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| 1 | Bactericidal and anti-adhesive properties of culinary and medicinal plants against Helicobacter pylori显示文摘AIM: To investigate the bactericidal and anti-adhesive properties of 25 plants against Helicobacter pylori (H pylori).METHODS: Twenty-five plants were boiled in water to produce aqueous extracts that simulate the effect of cooking. The bactericidal activity of the extracts was assessed by a standard kill-curve with seven strains of H pylori. The anti-adhesive property was assessed by the inhibition of binding of four strains of FITC-labeled H pylori to stomach sections. RESULTS: Of all the plants tested, eight plants, including Bengal quince, nightshade, garlic, dill, black pepper, coriander, fenugreek and black tea, were found to have no bactericidal effect on any of the isolates. Columbo weed, long pepper, parsley, tarragon, nutmeg, yellow-berried nightshade, threadstem carpetweed, sage and cinnamon had bactericidal activities against H pylori, but total inhibition of growth was not achieved in this study. Among the plants that killed H pylori, turmeric was the most efficient, followed by cumin, ginger, chilli, borage, black caraway, oregano and liquorice. Moreover, extracts of turmeric; borage and parsley were able to inhibit the adhesion of H pylori strains to the stomach sections.CONCLUSION: Several plants that were tested in our study had bactericidal and/or anti-adhesive effects on H pylori. Ingestion of the plants with anti-adhesive properties could therefore provide a potent alternative therapy for H pylori infection, which overcomes the problem of resistance associated with current antibiotic treatment. | Rachel O'Mahony Huda Al-Khtheeri Deepaka Weerasekera Neluka Fernando Dino Vaira John Holton Christelle Basset | 2005 | World Journal of Gastroenterology2005，11，47： | 29 |
| 2 | Helicobacterpylori virulence factors in duodenal ulceration:A primary cause or a secondary infection causing chronicity显示文摘感染不看十二指肠的溃疡的成比例地的高流行的来自有 Helicobacter pylori (H pylori ) 的高流行的国家的报告,建议 H pylori 不能是十二指肠的溃疡的一个原发性原因的可能性。这差异可能被变化在不同人口在毒力因素的流行解释,这被提出了。这篇论文的目的是决定出版文学是否支持这可能性。相关文学与 H pylori 感染和毒力因素的高、低的流行为国家独立被考察并且分析。尽管 H pylori 的剧毒的紧张是,更经常显著地与 H pylori 感染的低流行在国家比没有疾病与十二指肠溃疡在病人介绍在人口,在在十二指肠溃疡之间的毒力因素的流行没有差别,非-在许多国家的溃疡消化不良或正常题目,在两 H pylori 感染并且毒力因素的流行高的地方。在这些国家,毒力因素的存在不是预兆的临床的结果。为了在国家解释在毒力因素和十二指肠溃疡之间的协会,在 H pylori 流行是低的的地方,仅仅二份报纸被发现那几乎别把小支持给建议的平常的模型,也就是没有他们,有毒力因素的有机体是比那些更可能的开始十二指肠溃疡。我们提供建议毒力因素是更可能的防碍以前生产的溃疡愈合的一个其他的假设。毒力因素的存在仅仅在 H pylori 的流行是低的国家与十二指肠溃疡的流行相关。有很小的证据,毒力因素开始十二指肠的溃疡,但是他们可能与溃疡的失败有关愈合。 | FrankI Tovey Michael Hobsley John Holton | 2006 | World Journal of Gastroenterology2006，12，1： | 6 |
| 3 | Actual concept of 'probiotics':Is it more functional to science or business?显示文摘It is our contention that the concept of a probiotic as a living bacterium providing unspecified health benefits is inhibiting the development and establishment of an evidence base for the growing field of pharmacobiotics.We believe this is due in part to the current regulatory framework,lack of a clear definition of a probiotic,the ease with which currently defined probiotics can be positioned in the market place,and the enormous profits earned for minimum investment in research.To avoid this,we believe the following two actions are mandatory:international guidelines by a forum of stakeholders made available to scientists and clinicians,patient organizations,and governments;public research funds made available to the scientific community for performing independent rigorous studies both at the preclinical and clinical levels. | Michele Caselli Francesca Cassol Girolamo Calò John Holton Giovanni Zuliani Antonio Gasbarrini | 2013 | World Journal of Gastroenterology2013，19，10： | 3 |
| 4 | Time: The second dimension of risk显示文摘 | Holton G | 1992 | Financial Analysts Journal1992，48，6： | 3 |
| 5 | Precise role of H pylori in duodenal ulceration显示文摘The facts that H pylori infection is commoner in duodenal ulcer (DU) patients than in the normal population, and that eradication results in most cases being cured, have led to the belief that it causes DU. However, early cases of DU are less likely than established ones to be infected. H pylori-negative cases are usually ascribed to specific associated factors such as non-steroidal anti-inflammatory drugs (NSAIDs), Crohn’s disease, and hypergastrinaemia, but even after excluding these, several H pylori-negative cases remain and are particularly common in areas of low prevalence of H pylori infection. Moreover, this incidence of H pylori negative DU is not associated with a fall in overall DU prevalence when compared with countries with a higher H pylori prevalence. In countries with a high H pylori prevalence there are regional differences in DU prevalence, but no evidence of an overall higher prevalence of DU than in countries with a low H pylori prevalence. There is no evidence that virulence factors are predictive of clinical outcome. After healing following eradication of H pylori infection DU can still recur. Medical or surgical measures to reduce acid output can lead to long-term healing despite persistence of H pylori infection. Up to half of cases of acute DU perforation are H pylori negative. These findings lead to the conclusion that H pylori infection does not itself cause DU, but leads to resistance to healing, i.e., chronicity. This conclusion is shown not to be incompatible with the universally high prevalence of DU compared with controls. | Michael Hobsley Frank I Tovey John Holton | 2006 | World Journal of Gastroenterology2006，12，40： | 2 |
| 6 | Computerized performance monitoring: A review of human resource issues显示文摘 | Reid A. Bates Elwood F. Holton | 1995 | Human Resource Management Review1995，，4： | 2 |
| 7 | A simple and efficient method for direct cloning of PCR products using ddT-tailed vectors显示文摘 | Holton TA Graham MW | 1991 | Nucleic Acids Res1991，19，5： | 2 |
| 8 | First total synthesis of Taxol 显示文摘 | HOLTON RA SOMOZA C KIM HB | 1994 | J Am Chem Soc1994，116，4： | 1 |
| 9 | Genetics and biochemistry of anthocyanin biosynthesis显示文摘 | Timothy A Holton and Edwina C | 1995 | The Plant Cell1995，，7： | 1 |
| 10 | Cloning and expression of cytochrome P450 genes controlling flower colour显示文摘 | Holton T Brugliera F Lester D R | 1993 | Nature1993，366，18： | 1 |
| 11 | Time:The Second Dimension of Risk显示文摘 | Holton G | 1992 | Financial Analysts Journal1992，48，6： | 1 |
| 12 | Lumbar spondylolisthesis among elderly men: prevalence, correlates, and progression 显示文摘 | Denard PJ Holton KF Miller J | 2010 | Spine (Phila Pa 1976)2010，35，10： | 1 |
| 13 | A simple and efficient method for direct clonging of PCR products using ddTtailed vectors显示文摘 | Holton T A Graham M W | 1990 | Nucl Acids Res1990，19，： | 1 |
| 14 | Blue roses-a pigment of our imagination显示文摘 | HOLTON T A TANAKA Y | 1994 | Trends Biotechnology1994，12，： | 1 |
| 15 | Genetics and biochemistry of anthocyanin biosynthesis 显示文摘 | HOLTON T A CORNISH E C | 1995 | Plant Cell1995，7，7： | 1 |
| 16 | Designing to learn about complex systems显示文摘 | Hmelo C.E Holton D.L Kolodner J.L | | 0，，03： | 1 |
| 17 | Horizontal transport and the dehydration of the stratosphere 显示文摘 | Holton J R Gettelman A | 2001 | Geophysical Research Letters2001，14，： | 1 |
| 18 | Sporadic and familial cerebral amyloid angiopathies显示文摘 | Revesz T Holton JL Lashley T | 2002 | Brain Pathol2002，12，3： | 1 |
| 19 | Identification and mapping of polymorphic SSR markers from expressed gene sequences of barley and wheat显示文摘 | HOLTON T A CHRISTOPHER J T MCCLURE L HARKER N HENRY R J | 2002 | Molecular Breeding2002，9，： | 1 |
| 20 | Efficient differentiation of functional hepatocytes from human embryonic stem cells 显示文摘 | Agarwal S Holton KL Lanza R | 2008 | Stem Cells2008，26，5： | 1 |
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