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155篇 您的检索式：作者名="HOMME M"

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	题名	作者	年代	出处	被引量
1	Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets显示文摘	Hommes D W Peppelenbosch M P van Deventer S J	2003	Gut2003，52，1：	14
2	On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials.	Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong	2005	World Journal of Gastroenterology2005，11，35：	4
3	Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets显示文摘	Hommes D Peppelenbosch M van Deventer S	2003	Gut2003，52，1：	1
4	Critical appraisal ofthe current practice in murine TNBS-induced colitis显示文摘	te VeIde A A Verstege M I Hommes D W	2006	Inflamm Bowel Dis2006，12，10：	1
5	The French Version of the Palliative Care Quiz for Nursing (PCQN-F) : Development and Evaluation显示文摘	Gisele Carroll Diane Prud'Homme Brisson Margaret M Ross	2005	Journal of Palliative Care2005，21，1：	1
6	Kinetics of hydrolysis of fructooligosaccharides in mineral buffered aqueous solutions:influence of pH and temperature显示文摘	L'HOMME C ARBELOT M PUIGSERVER A	2003	Journal of Agricultural and Food Chemistry2003，51，1：	1
7	Infliximab treatment for Crohn's disease:one -year experience in a Dutch academic hospital显示文摘	Hommes D W van de Heisteeg B H van der Spek M	2002	Inflamm Bowel Dis2002，8，：	1
8	Moleculer mechanisms of glucocorticoid action and selective glucocorticoid eceptor agonists 显示文摘	Stahn C L~wenberg M Hommes DW	2007	Mol Cell Endocrino12007，275，12：	1
9	A com- plex systems approach to constructing better models for managing financial markets and the economy 显示文摘	Doyne F Gallegati M Hommes C	2012	The European Physical Journal Special Topics2012，，1：	1
10	Packing for control of hemorrhage in major liver trauma 显示文摘	Nicol A J Hommes M Primrose R	2007	World J Surg2007，31，3：	1
11	Novel insights into mechanisms of glucecorticoid action and the development of new glucocorticoid receptor ligands显示文摘	LOWENBETG M STAHN C HOMMES DW	2008	Steroids2008，73，：	1
12	Molecular mechanisms of glucocorticoid action and selective glucocorticoid receptor agonists显示文摘	Stahn C L?wenberg M Hommes DW		0，，1：	1
13	Molecular mechanisms of glucocorticoid action and selective glucocorticoid receptor agonists显示文摘	STAHN C LOWENBERG M HOMMES DW	2007	Mol Cell Endocrinol2007，275，12：	1
14	Activation of multiple transcription factor genes by tetrahydrocannabinol in rat forebrain显示文摘	Mailleux P Verslype M Preud'homme X	1994	Neuroreport1994，5，10：	1
15	Aquaporin-1 channel function is positively regulated by protein kinase C显示文摘	Zhang W Zitron E Homme M	2007	J Biol Chem2007，282，20：	1
16	Functionalized single graphene sheets derived from splitting graphite oxide 显示文摘	Schniepp H C Li J L McAllister M J Sai H Herrera Alonso M Adamson D H Prud'Homme R K Car R Saville D A Aksay I A	2006	J Phys Chem B2006，110，17：	1
17	Novel insights into mechanisms of glucocorticoid action and the development of new glucocorticoid receptor ligands 显示文摘	Lowenberg M Stahn C Hommes DW Buttgereit F	2008	Steroids2008，73，910：	1
18	Type II monocytes modulate T cell-mediated central nervous system autoimmune disease 显示文摘	Weber M S Prod′ homme T Youssef S	2007	Nat Med2007，13，8：	1
19	Molecular mechanisms of glucocorticoid actionand selective glucocorticoid receptor agonists 显示文摘	STAHN C LOWENBERG M HOMMES DW	2007	Mol Cell Endocrinol2007，275，12：	1
20	The force exerted on a body in inviscid unsteady non-uniform rotational flow显示文摘	HUNT J C R PRUD HOMME M	1988	Fluid Mechanics1988，，197：	1

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