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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | Hepatic cytochromes P450 2E1 is increased in patients with nonalocholic steatohepatitis显示文摘 | Weltman M D Farrekk G C Hall P | 1998 | Hepatology1998，27，2： | 2 |
| 3 | Standards and Intellectual Property Rights:An Economic and Legal Perspective 显示文摘 | Lea G P Hall | 2004 | Information Economics and Policy2004，16，1： | 1 |
| 4 | Role of sediment composition in tracemetal distribution in lake sediments显示文摘 | Blilali L El Rasmussen P E Hall G E M | 2002 | Applied Geochemistry2002，17，： | 1 |
| 5 | Treatment of chronic rhinosinusitis exacerbations due to methicillin-resistant Staphylococcus aureus with mupirocin irrigations显示文摘 | SOLARES C A BATRA P S HALL G S | 2006 | Am J Otolaryngol2006，27，： | 1 |
| 6 | Effect of luteinizing hormone deprivation in situ on steroidogenesis of rat Leydig cells purified by a multi step procedure 显示文摘 | Klinefelter G R Hall P F Ewing L L | 1987 | Biol Reprod1987，36，3： | 1 |
| 7 | Regeneration of adult axons in white matter tracts of the central nervous system显示文摘 | Davies S J Fitch M T Memberg S P Hall A K Raisman G Silver J | 1997 | Nature1997，390，： | 1 |
| 8 | Chemical fluxes and mass balances in a marine fish cage farm Carbon显示文摘 | HALL P O ANDERSON L G HOLBY O at al | 1990 | Mar Eco Prog Ser1990，61，： | 1 |
| 9 | Standards and intellectual property rights:An economic and legal perspective显示文摘 | Lea G Hall P | 2004 | Information Economics and Policy2004，16，： | 1 |
| 10 | Integrated processing equipment显示文摘 | Bader M E Hall R P Strasser G | 1990 | Solid State Technology1990，33，5： | 1 |
| 11 | Standards and intellectual property rights : an economic and legal perspective显示文摘 | Lea G & P Hall | 2004 | Information Economics and Policy2004，16，1： | 1 |
| 12 | Role of sediment composition in trace metal distribution in lake sediments显示文摘 | Bilali L E Rasmussen P E Hall G E M | 2002 | Applied Geochemistry2002，17，： | 1 |
| 13 | Glutathione and the response of malignant cells to chemotherapy显示文摘 | KEARNS P R HALL A G | 1998 | DDT1998，3，： | 1 |
| 14 | Integrated processing equipment显示文摘 | M E Bader R P Hall G Strasser | 1990 | Solid State Technology1990，33，5： | 1 |
| 15 | Identification the female sex pheromones of the moth,Chilo suppressaliz显示文摘 | Nesbitt B g Beevor P S Hall D R | 1975 | Journal of Insect Physiology1975，21，12： | 1 |
| 16 | The interpretation of spectral vegetation indexes显示文摘 | MYNENI R B HALL F G SELLERS P J | 1995 | Geoscience and Remote Sensing IEEE Transactions on1995，33，2： | 1 |
| 17 | Fluxes of Methane and Carbon Dioxide from a Small Productive Lake to the Atmosphere显示文摘 | CASPER P MABERLY S C HALL G H | 2000 | Biogeochemistry2000，49，： | 1 |
| 18 | The Interpretation ofSpectral Vegetation Indexes显示文摘 | Myneni R B Hall F G Sellers P J | 1995 | IEEE Transactions on Geo-science and Remote Sensing1995，33，： | 1 |
| 19 | Lime treatment of a hard water lake to reduce eutrophication显示文摘 | Murphy T P Hall K G Northcote T O | 1998 | Lake and Reservoir Management1998，4，2： | 1 |
| 20 | Changes in serum procalcitonin and C-reactive protein following antimicrobial therapy as a guide to antibiotic duration in the critically ill: a prospective evaluation显示文摘 | Venkatesh B Kennedy P Kruger P S Looke D Jones M Hall J Barruel G Ray | 2009 | Anaesthesia and Intensive Care2009，，1： | 1 |
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