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| 1 | Sharing Clinical Trial Data: A Proposal from the International Committee of Medical Journal Editors显示文摘The International Committee of Medical Journal Editors (ICMJE) believes that there is an ethical obligation to responsibly share data generated by interventional clinical trials because participants have put themselves at risk.In a growing consensus,many funders around the world-foundations,government agencies,and industry-now mandate data sharing.Here,we outline ICMJE's proposed requirements to help meet this obligation.We encourage feedback on the proposed requirements.Anyone can provide feedback at www.icmje.org by April 18,2016. | Darren B Taichman Joyce Backus Christopher Baethge Howard Bauchner Peter W de Leeuw Jeffrey M Drazen John Fletcher Frank Frizelle Irish Groves Abraham Haileamlak Astrid James Christine Laine Larry Peiperl Anja Pinborg Peush Sahni Si-Nan Wu | 2016 | Chinese Medical Journal2016，，2： | 20 |
| 2 | Risk for emerging bipolar disorder, variants, and symptoms in children with attention deficit hyperactivity disorder, now grown up显示文摘AIM: To determine the prevalence of bipolar disorder(BD) and sub-threshold symptoms in children with attention deficit hyperactivity disorder(ADHD) through 14 years' follow-up, when participants were between 21-24 years old.METHODS: First, we examined rates of BD type Ⅰ?and Ⅱ diagnoses in youth participating in the NIMH-funded Multimodal Treatment Study of ADHD(MTA). We used the diagnostic interview schedule for children(DISC), administered to both parents(DISC-P) and youth(DISCY). We compared the MTA study subjects with ADHD(n = 579) to a local normative comparison group(LNCG, n = 289) at 4 different assessment points: 6, 8, 12, and 14 years of follow-ups. To evaluate the bipolar variants, we compared total symptom counts(TSC) of DSM manic and hypomanic symptoms that were generated by DISC in ADHD and LNCG subjects. Then we sub-divided the TSC into pathognomonic manic(PM) and non-specific manic(NSM) symptoms. We compared the PM and NSM in ADHD and LNCG at each assessment point and over time. We also evaluated the irritability as category A2 manic symptom in both groups and over time. Finally, we studied the irritability symptom in correlation with PM and NSM in ADHD and LNCG subjects.RESULTS: DISC-generated BD diagnosis did not differ significantly in rates between ADHD(1.89%) and LNCG 1.38%). Interestingly, no participant met BD diagnosis more than once in the 4 assessment points in 14 years. However, on the symptom level, ADHD subjects reported significantly higher mean TSC scores: ADHD 3.0; LNCG 1.7; P < 0.001. ADHD status was associated with higher mean NSM: ADHD 2.0 vs LNCG 1.1; P < 0.0001. Also, ADHD subjects had higher PM symptoms than LNCG, with PM means over all time points of 1.3 ADHD; 0.9 LNCG; P = 0.0001. Examining both NSM and PM, ADHD status associated with greater NSM than PM. However, Over 14 years, the NSM symptoms declined and changed to PM over time(df 3, 2523; F = 20.1; P < 0.0001). Finally, Irritability(BD DSM criterion-A2) rates were significantly higher in ADHD than LNCG(χ2 = 122.2, P < 0.0001), but irritability was associated more strongly with NSM than PM(df 3, 2538; F = 43.2; P < 0.0001).CONCLUSION: Individuals with ADHD do not appear to be at significantly greater risk for developing BD, but do show higher rates of BD symptoms, especially NSM. The greater linkage of irritability to NSM than to PM suggests caution when making BD diagnoses based on irritability alone as one of 2(A-level) symptoms for BD diagnosis, particularly in view of its frequent presentation with other psychopathologies. | Ahmed Z Elmaadawi Peter S Jensen L Eugene Arnold Brooke SG Molina Lily Hechtman Howard B Abikoff Stephen P Hinshaw Jeffrey H Newcorn Laurence Lee Greenhill James M Swanson Cathryn A Galanter | 2015 | World Journal of Psychiatry2015，5，4： | 3 |
| 3 | 临床试验数据共享声明国际医学期刊编辑委员会统一要求显示文摘国际医学期刊编辑委员会(ICMJE)认为,由于临床试验参与者处于研究风险之中,我们有伦理义务来负责任地共享干预性临床试验产生的原始数据。2016年1月,ICMJE发表了1项关于临床试验数据共享的提案,旨在帮助创造共享去标识个体患者数据的常态化环境。迄今,应我们的反馈要求,ICMJE收到了很多来自个人和团体的意见。 | Darren B Taichman Peush Sahni Larry Peiperl Christine Laine Astrid James Sung-Tae Hong Abraham Haileamlak Laragh Gollogly Fiona Godlee Frank A Frizelle Fernando Florenzano Jeffrey M Drazen Howard Bauchner Christopher Baethge Deutsches Arzteblatt Joyce Backus 季媛媛 | 2017 | 英国医学杂志中文版2017，20，7： | 2 |
| 4 | 临床试验数据共享声明显示文摘国际医学期刊编辑委员会(ICMJE)认为,由于临床试验参与者处于研究风险之中,我们有伦理义务来负责任地共享干预性临床试验产生的原始数据。2016年1月,ICMJE发表了一项关于临床试验数据共享的提案,旨在帮助创造共享去标识个体患者数据的常态化环境。 | Darren B Taichman Peush Sahni Anja Pinborg Larry Peiperl Christine Laine Astrid James Sung-Tae Hong Abraham Haileamlak Laragh Gollogly Fiona Godlee Frank A Frizelle Fernando Florenzano Jeffrey M Drazen Howard Bauchner Christopher Baethge Joyce Backus 季媛媛 | 2017 | 中国医院院长2017，13，16： | 2 |
| 5 | Wound healing dressings and drug delivery systems: A review显示文摘 | Joshua S B Kerr H M Howard N E S | 2008 | J Pharma- ceutical Sci2008，97，8： | 1 |
| 6 | Sand transport model of barchan dune equilibrium显示文摘 | Howard A D Morton J B Gad-el-Hak M | 1978 | Sedimentology1978，25，： | 1 |
| 7 | Prevention conference VI: Diabetes and cardiovascular disease execu- tive summary conference proceeding for healthcare profes- sionals from a special writing group of the American heart association 显示文摘 | Grundy S M Howard B Smith S Jr | 2002 | Circulation2002，105，18： | 1 |
| 8 | A context- based theory of recency and contiguity in free recall 显示文摘 | Sederberg P B Howard M W Kahana M J | 2008 | Psychological Review2008，115，4： | 1 |
| 9 | Computer simulation of the impact performance of a wire rope safety fence显示文摘 | Bateman M B Howard I C Johnson A R | | 0，，1： | 1 |
| 10 | Protein expression profiling identifies macrophage migration inhibitory factor and cyclophilin A as potential molecular targets in non-small cell lung cancer 显示文摘 | Campa M J Wang MZ Howard B | 2003 | Cancer Res2003，63，7： | 1 |
| 11 | Can Australia Afford to Build a Comprehensive, Adequate and Representative Reserve Network by 2000? 显示文摘 | YOUNG M D HOWARD B | 1996 | Search1996，27，1： | 1 |
| 12 | Structural characterization of the SARS-coronavirus spike S fusion protein core显示文摘 | TRIPET B HOWARD M W JOBLING M | 2004 | Biol Chem2004，279，20： | 1 |
| 13 | Flame synthesis of single-walled carbon nanotubes显示文摘 | Height M J Howard J B Tester J W | 2004 | Carbon2004，42，11： | 1 |
| 14 | The estimation of dehydrogenase activity in soil显示文摘 | Benefield C B Howard P J A Howard D M 1977 | 1977 | Soil Biol Biochem1977，9，： | 1 |
| 15 | Sand transport model of barchan dune equilibrium 显示文摘 | HOWARD A D MORTON J B GAD-EL-HAK M et a/ | 1978 | Sedimentology1978，25，3： | 1 |
| 16 | Fish kills linked to a toxic ambushpredator dinoflagellate:distribution and environmental conditions显示文摘 | Burkholder J M Howard B G Jr Cecil W H | 1995 | Mar Ecol Prog Set1995，124，： | 1 |
| 17 | Product compositions and formation kinetics in rapid pyrolysis of pulverized coal-implications for combustion显示文摘 | SUUBERG E M PETERS W A HOWARD J B | 1980 | Fuels1980，59，6： | 1 |
| 18 | Corn as a production system for human and animal vaccines显示文摘 | Streatfield S J Lane J R Brooks C A Barker D K Poage M L Mayor J M Lamphear B J Drees C F Jilka J M Hood E E and Howard J A | 2003 | Vaccine2003，21，： | 1 |
| 19 | Flame Synthesis of Single-walled Carbon Nanotubes显示文摘 | Height M J Howard J B Tester J W | 2004 | Carbon2004，42，11： | 1 |
| 20 | Modularization and the impact on supply relationships 显示文摘 | Howard M Squire B | 2007 | International Journal of Operations&Production Management2007，27，11： | 1 |
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