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| 1 | Secukinumab provided significant and sustained improvement in the signs and symptoms of ankylosing spondylitis:results from the 52-week,PhaseⅢChina-centric study,MEASURE 5显示文摘Background:Secukinumab demonstrated sustained efficacy in patients with ankylosing spondylitis(AS)through 5 years in pivotal Phase III studies.Here,we present efficacy and safety results(52-week)of secukinumab in patients with AS from the MEASURE 5 study.Methods:MEASURE 5 was a 52-week,Phase III,China-centric study.Eligible patients were randomly assigned(2:1)to receive subcutaneous secukinumab 150 mg or placebo weekly for the first five doses and then once every 4 weeks(q4w).All placebo patients switched to secukinumab 150 mg q4w starting at Week 16.Primary endpoint was Assessments of SpondyloArthritis international Society(ASAS)20 at Week 16.Randomization was stratified by region(China vs.non-China).Results:Of 458 patients(secukinumab 150 mg,N=305;placebo,N=153)randomized,327(71.4%)were from China and 131(28.6%)were not from China.Of these,97.7%and 97.4%patients completed Week 16 and 91.1%and 95.3%(placebo-secukinumab)patients completed Week 52 of treatment.The primary endpoint was met;secukinumab significantly improved ASAS20 response at Week 16 vs.placebo(58.4%vs.36.6%;P<0.0001);corresponding rate in the Chinese population was 56.0%vs.38.5%(P<0.01).All secondary efficacy endpoints significantly improved with secukinumab 150 mg in the overall population at Week 16;responses were maintained with a trend toward increased efficacy from Week 16 to 52.No new or unexpected safety signals were reported up to Week 52.Conclusions:Secukinumab 150 mg demonstrated rapid and significant improvement in signs and symptoms of AS.Secukinumab was well tolerated and the safety profile was consistent with previous reports.Efficacy and safety results were comparable between the overall and Chinese populations. | Feng Huang Fei Sun Wei-Guo Wan Li-Jun Wu Ling-Li Dong Xiao Zhang Tae-Hwan Kim Raj Sengupta Ladislav Senolt Yi Wang Hao-Min Qiu Brian Porter Sibylle Haemmerle | 2020 | Chinese Medical Journal2020，，21： | 2 |
| 2 | Long non-coding RNAs in cancer and development:where do we go from here?显示文摘 | HAEMMERLE M GUTSCHNER T | 2015 | Int J Mol Sci2015，16，1： | 1 |
| 3 | Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase显示文摘 | Haemmerle G Lass A Zimmermann R | 2006 | Science2006，312，5774： | 1 |
| 4 | Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores 显示文摘 | R Zechner P C Kienesberger G Haemmerle | 2009 | J LipidRes2009，50，1： | 1 |
| 5 | Hormone - sensitive lipase deficiency in mice causes diglyceride accumulation in adipose tissue, muscle and testis 显示文摘 | HAEMMERLE G ZIMMERMANN R HAY N M | 2002 | J Biol Chem2002，277，7： | 1 |
| 6 | Hormonesensitive lipase deficiency in mice causes diglyceride accumulation in adipose tissue,muscle,and testis显示文摘 | Haemmerle G Zimmermann R Hayn M | 2002 | J Biol Chem2002，277，： | 1 |
| 7 | Defective lipolysisand altered energy metabolism in mice lacking adipose triglyceridelipase显示文摘 | Haemmerle G Lass A Zimmermann R | 2006 | Science2006，312，5774： | 1 |
| 8 | Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome 显示文摘 | LASS A ZIMMERMANN R HAEMMERLE G | 2006 | Cell Metab2006，3，5： | 1 |
| 9 | Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase显示文摘 | Haemmerle G Lass A Zimmermann R | 2006 | Science2006，312，5774： | 1 |
| 10 | Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase显示文摘 | Zimmermann R Strauss J G Haemmerle G | 2004 | Science2004，306，： | 1 |
| 11 | Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase 显示文摘 | ZIMMERMANN R STRAUSS J G HAEMMERLE G | 2004 | Science2004，306，19： | 1 |
| 12 | Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase显示文摘 | Zimmermann R Strauss JG Haemmerle G | 2004 | Sci- ence2004，306，5700： | 1 |
| 13 | Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase 显示文摘 | Zimmermann R Strauss J G Haemmerle G | 2004 | Sci- ence2004，306，： | 1 |
| 14 | Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase显示文摘 | Zimmermann R Strauss J Haemmerle G | 2004 | Science2004，306，5700： | 1 |
| 15 | Neonatal anoxia in rats : Hippoeampal cellular and subcellular changes related to cell death and spatial memory 显示文摘 | Takada S H Dos Santos Haemmerle C A Motta-Teixeira L C | 2015 | Neuroscience2015，284，1： | 1 |
| 16 | Adipose triglyc eride lipase-mediated lipolysisof cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome显示文摘 | Lass A Zimmermann R Haemmerle G | 2006 | Cell Metabolism2006，3，5： | 1 |
| 17 | Defective lipolysis and altered energy metabolism in mice laeking adipose triglye eride lipase 显示文摘 | Haemmerle G Lass A Zimmermann R | 2006 | Science2006，312，5774： | 1 |
| 18 | Adipose triglyc- eride lipase and hormone--sensitive lipase are the major enzymes in adipose tissue triacylglycerol catabolism 显示文摘 | Schweiger M Schreiber R Haemmerle G | 2006 | J Biol Chem2006，281，52： | 1 |
| 19 | Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase 显示文摘 | HAEMMERLE G LASS A ZIMMERMANN R | 2006 | Science2006，312，： | 1 |
| 20 | Amyg-dala fMRI lateralizes temporal lobe epilepsy显示文摘 | Schacher M Haemmerle B Woermann FG | 2006 | Neuro-logy2006，66，1： | 1 |
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