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| 1 | 皮质下小血管病诊断的共识声明显示文摘血管性认知损害是用于描述一组涉及大血管和小血管的散发性和遗传性异质性疾病的诊断术语。皮质下小血管病可导致腔隙性梗死和进行性白质损害。被称为宾斯旺格病(Binswanger's disease, BD)的进行性白质损害患者构成了从单纯血管性疾病到合并神经变性病变的疾病谱。BD患者是一个相对同质性的亚组,存在缺氧缺血、腔隙性梗死和炎症,它们协同作用破坏血脑屏障和髓鞘。通过临床、脑脊液、神经心理学和影像学检查获得的多模式疾病标记物能促进该亚组患者的鉴别。本共识声明确定了一系列基于基础病理学改变的潜在生物学标记物,这将有助于诊断以及将来协作性治疗试验的患者选择。 | Gary A Rosenberg Anders Wallin Joanna M Wardlaw Hugh S Markus Joan Montaner Leslie Wolfson Costantino Iadecola Berislav V Zlokovic Anne Joutel Martin Dichgans Marco Duering Reinhold Schmidt Amos D Korczyn Lea T Grinberg Helena C Chui Vladimir Hachinski 王训师 张劼 陈涵丰 俞娅美 徐子奇 罗本燕 | 2016 | 国际脑血管病杂志2016，24，6： | 18 |
| 2 | ST2可能并非心血管事件、心力衰竭和死亡有用的预测因子显示文摘研究人员假设可溶性ST2(soluble ST2,sST2)水平可识别出心血管疾病(cardiovascular disease,CVD)风险较高的人群,应将其纳入风险预测计算指标。ST2是炎症性细胞因子白细胞介素33的受体。sST2水平增加与急性心肌梗死患者和一般人群的心力衰竭及死亡相关。方法:研究人员测定FINRISK97前瞻性研究人群队列中的8444名男性和女性(25-74岁)的高敏sST2水平,应用Cox比例风险模型评估在15年的随访中,sST2对致命性或非致命性心力衰竭、CVD(冠状动脉性心脏病和脑卒中)、糖尿病和死亡情况的预测能力。研究者获取10年绝对风险识别和重新分类的统计数据, | 赵狄 叶鹏 Hughes MF Appelbaum S Havulinna AS Jagodzinski A Zeller T2 Kee F Blankenberg S Salomaa V | 2014 | 中华高血压杂志2014，22，8： | 2 |
| 3 | Haploinsufficiency of delta- like 4 ligand results in embryonic lethality due to ma:or defects in arterial and vascular development显示文摘 | Gale N W Dominguez M G Noguera I Pan L Hughes V Va]enzuela D M | 2004 | Proc Natl Acad Sci USA2004，101，15： | 1 |
| 4 | Induction of hepatitis A virus - neutralizing antibody by a virus - specific synthetic peptide 显示文摘 | Emini E A Hughes J V Perlow D S | 1985 | J Virol1985，55，3： | 1 |
| 5 | Acomparison of baseline and induced DNA damage in human spermatozoa from fertile and infertile men, using a modified comet assay显示文摘 | Hughes C M Lewis S E McKelvey-Martin V J | 1996 | Mol Hum Reprod1996，2，： | 1 |
| 6 | Induction of hepatitis A virus-neutralizing antibody by a virus-specific synthetic peptide显示文摘 | EMINI E A HUGHES J V PERLOW D S | 1985 | J Virol1985，55，3： | 1 |
| 7 | Angiographic embolisation in pelvic fracture显示文摘 | Perez J V Hughes T M Bowers K | 1998 | Injury1998，29，3： | 1 |
| 8 | Transient neurologic deficit after acetazolamide challenge for computed tomography perfusion imaging显示文摘 | Choksi V Hughes M Selwa L | 2005 | J Comput Assist Tomogr2005，29，2： | 1 |
| 9 | Induction of hepatitis a virus-neutlalizing antibody by a virus-specific synthetic peptide 显示文摘 | EMMINI E A HUGHES J V PERLOW D S | 1985 | J Viorol1985，55，3： | 1 |
| 10 | The prognostic effect of increased resting energy expenditure prior to treatment for lung cancer显示文摘 | Daly BD Hughes V | 1999 | Lung Cancer1999，23，2： | 1 |
| 11 | Osteopontin a molecule for all seasons显示文摘 | Mazzali M Kipari T Ophascharoensuk V Wesson J A Johnson R Hughes J | 2002 | QJM2002，95，： | 1 |
| 12 | Transcriptional response of the terpenoid indole alkaloid pathway to the overexpression of ORCA3 along with jasmonic acid elicitaion of Catharanthus roseus hairy roots over time显示文摘 | Peebles C A Hughes E H Shanks J V | 2009 | Metab Eng2009，11，： | 1 |
| 13 | Litigation Risk, Intermediation, and the Underpricing of Initial Public Offerings显示文摘 | Hughes P J Anjan V T | 1992 | Review of Financial Studies1992，5，： | 1 |
| 14 | Acdducin: a physical model with implications for function in assembly of spectrin-actin complexes显示文摘 | Hughes CA Bennett V | 1995 | J Biol Chem1995，270，18： | 1 |
| 15 | Baubion Netude de 1'action chronotrope del'ATP Chezl'homme显示文摘 | Hughes Fc Jan Y Bors V | 1980 | Coer Med intern1980，19，： | 1 |
| 16 | Induction of hepatitis A virus-neutralizing antibody by a virus-specfic synthetic peptide显示文摘 | Emini E A Hughes J V Perlow D S | 1985 | J Virol1985，55，： | 1 |
| 17 | Biomass, carbon, and nutrient dynamics of secondary forests in a humid tropical region of Mexico 显示文摘 | HUGHES R F J B KAUFFMAN V J JARAMILLO | 1999 | Ecology1999，80，6： | 1 |
| 18 | A cross-sectional study of muscle strength and mass in 45-to 78-yr-old men and women显示文摘 | FRONTERA W R HUGHES V A LUTZ K J | 1991 | J Appl Physiol1991，71，2： | 1 |
| 19 | Giant lymph node hyperplnsia a diagnostic dilemma in the neck 显示文摘 | Raut V Cullen J Hughes D | 2001 | Auris Nasus Larynx2001，28，2： | 1 |
| 20 | Contour dynamics for the Euler equations in two dimensions显示文摘 | ZABUSKY N J HUGHES M H ROBERTS K V | 1979 | Journal of Computational Physics1979，30，： | 1 |
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