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| 1 | Eosinophilic gastroenteritis:Approach to diagnosis and management显示文摘Eosinophilic gastroenteritis(EGE) is a rare and benign inflammatory disorder that predominantly affects the stomach and the small intestine.The disease is divided into three subtypes(mucosal,muscular and serosal) according to klein's classification,and its manifestations are protean,depending on the involved intestinal seg-ments and layers.Hence,accurate diagnosis of EGE poses a significant challenge to clinicians,with evidence of the following three criteria required:Suspicious clinical symptoms,histologic evidence of eosinophilic infiltration in the bowel and exclusion of other pathologies with similar findings.In this review,we designed and applied an algorithm to clarify the steps to follow for diagnosis of EGE in clinical practice.The management of EGE represents another area of debate.Prednisone remains the mainstay of treatment;however the disease is recognized as a chronic disorder and one that most frequently follows a relapsing course that requires maintenance therapy.Since prolonged steroid treatment carries of risk of serious adverse effects,other options with better safety profiles have been proposed;these include budesonide,dietary restrictions and steroid-sparing agents,such as leukotriene inhibitors,azathioprine,anti-histamines and mast-cell stabilizers.Single cases or small case series have been reported in the literature for all of these options,and we provide in this review a summary of these various therapeutic modalities,placing them within the context of our novel algorithm for EGE management according to disease severity upon presentation. | Antoine Abou Rached Weam El Hajj | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，4： | 24 |
| 2 | A randomized controlled trial of imipramine in patients with irritable bowel syndrome显示文摘AIM: To study the efficacy of low-dose imipramine in relieving symptoms associated with the irritable bowel syndrome (IBS). METHODS: A randomized, double-blind trial of 25 mg imipramine vs matched placebo for 12 wk was performed. Doubling the dose was allowed once at week 2 in case of an unsatisfactory early response. Primary efficacy variables were subjective global symptom relief and quality of life (QoL) using SF-36 at week 12. RESULTS: One hundred and seven patients were enrolled by advertisement or referral by general practitioners and 56 (31 imipramine: 25 placebo) completed the 16-wk study. Baseline characteristics were comparable. A high overall dropout rate was noted in the imipramine and placebo arms (47.5% vs 47.9%, P > 0.05), a mean of 25.0 and 37.4 d from enrollment, respectively (P < 0.05). At the end of 12 wk, there was a significant difference in global symptom relief with imipramine over placebo (per-protocol: 80.6% vs48.0%, P = 0.01) and a trend on intent-to-treat (ITT) analysis (42.4% vs 25.0%, P = 0.06). This improvement was evident early and persisted to week 16 (P = 0.024 and 0.053 by per-protocol and ITT analyses, respectively). Mean cumulative and componentspecific SF-36 scores improved in the imipramine group only (per-protocol, P < 0.01). Drug-related adverse events leading to patient dropout were more common in the imipramine group (25.4% vs 12.5%, P > 0.05). CONCLUSION: Imipramine may be effective in the treatment of IBS patients and is associated with improved QoL. Careful patient selection, initiation of a low dose with gradual escalation and monitoring for side effects may result in an improved therapeutic response. | Heitham Abdul-Baki Ihab I El Hajj Lara ElZahabi Cecilio Azar Elie Aoun Assaad Skoury Hani Chaar Ala I Sharara | 2009 | World Journal of Gastroenterology2009，15，29： | 11 |
| 3 | Dismicrobism in inflammatory bowel disease and colorectal cancer: Changes in response of colocytes显示文摘Patients with inflammatory bowel disease(IBD)have an increased risk of 10%-15%developing colorectal cancer(CRC)that is a common disease of high economic costs in developed countries.The CRC has been increasing in recent years and its mortality rates are very high.Multiple biological and biochemical factors are responsible for the onset and progression of this pathology.Moreover,it appears absolutely necessary to investigate the environmental factors favoring the onset of CRC and the promotion of colonic health.The gut microflora,or microbiota,has an extensive diversity both quantitatively and qualitatively.In utero,the intestine of the mammalian fetus is sterile.At birth,the intestinal microbiota is acquired by ingesting maternal anal or vaginal organisms,ultimately developing into a stable community,with marked variations in microbial composition between individuals.The development of IBD is often associated with qualitative and quantitative disorders of the intestinal microbial flora(dysbiosis).The healthy human gut harbours about10 different bacterial species distributed in colony forming units which colonize the gastrointestinal tract.The intestinal microbiota plays a fundamental role in health and in the progression of diseases such as IBD and CRC.In healthy subjects,the main control of intestinal bacterial colonization occurs through gastric acidity but other factors such as endoluminal temperature,competition between different bacterial strains,peristalsis and drugs can influence the intestinal microenvironment.The microbiota exerts diverse physiological functions to include:growth inhibition of pathogenic microorganisms,synthesis of compounds useful for the trophism of colonic mucosa,regulation of intestinal lymphoid tissue and synthesis of amino acids.Furthermore,mucus seems to play an important role in protecting the intestinal mucosa and maintaining its integrity.Changes in the microbiota composition are mainly influenced by diet and age,as well as genetic factors.Increasing evidence indicates that dysbiosis favors the production of genotoxins and metabolites associated with carcinogenesis and induces dysregulation of the immune response whichpromotes and sustains inflammation in IBD leading to carcinogenesis.A disequilibrium in gut microflora composition leads to the specific activation of gut associated lymphoid tissue.The associated chronic inflammatory process associated increases the risk of developing CRC.Ulcerative colitis and Crohn’s disease are the two major IBDs characterized by an early onset and extraintestinal manifestations,such as rheumatoid arthritis.The pathogenesis of both diseases is complex and not yet fully known.However,it is widely accepted that an inappropriate immune response to microbial flora can play a pivotal role in IBD pathogenesis. | Giovanni Tomasello Pietro Tralongo Provvidenza Damiani Emanuele Sinagra Benedetto Di Trapani Marie Noelle Zeenny Inaya Hajj Hussein Abdo Jurjus Angelo Leone | 2014 | World Journal of Gastroenterology2014，20，48： | 10 |
| 4 | Celecoxib-induced cholestatic liver failure requiring orthotopic liver transplantation显示文摘Selective cyclooxygenase-2 (COX-2) inhibitors are widely used due to their efficacy and good safety profile. However, recent case reports have described varying degrees of liver injuries associated with the use of COX-2 inhibitors. We report the case of a patient who developed acute cholestatic hepatitis progressing to hepatic failure requiring liver transplantation, following a 3-d course of celecoxib for treatment of generalized muscle aches and pains. The clinical presentation, the laboratory data, as well as the liver histopathology were supportive of the putative diagnosis of drug induced liver injury. | Ihab I El Hajj Shahid M Malik Hany R Alwakeel Obaid S Shaikh Eizaburo Sasatomi Hossam M Kandil | 2009 | World Journal of Gastroenterology2009，15，31： | 4 |
| 5 | Performance enhancement of wing-based piezoaeroelastic energy harvesting through freeplay nonlinearity显示文摘We investigate experimentally how controlled freeplay nonlinearity affects harvesting energy from a wing-based piezoaeroelastic energy harvesting system. This system consisits of a rigid airfoil which is supported by a nonlinear torsional spring (freeplay) in the pitch degree of freedom and a linear flexural spring in the plunge degree of freedom. By attaching a piezoelectric material (PSI-5A4E) to the plunge degree of freedom, we can convert aeroelastic vibrations to electrical energy. The focus of this study is placed on the effects of the freeplay nonlinearity gap on the behavior of the harvester in terms of cut-in speed and level of harvested power. Although the freeplay nonlinearity may result in subcritical Hopf bifurcations (catastrophic for real aircrafts), harvesting energy at low wind speeds is beneficial for designing piezoaeroelastic systems. It is demonstrated that increasing the freeplay nonlinearity gap can decrease the cut-in speed through a subcritical instability and gives the possibility to harvest energy at low wind speeds. The results also demonstrate that an optimum value of the load resistance exists, at which the level of the harvested power is maximized. | Abdessattar Abdelkefi Muhammad R. Hajj | 2013 | Theoretical & Applied Mechanics Letters2013，3，4： | 3 |
| 6 | 结构胶和结构泡沫——改善碰撞性能的可行技术(英文)显示文摘为了新能源车的整车轻量化并保证其安全性,Henkel公司完成了两项新技术——结构泡沫和结构胶。该文测量了该组材料的物理、化学特性,以便实际应用和提高整车性能。结果表明:一种结构泡沫具有质量轻、强度和刚度高的优点,应用该种泡沫可减轻车辆自重,节省成本,在碰撞情况下提高车辆骨架对能量的吸收;另一种结构胶可提供有效连接方式,优化连接处应力分布,提高结构整体的强度和刚度,防止不同金属材料之间的电腐蚀,从而也降低生产成本。许多汽车生产商已经将该两项技术用于整车生产线上。 | Kyle Royston Martin Hornung Micheal Hajj | 2010 | 汽车安全与节能学报2010，1，4： | 2 |
| 7 | Inflammatory bowel disease in rats:Bacterial and chemical interaction显示文摘AIM: To develop a novel model of colitis in rats, using a combination of iodoacetamide and enteropathogenic E. coli (EPEC), and to elucidate the pathophysiologic processes implicated in the development of ulcerative colitis (UC). METHODS: Male Sprague-Dawley rats (n = 158) were inoculated intrarectally on a weekly basis with 4 different combinations: (a) 1% methylcellulose (MC), (b) 100 μL of 6% iodoacetamide (IA) in 1% MC, (c) 200 μL containing 4 × 108 colony factor units (CFU) of EPEC, and (d) combined treatment of (IA) followed by bacteria (B) after 2 d. Thirty days post treatment, each of the four groups was divided into two subgroups; the inoculation was stopped for one subgroup and the other subgroup continued with biweekly inoculation until the end of the experiment. Colitis was evaluated by the clinical course of the disease, the macroscopic and microscopic alterations, activity of myeloperoxidase (MPO), and by TNF-α gene expression. RESULTS: Findings indicative of UC were seen in the combined treatment (IA + B) as well as the IA conti-nued treatment groups: the animals showed slow rate of increase in body weight, diarrhea, bloody stools, high colonic ulcer score, as well as histological altera- tions characteristic of UC, with an extensive inflamma- tory reaction. During the course of the experiment, the MPO activity was consistently elevated and the TNF-α gene expression was upregulated compared to the control animals. CONCLUSION: The experimental ulcerative colitis model used in the present study resembles, to a great extent, the human disease. It is reproducible with characteristics indicative of chronicity. | Inaya Abdallah Hajj Hussein Rania Tohme Kassem Barada Mostafa Hassan Mostafa Jean-Noel Freund Rosalyn A Jurjus Walid Karam Abdo Jurjus | 2008 | World Journal of Gastroenterology2008，14，25： | 2 |
| 8 | Stem cells in normal breast development and breast cancer 显示文摘 | Dontu G Al - Hajj M Abdallah WM | 2003 | Cell Prolif2003，36，1： | 1 |
| 9 | Rapid de- termination of benzo (a) pyrene in olive oil samples with solid - phase extraction and low - pressure, wide - bore gas chromatography - mass spectrometry and fast liquid chroma- tography with fluorescence detection 显示文摘 | BOGUSZ M J EI HAJJ S A EHAIDEB Z | 2004 | J Chromatogr A2004，1026，12： | 1 |
| 10 | Prospective identification of tumorigenic breast cancer ceils 显示文摘 | A3- Hajj M Wicha MS Morrison SJ | 2003 | Proc Natl Acad Sci USA2003，100，7： | 1 |
| 11 | Early locoregional high-dose radiotherapy is associated with long-term disease control in localized primary angiocentric lymphoma of the nose and nasopharynx显示文摘 | Ribrag V Ell Hajj M Janot F | 2001 | Leukemia2001，15，7： | 1 |
| 12 | A novel approach to atmospheric profiling with a mountain based or airborne GPS receiver显示文摘 | Zuffada C Hajj G Kursinski E R | 1999 | J Geophys Res1999，104，24： | 1 |
| 13 | Decrease in and management of urolithiasis after kidney transplantation显示文摘 | Verrier C Bessede T Hajj P | 2012 | J Urol2012，187，5： | 1 |
| 14 | Methylation status of imprinted genes and repetitive elements in sperm DNA from infertile males显示文摘 | E1 Hajj N Zechner U Schneider E | 2011 | Sex Dev2011，5，2： | 1 |
| 15 | Prospectivei identification of tumorigenic breast cancer cells显示文摘 | Al Hajj M Wicha M S Benito H A | 2003 | Proc Natl Acad Sci USA2003，100，7： | 1 |
| 16 | Prospective identification of tumorigenic breast cancer cells显示文摘 | Hajj M Wicha M S Benito-Hernandez A | 2003 | Proc Natf Acad Sc USA2003，100，7： | 1 |
| 17 | Early locoregional highdose radiotherapy is associated with long-term disease control in localized primary angiocentric lymphoma of the nose and nasopharynx显示文摘 | Ribrag V Ell Hajj M Janot F | 2001 | Leukemia2001，15，7： | 1 |
| 18 | Prospective identification of tumorigenic breast cancer cells 显示文摘 | A1 - Hajj M Wicha MS Benito - Hernandez A | 2003 | Proc Natl Acad Sci USA2003，100，7： | 1 |
| 19 | Prospective identification of tumorigenic breast cancer cells 显示文摘 | Al- Hajj M Wicha MS Benito - Hemandez A | 2003 | Proc Natl Acad Sci USA2003，100，： | 1 |
| 20 | A technical description of atmospheric sounding by GPS occultation 显示文摘 | Hajj G A Kursinski E R Romans L J | 2002 | Journal of Atmospheric and Solar-Terrestrial Physics2002，64，： | 1 |
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