsh Elizabeth Stephenson Robert Hamilton | 2007 | 中华心律失常学杂志2007，11，1： | 3 |
| 5 | The relationship of in vivo 31 P MR spectroscopy to histology in chronic hepatitis C显示文摘 | Adrian K.P. Lim Nayna Patel Gavin Hamilton Joseph V. Hajnal Robert D. Goldin Simon D. Taylor-Robinson | 2003 | Hepatology2003，，4： | 2 |
| 6 | Bending Strength of Steel Beams with Corrugated Webs显示文摘 | Mohamed Elgaaly Anand Seshadri Robert W. Hamilton | 1997 | Journal of Structural Engineering1997，，6： | 2 |
| 7 | Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial显示文摘 | Faramarz Ismail-Beigi Timothy Craven Mary Ann Banerji Jan Basile Jorge Calles Robert M Cohen Robert Cuddihy William C Cushman Saul Genuth Richard H Grimm Bruce P Hamilton Byron Hoogwerf Diane Karl Lois Katz Armand Krikorian Patrick O'Connor Rodica Pop-Bus | 2010 | The Lancet2010，，9739： | 2 |
| 8 | QT hysteresis in long-QT syndrome children with exercise testing显示文摘背景先天的长 QT 症候群(LQTS ) 是导致能引起与延长改正率的 QT 间隔和多态的室的心悸亢进联系的中略和突然的死亡的反常心脏的极化的继承离子隧道混乱。在成年人的几研究证明 LQTS 病人与哪个的正常题目相比改变了 QT 改编到心率变化在 QT 圆长度阴谋形成“一个磁滞现象环”。这研究是观察在长在孩子测试的锻练期间改变 QT 症候群(LQTS ) 病人的 QT 间隔,探索这些题目根据 1993 个 LQTS 诊断标准被划分成 3 个组的 LQTS.Methods 的新诊断方法。组 1:得分了的 LQTS 组(n=17 ) 或 4 削尖显示明确的 LQTS 的 = 。组 2:中间的组(n=16 ) ,延长了 QT 间隔,但是获得了 1.5 ~ 3.5 的病人。组 3:正常控制组(n=18 ) 。所有学习人口的平均年龄是(12.3 ??????( | GAO Dong-sheng FANG Wei-yi Christine Chiu-Man Joel Kirsh Gil Gross Robert M. Hamilton | 2007 | Chinese Medical Journal2007，，3： | 2 |
| 9 | A Work Criterion for Plastic Collapse 显示文摘 | Martin Muscat Donald Mackenzie Robert Hamilton | 2005 | Internation- al Journal of Pressure Vessels and Piping2005，80，： | 1 |
| 10 | Elective groin irradiation is not indicated for patients with adenocarcinoma of the rectum extending to the anal canal显示文摘 | Noah Taylor Christopher Crane John Skibber Barry Feig Lee Ellis Jean-Nicholas Vauthey Stanley Hamilton Karen Cleary Ronelle Dubrow Thomas Brown Robert Wolff Paulo Hoff Nicholas Sanfilippo Nora Janjan | 2001 | International Journal of Radiation Oncology Biology Physics2001，，3： | 1 |
| 11 | William D, The Evolution of Cooperation显示文摘 | Axelrod Robert and Hamilton | 1981 | Science1981，139，： | 1 |
| 12 | Pilot study of mutant ras peptide-based vaccine as an adjuvant treatment in pancreatic and colorectal cancers显示文摘 | Antoun Toubaji Moujahed Achtar Maurizio Provenzano Vincent E. Herrin Robert Behrens Michael Hamilton Sarah Bernstein David Venzon Barry Gause Francesco Marincola Samir N. Khleif | 2008 | Cancer Immunology Immunotherapy2008，，9： | 1 |
| 13 | Shear Strength of Beams with Corrugated Webs显示文摘 | Robert W Hamilton Anand Seshadri | 1996 | Journal of Structural Engineering1996，122，4： | 1 |
| 14 | The association between statin medication and progression after surgery for localized renal cell carcinoma显示文摘 | Robert J. Hamilton Daniel Morilla Fernando Cabrera Michael Leapman Ling Y. Chen Melanie Bernstein A Ari Hakimi Victor E. Reuter Paul Russo | 2013 | The Journal of Urology2013，，： | 1 |
| 15 | Left Ventricular Thrombus Enhancement After Intravenous Injection of Echogenic Immunoliposomes: Studies in a New Experimental Model显示文摘 | Andrew Hamilton Shao-Ling Huang Drew Warnick Adam Stein Mark Rabbat Taruna Madhav Bonnie Kane Ashwin Nagaraj Melvin Klegerman Robert MacDonald David McPherson | 2002 | Circulation: Journal of the American Heart Association2002，，23： | 1 |
| 16 | Bending Strength of Steel Beams with Corrugated Webs显示文摘 | Mohamed Elgaaly Anand Seshadri Robert W Hamilton | 1997 | Journal of Structural Engineering1997，，6： | 1 |
| 17 | Bending Strength of Steel Beams with Corrugated Webs显示文摘 | Mohamed Elgaaly Anand Seshadri Robert W Hamilton | 1997 | Journal of Structural Engineering1997，123，6： | 1 |
| 18 | Bending strength of steel beams with corrugated webs 显示文摘 | Mohamed Elgaaly A Seshadri Robert W Hamilton | 1997 | Journal of Structural Engineering1997，123，6： | 1 |
| 19 | In Vivo Molecular Imaging of Acute and Subacute Thrombosis Using a Fibrin-Binding Magnetic Resonance Imaging Contrast Agent显示文摘 | René M. Botnar Alexandra S. Perez Sonia Witte Andrea J. Wiethoff James Laredo James Hamilton William Quist Edward C. Parsons Anand Vaidya Andrew Kolodziej John A. Barrett Philip B. Graham Robert M. Weisskoff Warren J. Manning Michael T. Johnstone | 2004 | Circulation: Journal of the American Heart Association2004，，16： | 1 |
| 20 | 儿童先天性长QT综合征患者的QT滞后现象显示文摘目的 观察儿童先天性长QT综合征(LQTS)患者进行运动试验时QT间期的变化。方法 因QT间期延长而行运动平板试验的患儿共33例入选本研究,按照1993年Schwartz等的LQTS诊断标准的计分分值分为两组:LQTS组:总计分值为4分及以上的患者17例,男13例、女4例,年龄11.6±3.7岁;可疑组:评分为1.5—3.5分的患者16例,男9例、女7例,年龄13.8±4.2岁。另选行运动试验的18例正常儿童作为对照组,男11例、女7例,年龄12.4±3.1岁。记录整个运动试验中和恢复期的心电图,观察QT间期和心率的变化,记录并计算恢复期第1,2,4,6 min QT间期与运动过程中同心率时QT间期的差值(AQT)。结果 三组患者在运动中随着心率的增加,QT间期逐渐缩短。运动恢复期,随着心率的减慢,三组的QT间期也逐渐延长,但LQTS组恢复期QT间期却显著短于运动过程中处于同心率时的QT间期。LQTS组在恢复期1,2,4min的AQT值均显著大于其它两组(P均〈0.05)。LQTS组在QT间期与心动周期的关系图上呈现明显的“QT滞后环”。结论 儿童LQTS患者运动试验恢复期与运动过程中相比,QT间期的变化明显滞后于心率的变化。 | 高东升 Robert Hamilton Christine Chiu-man | 2006 | 中国心脏起搏与心电生理杂志2006，20，1： | 1 |
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